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Prognostic Significance of CD24 Expression in Gastric Carcinoma
Nevine S. Darwish,Min A Kim,Mee Soo Chang,Byung Lan Lee,Woo Ho Kim,이혜승,Yong Il Kim 대한암학회 2004 Cancer Research and Treatment Vol.36 No.5
Purpose: The human CD24 antigen is a small heavily glycosylated cell surface protein, which is expressed in hematological malignancies, as well as in a large variety of solid tumors. Its expression is now known to be related to the prognosis of several kinds of tumors. This study is designed to examine the prognostic significance of CD24 in Korean gastric cancer patients. Materials and Methods: In the present study, we examined CD24 expression in 300 consecutive cases of gastric carcinoma by immunohistochemical staining using the tissue-array method. We also investigated the clinicopathological profiles related to CD24 expression. Results: One hundred and three cases out of 300 (34.3%) showed the positive expression of CD24. The altered expression of CD24 was significantly associated with differentiated cancer (p=0.003), the intestinal subtype according to the Lauren classification (p〈0.001), the advanced stage cancer (p=0.027), with lymphatic invasion (p=0.038) and with vascular invasion (p=0.006). The survival analysis revealed that the patients with CD24 positive expression showed significantly poorer survival than those without CD24 expression. Moreover, a combined evaluation revealed that PTEN /CD24 cases showed the best survival compared to other groups (p=0.01). Conclusion: Positive CD24 expression occurs in a subset of gastric carcinomas and it correlates significantly with lymphatic invasion, blood vessel invasion and poor survival. (Cancer Res Treat. 2004;36:298-302)
Body Hair Scores and Total Hair Diameters in Healthy Women in Kirikkale Region, of Turkey
Nevin Sagsoz,Mansur Kamaci,Zerrin Orbak 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.SUP
It was aimed to determine the normal hair scores of women of Kırıkkale region according to the Ferriman- Gallwey scale and to investigate the relationship between the hair shaft diameter and hair scores. Hair scores were calculated in 204 healthy women, and hair shaft diameters were measured from the hair samples collected from 60 patients. Body mass index, waist to hip ratio, insulin resistance and blood androgen levels were determined. Neutral, hormonal and total hair scores were 2.1±1.4, 3.1±2.7 and 5.2±3.6, respectively. The average total hair diameter and hormonal hair diameter were 191.93±90.49μm and 121.8±75.9μm respectively. The correlation between total hair diameter and total hair score was statistically significant (r=0.704 p<0.001). Also, the correlation between hormonal hair diameter and hormonal hair score was statistically significant (r=0.724 p<0.001). While hair scores and diameters show meaningful positive correlation with androgen levels, they show negative correlation with age. In our population, 95% value of total hair score was 11, and for the hormonal score, it was 9. Hair diameters increase with hair score, regardless of total or hormonal of hair scores. Hair scores and hair diameters may be affected by blood androgens in healthy women.
Nevin Gamze Karsli,Okan Gul,Taner Yilmaz 한국섬유공학회 2022 Fibers and polymers Vol.23 No.4
This study aims to investigate the effect of graphene nanoplatelet (GNP) and terpolymer addition on themechanical, adhesive wear and thermal properties of carbon fiber (CF) reinforced poly(phenylene sulphide) (PPS) matrixcomposites. In the composites the CF content was fixed at 10 wt.% and the terpolymer content at 2 wt.%, while the GNPcontent was changed to 0.1, 0.3 and 0.5 wt.%. Physical properties of composites were evaluated by using tensile test,adhesive wear test, differential scanning calorimeter analysis and scanning electron microscopy analysis. As a result, it wasconcluded that the simultaneously addition of both 0.5 wt.% GNP and 2 wt.% terpolymer to CF reinforced compositesimproved the mechanical and tribological properties of composites. Thus, a solution has been developed to increase theefficiency of use of high performance composite materials produced for use in areas requiring good mechanical andtribological performance such as the aerospace and automotive industries.
