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Clinical Aspects of Hepatocellular Carcinoma
Okuda, Kunio 대한소화기학회 1976 대한소화기학회지 Vol.8 No.1
HCC which has long defied medical and surgical maliagement is coming within our approach thanks to the recent diagnostic armaments. It is also of vast interest from the point of view of oncogenesis, particularly in its relation to hepatitis B antigen. Korea as well as Japan are most suited for its study because of the ample clinical cases and the available research facilities. I personally would like to call for more cooperative investigation into these problems and would ilke to thank the Korean Gestroenterological Society for inviting me to this. Lecture. The member of your society is referred to the monograph entitled $quot;Hepatocellular Carcinoma$quot; edited by Prof. R.L. Peters and myself, published by John Wiley, New York, for more detail and recent information and developments in the field.
Okuda, Tomoaki,Isobe, Ryoma Korean Society for Atmospheric Environment 2017 Asian Journal of Atmospheric Environment (AJAE) Vol.10 No.2
A cyclone is an effective tool to facilitate the collection of aerosol particles without using filters, and in cell exposure studies is able to collect a sufficient amount of aerosol particles to evaluate their adverse health effect. In this study, we examined two different methods to improve the aerosol particle collection efficiency of a cyclone. The individual and combined effects of reducing the surface roughness of the inner wall of the cyclone and of using a circular cone attachment were tested. The collection efficiency of particles of diameter $0.2{\mu}m$ was improved by approximately 10% when using a cyclone with a smoothened inner wall (average roughness $Ra=0.08{\mu}m$) compared with the original cyclone ($Ra=5.1{\mu}m$). A circular cone attachment placed between the bottom section of the cyclone and the top section of a collection bottle, resulted in improved collection of smaller particles without the attachment. The 50% cutoff diameter of the modified cyclone (combined use of smoothened inner wall and attachment) was $0.23{\mu}m$ compared to $0.28{\mu}m$ in the original model. The combined use of these two techniques resulted in improved collection efficiency of aerosol particles.
Okuda, K.,Skarzynski, D.J. Asian Australasian Association of Animal Productio 2000 Animal Bioscience Vol.13 No.3
The corpus luteum (CL) is a temporary endocrine gland whose main function is to secrete progesterone to support pregnancy. On the other hand, the cyclic bovine CL has also been shown to be a site of prostaglandin $F_{2{\alpha}}$ ($PGF_{2{\alpha}}$) production. Although there is general agreement that endometrial $PGF_{2{\alpha}}$ is an essential luteolysin in cattle, luteal $PGF_{2{\alpha}}$ seems to play a luteotropic role as an autocrine and/or paracrine factor, especially for the development and maintenance of the CL. This supposition is based on evidence that some of the prerequisites for autocrine/paracrine mechanisms are present, including local production of $PGF_{2{\alpha}}$ and the existence of specific binding sites within the CL. The purpose of this paper is to review the regulation of luteal $PGF_{2{\alpha}}$ secretion, its action on CL as an autocrine and/or paracrine factor and the receptivity of bovine CL to. $PGF_{2{\alpha}}$.
Radiation Hydrodynamics of 2-D Accretion Disks
OKUDA TORU The Korean Astronomical Society 2001 Journal of The Korean Astronomical Society Vol.34 No.4
To examine the structure and dynamics of thick accretion disks, we use a two-dimensional viscous hydrodynamic code coupled with radiation transport. The $\alpha$-model and the full viscous stress-tensor description for the kinematic viscosity are used. The radiation transport is treated in the gray, flux-limited diffusion approximation. The finite difference methods used are based on an explicit-implicit method. We apply the numerical code to the Super-Eddington black-hole model for SS 433.@The result for a very small viscosity parameter a reproduces well the characteristic features of SS 433, such as the relativistic jets with $\~$0.26c, the small collimation degree of the jets, the mass-outflow rate of ${\ge}5{\times}10^{-7}M{\bigodot}yr^{-1}$, and the formation of the X-ray iron emission lines.
Okuda, Tomoaki,Yoshida, Tetsuro,Gunji, Yuma,Okahisa, Shunichi,Kusdianto, K.,Gen, Masao,Sato, Seiichi,Lenggoro, I. Wuled Korean Society for Atmospheric Environment 2015 Asian Journal of Atmospheric Environment (AJAE) Vol.9 No.2
This study focused on the measurement of the actual charging state of ambient aerosol particles, which is important for understanding the intricate process of adverse health effects caused by particulate matter (PM). The net electrostatic charging state of $PM_{2.5}$ collected on filter media was measured in this study. The Faraday cage method and surface potential measurements were used in this study. The results showed that the polarities of the net charging state measured using these two methods were in agreement for 42 out of 48 samples (87.5%), and 36 samples (75%) were negatively charged. The filters were not significantly charged by friction between the filters and air not containing PM. Charge addition to or leakage from the filters was not observed over a two-month storage period. Net charging state of $PM_{2.5}$ collected on the filters was concluded to be negative in most cases, based on data's support of the assumption that aerosol charging state is not altered by the process of PM collection using filter.
Antihypertensive and Antihyperlipemic Actions of Chitosan
Okuda, Hiromichi,Kato, Hideo,Tsujita, Takahiro 한국키틴키토산학회 1997 한국키틴키토산학회지 Vol.2 No.3
The effect of dietary fibers on the hypertensive action of NaCl was examined by administration of a high salt diet containing alginic acid, which readily absorbs cations or chitosan, which readily absorbs anions, to normotensive rats and SHRSP (Stroke-prone spontaneously hypertensive rats) for 40 days. Addition of alginic acid to the high salt diet increased the amount of sodium and the addition of chitosan increased the amount of chloride in the feces of normotensive rats. Addition of chitosan to the high salt diet resulted in a significantly lower systolic blood pressure than addition of alginic acid in both groups. Serum ACE(angiotensin converting enzyme)was significantly reduced in SHRSP fed with the high salt diet containing chitosan. Serum chloride ion was lower in the normotensive rats fed with the high salt diet containing chitosan than alginic acid. In humans, the high salt diet increased the systolic blood pressure and serum ACE activity and chloride concentration after 1 h and oral administration of chitosan inhibited these increases. It also reduced the serum bicarbonate level after 1 h, but did not affect the sodium concentration. Serum ACE in humans was found to be stimulated by chloride ion. These results suggest that chitosan prevents increase in the systolic blood pressure of humans induced by high salt intake by inhibiting intestinal absorption of chloride, an activator of ACE. Based on these results, the relationship between serum ACE and chloride concentration was discussed. Chitosan was found to inhibit strongly hydrolysis of triolein emulsified with soybean phosphatidylcholine by pancreatic lipases at its dose of 10yg/ml. Chitosan, however, failed to inhibit the hydrolysis of triolein emulsified with gum arabic. In vivo, oral administration of chitosan to rats reduced the plasma triglyceride concentration. Based on these results, antihyperlipemic action of chitosan was discussed.