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Nari Kim,Da Eun Kim,Ju Young Yoon 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Aim: South Korea is a super-aged society with higest suicide rate in the world, and frailty has become a prevalent issue among older people. Considering that frailty level affects psychosocial factors among older people, it is worth investigating the differences in individual and interpersonal factors related to suicide ideation (SI) according to frailty level. This study investigated the factors associated with SI among robust, pre-frail, and frail older people. Method: A total sample of 10,047 Korean older people from the 2017 National Survey of Older Koreans were included in this cross-sectional descriptive study. The respondents were classified into three groups based on the comprehensive Korean frailty index. Chi-square and logistic regression analyses were utilized in this study. Result: The robust (3.0%), pre-frail (6.1%), and frail (11.1%) groups had experienced SI. No common factors were associated with SI among the groups; however, younger age and low satisfaction with spouses were common associated factors in the pre-frail and frail groups. The total sample analysis results that related factors with SI were younger age, higher number of chronic diseases, lower levels of subjective health status, more depressive symptoms, and more satisfactions with spouses and children. In the analyses using specific samples by frailty levels, robust older people with high number of chronic diseases and depressive symptoms were more likely to have SI. In pre-frail group, the highly associated factors with SI were female, younger age, lower levels of subjective health status, more feeling of burdensomeness, and lower satisfaction with spouse. In frail group, those with younger ages, more depressive symptoms, less satisfied with their spouses and child had more SI. Conclusion: Satisfaction with family and depressive symptoms were significant factors in lessening SI, suggesting that older people need more family support and care as frailty progresses.
NaRi Kim,SamuelSukHyun Hwang,JungSeok Choi,DaiJin Kim,Zsolt Demetrovics,Orsolya Kiraly,Katalin Nagygyorgy,Mark. D. Griffiths,SoYeon Hyun,HyunChul Youn,SamWook Choi 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.1
Objective-The Section III of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) proposed nine diagnostic criteria and five cut-point criteria for Internet Gaming Disorder (IGD). We aimed to examine the efficacy of such criteria. Methods-Adults (n=3041, men: 1824, women: 1217) who engaged in internet gaming within last 6 months completed a self-report online survey using the suggested wordings of the criteria in DSM-5. Major characteristics, gaming behavior, and psychiatric symptoms of IGD were analyzed using ANOVA, chi-square, and correlation analyses. Results-The sociodemographic variables were not statistically significant between the healthy controls and the risk group. Among the participants, 419 (13.8%) were identified and labeled as the IGD risk group. The IGD risk group scored significantly higher on all motivation subscales (p<0.001). The IGD risk group showed significantly higher scores than healthy controls in all nine psychiatric symptom dimensions, i.e., somatization, obsession-compulsion, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism (p<0.001). Conclusion-The IGD risk group showed differential psychopathological manifestations according to DSM-5 IGD diagnostic criteria. Further studies are needed to evaluate the reliability and validity of the specific criteria, especially for developing screening instruments.
Nari Kim,Jin Han,Euiyong Kim 대한생리학회-대한약리학회 2001 The Korean Journal of Physiology & Pharmacology Vol.14 No.5
<P> An impaired smooth muscle cell (SMC) relaxation of coronary artery by alteration of K<SUP></SUP> channels would be the most potential explanation for reduced coronary reserve in left ventricular hypertrophy (LVH), however, this possibility has not been investigated. We performed morphometrical analysis of the coronary artery under electron microscopy and measured Ca<SUP>2</SUP>-activated K (K<SUB>Ca</SUB>) currents and delayed rectifier K (K<SUB>dr</SUB>) currents by whole-cell and inside-out patch-clamp technique in single coronary arterial SMCs from rabbits subjected to isoprenaline-induced cardiac hypertrophy. Coronary arterial SMCs underwent significant changes in ultrastructure. The unitary current amplitude and the open-state probability of K<SUB>Ca</SUB> channel were significantly reduced in hypertrophy without open-time and closed-time kinetic. The concentration-response curve of K<SUB>Ca</SUB> channel to Ca<SUP>2</SUP> is shifted to the right in hypertrophy. The reduction in the mean single channel current and increase in the open channel noise of K<SUB>Ca</SUB> channel by TEA were more sensitive in hypertrophy. K<SUB>dr</SUB> current density is significantly reduced in hypertrophy without activation and inactivation kinetics. The sensitivity of K<SUB>dr</SUB> current on 4-AP is significantly increased in hypertrophy. This is the first study to report evidence for alterations of K<SUB>Ca</SUB> channels and K<SUB>dr</SUB> channels in coronary SMCs with LVH. The findings may provide some insight into mechanism of the reduced coronary reserve in LVH.
Na-Ri Kim,Sujin Kim,Jin Dong Kim,Do Sung Huh,Young Key Shim,Sang Joon Choe 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.1
This study reports on the geometry optimizations and electronic structure calculations for methyl pyropheophorbide (MPPa), tropolonyl methyl pyropheophorbides (TMPPa, ITMPPa), and cationic tropolonyl methyl pyropheophorbides (TMPPa+․BF4 -, ITMPPa+․BF4 -, TMPPa+, and ITMPPa+) using Local Spin Density Approximation (LSDA/ 6-31G*) and the Restricted Hatree-Fock (RHF/6-31G*) level theory. From the calculated results, we found that substituted cationic tropolonyl groups have larger structural effects than those of substituted neutral tropolonyl groups. The order of structural change effects is ITMPPa+ > ITMPPa+․BF4 - > ITMPPa, as a result of the isopropyl group. Because it is an electron-releasing group, the substituted isopropyl group electronic effect on a 3-position tropolone increases the Highest Occupied Molecular Orbital and Lowest Unoccupied Molecular Orbital (HOMO-LUMO) energy gap. It was constituted that the larger the cationic characters of these photosensitizers, the smaller the HOMOLUMO band gaps are. The orbital energies of the cationic systems and the ions are stronger than those of a neutral system because of a strong electrostatic interaction. However, this stabilization of orbital energies are counteracted by the distortion of chlorin macrocycle, which results in a large destabilization of chlorin-based compound HOMOs and smaller destabilization of LUMOs as shown in TMPPa (ITMPPa), TMPPa+․BF4 - (ITMPPa+․BF4 -), and TMPPa+ (ITMPPa+) of Figure 6 and Table 6-7. These results are in reasonable agreement with normal-coordinate structural decomposition (NSD) results. The HOMO-LUMO gap is an important factor to consider in the development of photodynamic therapy (PDT).