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      • KCI등재

        Appropriate level of alfalfa hay in diets for rearing Simmental crossbred calves in dryland China

        Nobuyuki Kobayashi,Fujiang Hou,Ausushi Tsunekawa,Xianjiang Chen,Tianhai Yan,Toshiyoshi Ichinohe 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.12

        Objective: In dryland areas of China, alfalfa hay (AH) is a possible substitute for concentrate feed for beef cattle. To evaluate the potential benefits of this substitution, we studied the effect of the ratio of AH intake to total dry matter (DM) intake on average daily body-weight gain (ADG), dietary energy utilization status, and economic benefit in Gansu province. Methods: In each of two feeding trials in 2016 (trial 1 [T1], July 3 to 17; trial 2 [T2], August 15 to September 23), crossbred male Simmental calves were allocated to low AH (LA), medium AH (MA), and high AH (HA) feeding groups (n = 4 per group). The target ADG was set as 1 kg for both trials. In a one-way-layout design based on conventional feeding practices in the province, calves received diets containing the different AH amounts, with a constant ratio of corn stover:total DM and decreasing rations of concentrate feed proportional to the increase in AH. Calves in T1 received AH at 15% (T1-LA), 23% (T1-MA), or 31% (T1-HA) of their dietary DM allowances; those in T2 received 9% (T2-LA), 24% (T2-MA), or 34% (T2-HA) AH. Results: Among the T1 groups, both ADG and economic benefit were highest in T1-LA; whereas in T2, they were higher in the T2-LA and T2-MA groups than in T2-HA. Energy digestibility did not significantly differ among the groups in either trial. The dietary AH inclusion ratios of 14% in the warm season and 8% to 21% in the cool season appeared to yield optimal ADG, metabolizable energy intake, and economic benefit. Conclusion: Low-level inclusion of AH, ranging from 8% to 21%, is a practical approach for beef cattle feeding. This modified feeding regimen likely will promote increased growth performance during the fattening stage of beef steers in dryland areas of Gansu province, China.

      • Fertility-preserving hormonal therapy in young patients with early-stage endometrial cancer

        ( Nobuyuki Susumu ) 대한산부인과학회 2017 대한산부인과학회 학술대회 Vol.103 No.-

        Endometrial cancer (EC) is the most common gynecological cancer in developed countries, and it’s incidence is constantly increasing. Atypical endometrial hyperplasia (AEH) is the precursor of type 1 EC. EC and AEH sometimes occur before the age of 40. Risk factors for endometrial carcinoma include a history of nulliparity or infertility including polycystic ovarian syndrome (PCOS), irregular menstrual cycles, obesity, diabetes mellitus, and hypertension, and so on. Standard treatment for EC and AEH is total hysterectomy and bilateral salpingo-oophorectomy, however, young patients with early-stage EC and AEH in reproductive age often hope to preserve their fertility. Criteria for conservative treatment include well-differentiated (grade1) endometrioid adenocarcinoma, or AEH, no myometrial invasion, no extra-uterine involvement, no contraindications for medical management, and strong desire for preservation of fertility. However, the data of long-term and pregnancy-related outcomes are limited for fertility- preserving therapy for EC and AEH. Medroxyprogesterone acetate (MPA), megestrol acetate (MA), and intrauterine system-levonorgestrel (IUS-LNG) are often used for fertility-preserving therapy. KGOG2002 study retrospectively analyzed the long-term oncologic outcomes of a fertility-sparing management using oral progestin MPA or MA in 148 patients of presumed stage IA, grade 1, with no myometrial invasion, and showed 78% as complete response (CR) rate, 68% as 5-year recurrence- free survival (RFS) rate. A multicenter prospective phase II study in Japan enrolled 28 patients having EC at presumed stage IA and 17 patients with AEH, and revealed that CR rate was 55% in EC and 82% in AEH, and 47% recurred between 7 and 36 months. In Keio University hospital, we retrospectively reviewed the long-term outcomes of fertility-preserving hormonal therapy using MPA for 142 grade 1 EC patients, 4 grade 2 EC patients, and 102 AEH patients. Median follow-up period was 38 months. In initial MPA therapy, pathological CR rate was 97% in AEH, 90% in G1/G2. After MPA therapy, we experienced 116 times pregnancies in 84 patients, and got 84 alive children. The pregnancy rate was 34% in AEH, 32% in G1/G2. 5 year-RFS rate was 45% in AEH, 17% in G1/G2, and after delivery or abortion, 5 year-RFS rate was 65% in AEH, 38% in G1/G2. We experienced 15 double cancers, including 11 patients with ovarian cancers. Fertility-preserving hormonal therapy in young patients with early-stage endometrial cancer is highly effective and safe, however, careful management is needed during and after hormonal therapy, and even after successful pregnancy.

