Adjuvant therapy with 1% alendronate gel for experimental periodontitis treatment in rats

Natália de Campos Kajimoto,Yvonne de Paiva Buischi,Peter Michael Loomer,Timothy G. Bromage,Edilson Ervolino,Stephen Enrico Fucini,Natália Marcumini Pola,Beatriz Ommati Pirovani,Maria Juliana Sismeiro 대한치주과학회 2021 Journal of Periodontal & Implant Science Vol.51 No.6

Purpose: The aim of this study was to evaluate the effects of locally delivered 1% alendronate (ALN) gel used as an adjunct to non-invasive periodontal therapy. Methods: Ligature-induced periodontitis was performed in 96 rats. The ligature was tied in the cervical area of the mandibular left first molar. The animals were randomly divided into 4 groups: 1) NT, no treatment; 2) SRP, scaling and root planning; 3) SRP/PLA, SRP followed by filling the periodontal pocket with placebo gel (PLA); and 4) SRP/ALN, SRP followed by filling the periodontal pockets with 1% ALN gel. Histomorphometric (percentage of bone in the furcation region [PBF]) and immunohistochemical (receptor activator of nuclear factor-κB ligand, osteoprotegerin, and tartrate-resistant acid phosphatase) analyses were performed. Data were statistically analyzed, with the threshold of statistical significance set at P≤0.05. Results: The SRP, SRP/PLA, and SRP/ALN groups presented a higher PBF than the NT group (P≤0.01) at 7, 15, and 30 days. The SRP/ALN group presented a higher PBF than the SRP/PLA group in all experimental periods, as well as a higher PBF than the SRP group at 15 and 30 days. No differences were observed in the immunohistochemical analyses (P>0.05 for all). Conclusions: Locally delivered 1% ALN gel used as an adjunct to SRP enhanced bone regeneration in the furcation region in a rat model of experimental periodontitis.

Impact of Acupuncture Intervention on the Pain Intensity of Patients Treated at a Tertiary Hospital in Brazil

Natália F. Valente,Eliezer de Sousa Cardoso,Juliana A. da Silva Rezende,Jeferson A. Santos 사단법인약침학회 2020 Journal of Acupuncture & Meridian Studies Vol.13 No.5

Background: Nowadays, in western societies, acupuncture is widely used over the control of pain and this analgesic approach is still the most studied aspect of acupuncture. Several studies have shown that most patients go through a significant pain decrease soon after the first sessions of acupuncture. Objectives: This research has as a goal the evaluation on the effect of acupuncture treatment regarding the relief of pain intensity of different etiologies, through the visual analog scale. Methods: This research constitutes a retrospective, descriptive study, carried out with 449 patients attended in the Institute Hospital de Base of the Federal District, in Brasilia citye Brazil. Every data was gathered from our own form, with detailed clinical history which included age, marital status, work activity, reason for referral to acupuncture, main and secondary complaints, pain intensity evaluated by the Visual Analog Scale (VAS), number of sessions completed and drug therapy. All data was organized in the Microsoft Excel and processed in the Statistical Package for the Social Sciences (SPSS), version 20.0. Results: Regarding the main complaint, the mean pain decreased from 7.3 (initial VAS) to 3.2 (final VAS), a reduction that meant more than 50% relief in pain intensity. This 50% reduction in initial pain was also observed in secondary complaints (initial VAS = 6.5 and final VAS = 3.1). Conclusions: The results of this research suggest that acupuncture treatment was effective in relieving pain intensity, providing a 50% reduction on the visual analogue scale, in relation to painful complaints of different etiologies.

