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RISS 인기검색어
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- 저자 : Nesibe (검색결과 6 건)
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Yamak, Nesibe,Yaykasli, Kursat Oguz,Yilmaz, Umit,Eroz, Recep,Uzunlar, Ali Kemal,Ankarali, Handan,Sahiner, Cem,Baltaci, Davut Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20
Background: Colon cancer is one of the most common cancers worldwide. Apoptosis is a necessary physiological process for cell elimination which is very important both cellular homeostasis and cell proliferation and differantiation. Dysregulation can lead to uncontrolled cell growth and tumor development. Survivin, a member of the IAP family, plays a key role in promotion of cell proliferation as well as inhibition of apoptosis in cancer cells. The aim of this study was to investigate whether specific genetic polymorphisms of survivin could be associated with colon cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between colon cancer risk and survivin gene polymorphisms. Materials and Methods: The relation between colon cancer and survivin -31 G/C (rs9904341), -241 C/T (rs17878467) and -625 C/G (rs8073069) polymorphism in promotor site of survivin gene associated with apoptosis was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Individuals with -31C allele and CC genotype were found to have a higher risk of developing colon cancer (OR=13.4, p=0.01). The -241 CT genotype considerably increased the risk of colon cancer (OR=12.0, p=0.0001). However, there was no significant varaition of the survivin -625 C/G polymorphism among colon cancer patients and controls in our study. Conclusions: This study provides the first evidence that survivin -31 G/C and -241 C/T SNP significantly contribute to the risk of colon cancer in the Turkish population.
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Dogan, Nesibe A.,Ozdemir, Ercan,Yavuz, Cafer T. Wiley (John WileySons) 2017 CHEM SUS CHEM Vol.10 No.10
<P>Chemical tuning of nanoporous, solid sorbents for ideal CO2 binding requires unhindered amine functional groups on the pore walls. Although common for soluble organics, post-synthetic reduction of nitriles in porous networks often fails due to insufficient and irreversible metal hydride penetration. In this study, a nanoporous network with pendant nitrile groups, microsphere morphology was synthesized in large scale. The hollow microspheres were easily decorated with primary amines through in situ reduction by widely available boranes. The CO2 capture capacity of the modified sorbent was increased to up to four times that of the starting nanoporous network with a high heat of adsorption (98 kJ mol(-1)). The surface area can be easily tuned between 1 and 354 m(2)g(-1). The average particle size (ca. 50 mu m) is also quite suitable for CO2 capture applications, such as those with fluidized beds requiring spheres of micron sizes.</P>
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New extremal binary self-dual codes of lengths 66 and 68 from codes over Rk,m
Abidin Kaya,Nesibe Tufekci 대한수학회 2017 대한수학회보 Vol.54 No.1
In this work, four circulant and quadratic double circulant (QDC) constructions are applied to the family of the rings $R_{k,m}$. Self-dual binary codes are obtained as the Gray images of self-dual QDC codes over $ R_{k,m}$. Extremal binary self-dual codes of length 64 are obtained as Gray images of $\lambda$-four circulant codes over $R_{2,1}$ and $R_{2,2}$. Extremal binary self-dual codes of lengths 66 and 68 are constructed by applying extension theorems to the $\mathbb{F}_{2}$ and $R_{2,1}$ images of these codes. More precisely, 10 new codes of length 66 and 39 new codes of length 68 are discovered. The codes with these weight enumerators are constructed for the first time in literature. The results are tabulated.
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NEW EXTREMAL BINARY SELF-DUAL CODES OF LENGTHS 66 AND 68 FROM CODES OVER R<sub>k,m</sub>
Kaya, Abidin,Tufekci, Nesibe Korean Mathematical Society 2017 대한수학회보 Vol.54 No.1
In this work, four circulant and quadratic double circulant (QDC) constructions are applied to the family of the rings $R_{k,m}$. Self-dual binary codes are obtained as the Gray images of self-dual QDC codes over $R_{k,m}$. Extremal binary self-dual codes of length 64 are obtained as Gray images of ${\lambda}-four$ circulant codes over $R_{2,1}$ and $R_{2,2}$. Extremal binary self-dual codes of lengths 66 and 68 are constructed by applying extension theorems to the ${\mathbb{F}}_2$ and $R_{2,1}$ images of these codes. More precisely, 10 new codes of length 66 and 39 new codes of length 68 are discovered. The codes with these weight enumerators are constructed for the first time in literature. The results are tabulated.
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Investigation of ICAM-1 and β3 Integrin Gene Variations in Patients with Brain Tumors
Yilmaz, Umit,Zeybek, Umit,Kahraman, Ozlem Timirci,Kafadar, Ali Metin,Toptas, Bahar,Yamak, Nesibe,Celik, Faruk,Yaylim, Ilhan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Background: Primary brain tumors constitute a small percent of all malignant cancers, but their etiology remains poorly understood. ${\beta}3$ integrin (ITGB3) has been recognized to play influential roles in angiogenesis, tumor growth and metastasis. Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and ITGB3 could be associated with brain cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between brain tumor risk and ICAM-1 and ${\beta}3$ integrin gene polymorphisms. Materials and Methods: The study covered 92 patients with primary brain tumors and 92 age-matched healthy control subjects. Evaluation of ${\beta}3$ integrin (Leu33Pro (rs5918)) and ICAM-1 (R241G (rs1799969) and K469E (rs5498)) gene polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: According to results of our research, the A allele of the ICAM-1 R241G gene polymorphism appeared to be a risk factor for primary brain tumors (p<0.001). Similarly, the frequency of the A mutant allele of ICAM-1 R241G was statistically significant in patients with brain tumors classified as glioma (p<0.001). When allele and genotype distributions of ICAM-1 K469E, ICAM-1 R241G and ${\beta}3$ integrin Leu33Pro gene polymorphisms were evaluated with age, sex, and smoking, there were no statistically significant differences. Haplotype analysis revealed that the frequencies of GAC (rs1799969-rs5498-rs5918) and GAT (rs1799969-rs5498-rs5918) haplotypes were significantly lower in patients as compared with controls (p=0.001; p=0.036 respectively). Conclusions: This study provides the first evidence that ICAM-1 R241G SNP significantly contributes to the risk of primary brain tumors in a Turkish population. In addition, our results suggest that ICAM-1 R241G in combination ICAM-1 K469E may have protective effects against the development of brain cancer.
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