Drug voyager: a computational platform for exploring unintended drug action

Oh, Min,Ahn, Jaegyoon,Lee, Taekeon,Jang, Giup,Park, Chihyun,Yoon, Youngmi BioMed Central 2017 BMC bioinformatics Vol.18 No.1

<P><B>Background</B></P><P>The dominant paradigm in understanding drug action focuses on the intended therapeutic effects and frequent adverse reactions. However, this approach may limit opportunities to grasp unintended drug actions, which can open up channels to repurpose existing drugs and identify rare adverse drug reactions. Advances in systems biology can be exploited to comprehensively understand pharmacodynamic actions, although proper frameworks to represent drug actions are still lacking.</P><P><B>Results</B></P><P>We suggest a novel platform to construct a drug-specific pathway in which a molecular-level mechanism of action is formulated based on pharmacologic, pharmacogenomic, transcriptomic, and phenotypic data related to drug response (http://databio.gachon.ac.kr/tools/). In this platform, an adoption of three conceptual levels imitating drug perturbation allows these pathways to be realistically rendered in comparison to those of other models. Furthermore, we propose a new method that exploits functional features of the drug-specific pathways to predict new indications as well as adverse reactions. For therapeutic uses, our predictions significantly overlapped with clinical trials and an up-to-date drug-disease association database. Also, our method outperforms existing methods with regard to classification of active compounds for cancers. For adverse reactions, our predictions were significantly enriched in an independent database derived from the Food and Drug Administration (FDA) Adverse Event Reporting System and meaningfully cover an Adverse Reaction Database provided by Health Canada. Lastly, we discuss several predictions for both therapeutic indications and side-effects through the published literature.</P><P><B>Conclusions</B></P><P>Our study addresses how we can computationally represent drug-signaling pathways to understand unintended drug actions and to facilitate drug discovery and screening.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s12859-017-1558-3) contains supplementary material, which is available to authorized users.</P>

Dependence of the Lasing Characteristics of a Yb-doped Fiber Laser on the Core Diameters of the Fibers and the Pumping Diode Laser's Wavelengths

Oh, Min,Kim, Jinkwon,Yi, Jonghoon,Park, Junyoung,Lee, Dongkwan,Lee, Hangyeol,Chang, Wonjong,Kim, Kyungyung Korean Physical Society 2016 New Physics: Sae Mulli Vol.66 No.3

