제2형 당뇨병 남성 환자에서 유리 테스토스테론과 성호르몬 결합 글로블린 농도

남기덕,김영설,박철영,오승준,김덕윤,우정택,김성운,양인명,김진우,최영길 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.6

연구배경:인슐린저항성은 제2형 당뇨병과 심혈관질환의 주요한 위험 인자로 성호르몬과 상호 관계가 있다고 알려져 있다. 그러나 여성과는 달리 남성에서는 연령과 인슐린저항성에 따른 유리 테스토스테론과 성호르몬 결합 글로블린 농도의 변화에 대한 연구가 부족한 실정이다. 그러므로, 본 저자등은 제2형 당뇨병 남성 환자에서 정산인과 비교해서 유리 테스토스테론과 성호르몬 결합 글로블린 농도를 측정하고 연령에 따른 변화 정도를 알아보고자 하였다. 방법:대상 환자 모두에서 연령과 체질량지수, 총 콜레스테롤, 중성지방, 공복혈당과 인슐린 농도를 측정하였다. 혈중 유리 테스토스테론 농도는 방사면역측정법(radioimmunoassay)을 이용해서 측정하였고, 혈중 성호르몬 결합글로불린은 면역방사계측측정법(immunoradiometric assay)을 이용해서 측정하였다(Diagnostic System Laoratories, Wbster, TX, USA). 결과:1)제2형 당뇨병 남성 환자에서 정상 대조군 남성에 비해 성호르몬 결합글로불린은 104.1±35.0 vs 25.7±3.5 mole×10??로 의미 있게 높았으나(p<0.001), 유리 테스토스테론은 13.7±9.5 vs 13.6±6.5 ng/dL로 차이가 없었다. 2)연령과 성호르몬 결합 글로블린 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.40로 중등고의 양의 상관 관계를 보였고(p<0.001), 정상 대조군 남성에서 0.11로 유의한 상관 관계를 보이지 않았다. 연령과 유리 테스토스테론 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.08, 정상 대조군 남성에서-0.17로 모두에서 유의한 상관 관계를 보이지 않았다. 3)연령과 체질량지수를 보정한 후에 제2형 당뇨병 남성 환자와 정상 대조군 남성에서 혈중 인슐린 농도, 유리 테스토스테론과 성호르몬 결합 글로블린 사이에는 상관 관계가 없었다. 결론:제2형 당뇨병 남성 환자에서 정상 남성에 비해 성호르몬 결합 글로블린 농도가 증가되어 있었으며, 유리 테스토스테론은 차이가 없었다. 연령이 증가함에 따라 성호르몬 결합 글로블린이 제2형 당뇨병 남성 환자에서 정상 남성에 비해 증가 폭이 의미있게 컸으며, 유리 테스토스테론은 변화가 없었다. Background: Insulin resistance is a risk factor for cardiovascular disease and type 2 diabetes mellitus. There are many previous studies indicating that insulin lowers serum sex hormone-binding globulin levels, and there is inverse correlation between insulin resistance and serum sex hormone-binding globulin levels in women. However, in men, a limited number of studies are available to explain the effect of sex hormone on age and insulin. Therefore, the present study was undertaken to investigate the relationship among free testosterone, hormone-binding globulin and age in type 2 diabetic men and control subjects. Method: Age, body mass index, total cholesterol, triglyceride, fasting blood sugar, and insulin concentrations were examined on 89 type 2 diabetic men and 47 control subjects. The free testosterone level was measured by commercially available double-antibody system (Radioimmunoassay). The sex hormone-binding globulin level was also measured by commercially available double-antibody system(Immunoradiometric assay). Results: 1) Sex hormone-binding globulin level was significantly increased in patients with type 2 diabetes. However, there was no significantly difference in free testosterone level between the two groups. 2) Sex hormone-binding globulin was positively correlated with age (r=0.4, p <0.001) in patients with type 2 diabetes. Sex hormone-binding globulin and free testosterone were not correlated with age in control sujects. 3) Free testosterone and sex hormone-binding globulin concentrations were not significantly related to serum insulin concentration after adjusting for age and body mass index. Conclusions: We observed increased sex hormone-binding globulin concentration in diabetes man, and was a positively related to age. Further studies are needed to understand the relationships between age, insulin resistance, testosterone, and sex hormone-binding globulin concentrations(J Kor Diabetes Asso 24:699~707,2000).

