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윤규태,최기수,안의태,고정식,양남길,박경호 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2
본 연구에서는 계열에 따른 고등학생들의 대뇌반구기능의 특성화 또는 편재화의 경향을 알아보고, 전공분야에 대한 적응력과의 상관관계를 검토하고자 했다. 일반고등학교 인문계열 학생 359명, 자연계열 학생 371명, 음악과 미술전공 학생을 포함한 예능계열 196명, 체육특기자를 포함한 체육계열 학생 151명 등 1,077명을 대상으로 각 계열별, 남녀별, 성적별 고등학생 집단들의 대뇌반구의 특성화, 편재화 경향을 시나가와(품川)질문지법을 이용하여 분석하였으며, 다음과 같은 결과를 얻었다. 1. 인문계열 고등학생의 뇌기능의 편재화 경향은 우뇌형 54.3%, 양쪽뇌형 32.6% 및 좌뇌형 13.1%였다. 남녀별로는 남학생은 우뇌형 62.9% 양쪽뇌형 27.9% 및 좌뇌형 9.5%로 나타났으며, 여학생은 각각 43.7%, 38.6% 및 17.7%로서 여학생이 남학생에 비하여 죄뇌화 경향을 보였다. 2. 자연계열 고등학생의 경우는 우뇌형 56.9%, 양쪽뇌형 29.9% 및 좌뇌형 13.2%로서 인문계열 고등학생과 비슷한 분포를 보였다 이를 남녀별로 구별하여 보면 남학생은 62.2%, 27.1% 및 10.2%, 여학생은 51.5%, 32.5%및 16.0%의 분포를 보여, 역시 여학생의 좌뇌화 경향이 뚜렷했다. 3. 예능계열 고등학생의 경우는 우뇌형 56.1%, 양쪽뇌형 35.2% 및 좌뇌형 8.7%의 분포를 보였으며, 이를 전공별로 세분해서 살펴보면 음악전공학생의 경우 53.7%, 35.5% 및 10.7%로서 전체 평균과 거의 비슷한 분포를 보였으나, 미술전공학생의 경우 60.0%, 34.7% 및 5.3%로서 , 특히 좌뇌형의 경우 음악전공에 비해 절반수준에도 못 미치는 경향을 보였다. 4. 체능계열 고등학생 집단의 경우 우뇌형 50.3%, 양쪽뇌형 37.7% 및 좌뇌형 11.9% 분포를 보였다. 5. 성적별로 보면 일반고등학교 학생 가운데 성적 우수 집단은 뚜렷하게 좌뇌형 경향(25.6% 및 25.0%)을 보였다. 6. 예능계열의 우수집단은 양쪽뇌형의 분포비율(50.0% 및 44.4%)이 특히 높았다. 7. 체육계열의 우수집단은 좌뇌형 분포(21.6%)가 높았다. According to the advanced study on differential theory of brain function, the left hemispheric functions are concerned more on the verbal, logical, sequential and arithmetic abilities, whereas the right hemisphere has characteristics of non-lingual, general, creative and aesthetic abilities. The authors compared the tendency of hemispheric specialization in high school students with different educational condition and facilities. Sinakawa's questionnaire method was the instrument for this study. The results obtained were as follows: Among 1,077 of whole subjects, right hemispheric dominant type was 55.0% (59.1% in male, 51.0% in female), bilateral type was 32.9% (10.6% in male, 35.1% in female) and left hemispheric dominant type was 12.2% (10.4% in male, 13.9% in female). 1. Of the 359 subjects in the field of humanity science, right hemispheric dominant type was 54.3% (62.9% in male, 43.7% in female), bilateral type was 32.6% (27.9% in male, 38.6% in female) and left hemispheric dominant type was 13.1% (9.5% in male, 17.7% in female). 2. Of the 371 subjects in the field of natural science, right hemispheric dominant type was 56.9% (62.2% in male, 51.5% in female), bilateral type was 29.9% (27.1% in male, 32.5% in female) and left hemispheric dominant type was 13.2% (10.2% in male, 16.0% in female). 3. Of the 196 art school students, 56.1% was regraded as right hemispheric dominant type, students majoring music was 53.7%, 35.5% and 10.7%, respectively, whereas the frequency for students majoring find art was 60.0%, 34.7% and 5.3%. 4. In students majoring physical education, 50.3% were shown in right hemispheric dominant type, 37.7% were bilateral type and 11.9% were left hemispheric dominant type. 5. Laterality patterns of students who adapt more successfully to their specific studying fields show following characteristics; Successful students of general high school show pronounced left shift in their laterality pattern, whereas successful students of art school exhibit more bilateral type. And successful students of physical education school show left shift in their laterality patterns.
