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Metabolic, Metallic and Mitotic Sources of Oxidative Stress in Alzheimer Disease
Smith, Mark A.,Zhu, Xiongwei,Nunomura, Akihiko,Raina, Arun K.,Rottkamp, Catherine A.,Takeda, Atsushi,Perry, George 한림대학교 환경·생명과학연구소 2000 국제학술회의 Vol.2000 No.-
Alzheimer disease(AD) is marked by increases in oxidative damage to macromolecules such as sugars, lipids, proteins and nucleic acids. Notably, such damage is not limited to the lesions of the disease but instead involves all vulnerable neurons. These findings of oxidative abnormalities clearly predate gross described neuronal cytopathology and support the primacy of oxidative damage as an early and dynamic change of AD. Here, we review possible sources of oxidative damage as it applies to AD. Contrary to in vitro findings, correlations between cases with various extents of amyloid-β deposits or neurofibrillary tangles(NFT) show that oxidative damage is in fact reduced with increasing senile plaque and neurofibrillary tangle density (Nunomura et at., 1999a). For amyloid-β, there is a direct negative linear correlation with oxidative damage (Nunomura et at., 1999b). These findings indicate that the formation of the amyloid-β plaques and NFT, long thought of as a deleterious process leading to neuronal death, may in fact be a cytoprotective response(Morsch et at., 1999) to reduce oxidative damage.
Metabolic, Metallic and Mitotic Sources of Oxidative Stress in Alzheimer Disease
Smith, Mark A.,Zhu, Xiongwei,Nunomura, Akihiko,Raina, Arun K.,Rottkamp, Catherine A.,Takeda , Atsushi,Perry, George 한림대학교 환경·생명과학연구소 2000 [일송 국제심포지엄] 노화와 만성퇴행성 신경질환 Vol.- No.3
Alzheimer disease (AD) is marked by increases in oxidative damage to macromolecules such as sugars, lipids, proteins and nucleic acids. Notably, such damage is not limited to the lesions of the disease but instead involves all vulnerable neurons. These findings of oxidative abnormalities clearly predate gross described neuronal cytopathology and support the primacy of oxidative damage as an early and dynamic change of AD. Here, we review possible sources of oxidative damage as it applies to AD. Contrary to in vitro findings, correlations between cases with various extents of amyloid-β deposits or neurofibrillary tangles (NFT) show that oxidative damage is in fact reduced with increasing senile plaque and neurofibrillary tangle density (Nunomura et al., 1999a). for amyloid-β, there is a direct negative linear correlation with oxidative damage (Nunomura et al., 1999b). These findings indicate that the formation of the amyloid-β plaques and NFT, long thought of as a deleterious process leading to neuronal death, may in fact be a cytoprotective response (Morsch et al.,1999) to reduce oxidative damage.
Will a systematic coach education program move us forward or backwards?
Myrian Nunomura,Yoshinori Okade 한국코칭능력개발원 2008 Coach Vol.24 No.2
There are many studies of coaching and sport development worldwide. Currently in Brazil there is no certification system or centralised coach education (CE) program, nor research & training centre. Nonetheless, it is worthwhile to research and even dream of a system to promote the development of sport as in Australia, Canada, Great Britain, New Zealand, and other nations. The purpose of the study was to explain the coaching knowledge base of our coaches and the current situation regarding sport in Brazil. The study also included sport and coach education in Brazil and an overview of coach education and coaches' knowledge which is showed formal education, background experience as athlete, pedagogical knowledge. Closing thoughts and future directions are also explained.
Sayed Samim Rahpaya,Shinobu Tsuchiaka,Mai Kishimoto,Mami Oba,Yukie Katayama,Yuka Nunomura,Saki Kokawa,Takashi Kimura,Atsushi Kobayashi,Yumi Kirino,Tamaki Okabayashi,Nariaki Nonaka,Hirohisa Mekata,Hiro 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.3
Bovine abortion, diarrhea, and respiratory disease complexes, caused by infectious agents, result in high and significant economic losses for the cattle industry. These pathogens are likely transmitted by various vectors and reservoirs including insects, birds, and rodents. However, experimental data supporting this possibility are scarce. We collected 117 samples and screened them for 44 bovine abortive, diarrheal, and respiratory disease complex pathogens by using Dembo polymerase chain reaction (PCR), which is based on TaqMan real-time PCR. Fifty-seven samples were positive for at least one pathogen, including bovine viral diarrhea virus, bovine enterovirus, Salmonella enterica ser. Dublin, Salmonella enterica ser. Typhimurium, and Neospora caninum; some samples were positive for multiple pathogens. Bovine viral diarrhea virus and bovine enterovirus were the most frequently detected pathogens, especially in flies, suggesting an important role of flies in the transmission of these viruses. Additionally, we detected the N. caninum genome from a cockroach sample for the first time. Our data suggest that insects (particularly flies), birds, and rodents are potential vectors and reservoirs of abortion, diarrhea, and respiratory infectious agents, and that they may transmit more than one pathogen at the same time.