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Namgoong, S. Y.,Son, K. H.,Chang, H. W.,Kang, S. S.,Kim, H. P. 영남대학교 약품개발연구소 1994 영남대학교 약품개발연구소 연구업적집 Vol.4 No.-
In this investigation, 34 structurally different flavonoids including derivatives of chalcone, flavanone, flavan-3-ol, flavone, flavonol, and their glycosides were evaluated for in vitro suppression of mitogen-induced lymphocyte proliferation and mixed lymphocyte culture from mouse spleen. Flavonoids, mainly derivatives of flavone and flavonol, clearly demonstrated the suppressive effects on lymphocyte proliferation at higher than 10^(-6) M depending on the structures of flavonoid molecules, although their suppressive activities were less than that of cyclosporin A or prednisolone. Various glycosidic substitutions to A- and/or C-ring of the flavonoid aglycones were found to eliminate the suppressive activities of their aglycones, regardless of sugar compositions and positions of substitutions. In concanavalin A-induced lymphocyte proliferation, derivatives of flavone and flavonol having 2, 3-unsaturation and at least 1 hydroxyl group showed the suppressive activity. In lipopolysaccharide-induced lymphocyte proliferation, only myricetin was active among flavonoids tested at the concentrations up to 10^(-5) M. In mixed lymphocyte culture, some derivatives of flavone and flavonol with 2, 3-unsaturation were active and especially flavone derivatives showed the higher suppressive activities than those of the flavonol derivatives.
Namgoong, Jin Woong,Kim, Se Hun,Chung, Sei-Won,Kim, Young Hoon,Kwak, Moo Sun,Kim, Jae Pil Elsevier 2018 Dyes and pigments Vol.154 No.-
<P><B>Abstract</B></P> <P>In the development of display devices, a color filter is still considered an indispensable component. For a thinner display panel, the thickness of the color filter also needs to be decreased. However, if the thickness of the color filter is reduced, the color properties, including the color purity and color gamut are simultaneously diminished. Therefore, introduction of new colorants is needed to lower the thickness without diminishing the color performance. In this study, four phthalocyanine green dyes were synthesized for use in color filters. The molecular geometry and absorption properties were predicted by density functional theory (DFT) and time-dependent DFT, and UV-Vis spectroscopy was employed to measure the optical properties. The thermal stabilities of the dyes were examined by thermogravimetric analysis. A dye with suitable solubility and color properties was adopted in the color filter, and the optical properties and thickness of the dye-based color filter were compared to those of the pigment-based color filter. The chromatic performance and thickness of the color filter were determined by color spectrometry and Alpha step, respectively. Finally, we confirmed that the dye could enable the decrease in the thickness of the filter and provide a superior color property.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Chloro- substituted (α positions) zinc phthalocyanine (Dye 3b) possessed a saddle core structure. </LI> <LI> The enhancing bulkiness inhibits the π-π stacking of the phthalocyanine molecules, thus increasing solubility. </LI> <LI> The dye decreases a thickness of color filter by 20%, owing to its higher color strength than that of pigments. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Namgoong Jung-Man,Hwang Shin,Kim Dae-Yeon,Ha Tae-Yong,Song Gi-Won,Jung Dong-Hwan,Kim Kyung Mo,Oh Seak Hee 대한이식학회 2021 Korean Journal of Transplantation Vol.35 No.1
Congenital absence of the portal vein (CAPV) is a rare venous malformation in which mesenteric venous blood drains directly into systemic circulation. Herein, we report a case of pediatric deceased donor liver transplantation (DDLT) for symptomatic CAPV with whole liver graft from a hepatitis B surface antigen (HBsAg)-positive donor. A 4-year-old boy suffered from CAPV and secondary portal hypertension. He was also diagnosed with DiGeorge syndrome and heart anomalies. After waiting for 4 months, a 5-year-old donor weighing 19 kg with positive HBsAg was allocated to this 4-year-old patient weighing 15 kg. Recipient operation was performed according to the standard procedures of pediatric DDLT. Portal vein reconstruction was performed using interposition of a vascular homograft conduit to the superior mesenteric vein-splenic vein confluence. The patient recovered uneventfully from DDLT. He has been administered with lamivudine to prevent hepatitis B virus infection. This patient has been doing well for 5 years after DDLT without growth retardation. In conclusion, CAPV patients can have various vascular anomalies, thus combined vascular anomalies should be thoroughly assessed before and during liver transplantation operation. The most effective reconstruction techniques should be used to achieve satisfactory results following liver transplantation.