업종별 수협 대출사업의 기술적 효율성 추정에 관한 연구

권오민 ( Kwon¸ Oh-min ),박철형 ( Park¸ Cheol-hyung ) 한국도서(섬)학회 2021 韓國島嶼硏究 Vol.33 No.2

수협은 대출과 같은 금융사업을 통해 어업인의 경영 안전을 보조하고, 삶의 질 향상에 도움을 줄 의무가 있다. 그러나 일부 수협에서는 대출에 대한 연체율이 상승하고 손실이 늘어나는 문제가 있다. 이에 본 연구는 우리나라 업종별 수협의 대출사업에 대한 SFA생산함수를 추정하여, 보다 효율적으로 대출사업이 운영될 수 있는 기술적인 정보를 분석하여 제공하고자 한다. 따라서 기술적 비효율성의 한계효과를 도출하고 규모의 경제를 검정하는 등 다양한 결과를 제시하였다. 연구의 분석 대상은 20개 업종별 수협이며, 금융사업 생산함수의 투입변수로 수협의 조합원수, 유형자산, 영업비용을 사용하였고 산출변수에는 대출금을 사용하였다. 또한 기술적 비효율성을 결정하는 외생변수의 도입을 통해 기술적 비효율성에 미치는 직접적인 영향을 추정하였는데, 외생변수로는 수협의 영업수입과 수협의 업종이 어선어업인지 아닌지를 구분하는 더미변수를 사용하였다. 분석 결과에 따라 전남정치망수협을 포함한 8개 수협이 규모수익 증대의 대출사업 운영을 하고, 나머지 수협은 규모수익 불변의 대출사업 운영을 하는 것으로 나타났다. 투입요소의 대출에 대한 생산탄력성은 어업비용만이 모든 수협에서 정(+)의 효과로 나타나, 모든 수협은 어업비용을 늘릴수록 대출금 규모가 증가한 것을 알 수 있다. 한편 조합원 수와 유형자산은 수협마다 상이한 결과를 보였다. 업종별 수협의 전체 효율성 추정결과는 2017년 87.7%에서 2019년 81.1%로 감소세를 보여, 최근 문제가 되고 있는 비어업인 대출 규모 확대, 대출 손실 등의 상황이 반영되었다고 볼 수 있다. 업종별로는 제주어류양식수협이 87.7%로 기술적 효율성이 가장 높고, 반대로 굴수하식 수협이 41.3%로 가장 낮은 것으로 나타났다. 기술적 효율성의 외생적 결정요인인 영업수입은 예상대로 대출사업의 효율성에 긍정적인 영향을 미쳤으며, 업종별 더미변수 결과로는 어선어업 수협이 비어선어업 수협, 특히 양식업 수협에 비해 효율적인 것으로 나타났다. 이는 어선어업 수협의 전반적인 경영규모가 양식업 수협보다 크기 때문에 나타난 결과로 보이며, 따라서 향후 정부가 수협에 대한 지원사업을 시행하게 된다면 경영규모가 작고 대출사업 효율성이 상대적으로 낮은 양식업 수협에 대한 고려가 있어야할 것으로 판단된다. Fishery cooperatives are obliged to assist fishermen in their management safety and help to improve their quality of life through financial projects such as loans. However, some fishery cooperatives have experienced problems with increases in overdue loans and through incurring losses. Therefore, this study aims to provide technical information on the operation of the loan business efficiency by estimating the SFA production function for the loan business of fishery cooperatives. In addition, this study presented various results such as deriving the marginal effects of technical inefficiency and testing economies of scale. The sample for this study was twenty industrial fishery cooperatives, while the number of union members, tangible assets, and operating expenses were used as input variables, while loans were used for output variables. In addition, this study used exogenous variables that directly affect the technical inefficiency, which are the operating income and dummy variables of whether a fishery cooperative is involved in fishing or aquaculture. According to the analysis results, eight fishery cooperatives, including the Jeonnam fixed shore net fishing, were in IRS, while the rest of them were in CRS. The production elasticity of input elements for loans showed that only fishing costs were positive in all fishery cooperatives, which means that the size of loans increased as fishery costs increased. The number of union members and tangible assets were different in each fishery cooperative. The overall efficiency of the industry fishery cooperatives showed a decline from 87.7 percent in 2017 to 81.1 percent in 2019, which is reflecting recent situations such as the expansion of the size of loans and loan losses. By industry, the Jeju fish aquaculture cooperative has the highest technical efficiency of 87.7%. On the contrary, the oyster aquaculture cooperative is the lowest with estimates of 41.3%. Operating incomes, which are the external determinants of technical efficiency, had a positive impact on efficiency of the loan business as expected, and the result of the dummy variables by industry showed that fishery cooperatives, which operate fishing, are more efficient than aquaculture. This result comes from the fact that the management size of fishery cooperatives which operate fishing is larger than those whithou an involvement in fishing. Therefore, if the government implements support projects for fishery cooperatives in the future, it is necessary to consider aquaculture cooperatives with small management with relatively low loan business efficiency.

Delayed Feedback Non-fragile H1 Controller Design for Uncertain Time-Delay Systems

Ohmin Kwon,Sangchul Won 제어로봇시스템학회 2002 제어로봇시스템학회 국제학술대회 논문집 Vol.2002 No.10

A Configuration of Power Divided Diplexer for Satellite Onboard Application in Ku-Band

Ohmine, Hiroyuki,Yabushita, Takeshi,Yamato, Masao,Yoneda, Naofumi,Konishi, Yoshihiko 통신위성우주산업연구회 2004 Joint Conference on Satellite Communications Vol.2004 No.-

In designing of high power satellite communication antenna, the high precise design is necessary to avoid multipactor generation under the condition of high vacuum space environment. Especially, realizing high power-handling diplexer, which separates transmitting and receiving power, os required for antenna feed circuit. This paper proposes a new configuration of high power handling diplexer for satellite onboard application and test results in Ku-band. For surviving high power handling, two methods are applied. One is input power to band pass filter (BPF) is divided into half power using hybrid coupler, and the other is input power of stub of BPF is divided into half power using double sided stub configuration. This configuration can decrease to a quarter power of input to avoid power concentration. And design method of stub filter with optimized procedure to obtain good isolation performance in receiving band is described. Drastic improvement can be achieved by introducing this technique. Further, electric field is also calculated using simulator and power limitation to multipactor is estimated. A diplexer has been designed and manufactured in the Ku-band and its design effectiveness has been confirmed through test results.

