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Ohtsuki, Sumio,Yamaguchi, Hirofumi,Kang, Young-Sook,Hori, Satoko,Terasaki, Tetsuya Pharmaceutical Society of Japan 2010 Biological & pharmaceutical bulletin Vol.33 No.7
<P>The blood–brain barrier (BBB) expresses transporters that influence both dopaminergic neuronal function and drug therapy for Parkinson's disease (PD). The purpose of the present study was to clarify changes of transporter mRNA expression at the BBB in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a model of PD, in order to understand the pathophysiological role of BBB transport function in PD. At 7 d after MPTP treatment, mice showed a motor deficit and a loss of dopaminergic neurons. At the same time, L-type amino acid transporter 1 (LAT1) mRNA expression in the brain capillary fraction of the MPTP-treated mice was significantly reduced by 62.6% compared with saline-treated mice, while no significant change was observed in the expression of glucose transporter 1, creatine transporter 1, taurine transporter, organic cation transporter 2, serotonin transporter, norepinephrine transporter and dopamine transporter. LAT1 mRNA expression in whole brain was not affected at 1, 3 and 5 d after the treatment, but was reduced by 46.3% at 7 d. LAT1 mediates the transport of large neutral amino acids, including tyrosine, as well as the PD-therapeutic drug levodopa, across the BBB. Our findings indicate that decreased LAT1 expression at the BBB in PD patients may adversely affect amino acid supply from the circulating blood and levodopa distribution into the brain.</P>
K. Hirose,T. Ohtsuki,Y. Shibasaki,N. Iwasa,J. Hori,S. Sekimoto,K. Takamiya,H. Yashima,K. Nishio,Y. Kiyanagi 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The cross section for the neutron-induced fission of ^(237)Np was measured in an energy range from 0.1 eV to 2 keV using the lead slowing-down neutron spectrometer at the Research Reactor Institute, Kyoto University. The relative cross sections were obtained from the energy-dependent neutron flux measured using a BF^3 counter. The relative cross section for each (n,f) was normalized to the absolute value which obtained using the reference cross section for ^(235)U(n,f) between 100 eV and 1 keV.
Togawa, Nozomu,Sato, Masao,Ohtsuki, Tatsuo 대한전자공학회 1996 APCCAS:Asia Pacific Conference on Circuits And Sys Vol.1 No.1
This paper proposes a circuit partitioning algorithm in which the delay of each critical signal path is within a specified upper bound. Its core is recursive bipartitioning of a circuit which consists of three stages: 0) detection of critical paths; 1) bipartitioning of a set of primary inputs and outputs; and 2) bipartitioning of a set of logic-blocks. In 0), the algorithm detects the critical paths based on their lower bounds of delays. The delays of the critical paths are reduced with higher priority. In 1), the algorithm attempts to assign the primary input and output on each critical path to one chip. In 2), the algorithm not only decreases the number of crossings between chips but also assigns the logic-blocks on each critical path to one chip by exploiting a network flow technique with logic-block replication. The experimental results demonstrate that it resolves almost all path delay constraints with maintaining the maximum number of required I/O blocks per chip small compared with conventional algorithms.