http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Nuyen Thi Phuong,Kyung Ah Lee,Kyung Ho Kim,Jung Kap Choi,Jong Moon Kim,강종성 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.12
The β-blockers possess at least one chiral center and the S(-)-enantiomer shows higher affinity for binding to the β-adrenergic receptors than antipode. The stability constants of acebutolol, celiprolol, propranolol and terbutaline in the inclusion complexes with single-isomer heptakis (2,3-dimethyl-6-sulfato)-β-cyclodextrin (HDMS-β-CD) were determined by capillary electrophoresis. The approximation and linear double reciprocal methods were adapted with comparable results. Among the β-blockers studied, propranolol had the lowest stability constant but the highest enantioselectivity, indicating that the magnitudes of the stability constants carried little information about enantioseparation. The magnitudes of enantioselectivities between the enantiomer pair were in the order of propranolol > celiprolol > terbutaline > acebutolol.
Enantioselective Pharmacokinetics of Carvedilol in Human Volunteers
Nuyen Thi Phuong,Beom Jin Lee,Jung Kap Choi,강종성,권광일 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.9
Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although they exhibit different pharmacological effects. To investigate the stereoselective pharmacokinetics, the enantiomeric separation of carvedilol in human plasma was undertaken using capillary electrophoresis (CE). Resolution of the enantiomers was achieved using 2-hydoxypropyl- β-cyclodextrin as the chiral selector. Phosphate buffer (50 mM, pH 4.0) containing 10 mM of 2- hydoxypropropyl-β-cyclodextrin was used as electrolytic buffer. Achiral separation was carried out with the same electrolytic buffer without chiral selector. Following a single oral administration of 25-mg carvedilol to 11 healthy, male volunteers, stereoselective pharmacokinetic analysis was undertaken. The maximum plasma concentrations (Cmax) were 48.9 and 21.6 ng/mL for (R)-carvedilol and (S)-carvedilol, respectively, determined by the chiral method. The profiles of the plasma concentration of (RS)-carvedilol showed Cmax of 71.5, 72.2, and 73.5 ng/mL, as determined by the CE, HPLC/FD methods and calculations from the data of the chiral method, respectively.
Privacy and Biomedical Research : A Role-based Approach
Nuyen, A.T. Ewha Institute for Biomedical Law & Ethics 2009 BIOMEDICAL LAW & ETHICS Vol.3 No.2
The standard approach to privacy generally and to privacy in biomedical ethics in particular is the rights-based approach. In this approach privacy is thought of as a right, which entails a duty on others’ part to respect a person’s privacy. However, the rights-based approach presupposes a certain social arrangement in which conflicts and discords are fore-grounded, and co-operation and social solidarity have no role to play. Such presupposition undermines the noble aims of biomedical research and leads to legal privacy provisions that are cumbersome and counterproductive. By contrast, the role-based approach puts privacy in the context of fulfilling social roles and trust in others to fulfill their social roles. While this approach may not lead to the right amount of protection of privacy generally, it is arguably a better approach for privacy in the biomedical context.
Enantioselective Pharmacokinetics of Carvedilol in Human Volunteers
Phuong, Nuyen-Thi,Lee, Beam-Jin,Choi, Jung-Kap,Kang, Jong-Seong,Kwon, Kwang-il The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.9
Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although they exhibit different pharmacological effects. To investigate the stereoselective pharmacoki-netics, the enantiomeric separation of carvedilol in human plasma was undertaken using capil-lary electrophoresis (CE). Resolution of the enantiomers was achieved using 2-hydoxypropyl-$\beta$-cyclodextrin as the chiral selector. Phosphate buffer (50 mM, pH 4.0) containing 10 mM of 2-hydoxypropropyl-$\beta$-cyclodextrin was used as electrolytic buffer. Achiral separation was carried out with the same electrolytic buffer without chiral selector. Following a single oral administra-tion of 25-mg carvedilol to 11 healthy, male volunteers, stereoselective pharmacokinetic analy-sis was undertaken. The maximum plasma concentrations ( $C_{max}$) were 48.9 and 21.6 ng/mL for (R)-carvedilol and (S)-carvedilol, respectively, determined by the chiral method. The profiles of the plasma concentration of (RS)-carvedilol showed $C_{max}$ of 71.5, 72.2, and 73.5 ng/mL, as determined by the CE, HPLC/FD methods and calculations from the data of the chiral method, respectively.y.y.
Phuong, Nuyen Thi,Lee, Kyung-Ah,Kim, Kyung-Ho,Choi, Jung-Kap,Kim, Jong-Moon,Kang , Jong-Seong The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.12
The ${\beta}$-blockers possess at least one chiral center and the S(-)-enantiomer shows higher affinity for binding to the ${\beta}$-adrenergic receptors than antipode. The stability constants of acebutolol, celiprolol, propranolol and terbutaline in the inclusion complexes with single-isomer heptakis (2,3-dimethyl-6-sulfato)- ${\beta}$-cyclodextrin (HDMS-${\beta}$-CD) were determined by capillary electrophoresis. The approximation and linear double reciprocal methods were adapted with comparable results. Among the ${\beta}$-blockers studied, propranolol had the lowest stability constant but the highest enantioselectivity, indicating that the magnitudes of the stability constants carried little information about enantioseparation. The magnitudes of enantioselectivities between the enantiomer pair were in the order of propranolol > celiprolol > terbutaline > acebutolol.