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Hao Tang,Nian-Guang Li,Zhi-Hao Shi,Yu-Ping Tang,Qian-Ping Shi,Ze-Xi Dong,Peng-Xuan Zhang,Jin-ao Duan 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
The binding abilities of scutellarin (Scu) andscutellarein (Scue) with bovine serum albumin (BSA) wereinvestigated using equilibrium dialysis, high performanceliquid chromatography, fluorescence spectroscopy, competitivesite marker and molecular docking. The resultsshowed that the average protein binding ratios of Scu andScue with BSA were (79.85 ± 1.83) and (85.49 ± 1.21) %respectively. Under simulated physiological conditions, thefluorescence data indicated that Scu and Scue bound withBSA through a static mechanism. The thermodynamicparameters indicated that the interactions of Scu-BSA andScue-BSA mainly occurred by van der Waals forces andhydrogen bonds and it was easier for Scue to bind withBSA than Scu, indicating that the glucuronic acid moleculein Scu decreased the binding affinity. Site competitivemarker experiments showed that the binding sites of Scuand Scue mainly located within the sub-domain IIA ofBSA. Furthermore, molecular docking studies indicatedthat one BSA could bind three Scue, while one BSA couldcarry only two Scu. All these results clearly indicated theinteractions of Scu and Scue with BSA, which will lay thefoundation for further research to determine the pharmacologyand pharmacodynamics of Scu and Scue for treatingischemic cerebrovascular disease.
Geng, Chuan-Ying,Liu, Nian,Yang, Guang-Zhong,Liu, Ai-Jun,Leng, Yun,Wang, Hui-Juan,Li, Li-Hong,Wu, Yin,Li, Yan-Chen,Chen, Wen-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
At present, multiple myeloma (MM) remains an incurable disease and cologenic cells may be responsible for disease relapse. It has been proposed that CD20+/CD138- NCI-H929 cells could be hallmarks of MM clonogenic cells. Here, the immunology phenotype of NCI-H929 cells is described. Only a small population of CD20+/CD138- cells (<1%) was found in the NCI-H929 cell line, but CD20+/CD138- cells were not detected. We found that CD20+/CD138+ cells were able to exhibit cologenic capacity by colony formation assay and continuous passage culture. Proteins were analyzed by 1D-SDS-PAGE and TMT based quantitative differential liquid chromatography tandem mass spectrometry (LC-MS/MS). 1,082 non-redundant proteins were identified, 658 of which were differentially expressed with at least a 1.5-fold difference. 205 proteins in CD20+ cells were expressed at higher levels and 453 proteins were at lower levels compared with CD20- cells. Most proteins had catalytic and binding activity and mainly participated in metabolic processes, cell communication and molecular transport. These results proved that there are different biological features and protein expression profile between CD20+ and CD20- cells in the NCI-H929 cell line.
Dun Sheng Shang,Guang Fu Bai,Jian Tang,Yan Ling Tang,Guang Xin Wang,Nian Xie 한국광학회 2023 Current Optics and Photonics Vol.7 No.5
A scheme is proposed to generate triangular waveforms with alterable symmetry. The key component is a cascaded single-drive Mach-Zehnder modulator (SD-MZM) and optical polarization beam splittercombiner architecture. In this triangular waveform generator, the bias-induced phase shift, modulation index and controllable delay difference are changeable. To generate triangular waveform signals with different symmetry indexes, different combinations of these variables are selected. Compared with the previous schemes, this generator just contains one SD-MZM and the balanced photodetector (BPD) is not needed, which means the costs and energy consumption are significantly reduced. The operation principle of this triangular waveform generator has been theoretically analyzed, and the corresponding simulation is conducted. Based on the theoretical and simulated results, some experiments are demonstrated to prove the validity of the scheme. The triangular waveform signals with a symmetry factor range of 20–80% are generated. Both experiment and theory prove the feasibility of this method.
A simulant study of the Network of Five Elements by using the computer
Yang, jian hua,Zhang, zhi guang,Zhang, guang nian,Lin, Shu huang 한국정신과학학회 1997 한국정신과학회 학술대회 논문집 Vol.7 No.-
The theory of Chinese medicine is a based theory to research the paranomarl function of human body including ESP and PK etc. The theory of the traditional Chinese medicine indictes that the life prosesses can be discribed by the system of five elements (SFE), which are: wood, fire, earth, metal and water. We take the SFE for a network consisted of this five elements (NFE), and study the characteries of the structure of this NFE. they include multi-cross character; directiong and irreversible character; mesomerism character; "open" character and Fuzzy character etc. Then, based on these characters, we simulate the partial function of NFE by using computer. The results of simulation show that the NFE is a very useful network to explain the physiological and pathological phenomenan of human body according to the theory of traditional Chinese medicine.