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        Different reference ranges affect the prevalence of osteoporosis and osteopenia in an urban adult Malaysian population

        Swan Sim Yeap,Subashini C. Thambiah,Intan Nureslyna Samsudin,Geeta Appannah,Nurunnaim Zainuddin,Safarina Mohamad-Ismuddin,Nasrin Shahifar,Salmiah Md-Said,Siti Yazmin Zahari Sham,Subapriya Suppiah,Fen 대한골다공증학회 2020 Osteoporosis and Sarcopenia Vol.6 No.4

        Objectives: To determine the prevalence of osteopenia (OPe) and osteoporosis (OP) in an urban adult population in Malaysia, and to compare the change in the prevalence when using a Caucasian compared to an Asian reference range. Methods: A cross-sectional random sample of the population aged between 45 and 90 years from the state of Selangor, Malaysia, was invited to attend a bone health check-up. Participants with diseases known to affect bone metabolism or who were on treatment for OP were excluded. Bone mineral density was measured using dual energy X-ray absorptiometry. Based on the World Health Organization definitions, the prevalence of OPe and OP was calculated using the Asian and Caucasian T-scores. Results: A total of 342 subjects (222 females, 120 males), with a mean age of 59.68 (standard deviation: 8.89) years, who fulfilled the study criteria were assessed. Based on the Asian reference range, there were 140 (40.9%) subjects with OPe and 48 (14.0%) with OP. On applying the Caucasian reference range, there were 152 (44.4%) subjects with OPe and 79 (23.1%) with OP, with significant increases in males, females, and Chinese ethnic groups. Overall, 75 (21.9%) of subjects had a change in their diagnostic status. T-scores were consistently lower when the Caucasian reference range was used. Conclusions: In a healthy urban Malaysian population, the prevalence of OP is 14.0% and OPe is 40.9%. Application of a Caucasian reference range significantly increased the number of subjects with OP and may potentially lead to over-treatment.

      • KCI등재후보

        Trends in post osteoporotic hip fracture care from 2010 to 2014 in a private hospital in Malaysia

        Swan Sim Yeap,M.F.R. Nur Fazirah,C. Nur Aisyah,Siti Yazmin Zahari Sham,Intan Nureslyna Samsudin,Subashini C. Thambiah,Fen Lee Hew,Boon Ping Lim,Yew Siong Siow,Siew Pheng Chan 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.2

        Objective: Following an osteoporotic fracture, pharmacological treatment is recommended to increase bone mineral density and prevent future fractures. However, the rate of starting treatment after an osteoporotic hip fracture remains low. The objective of this study was to survey the treatment rate following a low-trauma hip fracture at a tertiary private hospital in Malaysia over a period of 5 years. Methods: The computerised hospital discharge records were searched using the terms “hip,” “femur,” “femoral,” “trochanteric,” “fracture,” or “total hip replacement” for all patients over the age of 50, admitted between 2010 and 2014. The medical charts were obtained and manually searched for demographic data and treatment information. Hip operations done for nonelow-trauma-related fracture and arthritis were excluded. Results: Three hundred seventy patients over the age of 50 years were admitted with a hip fracture, of which 258 (69.7%) were low trauma, presumed osteoporotic, hip fractures. The median age was 79.0 years (interquartile range [IQR], 12.0). Following a hip fracture, 36.8% (95 of 258) of the patients received treatment, but out of these, 24.2% (23 of 95) were on calcium/vitamin D only. The median duration of treatment was 1 month (IQR, 2.5). In 2010, 56.7% of the patients received treatment, significantly more than subsequent years 2011e2014, where approximately only 30% received treatment. Conclusions: Following a low-trauma hip fracture, approximately 72% of patients were not started on active antiosteoporosis therapy. Of those who were, the median duration of treatment was 1 month. This represents a missed opportunity for the prevention of future fractures.

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