Osseous changes in the temporomandibular joint in rheumatoid arthritis: A cone-beam computed tomography study

Ola Mohamed Rehan,Hoda Abdel Kader Saleh,Hala Ahmed Raffat,Noha Saleh Abu-Taleb 대한영상치의학회 2018 Imaging Science in Dentistry Vol.48 No.1

Purpose: To evaluate osseous changes of temporomandibular joint (TMJ) in patients with rheumatoid arthritis (RA) using cone-beam computed tomography (CBCT) and to correlate the imaging findings with the severity of TMJ dysfunction, clinical findings, and laboratory findings. Materials and Methods: This study consisted of 28 subjects, including 14 RA patients and 14 controls, who were scheduled to undergo CBCT imaging for the diagnosis of a complaint not related to or affecting the TMJ. The Fonseca’s questionnaire was used to assess the severity of TMJ dysfunction. Rheumatoid factor (RF) and the erythrocyte sedimentation rate (ESR) were assessed in the RA patients. CBCT was then performed in all subjects and osseous TMJ abnormalities were assessed. Results: According to the Fonseca’s questionnaire, 14.3% of the patients had no TMJ dysfunction, while 50%, 21.4%, and 14.3% had mild, moderate, and severe dysfunction, respectively. RF was positive in 64.3% of patients, and the ESR level was high in 100%. Imaging findings revealed a statistically significantly higher prevalence of erosion (85.7%), flattening (89.3%), osteophyte formation (32.1%), subchondral cyst (32.1%), sclerosis (64.3%), and condylar irregularities (28.6%) in the RA patients than in the controls. No correlations were found between CBCT findings and the clinical findings, the severity of TMJ dysfunction, disease duration, or laboratory results. Conclusion: RA patients might show extensive osseous abnormalities with no/mild clinical signs or symptoms of TMJ dysfunction that necessitate TMJ imaging for these patients. CBCT is a valuable and efficient modality that can assess osseous TMJ changes in RA patients.

Free vibration analysis of nonlocal viscoelastic nanobeam with holes and elastic foundations by Navier analytical method

Ola A. Siam,Rabab A. Shanab,Mohamed A. Eltaher,Norhan A. Mohamed Techno-Press 2023 Advances in aircraft and spacecraft science Vol.10 No.3

This manuscript is dedicated to deriving the closed form solutions of free vibration of viscoelastic nanobeam embedded in an elastic medium using nonlocal differential Eringen elasticity theory that not considered before. The kinematic displacements of Euler-Bernoulli and Timoshenko theories are developed to consider the thin nanobeam structure (i.e., zero shear strain/stress) and moderated thick nanobeam (with constant shear strain/stress). To consider the internal damping viscoelastic effect of the structure, Kelvin/Voigt constitutive relation is proposed. The perforation geometry is intended by uniform symmetric squared holes arranged array with equal space. The partial differential equations of motion and boundary conditions of viscoelastic perforated nonlocal nanobeam with elastic foundation are derived by Hamilton principle. Closed form solutions of damped and natural frequencies are evaluated explicitly and verified with prestigious studies. Parametric studies are performed to signify the impact of elastic foundation parameters, viscoelastic coefficients, nanoscale, supporting boundary conditions, and perforation geometry on the dynamic behavior. The closed form solutions can be implemented in the analysis of viscoelastic NEMS/MEMS with perforations and embedded in elastic medium.

A novel new correlation measure for cubic Pythagorean fuzzy sets related to structures of $KU$-ideals on $KU$-algebras

Ola W. Abd El-Baseer,Jeong Gon Lee,Young Bae Jun,Amany M. Menshawy,Kul Hur,Samy M. Mostafa 원광대학교 기초자연과학연구소 2023 ANNALS OF FUZZY MATHEMATICS AND INFORMATICS Vol.25 No.1

In this paper, the concepts of cubic Pythagorean $KU$-ideals are introduced and several properties are investigated. Also, relations between cubic Pythagorean $KU$-ideals and cubic Pythagorean ideals are given. The pre-image of cubic Pythagorean $KU$-ideals under homomorphism of $KU$-algebras are defined and how the pre-image of cubic Pythagorean $KU$-ideals under homomorphism of $KU$-algebras become cubic Pythagorean $KU$-ideal are studied. Moreover, the Cartesian product of cubic Pythagorean $KU$-ideals in Cartesian product $KU$-algebras is given. Finally, novel new correlation coefficient between two cubic Pythagorean fuzzy sets are also studied.

