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Heavy Metal Tolerance of Novel Papiliotrema Yeast Isolated from Vietnamese Mangosteen
( Kim Cuc Thi Nguyen ),( Phu Van Nguyen ),( Hai Thi Hong Truong ) 한국균학회 2020 Mycobiology Vol.48 No.4
Three yeast strains (Hue-1, Hue-8, and Hue-19) with strong heavy metal tolerance were isolated from mangosteen from Hue city, Vietnam. They exhibited identical phenotype and phylogeny. Sequence analysis of the D1/D2 region of the LSU rRNA gene and the internal transcribed spacer (ITS) region demonstrated that the closest relative of these strains is Papiliotrema sp. with 2.12% and 3.55-3.7% divergence in the D1/D2 domain, and ITS domain, respectively. Based on the physiological, biochemical, and molecular data, the three strains belong to a novel species of Papiliotrema genus, for which the name Papiliotrema huenov sp. nov. is proposed. These strains are highly tolerant of heavy metals compared to other yeasts, being able to grow in the presence of 2mM Pb (II), 2mM Cd (II), and up to 5mM Ni (II), but no growth was observed in the presence of 1mM As (III).
Versatile Functions of Caveolin-1 in Aging-related Diseases
Kim Cuc Thi Nguyen,조경아 전남대학교 의과학연구소 2017 전남의대학술지 Vol.53 No.1
Caveolin-1 (Cav-1) is a trans-membrane protein that is a major component of the caveolae structure on the plasma membrane. Cav-1 is involved in the regulation of various cellular processes, including cell growth, differentiation, endocytosis, and in particular it has been implied in cellular senescence. Here we review current knowledge about Cav-1 in cellular signaling and discuss the role of Cav-1 in aging-related diseases.