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Photoluminescent Graphene Nanoparticles for Cancer Phototherapy and Imaging
Nurunnabi, Md,Khatun, Zehedina,Reeck, Gerald R.,Lee, Dong Yun,Lee, Yong-kyu American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.15
<P>Graphene-based nanomaterials are of great interest in a wide range of applications in electronics, the environment, and energy as well as in biomedical and bioengineering. Their unique properties make them generally applicable as prognostic, diagnostic, and therapeutic agents in cancer. In this work, we focused on photodynamic and photothermal therapeutic properties of our previously synthesized carboxylated photoluminescent graphene nanodots (cGdots). The cGdots are ∼5 nm in diameter and excited at 655 nm. Our findings reveal that, upon laser irradiation by near-infrared (wavelength 670 nm) sensitizer, electrons of the cGdots starts to vibrate and form electron clouds, thereby generating sufficient heat (>50 °C) to kill the cancer cells by thermal ablation. The generation of singlet oxygen also occurs due to irradiation, thus acting similarly to pheophorbide-A, a well-known photodynamic therapeutic agent. The cGdots kills MDA-MB231 cancer cells (more than 70%) through both photodynamic and photothermal effects. The cGdots were equally effective in the <I>in vivo</I> model of MDA-MB231 xenografted tumor-bearing mice also as observed for 21 days. The cGdot was intravenously injected, and the tumor was irradiated by laser, resulting in final volume of tumor was ∼70% smaller than that of saline-treated tumor. It indicates that the growth rate of cGdot-treated tumor was slower compared to saline-treated tumor. The synthesized cGdots could enable visualization of tumor tissue in mice, thereby illustrating their use as optical imaging agents for detecting cancer noninvasively in deep tissue/organ. Collectively, our findings reveal that multimodal cGdots can be used for phototherapy, through photothermal or photodynamic effects, and for noninvasive optical imaging of deep tissues and tumors simultaneously.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-15/am504071z/production/images/medium/am-2014-04071z_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am504071z'>ACS Electronic Supporting Info</A></P>
Nurunnabi, Md,Lee, Seung-Ah,Revuri, Vishnu,Hwang, Yong Hwa,Kang, Sung Hun,Lee, Minhyung,Cho, Sungpil,Cho, Kwang Jae,Byun, Youngro,Bae, You Han,Lee, Dong Yun,Lee, Yong-kyu Elsevier 2017 Journal of controlled release Vol.268 No.-
<P><B>Abstract</B></P> <P>The number of people suffering from insulin-independent type 2 diabetes mellitus (T2DM) is ever increasing on a yearly basis. Current anti-diabetic medications often result in adverse weight gain and hypoglycemic episodes. Hypoglycemia can be avoided with glucagon-like peptide (GLP)-1 receptor agonists, which are expensive and require daily injections that may result immune activation. This study demonstrates the use of non-viral vector based oral delivery of GLP-1 gene through enterohepatic recycling pathways of bile acids. Oral administration of the plasmid DNA (pDNA) encoding GLP-1 decreased diabetic glucose levels to the normoglycemic range with significant weight reduction in a high-fat diet (HFD) induced diabetic mouse model and a genetically engineered T2DM rat model. This novel oral GLP1 delivery system is an attractive alternative to treat late-stage T2DM conditions that require repeated insulin injection and can potentially minimize the occurrence of hypoglycemic anomalies.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Nurunnabi, Md,Nafiujjaman, Md,Lee, Sang-Joon,Park, In-Kyu,Huh, Kang Moo,Lee, Yong-kyu unknown 2016 Chemical communications Vol. No.