Assessment of stability of early loaded nano-coated hydroxyapatite implants in posterior maxilla

Ola Abdelsamad Amin,Ingy Mohamed Shehata,Heba Mohamed Kamel,Nader Nabil Elbokle 대한치과이식임플란트학회 2024 The Korean Academy of Implant Dentistry Vol.43 No.1

Purpose: This study assessed the stability of nano-coated hydroxyapatite implants in the posterior maxilla after early loading. Materials and Methods: This study was conducted on nine patients missing at least one maxillary posterior tooth. Ten nano-coated hydroxyapatite implants were inserted in nine patients and subjected to early loading according to the secondary stability readings taken by Osstell®. The implant stability was measured at the time of implant insertion (T0), 4 (T1), 6 (T1 modified), weeks, and four months (T2) after surgery. Cone-beam computed tomography (CBCT) was performed in all patients before treatment started. Nine implants healed well, but one implant failed due to infection. Results: The secondary stability results six weeks after implant insertion were sufficient for implant loading. Significant differences were observed between T0, T1, T1 modified, and T2. Conclusions: Nano-coated hydroxyapatite implants are a good choice in the posterior maxilla because they allow early loading.

Beta-Cell Function, Self-rated Health, and Lifestyle Habits in 64-Year-Old Swedish Women with Metabolically Healthy Obesity Phenotype

Ola Hjelmgren,Anders Gummesson,Göran Bergström,Caroline Schmidt 대한비만학회 2020 The Korean journal of obesity Vol.29 No.1

Background: A subset of obese individuals do not present metabolic abnormalities that commonly define the metabolic syndrome (MetS). This is referred to as a metabolically healthy obese (MHO) phenotype. The aim of the present study was to evaluate the prevalence of the MHO phenotype and its relationship with beta cell dysfunction by measuring C-peptide and proinsulin, anthropometric-, metabolic- and lipid appearance, as well as lifestyle behaviors and self-rated health in a cohort of 64-year-old Swedish women. Methods: The National Cholesterol Education Program definition was used to assess MetS. We defined normal weight as body mass index (BMI) 18.5–24.9 kg/m2 and obesity as BMI ≥30 kg/m2 to categorize participants as metabolically healthy normal weight, MHO, and metabolically unhealthy obese. Results: The MHO phenotype represented 36.3% of obese participants and 16.3% of total participants. The MHO group were at greater risk of having proinsulin levels >11 pmol/L, indicating impaired beta cell function. Further, homeostatic model assessment for insulin resistance, fasting plasma levels of insulin, and C-peptide showed significant trends, with the MHO phenotype group having intermediate levels among three groups. Health behaviors such as leisure time physical activity and alcohol intake were also intermediate in individuals with the MHO phenotype. Conclusion: In this study, we demonstrate that over a third of the obese women in our sample were MHO. Further, women with the MHO phenotype showed intermediate profiles considering beta cell function and insulin resistance, as well as metabolic variables, and tended to rate their general health as worse than otherwise similar individuals of normal weight.

Antioxidant and Anticholinesterase Potential of Two Nigerian Bitter Yams Using a Simulated Gastrointestinal Digestion Model and Conventional Extraction

Sule Ola Salawu,Praise Blessing Ajiboye,Akintunde Afolabi Akindahunsi,Aline Augusti Boligon 한국식품영양과학회 2017 Preventive Nutrition and Food Science Vol.22 No.2