      • KCI등재

        Macroscopic Features of Surge Behaviors in Axial Flow Compressors

        Nobuyuki Yamaguchi 한국유체기계학회 2020 International journal of fluid machinery and syste Vol.13 No.2

        An essential parameter governing the surge behaviors in compressor systems was found on the basis of numerical-experimental results by surge simulations. It is named “flowpath-average reduced resonance frequency”, consisted of the resonance frequency, the total flowpath length and the average velocity. The reduced frequency normalized by the compressor tip Mach number tends to be basically about 1.5 at the stall stagnation boundaries for compressors having few stages and low pressure-ratios, although the value could vary to some extent affected by various circumstantial factors. It means that the stall stagnations could be caused by insufficient number of times of excitations by the resonant frequency on the fluid particles in passing through the whole flowpath. Deep surges tend to occur for the parameter values greater than around 1.5. On the foundation of the normalized flowpath-average reduced resonance frequency can be formed a basic framework for the surge behaviors in terms of non-dimensional surge frequencies and stall-stagnation points. In reference to the framework, several general features of the surge behaviors are described in a relatively unified manner, including the behaviors of surge frequencies and stall stagnation boundaries, which are affected in a complicated manner by compressor conditions of speeds, pressure ratios, and number of stages, and flowpath geometries, relative compressor locations in the flowpath, etc. The framework contributes much to clarification of the characteristic behaviors in surges hitherto unexplained and could provide keys to further surge studies. It could also be useful to devise countermeasures against stall stagnation problems.

      • KCI등재

        Radiologic results of additional single screw fixation with lateral locking plate after hybrid closed-wedge high tibial osteotomy

        ( Nobuyuki Hiraoka ),( Shuji Nakagawa ),( Eigo Otakara ),( Hiroaki Inoue ),( Kenji Takahashi ),( Yuji Arai ) 대한슬관절학회 2021 대한슬관절학회지 Vol.33 No.-

        Background: Hybrid closed-wedge high tibial osteotomy (hybrid CWHTO) is an effective surgical treatment for medial compartment osteoarthritis of the knee. Our study investigated whether the combination of a lateral locking plate and a single medial screw promoted bone union after hybrid CWHTO. Methods: The study cohort consisted of 30 patients (15 men and 15 women) who underwent hybrid CWHTO for medial compartment osteoarthritis or spontaneous osteonecrosis of the knee. Sixteen knees were fixed with a lateral locking plate (LP group), and 17 were fixed with both a lateral locking plate and a cannulated cancellous screw on the medial side of the tibia (LPS group). The times to bone union, radiolucency, and callus formation at the osteotomy site were evaluated radiographically. Results: The mean postoperative time to radiographic confirmation of bone union was 5.5 ± 2.6 months in the LP group and 3.4 ± 1.5 months in the LPS group. Radiolucency at the osteotomy site and excess callus formation on the posterior side of the tibia were lower in the LPS group than in the LP group. Conclusions: This modified hybrid CWHTO combining a lateral locking plate and a cannulated cancellous screw on the medial side of the tibia improves the stability of the osteotomy site and shortens the period of bone union.

      • KCI등재

        Updated Nuclear Data of Lanthanoids in Fission Products for JENDL-4.0

        Nobuyuki Iwamoto 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23

        The fourth version of the Japanese Evaluated Nuclear Data Library(JENDL-4.0) was developed with one of the aims of improving the neutron nuclear data of fission products.The isotopes of Nd, Pm, Sm, Eu, Gd, Tb and Dy of lanthanoids were newlyevaluated. The resolved resonance parameters were updated and thereaction cross sections in the energy region above resolvedresonances were calculated by applying a new nuclear reaction modelcode developed in JAEA Nuclear Data Center. The γ-ray productiondata were added for all of these nuclides. The obtained cross sections are compared with available experimental dataand existing evaluated libraries, and show good performance.

      • KCI등재후보

        Analytical Study on Stall Stagnation Boundaries in Axial-Flow Compressor and Duct Systems

        Nobuyuki Yamaguchi 한국유체기계학회 2013 International journal of fluid machinery and syste Vol.6 No.2

        Stall stagnations in the system of axial-flow compressors and ducts occur in transition from deep surge conditions to decayed or converged stall conditions. The present study is concerned with the boundaries between the deep surges and the stagnation stalls on the basis of analytical results by a code on surge transients analysis and simulation. The fundamental acoustical-geometrical stagnation boundaries were made clear from examinations of the results on a variety of duct configurations coupled with a nine-stage compressor and a single stage fan. The boundary was found to be formed by three parts, i.e., B- and A-boundaries, and an intermediate zone. The B-boundary occurs for the suction-duct having a length of about a quarter of the wave-length of the first resonance in the case of very short and fat plenum-type delivery duct. On the other hand, the A-boundary occurs for the long and narrow duct- type delivery flow-path having a length about a fifth of the wavelength and relatively small sectional area in the case of short and narrow suction ducts. In addition to this, the reduced surge-cycle frequencies with respect to the duct lengths are observed to have respective limiting values at the stagnation boundaries. The reduced frequency for the B-boundary is related with a limiting value of the Greitzer's B parameter. The tendency and the characteristic features of the related flow behaviors in the neighborhood of the boundaries were also made clearer.

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