Prognostic Value of Prepro-Gastrin Releasing Peptide in Lung Cancer Patients; NCI-Prospective Study
Shafik, Nevine F,Rahoma, M,Elshimy, Reham AA,El kasem, Fatma M Abou Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Background: Prior series investigated the expression of prepro-gastrin releasing peptide (prepro-GRP) in the peripheral blood of lung cancer patients. Our aim was to assess any prepro-GRP role as a prognostic factor for small cell lung cancer (SCLC) and NSCLC and correlations with clinical presentation and treatment outcome. Methods: A prospective study was conducted during the time period from the beginning of January 2012 till the end of January 2014. Prepro-GRP expression was analysed using a nested RT-PCR assay in peripheral blood of 62 untreated lung cancer patients attending the National Cancer Institute (NCI), Cairo University, and 30 age and sex matched healthy volunteers. Results: Among the 62 lung cancer cases, there were 24 (38.7%) SCLC, and 38 (61.3%) NSCLC (10 squamous cell carcinomas, 12 adenocarcinomas, 11 large cell carcinomas, 4 undifferentiated carcinomas, and 1 adenosquamous carcinoma). Twenty six patients (41.9%) were prepro-GRP positive. Prepro-GRP expression was higher (58.3%) among SCLC patients compared to NSCLC (squamous cell carcinoma (15.4%), large cell carcinoma (36.4%), and adenocarcinoma (25%)). Mean OS among prepro-GRP negative cases was longer than that among preprogastrin positive cases (17.6 vs 14.9 months). The mean PFS durations among preprogastrin negative versus positive cases were 7.7 vs 4.6 months (p= 0.041). No difference in response to chemotherapy was identified between the groups (p=0.983). Conclusion: Prepro-GRP is suggested to be a useful prognostic marker for lung cancer patients, especially with the fast- growing, bad prognostic SCLC type. More studies should aim at detailed understanding of the mechanisms of prepro-GRP action and its use in monitoring the response to treatment in a larger cohort.
The Role of Genetic Polymorphisms in Nrf2 and P73 in Egyptian Women with Breast Cancer
Azhary, Nevin M Al,Kamel, Mahmoud M,Ismail, Yahia M,Mahmoud, Amal A,Radwan, Enas M Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.11
Background: Breast cancer is the commonest cancer in Egyptian females. Nrf2 is involved in oxidative stress while P73 functions in response to DNA damage. This study aimed to assess the role of Nrf2 promoter and P73 G4C14 to A4T14 SNPs in breast cancer in Egypt. Patients: Eighty-five female patients with breast tumours (41 malignant, 44 benign) were included. Nrf2 (rs6721961) and p73 (G4A) SNPs were determined by PCR- CTPP assay. Results: Genotype frequencies of the Nrf2 promoter SNP were 34.2% and 37.9% for AA in benign and malignant groups respectively, and 43.9% and 40.5% for CC and, 21.9 % and 21.6% for CA. Genotype frequencies for the P73 G4A SNP were 52.9% and 44.7% for GA in benign and malignant groups respectively, and 47.1% and 55.3% for GG. Discussion: Nrf2 genotypes in pre - and post-menopausal patients, showed significantly different distributions in the 2 patient groups, the AA genotype being significantly more common in pre-menopausal patients. The P73 G4A SNP showed no relation to age of disease onset. Conclusion: The Nrf2 (rs6721961) AA genotype might be related to early breast cancer onset. In contrast the P73 G4A polymorphism showed no relation to either disease risk or age at presentation.
Prognostic Value of a CYP2B6 Gene Polymorphism in Patients with Acute Myeloid Leukemia
Alazhary, Nevin M,Shafik, Roxan E,Shafik, Hanan E,Kamel, Mahmoud M Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11
Background: The objectives of this study aimed to detect a CYP2B6 polymorphism in de novo cases of acute myeloid leukemia patients and identify any role in disease progression and outcome. Materials and Methods: DNA was isolated from peripheral blood of 82 newly diagnosed acute myeloid leukemia cases and the CYP2B6 G15631T gene polymorphism was assayed by PCR restriction fragment length polymorphism (PCR-RFLP). Results: The frequency of the GG genotype (wild type) was 48 (58.5%) and that of the mutant type T allele was 34 (41.9%). GT genotype heterozygous variants were found in 28 (34%), and TT genotype homozygous variants in 6 (7.3%) cases. We found no significant association between the CYP2B6 G15631T polymorphism and complete response (CR) (p-value=0.768), FAB classification (p-value=0.51), cytogenetic analysis (p-value=0.673), and overall survival (p-value=0.325). Also, there were no significant links with early toxic death (p-value=0.92) or progression-free survival (PFS) (p-value=0.245). Conclusions: Our results suggest that the CYP2B6 polymorphism has no role in disease progression, therapeutic outcome, patient free survival, early toxic death and overall survival in acute myeloid leukemia patients.