결락이 있는 3×3 교차설계법에서의 생물학적 동등성시험
임남규,김정일 대전대학교 기초과학연구소 2000 自然科學 Vol.11 No.2
최근 동일한 유효 성분을 가지면서 용량 혹은 형식만이 다른 제제의 개발이 증가되고 이에 따라 두 제제 이상에 대한 생물학적 동등성 시험의 필요성이 제기되고 있다. 중앙약심은 한 회사에서 개발된 제품으로서 동일한 유효성분을 함유하고 용량만이 다른 두 시험제제에 대하여 동시에 시험을 행할 경우에 3×3 교차설계법에 의한 생물학적 동등성 시험을 인정하기로 하였다. 이에 이영주 등 (1998)은 온단세트론 제제에 대한 생물학적 동등성시험에서 3×3 교차설계법을 적용하였다. 그러나 오현숙 등(1999)에 의하면 3×3 교차설계법에서 각각 순서에 피험자의 수가 다르거나 실험 중에 결락(dropout)되는 피험자가 발생하는 경우에는 일반적인 통계적 방법을 적용하기 어려웠다. 이에 본 연구에서는 이러한 경우에 제제효과의 추론과 생물학적 동등성 시험에 대한 통계적 방법에 대해 논의하였다. In recent years, the generic drug products which provide the same therapeutic effect with an innovator drug product have become very popular in pharmacokinetic area. Since assessing bioequivalence of a generic drug with the innovator is required prior to distribution in markets, bioavailablity/bioequivalence studies in comparing several generic drugs simultaneously with the innovator is highly interested. In such circumstance, the Korean Drug Administration announces officially the partial acceptance regulation for the bioequivalence with the results from a 3 x 3 crossover designs when the generic drugs which contain same active ingredients and are produced by a same company are compared with the innovator in an experiment. Lee et a1.(1998), motivated from this new policy, try to assess hioequivalence of Ondensetron drugs using the 3 X 3 latin squares. In bioavailability and bioequivalence studies, the observed data set from a 3 x 3 cross-over design is unbalanced so that standard statistical methods for a cross-over design may not apply drectly. For drug and period effects, we propose a method based on differences of the observations that eliminates the random subject effects and thus does not require any distributional condition on the random subject effects.
박남규,최준호 건국대학교 사회정책연구소 1999 사회과학연구 Vol.11 No.-
With the launch of the WTO regime in 1995, many changes have taken place in the International Trade Environment. Among other things, means for direct export support of government have been curtailed or abolished. But, the relative importance of export insurance is becoming greater as the very efficient means for indirect export support under the IMF supported regime as well as the WTO regime. The Korea Export Insurance System, began for export support, is highly valued in that whenever any difficulty has occurred in export activity and export financing, it has made a great contribution to overcome it, But the Export Insurance System is still poorly used in Korea compared to advanced countries. Therefore, this study attempted to present the following improvement to attain the goal of the export insurance system that is said to contribute to the increase in export: First, in order to cope actively with changes in the International Trade Environment, it is necessary to improve the content of the existing system, to increase its utilization rate of the current 20.5% and to expand export insurance funds. Second, it is necessary to secure the active operation of export insurance, the reasonable operation of the premium rate, the diversification of the items intended for export insurance. Third, it is necessary to reinforce the publicity and marketing activity for export insurance, diversify the overseas credit research method. In conclusion, there is a need the activate export insurance through effective support so as to increase exports based on these improvements.
李春根,金圭植,南日祐,河正洙 中央醫學社 1967 中央醫學 Vol.12 No.1
We have studied on clinical and statistical studies of periodontal cysts developed from 46 patients. The results were obtained as follows, 1) Periodontal cysts are more frequent in females (52.17%) than that in males (47.83%). 2) Predominant ages are third decade (34.78 % ), fifth decade (23. 91 % ), second decade and fourth decade (each other 17.39%) and sixth decade (6.52 %) in the orders. 3) In the etiological teeth of periodontal cysts, the upper central and lateral incisors, lower first and second molars are prevalent. 4) periodontal cysts are more frequent in maxilla (70 %) than that in mandible (30%). The predominant region of periodontal cysts are anterior region of maxilla and molar region of mandible. 5) The 46 periodontal cysts have been treated by means of direct enucleation technique of cyst walls in 43 cases and apicoectomy in 3 cases.
박상규,임남규,이용흔 중앙대학교 수학통계연구소 2000 수학통계논문집 Vol.- No.7
Statistiscal methods for assessing of bioequivalence in 2×2 crossover design are discussed and compared with KFDA criterion. Simulation study for this comparison is conducted and summarized. The simulation result suggests that KFDA should reconsider the current guidelines for bioequivalence. Keywords - Bioequivalence, Crossover design, Power approach