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Radioprotective role of amifostine on osteointegration of titanium implants in the tibia of rats
Nevra Aydemir Celep,Hülya Kara,Elif Erbaş,Elif Doğan 대한수의학회 2023 Journal of Veterinary Science Vol.24 No.3
Background: Titanium is the most widely used metal for bone integration, especially for cancer patients receiving ionizing radiation. This study aimed to investigate the amifostine administration that would reduce the effects of radiation on bone healing and osseointegration in rat models. Objectives: It is aimed that the application of amifostine in rats receiving radiotherapy treatment will reduce the negative effects of ionizing radiation on the bone. Methods: Thirty-five adult male Wistar rats were randomly divided into one healthy and four experimental groups. In three consecutive days, two experimental groups of rats (AMFRT-IMP and RT-IMP) were exposed to radiation (15 Gy/3 fractions of 5 Gy each). Then the titanium implants were inserted into the left tibia. Before the radiotherapy process, a 200 mg/kg dose of amifostine (AMF) was administered to the rats in the AMF-IMP and AMF-RTIMP groups. Twenty-eight days after the screw implant, all rats were sacrificed, and their blood samples and tibia bones were collected for analysis. Results: The results indicated an accelerated bone formation and a more rapid healing process in the screw implants in the AMF-IMP, AMF-RT-IMP, and AMF-RT groups than in the RT-IMP group. Also, bone-implant contact area measurement and inflammation decreased with amifostine treatment in the implants subjected to irradiation (p < 0.05). Conclusions: The results obtained in the present study suggested that amifostine prevents the losses of bone minerals, bone integrity, and implant position from ionizing-radiation when given before exposure.
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Cholesterol removal onto the different hydrophobic nanospheres: A comparison study
Tulden Kalburcu,Nevra Ozturk,Nalan Tuzmen,Adil Denizli,Sinan Akgo¨ l 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.1
The aim of this study is to prepare two different hydrophobic polymeric nanospheres for cholesterolremoval. Poly(HEMA–MAT) nanospheres with an average size of 100 nm and poly(HEMA–MAP)nanospheres with an average size of 158 nm were produced by surfactant free emulsion polymerizationof HEMA and MAT and MAP monomers. These hydrophobic nanospheres were characterized by FTIR,SEM, elemental analysis, particle size and surface area measurements. Cholesterol removal experimentswere performed in a batch experimental set-up and removal medium was methanol. Cholesteroladsorption capacity of poly(HEMA–MAP) nanospheres was approximately three times higher than thatof poly(HEMA–MAT) nanospheres.
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Deniz Akta Uygun,Nevra Öztürk,Sinan Akgöl,Adil Denizli 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.1
A new metal-chelate adsorbent utilizing 2-methacryloylamidohistidine (MAH) was prepared as a metalchelating ligand. MAH was synthesized using methacryloly chloride and histidine. Monosize nanospheres with an average diameter of 450 nm were produced by emulsion polymerization of 2-hydroxyetylmethacrylate (HEMA) and MAH. Then, Fe^(3+) ions were chelated directly onto the monosize nanospheres. Mon-poly(HEMA-MAH) nanospheres were characterized by Fourier transform infrared spectroscopy,scanning electron microscopy, and elemental analysis. Fe^(3+) chelated monosize nanospheres were used in ferritin adsorption from an aqueous solution. The maximum ferritin adsorption capacity of Fe^(3+)-chelated mon-poly(HEMAMAH)nanospheres was 202 mg/g at pH 4.0 in acetate buffer. The non-specific ferritin adsorption on the monpoly(HEMA-MAH) nanospheres was 20 mg/g. The adsorption behavior of ferritin could be modeled using both Langmuir and Freundlich isotherms. The adsorption capacity decreased with increasing ionic strength of the binding buffer. High desorption ratios (> 95% of the adsorbed ferritin) were achieved with 1.0 M NaCl at pH 7.0. Ferritin could be repeatedly adsorbed and desorbed with the Fe^(3+)-chelated mon-poly(HEMA-MAH) nanospheres without significant loss of adsorption capacity.
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Hydatid Disease Involving Some Rare Locations in the Body: a Pictorial Essay
Murvet Yuksel,Gulen Demirpolat,Ahmet Sever,Sevgi Bakaris,Ertan Bulbuloglu,Nevra Elmas 대한영상의학회 2007 Korean Journal of Radiology Vol.8 No.6
Hydatid disease (HD) is an endemic illness in many countries, and it poses an important public health problem that's influenced by peoples' socioeconomic status and migration that spreads this disease. Although rare, it may occur in any organ or tissue. The most common site is the liver (59 75%), followed in frequency by lung (27%), kidney (3%), bone (1 4%) and brain (1 2%). Other sites such as the heart, spleen, pancreas and muscles are very rarely affected. Unusual sites for this disease can cause diagnostic problems. This pictorial essay illustrates various radiological findings of HD in the liver, spleen, kidney, pancreas, peritoneal cavity, omentum, adrenal, ovary, lung, mediastinum and retroperitoneum. Familiarity with the imaging findings of HD may be helpful in making an accurate diagnosis and preventing potential complications.
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