The purpose of this study was to evaluate the antioxidant and anticholinesterase activities of yellow and white bitter yams from South Western Nigeria using methanolic extraction and simulated gastrointestinal digestion models. The phenolic compounds in the bitter yam varieties were evaluated by high performance liquid chromatography with a diode array detector (HPLC-DAD). The total phenolic content of the bitter yams was measured by the Folin-Ciocalteu method, reductive potential by assessing the ability of the bitter yam to reduce FeCl₃ solution, and the antioxidant activities were determined by the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·) scavenging activity, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS<SUP>·+</SUP>) scavenging activity, nitric oxide radical (NO<SUP>·</SUP>) scavenging ability, hydroxyl radical scavenging ability, and ability to inhibit Fe<SUP>2+</SUP>-induced lipid oxidation. The HPLC-DAD analysis revealed the presence of some phenolic compounds in the studied bitter yam varieties, with varying degree of quantitative changes after cooking. The antioxidant indices (total phenolic content, total flavonoid content, reducing power, DPPH<SUP>·</SUP> scavenging activity, ABTS<SUP>·+</SUP> scavenging activity, and NO<SUP>·</SUP> scavenging activity) were higher in the simulated gastrointestinal digestion model compared to the methanolic extract, with the in vitro digested cooked white bitter yam ranking higher. Similarly, the in vitro digested yams had a higher inhibitory action against lipid oxidation compared to the methanolic extracts, with the cooked white bitter yam ranking high. The methanolic extracts and in vitro enzyme digests showed no acetylcholinesterase inhibitory abilities, while methanolic extracts and the in vitro enzyme digest displayed some level of butyrylcholinesterase inhibitory activities. Therefore the studied bitter yams could be considered as possible health supplements.

Osseous changes in the temporomandibular joint in rheumatoid arthritis: A cone-beam computed tomography study

Rehan, Ola Mohamed,Saleh, Hoda Abdel Kader,Raffat, Hala Ahmed,Abu-Taleb, Noha Saleh Korean Academy of Oral and Maxillofacial Radiology 2018 Imaging Science in Dentistry Vol.48 No.1

Purpose: To evaluate osseous changes of temporomandibular joint (TMJ) in patients with rheumatoid arthritis (RA) using cone-beam computed tomography (CBCT) and to correlate the imaging findings with the severity of TMJ dysfunction, clinical findings, and laboratory findings. Materials and Methods: This study consisted of 28 subjects, including 14 RA patients and 14 controls, who were scheduled to undergo CBCT imaging for the diagnosis of a complaint not related to or affecting the TMJ. The Fonseca's questionnaire was used to assess the severity of TMJ dysfunction. Rheumatoid factor (RF) and the erythrocyte sedimentation rate (ESR) were assessed in the RA patients. CBCT was then performed in all subjects and osseous TMJ abnormalities were assessed. Results: According to the Fonseca's questionnaire, 14.3% of the patients had no TMJ dysfunction, while 50%, 21.4%, and 14.3% had mild, moderate, and severe dysfunction, respectively. RF was positive in 64.3% of patients, and the ESR level was high in 100%. Imaging findings revealed a statistically significantly higher prevalence of erosion (85.7%), flattening (89.3%), osteophyte formation (32.1%), subchondral cyst (32.1%), sclerosis (64.3%), and condylar irregularities (28.6%) in the RA patients than in the controls. No correlations were found between CBCT findings and the clinical findings, the severity of TMJ dysfunction, disease duration, or laboratory results. Conclusion: RA patients might show extensive osseous abnormalities with no/mild clinical signs or symptoms of TMJ dysfunction that necessitate TMJ imaging for these patients. CBCT is a valuable and efficient modality that can assess osseous TMJ changes in RA patients.

Influence of Sintering Parameters on the Mechanical Performance of PM Steels Pre-alloyed with Chromium

Bergman Ola,Lindqvist Bjorn,Bengtsson Sven 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1

Powder grades pre-alloyed with 1.5-3 wt% chromium can be successfully sintered at the conventional temperature although well-monitored sintering atmospheres are required to avoid oxidation. Mechanical properties of the Cr-alloyed PM grades are enhanced by a higher sintering temperature in the range , due to positive effects from pore rounding, increased density and more effective oxide reduction. Astaloy CrM (Fe-3 wt% Cr-0.5 wt% Mo) with 0.6 wt% graphite added obtains an ultimate tensile strength of 1470 MPa and an impact strength of 31 J at density , after sintering at followed by cooling at and tempering.