A Review on Acupuncture Efficiency in Human Polycystic Ovary/Ovarian Syndrome

Oliveira Natália M. de,Machado Jorge,Lopes Lara,Criado Maria Begoña,Oliveira Natália M. de 대한약침학회 2023 Journal of pharmacopuncture Vol.26 No.2

Objectives: Human Polycystic Ovary/Ovarian Syndrome (PCOS), a frequent endocrine pathophysiology among women of fertile age, is associated with woman’s lifespan endocrine, metabolic and psychological implications. Long-term usage side effects of allopathic strategies and their low efficacy made complementary medicine treatments a relevant subject for these patients. The main aim of this work is to review the efficiency of the acupuncture treatment reported in the latest studies on literature regarding PCOS patients. Methods: A comprehensive literature search, in English language, about the use of acupuncture on the management of PCOS, was conducted in October 2020 using EBSCO, Cochrane, PubMed, Medline, Embase, databases for randomised and non-randomised controlled trials between 2015 and 2020 (09/2015-10/2020), following the PRISMA protocol. Results: This research led us to an analysis, according to PICOS, of six final papers selected among 178 in total. The articles addressed distinct aspects of the PCOS condition, diverse acupuncture techniques and different main and secondary outcomes in agreement to the respective main objective. According to this review, acupuncture seems to be useful for the treatment of this debilitating and chronic health condition which affects millions of women worldwide, many of them part of the workforce in their community. Conclusion: Despite of the display of these positive results addressing acupuncture treatments to manage PCOS major symptoms - whether they are reproductive, metabolic, or mental health features - more research is urgent. Randomized, double blinded controlled trials with improved quality design and following STRICTA and/or CONSORT recommendations are necessary to engage acupuncture as a standardized and scientific validated technique in PCOS condition.

WHO IS TO BLAME? EFFECTS OF CAUSAL LOCUS WHEN CO-PRODUCTION RESULTS ARE UNSATISFACTORY

Larissa Carine Braz Becker,Natália Araújo Pacheco,Vinicius Andrade Brei 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.10

Co-production is defined as customer participation in production activities that generate a result to be consumed (Etgar, 2008). Previous research has shown the positive effects of co-production, such as satisfaction, perceived control, and perceived quality (Chan, Yim, & Lam, 2010; Golder, Mitra, & Moorman, 2012; Hunt, Oneto, & Varca, 2012). However, knowledge about the potential negative consequences from co-production is scarce. Despite the importance of the role of causal locus in the generation of unsatisfactory results, to date, this subject has not been properly studied. Considering that co-production is increasingly common in contemporary consumption contexts, this paper aims to broaden knowledge about unsatisfactory results from co-production. Based on two experimental studies, we analyze the role of the causal locus of failures on customer regret and disappointment, taking into consideration the self-serving bias. The results show that a consumption situation with an unsatisfactory regret tends to be higher when the consumer takes the blame than when the causal locus is attributed to the company. When the causal locus is uncertain, regret is higher than disappointment and higher than the regret experienced when the company or the service employee is blamed. Because regret is associated with internal causal attribution, these results contradict the self-serving bias literature, which affirms that people are more likely to make external than internal attributions for failures (Mezulis, Abramson, Hyde, & Hankin, 2004; Weiner, 2010). The internal failure attribution converges with the idea that consumer participation in production implies more responsibility over the result (Bitner, Faranda, Hubbert, & Zeithaml, 1997; Prahalad & Ramaswamy, 2004).When the causal locus is attributed to the company or to the service employee, disappointment towards the company tends to be higher than in the other conditions and higher than regret. Study 2 tested whether consumers who co-produce would take responsibility for a failure and blame themselves in situations where the causal locus was undetermined. The results once again contradicted the self-serving bias literature in a scenario with co-production. Consumers who co-produced experienced more regret and less disappointment towards the company, and they blamed themselves more intensely than the consumers who did not co-produce. Therefore, the consumers who co-produce take more responsibility for dissatisfying results and, consequently, regret their actions to a higher degree than those consumers who do not co-produce. These results show that even when co-production fails to generate a satisfying result for the consumer, it may be positive for the company because it provides a context in which both the consumer and the company may be responsible for the failure. When the company is blamed, consumers experience less regret and more disappointment towards the company than when the consumer is the one to blame. But when the consumer is blamed or the causal locus is uncertain, situations that are both possible in a co-production context, then consumers experience more regret and less disappointment towards the company.