The Prolyl Isomerase Pin1 Induces LC-3 Expression and Mediates Tamoxifen Resistance in Breast Cancer
Namgoong, G.M.,Khanal, P.,Cho, H.-G.,Lim, S.-C.,Oh, Y.K.,Kang, B.S.,Shim, J.-H.,Yoo, J.-C.,Choi, H.S. The American Society for Biochemistry and Molecula 2010 The Journal of biological chemistry Vol.285 No.31
Analysis of the Traditional Setting-up as an Application for Spatial Composition
NamGoong, Sun,Lee, Yu-Ri Korea Furniture Society 2010 한국가구학회지 Vol.21 No.3
Recently, there is a new issue, among the contemporary people, for new life style, such as green design and well being. This trend brought up the necessity that there should be alternatives for interior spatial design. In order to catch up with these new issues, the new convenient and environment friendly methods are in need. Space composition using setting-up is skill that can express both the structural aspect and esthetic because it represents traditional beauty into the contemporary age through the structural rigidity and formal beauty. Also the lumber, as main materials for setting up, is in line with well being life style and environment friendliness. The construction of structure by setting-up has advantages in terms of the reuse and the convenience in that the construction of structure is adjustable according to environment. And setting-up has enough plasticity not only because of its own role as linking the objects but also because of being framed by itself. Therefore setting-up will be a design element, if it is expressed outward. Thus, this study aims to give a guide line about how to apply the result from the evaluating that "what is the most suitable setting-up" and "what is the most suitable detail setting-up", based on that structural rigidity, decorativeness and the ease of works. As a result of evaluation, the most excellent types of setting-up in terms of structural rigidity are "Jangbu" and "Panjae" and "Yeongui". The most excellent types of setting-up in terms of decorativeness are "Panjae" and "Yeongui", and the most excellent type of the ease of work is "Mat". And also the most applicable detail setting-up for the utilization of spatial composition is proposed.
Micro-Chemical Structure of Polyaniline Synthesized by Self-Stabilized Dispersion Polymerization
NamGoong, Hyun,Woo, Dong-Jin,Lee, Suck-Hyun The Polymer Society of Korea 2007 Macromolecular Research Vol.15 No.7
A variety of NMR techniques were applied to the micro-chemical structural characterization of polyanilines prepared via an efficient synthetic method in a self-stabilized dispersion medium in which the polymerization was conducted in a heterogeneous organic/aqueous biphasic system without any stabilizers. Here, the monomer and growing polymer chain were shown to function simultaneously as a stabilizer, imparting compatibility for the dispersion of the organic phase, and as a form of flexible template in an aqueous reaction medium. Polymerizations predicated on this concept generated polyanilines with a low defect content: solution state $^{13}C-NMR$ and solid $^{13}CDD/CP/MAS$ spectroscopy indicated that the synthesized HCPANi and its soluble derivative, HCPANi-t-BOC, evidenced distinctly different NMR spectra with fewer side peaks, as compared to conventionally prepared PANis, and the complete structural assignments of the observed NMR peaks could be determined via the combination of both 1D and 2D techniques. Ortho-linked defects in HCPANi were estimated to be as low as 7%, as shown by a comparison of the integration of the carbonyl carbon resonance peaks.
Namgoong, Jin Woong,Chung, Sei-Won,Jang, Hyeyoun,Kim, Young Hoon,Kwak, Moo Sun,Kim, Jae Pil Elsevier 2018 Journal of industrial and engineering chemistry Vol.58 No.-
<P><B>Abstract</B></P> <P>Four synergists were synthesized to enhance pigment nanoparticles dispersion and the contrast ratio. The interaction between the synergist and the dispersant was confirmed by infra-red (IR) spectrometry. We demonstrate that the hydrogen bonds forming between the synergist and the dispersant act as a key factor. To analyze the dispersion properties, dynamic light scattering (DLS), and electron microscopic analysis was examined. The spectral and color characteristics was also measured by UV–vis spectrometry and colorimetry, and the contrast ratio of color filters was evaluated. This study confirms that the prepared synergist can increase the contrast ratio of green color filter.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>