Mineral Elements Bio-Accessibility and Antioxidant Indices of Blanched Basella rubra at Different Phases of in vitro Gastrointestinal Digestion

Sule Ola Salawu,Bukola Eugenia Olukemi,Ikuosho Charity Asikhia,Akintunde Afolabi Akindahunsi 한국식품영양과학회 2018 Preventive Nutrition and Food Science Vol.23 No.1

The present investigation was designed to evaluate the mineral element bio-accessibility and antioxidant indices of blanched Basella rubra at different phases of simulated in vitro digestion (oral, gastric, and intestinal). The phenolic composition of processed vegetable was determined using high-performance liquid chromatography (HPLC)-diode-array detection method. Mineral composition, total phenolic content (TPC), total flavonoid content (TFC), ferric reducing antioxidant power (FRAP), and total antioxidant activity (TAA) of the in vitro digested blanched and raw vegetable were also determined. HPLC analysis revealed the presence of some phenolic compounds, with higher levels (mg/g) of polyphenols in raw B. rubra (catechin, 1.12; p-coumaric acid, 6.17; caffeic acid, 2.05) compared with the blanched counterpart, with exeption of chlorogenic acid (2.84), that was higher in blanched vegetable. The mineral content (mg/100 g) showed a higher value in enzyme treated raw vegetable compared to their blanched counterparts, with few exceptions. The results revealed a higher level of some of the evaluated minerals at the intestinal phase of digestion (Zn, 6.36/5.31; Mg, 5.29/8.97; Ca, 2,307.69/1,565.38; Na, 5,128/4,128.21) for raw and blanched respectively, with the exception of Fe, K, and P. The results of the antioxidant indices of in vitro digested B. rubra revealed a higher value at the intestinal phase of in vitro digestion, with raw vegetal matter ranking higher (TPC, 553.56 mg/g; TFC, 518.88 mg/g; FRAP, 8.15 mg/g; TAA, 5,043.16 μM Trolox equivalent/g) than the blanched counterpart. The studied vegetable contains important minerals and antioxidant molecules that would be readily available after passing through the gastrointestinal tract and could be harnessed as functional foods.

Altered Cell to Cell Communication, Autophagy and Mitochondrial Dysfunction in a Model of Hepatocellular Carcinoma: Potential Protective Effects of Curcumin and Stem Cell Therapy

Tork, Ola M,Khaleel, Eman F,Abdelmaqsoud, Omnia M Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18

Background: Hepato-carcinogenesis is multifaceted in its molecular aspects. Among the interplaying agents are altered gap junctions, the proteasome/autophagy system, and mitochondria. The present experimental study was designed to outline the roles of these players and to investigate the tumor suppressive effects of curcumin with or without mesenchymal stem cells (MSCs) in hepatocellular carcinoma (HCC). Materials and Methods: Adult female albino rats were divided into normal controls and animals with HCC induced by diethyl-nitrosamine (DENA) and $CCl_4$. Additional groups treated after HCC induction were: Cur/HCC which received curcumin; MSCs/HCC which received MSCs; and Cur+MSCs/HCC which received both curcumin and MSCs. For all groups there were histopathological examination and assessment of gene expression of connexin43 (Cx43), ubiquitin ligase-E3 (UCP-3), the autophagy marker LC3 and coenzyme-Q10 (Mito.Q10) mRNA by real time, reverse transcription-polymerase chain reaction, along with measurement of LC3II/LC3I ratio for estimation of autophagosome formation in the rat liver tissue. In addition, the serum levels of ALT, AST and alpha fetoprotein (AFP), together with the proinflammatory cytokines $TNF{\alpha}$ and IL-6, were determined in all groups. Results: Histopathological examination of liver tissue from animals which received DENA-$CCl_4$ only revealed the presence of anaplastic carcinoma cells and macro-regenerative nodules. Administration of curcumin, MSCs; each alone or combined into rats after induction of HCC improved the histopathological picture. This was accompanied by significant reduction in ${\alpha}$-fetoprotein together with proinflammatory cytokines and significant decrease of various liver enzymes, in addition to upregulation of Cx43, UCP-3, LC3 and Mito.Q10 mRNA. Conclusions: Improvement of Cx43 expression, nonapoptotic cell death and mitochondrial function can repress tumor growth in HCC. Administration of curcumin and/or MSCs have tumor suppressive effects as they can target these mechanisms. However, further research is still needed to verify their effectiveness.