Microbial Community Response to a Simulated Hydrocarbon Spill in Mangrove Sediments

Rodrigo Gouvêa Taketani,Natália Oliveira Franco,Alexandre Soares Rosado,Jan Dirk van Elsas 한국미생물학회 2010 The journal of microbiology Vol.48 No.1

In this study, we examined the hypothesis that the microbial communities in mangrove sediments with different chemical and historical characteristics respond differently to the disturbance of a hydrocarbon spill. Two different mangrove sediments were sampled, one close to an oil refinery that had suffered a recent oil spill and another that had not been in contact with oil. Based on the sampled sediment, two sets of mesocosms were built, and oil was added to one of them. They were subjected to mimicked mangrove conditions and monitored for 75 days. Archaeal and bacterial communities were evaluated through PCRDGGE. Both communities showed the emergence of small numbers of novel bands in response to oil pollution. 16S rRNA gene clone libraries were constructed from both mesocosms before the addition of oil and at day 75 after oil addition. LIBSHUFF analysis showed that both mangrove-based mesocosms contained similar communities at the start of the experiment and that they were different from the initial one, as well as from each other, after 75 days. These results hint at a role of environmental history that is not obvious from community diversity indicators, but is apparent from the response to the applied stress.

Predisposing factors for external apical root resorption associated with orthodontic treatment

Luciana Quintanilha Pires Fernandes,Natália Couto Figueiredo,Carina Cristina Montalvany Antonucci,Elizabeth Maria Bastos Lages,Ildeu Andrade Jr,Jonas Capelli Junior 대한치과교정학회 2019 대한치과교정학회지 Vol.49 No.5

Objective: This study aimed to identify possible risk factors for external apical root resorption (EARR) in the maxillary incisors after orthodontic treatment. Methods: The root length of 2,173 maxillary incisors was measured on periapical radiographs of 564 patients who received orthodontic treatment. The Kappa test was performed to evaluate intraexaminer and interexaminer reproducibility. Multiple binary logistic regression was used to determine the association between EARR and various factors. Odds ratios and 95% confidence intervals were reported. Results: The risk of developing EARR was 70% higher in orthodontic treatment with maxillary premolar extraction (p = 0.004), 58% higher in patients with increased overjet (p = 0.012), 41% lower in two-phase orthodontic treatment (p = 0.037), and 33% lower in patients with deep bite (p = 0.039). The lateral incisors were 54% more likely to develop EARR (p < 0.001), dilacerated roots were 2.26 times more likely to develop EARR (p < 0.001), and for each additional millimeter of root length, the risk of EARR increased by 29% (p < 0.001). Conclusions: The potential risk factors for EARR after orthodontic treatment included treatment with maxillary premolar extraction, increased overjet at the beginning of treatment, and dilacerated roots.

Social vulnerability and COVID-19 in Maringá, Brazil

Matheus Pereira Libório,Oseias da Silva Martinuci,Patrícia Bernardes,Natália Cristina Alves Caetano Chaves Krohling,Guilherme Castro,Henrique Leonardo Guerra,Eduardo Alcantara Ribeiro,Udelysses Janete 대한공간정보학회 2023 Spatial Information Research Vol.31 No.1

This research explores the relationship between COVID-19 and social vulnerability on an intra-urban scale. For this, two composite indicators of social vulnerability have been constructed. The composite indicator constructed by the Benefit-of-the-Doubt considers spatial heterogeneity. It weakly captures the conceptually most significant individual indicator of social vulnerability (R=-0.39), as it overestimates the above-average performance sub-indicators. The composite indicator constructed by the Principal Component Analysis considers that the sub-indicators have the same weights in different census tracts, resulting in a highly consistent composite indicator as a multidimensional phenomenon concept (R=-0.93). These findings allow reaching four conclusions. First, the direction and strength of correlations associated with COVID-19 are sensitive to the method employed to construct the composite indicator and not just the geographic scale and space. Second, Medium and High social vulnerability census tracts concentrate 97% of the population but only 93% of COVID-19 cases and deaths. Third, people living in census tracts of None and Low social vulnerability are 3.87 and 2.13 times more likely to be infected or die from COVID-19. Fourth, policies to combat COVID-19 in the study area should prioritize older populations regardless of their social conditions.