Delay-Dependent Guaranteed Cost Control for Uncertain Time Delay Systems

Ohmin Kwon,Sangchul Won,Dong Yue 제어로봇시스템학회 2001 제어로봇시스템학회 국제학술대회 논문집 Vol.2001 No.10

GPU를 이용한 보안 솔루션에 대한 조사

권오민(Ohmin Kwon ),윤현수(Hyunsoo Yoon) 한국정보과학회 2017 한국정보과학회 학술발표논문집 Vol.2017 No.12

『東醫寶鑑』과 『本草綱目』의 한국적 專有와 조선후기 의학 특징의 형성 : 『本草類函』과 『本草類函要領』을 중심으로

권오민(Ohmin Kwon),차웅석(Wungseok Cha),박상영(Sangyoung Park),오준호(Junho Oh),안상우(Sangwoo Ahn) 한국한의학연구원 2011 한국한의학연구원논문집 Vol.17 No.3

Bonchoyuham Nyoryeong(本草類函要領) shows how Donguibogam(東醫寶鑑) -Mirror of Eastern Medicine- is understood, digested into Korean medicine, and at the same time how it participated in the historical shaping of Korean medicine since the publishing in the early 17th century. The author, Hyeon Jae-deok, internalized the structure, content, and significance of Donguibogam and drew out a novel, concise, but comprehensive type of medical manual, while many other medical books since the 17century in Korea are estimated to have been an abridged edition of the Donguibogam. It may well be estimated as exemplar of the extent to which Donguibogam informed Korean medicine since the 17 century. The book shows as well how Bencao Gangmu(本草綱目) -Compendium of Materia Medica- and Donguibogam are merged and set a new medical stream in the 19th century Korea. Hyeon Jae-deok looked at the Bencao Gangmu from the lens of clinical treatment and prescription such that he focused on sections, elements, or parts of procedures, treatments, and prescriptions, not on the herbal taxonomic knowledge of the book. This perspective was embodied in Bonchoyuham(本草類函), which cited simple remedies, prescriptions, or treatments from Bencao Gangmu.

Professional Project and the Evolution of Non-Dominant Medicines

Kwon Ohmin,Ahn Sangwoo 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.3

This article explores how non-dominant medical practitioners shape their own self-images and the identity of relevant medicine and in what ways fashioning of self-images and accompanying modalities of medical practice informs the social evolution of the medicines at specific times and over specific places, by means of the historical configuration of osteopathy and chiropractic in the UK and the US. Attention is directed onto motivations and pursuits for professional recognition and actual strategies and activities of non-dominant medicines and its practitioners by turning to historical instances such as osteopathy and chiropractic in the UK and the US, not least drawing focus on professional desires with regard to circumstances it faces within and without. Some non-dominant medicines as a way with which to acquire and protect the exclusive monopoly of its knowledge and practical skills, adopted various forms of professionalism project, as dominant biomedical groups pressed up non-dominant medicines by virtue of marginalizing tactics. Meanwhile, non-dominant medicines took somewhat distinctive professionalisation strategies from each other. Strategies they took were diversified depending on medical philosophy, healing modality, the degree of occupational solidarity embodied as forms of medical organisation, and especially vocational aspiration and prospect. Change of socio-medical culture and the state's policy seems to have wielded critical influenceon the determination of the ups and downs of non-dominant medicines. From the perspective of long-term time span, dominant biomedicine eventually did not have much influence on the ups and downs of marginalized medicines in so far as in the case of osteopathy and chiropractic in Englandand the U. S.

클라우드 데이터 무결성 검증 방법 조사

권오민(Ohmin Kwon),윤현수(Hyunsoo Yoon) 한국정보과학회 2013 한국정보과학회 학술발표논문집 Vol.2013 No.6