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Naotaka Ogasawara,Mari Mizuno,Ryuta Masui,Yoshihiro Kondo,Yoshiharu Yamaguchi,Kenichiro Yanamoto,Hisatsugu Noda,Noriko Okaniwa,Makoto Sasaki,Kunio Kasugai 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.2
Background/Aims: Despite improvements in endoscopic hemostasis and pharmacological therapies, upper gastrointestinal (UGI) ulcersrepeatedly bleed in 10% to 20% of patients, and those without early endoscopic reintervention or definitive surgery might be at ahigh risk for mortality. This study aimed to identify the risk factors for intractability to initial endoscopic hemostasis. Methods: We analyzed intractability among 428 patients who underwent emergency endoscopy for bleeding UGI ulcers within 24hours of arrival at the hospital. Results: Durable hemostasis was achieved in 354 patients by using initial endoscopic procedures. Sixty-nine patients with Forrest typesIa, Ib, IIa, and IIb at the second-look endoscopy were considered intractable to the initial endoscopic hemostasis. Multivariate analysisindicated that age ≥70 years (odds ratio [OR], 2.06; 95% confidence interval [CI], 1.07 to 4.03), shock on admission (OR, 5.26; 95% CI,2.43 to 11.6), hemoglobin <8.0 mg/dL (OR, 2.80; 95% CI, 1.39 to 5.91), serum albumin <3.3 g/dL (OR, 2.23; 95% CI, 1.07 to 4.89), exposedvessels with a diameter of ≥2 mm on the bottom of ulcers (OR, 4.38; 95% CI, 1.25 to 7.01), and Forrest type Ia and Ib (OR, 2.21;95% CI, 1.33 to 3.00) predicted intractable endoscopic hemostasis. Conclusions: Various factors contribute to intractable endoscopic hemostasis. Careful observation after endoscopic hemostasis is importantfor patients at a high risk for incomplete hemostasis.
Activated Protein C Anticoagulant System Dysfunction and Thrombophilia in Asia
Naotaka Hamasaki,Hiroyuki Kuma,Hiroko Tsuda 대한진단검사의학회 2013 Annals of Laboratory Medicine Vol.33 No.1
Thrombophilia that is common among Caucasians is caused by genetic polymorphisms of coagulation factor V Leiden (R506Q) and prothrombin G20210A. Unlike that in Caucasians, thrombophilia that is common in the Japanese and Chinese involve dysfunction of the activated protein C (APC) anticoagulant system caused by abnormal protein S and protein C molecules. Approximately 50% of Japanese and Chinese individuals who develop venous thrombosis have reduced activities of protein S. The abnormal sites causing the protein S molecule abnormalities are distributed throughout the protein S gene, PROS1. One of the most common abnormalities is protein S Tokushima (K155E), which accounts for about 30% of the protein S molecule abnormalities in the Japanese. Whether APC dysfunction occurs in other Asian countries is an important aspect of mapping thrombophilia among Asians. International surveys using an accurate assay system are needed to determine this.
Low Complexity Iterative Precoder for Downlink MU-MIMO Systems
Naotaka Yoshida,Yuji Yokota,Yuhei Nagao,Hiroshi Ochi 대한전자공학회 2015 ITC-CSCC :International Technical Conference on Ci Vol.2015 No.6
Block diagonalization (BD) precoder is used for Multi-User Multiple Input Multiple Output (MU-MIMO) IEEE 802.11ac Wireless LAN. To improve the latency of the MU-MIMO systems, the BD precoder using iterative calculation has been proposed. We call this method Iterative BD (IBD). IBD can start the MU-Precoder weight matrix calculation even before all user’s channel state information (CSI) are received. However IBD has a higher complexity compared to non-iterative BD because of the overhead of iterative calculation. In this paper, we reduce the complexity due to the iteration process by computing the null space needed in the IBD method together with the channel matrix decompression which is applied by CSI feedback process based on IEEE802.11ac. We show that our method can significantly reduce the complexity of IBD.
Naotaka Ogasawara,Yasushi Funaki,Kunio Kasugai,Masahide Ebi,Yasuhiro Tamura,Shinya Izawa,Makoto Sasaki 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.2
Background/AimsDetailed evaluations of overlapping constipation and gastroesophageal reflux disease (GERD) have not been conducted in Japan. The REACTION-J2 study examined the overlap of these diseases in Japan. MethodsThis internet-based survey recruited participants from general public survey panels. Questions included demographic and medical data and assessments based on validated measures for constipation and GERD. Associations between background factors affecting constipation/GERD overlap, disease measures, and treatment were also evaluated. ResultsAmong 10 000 survey responses received, functional constipation (Rome IV diagnostic criteria) was reported by 439 participants; chronic constipation (Japanese guidelines) by 3804 participants; and subjective constipation symptoms by 2563 participants. The number of participants with constipation/GERD overlap ranged from 73 to 1533 depending on the criteria used. Regardless of the definition used, all GERD groups had significantly higher odds of being constipated than non-GERD participants: the OR (95% CI) for all 9 combinations of definitions ranged between 1.56 (1.21, 2.01) and 2.67 (2.44, 2.92) (all P ≤ 0.001). Straining, hard stools, and sensations of incomplete evacuation and anorectal obstruction/blockage, according to chronic constipation criteria, were common. Participants with constipation/GERD overlap had poorer quality of life (P < 0.001) and worse GERD symptom scores (P < 0.001). The frequency of abnormal stools was highest (P < 0.001) in the constipation/GERD overlap group. In the overlap group, 52.4% and 26.0% used gastric and constipation medication, respectively. ConclusionIndividuals with constipation/GERD overlap tend to have worsened symptoms and quality of life.
CLINICAL STUDY OF VITAMIN INFLUENCE IN DIABETES MELLITUS
Naotaka Hashizume 한국식품영양과학회 2001 한국식품영양과학회 학술대회발표집 Vol.50 No.-
Vitamin deficiency is a result of an inadequate diet. Education on the importance of trace nutrients in diabetic patients with poor blood sugar control is examined. Those who prepare meals must consider the loss of vitamins in the process of cooking. Our study also suggested that marginal vitamin deficiency plays an indirect but important role in the development of diabetic complications. Vitamin C as altering total cholesterol and vitamin E as altering triglyceride could modify diabetic retinopathy. Pharmacologically, niacin might be responsible for the decrease in lipoprotein (a) and vitamin C would inhibit the influence of rapid blood glucose control on diabetic retinopathy.