Dietary crude protein levels during growth phase affects reproductive characteristics but not reproductive efficiency of adult male Japanese quails

Retes Pâmela Lacombe,Neves Danusa Gebin das,Bernardes Laryssa Fernanda,Alves Victoria Veiga,Gonçalves Natália de Castro,Lima Diego de Rezende,Alvarenga Renata Ribeiro,Pereira Barbara Azevedo,Seidavi A 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.3

Objective: The objective was to evaluate the influence of different dietary crude protein (CP) levels during the growth phase on reproductive characteristics and reproductive efficiency as well as the body development of adult male Japanese quail. Methods: Three hundred one-day-old male quails were distributed into five treatments with diets containing different CP levels (18%, 20%, 22%, 24%, and 26%) in a completely randomized design, with six replicates of ten birds each. The CP diets were applied only during the growth phase (1 to 35 days). At 36 days of age, the birds were transferred to 30 laying cages with three males and nine females each, and all birds received the same diet formulated to meet production-phase requirements until 96 days of age. Results: The growth rate of the birds increased linearly (p<0.01) with increasing dietary CP, but the age of maximum growth decreased (p<0.05). At growth maturity, all birds had the same body weight (p>0.05). At 35 days of age, higher weight gain was obtained (p<0.05) with diets containing 22% CP or higher. No effects on feed conversion were observed in this phase. The increase in dietary CP enhanced (p<0.01) nitrogen intake and nitrogen excretion but did not affect (p>0.05) nitrogen retention. Testis size, seminiferous tubular area, number of spermatogonia, and germinal epithelial height at 35 days of age increased linearly (p<0.05) with dietary CP, while the number of Leydig cells decreased (p<0.01). The Sertoli cell number at 60 days of age increased linearly (p<0.01) with dietary CP. Dietary CP levels did not affect cloacal gland size, foam weight, foam protein concentration, semen volume, or flock fertility at 90 days of age. Conclusion: Dietary CP concentration affected body and testicular development in male Japanese quails but did not affect reproductive efficiency. Objective: The objective was to evaluate the influence of different dietary crude protein (CP) levels during the growth phase on reproductive characteristics and reproductive efficiency as well as the body development of adult male Japanese quail.Methods: Three hundred one-day-old male quails were distributed into five treatments with diets containing different CP levels (18%, 20%, 22%, 24%, and 26%) in a completely randomized design, with six replicates of ten birds each. The CP diets were applied only during the growth phase (1 to 35 days). At 36 days of age, the birds were transferred to 30 laying cages with three males and nine females each, and all birds received the same diet formulated to meet production-phase requirements until 96 days of age.Results: The growth rate of the birds increased linearly (p<0.01) with increasing dietary CP, but the age of maximum growth decreased (p<0.05). At growth maturity, all birds had the same body weight (p>0.05). At 35 days of age, higher weight gain was obtained (p<0.05) with diets containing 22% CP or higher. No effects on feed conversion were observed in this phase. The increase in dietary CP enhanced (p<0.01) nitrogen intake and nitrogen excretion but did not affect (p>0.05) nitrogen retention. Testis size, seminiferous tubular area, number of spermatogonia, and germinal epithelial height at 35 days of age increased linearly (p<0.05) with dietary CP, while the number of Leydig cells decreased (p<0.01). The Sertoli cell number at 60 days of age increased linearly (p<0.01) with dietary CP. Dietary CP levels did not affect cloacal gland size, foam weight, foam protein concentration, semen volume, or flock fertility at 90 days of age.Conclusion: Dietary CP concentration affected body and testicular development in male Japanese quails but did not affect reproductive efficiency.