<P>A facile and convenient process was optimized for preparing water-soluble hydroxyl-functionalized hexagonal boron nitride (hBN-OH) from hBN. The hBN-OH (2-3 nm thickness) contains similar to 40% oxygen and exhibits blue emission with a quantum yield of approximately 36%. The hBN-OH could be used for imaging cells and for the in vitro detection of biomolecules through electrochemical analysis.</P>
Nurunnabi, Md,Khatun, Zehedina,Reeck, Gerald R.,Lee, Dong Yun,Lee, Yong-kyu The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.44
<P>A simple reaction process is developed to synthesize blue, green, yellow and red colour graphene nanoparticles (GNPs) from carbon fibers. Here, we have focused on synthesis of near infra-red GNPs and their biological application for optical imaging of deep tissues and organs.</P> <P>Graphic Abstract</P><P>The near infra-red (NIR) graphene nanoparticles (GNPs) have been synthesized from carbon fiber by controlling the reaction parameters. The NIR GNPs have been injected into nude mice through tail vain and tested for noninvasive optical imaging. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc42334d'> </P>
Tauhidur R. Nurunnabi,Farah Sabrin,Dilara I. Sharif,Lutfun Nahar,Md. H. Sohrab,Satyajit D. Sarker,S.M. Mahbubur Rahman,Md. Morsaline Billah 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.3
Endophytic fungi reside in the intercellular space of plant nourished by the plant. In return, they provide bioactive molecules which can play critical roles on plant defense system. Fifty six endophytes were isolated from the leaves, root, bark and fruits of Sonneratia apetala, a pioneer mangrove plant in the Sundarbans, Bangladesh. A total of 56 isolates were obtained and 12 different species within 8 genera were identified using morphological and molecular characteristics. Antimicrobial activity of ethyl acetate (EtOAc) and methanolic (MeOH) extracts of these 12 different species were analyzed by resazurin assay and the minimum inhibitory concentrations (MICs) were determined. The fungal extracts showed antimicrobial activities against more than one tested bacterium or fungus among 5 human pathogenic microbes, i.e. Escherichia coli NCTC 12241, Staphylococcus aureus NCTC 12981, Micrococcus lutus NCTC 7508, Pseudomonas aeruginosa NCTC 7508 and Candida albicans ATCC 90028. Overall, methanolic extracts showed greater activity than that of ethyl acetate extracts. Of the isolates identified, Colletotrichum gloeosporioides, Aspergillus niger and Fusarium equiseti were the most active isolates and showed activity against microorganisms under investigation. Methanolic extracts of C. gloeosporioides and A. niger showed the lowest MIC (0.0024 mg/mL) against P. aeruginosa. The study indicates that endophytic fungi isolated from S. apetala species possess potential antimicrobial properties, which could be further investigated.
( Abu Sadat Mohammad Nurunnabi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: In Bangladesh, the estimated incidence of 12.7 million new cancer cases will rise to 21.4 million by 2030. The study was proposed to provide information about the common cancer types, predisposing risk factors and modalities of treatment among the Bangladeshi cancer patients. Methods: Interviews were conducted based on a semi-structured questionnaire with 550 histopathologically confi rmed cancer patients or patients having radiological and clinical evidences of cancer (339 men and 211 women), between July 2013 and June 2014 from different cancer hospitals located in Dhaka city. Results: Among the male patients, the leading cancers were lung (23%), followed by mouth and oropharynx (16.52%), stomach (14.45%), colorectal (10.91%) cancers etc. Among the female, breast cancer (31.75%) was the highest, followed by cancer of cervix (27.96%), ovary (18%), mouth and oropharynx (13.27%), stomach (4.74%) etc. Among the risk factors of male cancer patients, tobacco smoking was considered highest (76.4%), followed by chewing betel leaf and nuts (61.65%) and chronic disease (58.4%). Among women, the attributable fraction of cancer causing by recurrent STDs (37.91%) was highest, followed by obesity (36.97%), chronic disease (32.7%), chewing betel leaf and nuts (23.22%) and tobacco smoking (26.54%). Main treatment modalities are surgery, chemotherapy and radiotherapy applied either invidually or in combination. Most of the patients received chemotherapy (54.72%), followed by chemotherapy with radiation (32%). Only 7.81% patients got pallitive care. Conclusions: There are resource-strained oncology units in different public hospitals along with few private hospitals in Dhaka. However, this survey revealed that many patients lack access to cancer awareness programme, cancer screening facilities, availability of low cost drugs, therapies and palliative care. Hence, promotion of health education, behavioural change communication and development of treatment facilities and manpower are recommended.
( Abu Sadat Mohammad Nurunnabi ),( Sunjida Shahriah ),( A Z M Raihanur Rahman ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: In Bangladesh, several tools like Autism Behavior Checklist (ABC), Modifi ed Checklist for Autism in Toddlers (M-CHAT), Childhood Autism Rating Scale (CARS), and Autism Diagnostic Observation Schedule (ADOS) are widely used for either screening or diagnosis of autism; however, none of these measures have been validated for this population for autism spectrum disorders (ASDs) in Bangladesh. We evaluated the diagnostic reliability and validity of Help Autism Rating Scale (HARS), which was locally developed in 2012 and not widely used. Methods: This study was conducted in the Centre for Neurodevelopment and Autism in Children (CNAC) of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, on 200 Autistic Spectrum Disorder children in between January and December 2013. Item level scores of HARS were collected and analyzed. For internal consistency, Cronbach`s a coeffi cient was calculated. Convergent and divergent validity was calculated. The factor structure of HARS was demonstrated by principal components analysis. Results: The adequate face and content validity, HARS demonstrated good internal consistency (Cronbach`s a=0.962) and item-total correlation 0.790. The convergent validity between the HARS and BKT or GDS, calculated with Pearson`s product-moment correlation coeffi cient was 0.741, P=0.01. Divergent validity calculated by correlating HARS scores to ACTeRS showed non-signifi cant associations (r=-0.18; P=0.4) demonstrating that HARS discriminates autism from other childhood psychiatric disorders like ADHD. A 5-factor structure explained 43.34% of variance. Conclusions: The HARS has strong psychometric properties and is recommended for clinical and research work in autism spectrum disorders (ASDs) in Bangladesh.