Retrospective study of osteoradionecrosis in the jaws of patients with head and neck cancer

Brena Rodrigues Manzano,Natá,lia Garcia Santaella,Marco Auré,lio Oliveira,Cá,ssia Maria Fischer Rubira,Paulo Sé,rgio da Silva Santos 대한구강악안면외과학회 2019 대한구강악안면외과학회지 Vol.45 No.1

Objectives: Osteoradionecrosis (ORN) is one of the most severe complications resulting from radiotherapy (RT) in patients with head and neck cancer (HNC). It is characterized by persistent exposed and devitalized bone without proper healing for greater than 6 months after a high dose of radiation in the area. To describe the profile and dental management of ORN in HNC patients undergoing RT in an oncological clinical research center. Materials and Methods: A retrospective descriptive study was performed to analyze dental records from HNC patients with ORN treated at an oncological clinical research center from 2013 to 2017. A total of 158 dental records for HNC patients were selected from a total of 583 records. Afterwards, this number was distributed to three examiners for manual assessments. Each examiner was responsible for selecting dental records that contained an ORN description, resulting in 20 dental records. Results: Mean patient age was 60.3 years with males being the most affected sex (80.0%). The most affected area was the posterior region of the mandible (60.0%) followed by the anterior region of the mandible (20.0%) and the posterior region of the maxilla (10.0%). The factors most associated with ORN were dental conditions (70.0%) followed by isolated systemic factors (10.0%) and tumor resection (5.0%). There was total exposed bone closure in 50.0% of cases. The predominant treatment was curettage associated with chlorhexidine 0.12% irrigation (36.0%). Conclusion: Poor dental conditions were related to ORN occurrence. ORN management through less invasive therapies was effective for the closure of exposed bone areas and avoidance of infection.

WHO IS TO BLAME? EFFECTS OF CAUSAL LOCUS WHEN CO-PRODUCTION RESULTS ARE UNSATISFACTORY

Larissa Carine Braz Becker,Nat?lia Ara?jo Pacheco,Vinicius Andrade Brei 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7

Co-production is defined as customer participation in production activities that generate a result to be consumed (Etgar, 2008). Previous research has shown the positive effects of co-production, such as satisfaction, perceived control, and perceived quality (Chan, Yim, & Lam, 2010; Golder, Mitra, & Moorman, 2012; Hunt, Oneto, & Varca, 2012). However, knowledge about the potential negative consequences from co-production is scarce. Despite the importance of the role of causal locus in the generation of unsatisfactory results, to date, this subject has not been properly studied. Considering that co-production is increasingly common in contemporary consumption contexts, this paper aims to broaden knowledge about unsatisfactory results from co-production. Based on two experimental studies, we analyze the role of the causal locus of failures on customer regret and disappointment, taking into consideration the self-serving bias. The results show that a consumption situation with an unsatisfactory regret tends to be higher when the consumer takes the blame than when the causal locus is attributed to the company. When the causal locus is uncertain, regret is higher than disappointment and higher than the regret experienced when the company or the service employee is blamed. Because regret is associated with internal causal attribution, these results contradict the self-serving bias literature, which affirms that people are more likely to make external than internal attributions for failures (Mezulis, Abramson, Hyde, & Hankin, 2004; Weiner, 2010). The internal failure attribution converges with the idea that consumer participation in production implies more responsibility over the result (Bitner, Faranda, Hubbert, & Zeithaml, 1997; Prahalad & Ramaswamy, 2004).When the causal locus is attributed to the company or to the service employee, disappointment towards the company tends to be higher than in the other conditions and higher than regret. Study 2 tested whether consumers who co-produce would take responsibility for a failure and blame themselves in situations where the causal locus was undetermined. The results once again contradicted the self-serving bias literature in a scenario with co-production. Consumers who co-produced experienced more regret and less disappointment towards the company, and they blamed themselves more intensely than the consumers who did not co-produce. Therefore, the consumers who co-produce take more responsibility for dissatisfying results and, consequently, regret their actions to a higher degree than those consumers who do not co-produce. These results show that even when co-production fails to generate a satisfying result for the consumer, it may be positive for the company because it provides a context in which both the consumer and the company may be responsible for the failure. When the company is blamed, consumers experience less regret and more disappointment towards the company than when the consumer is the one to blame. But when the consumer is blamed or the causal locus is uncertain, situations that are both possible in a co-production context, then consumers experience more regret and less disappointment towards the company.