비볼록 목적함수에서 M-추정법

남호수,조증성,주철민 東西大學校 1998 동서논문집 Vol.4 No.-

일반적인 위치모수의 추정문제에서 로버스트 방법으로 흔히 고려되는 것이 M-추정법이다. M-추정법에서는 추정량이 명시적 형태로 주어지지 않으며, 특히 비볼록(non-convex)목적함수에서의 M-추정에 기존의 뉴튼 방법을 적용할 경우 목적함수의 대역최소점에서 해를 찾는데 실패할 위험이 있다. 본 논문에서는 이런 문제점을 유전자 알고리즘(genetic algorithm)을 이용하여 해결하고자 한다. 즉, M-추정에서 고려하는 목적함수를 미분하지 않고 목적함수 자체를 최적화(최소화)시키는 방법으로 해를 구하는 방안을 제시하고자 한다. 또한, M-추정에서 널리 쓰이는 뉴튼 방법에 의한 해의 문제점을 지적하고 제안된 방법에 의한 M-추정의 타당성을 예를 들어 보이고자 한다. The M-estimation is frequently considered as a robust procedure in the estimation of location parameter. Usually the M-estimator can not be represented as an explicit form. In this paper, we propose an M-estimation method in non-convex object function by using the genetic algorithm. The proposed method cirectly optimizes(minimizes)the object function without differentiating the function, and it approximates the global solution regardless of the initialization. An illustrative example shows that the proposed estimation method is stable and has elegant behavior, compared to the classical M-estimation.

소아나 협조가 힘든 환자에서 봉합사 제거가 쉬운 봉합법

남수봉,오흥찬,강철욱,최수종,배용찬 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

실혈성쇼크의 회복에 미치는 고장성욕액의 영향

南基鏞,廉哲鎬 朝鮮大學校 附設 醫學硏究所 1984 The Medical Journal of Chosun University Vol.9 No.1

This study was to investigate the effects of hypertonic saline solution on the recovery of hemorrhagic shock in rabbits, Infusions of hyperosmotic NaCl (2,400 mOsm/L) solution were given to the anesthetized rabbits in severe hemorrhagic hypotension by intravenous injection. Arterial pressure, heart rate, plasma osmolarity, plasma electrolyte, hematocrit and plasma volume were measured in rabbits during experiments. The results obtained were as follows : 1) Increase of arterial pressure and diminution of heart rate were observed after infusions of hypertonic saline solution in hemorrhagic shock as compared with physiological saline solution infusion. 2) Plasma osmolarity and plasma sodium concentration increased slightly after infusions of hypertonic saline solution in hemorrhagic shock as compared with physiological saline solution infusion, and hematocrit diminished slightly in both groups. 3) Increase of plasma volume was observed after infusions of hypertonic saline solution in hemorrhagic shock. 4) Infusions of hypertonic NaCl showed almost no influence on hemodynamic factors in nonhemorrhagic state. 5) The effects of hypertonic NaCl infusions on hemorrhagic shock in rabbits were transient.

MAGFET의 동작 특성에 미치는 형상효과

남태철,이철우,이지연 嶺南大學校 工業技術硏究所 1997 工業技術硏究所論文集 Vol.25 No.1

We have investigated the galvanomagnetic properties of the MAGFET with two splitted drains. The model shows that the sensitivity of the MAGFET is primarily a function of the Hall voltage which is proportional to ratio of the gate, W/L. We have shown the distributions of potential and current density and attained the relative sensitivity of 3.2[%/T]

돼지에서 개량된 회장 캐눌러 삽관법 1례

김명철,이재일,이수진,조종민,김남중 충남대학교 수의과대학 동물의과학연구소 2001 動物醫科學硏究誌 Vol.9 No.-

Intestinal cannulation was developed for the study of enteric microflora, nutritional requirements and status. However, already established techniques revealed cause often leakage of the intestinal contents and necrosis of skin. For the prevention of contamination from the ingesta, modified ileal cannulation was performed in a pig. The pig was anesthetized by tiletamine-zolazepam(4.4㎎/㎏, IM) administration 10 minutes after administration of xylazine(0.5㎎/㎏, IM). We inserted resin cannula in the ileum incised and put the inner ring after employing purse-string suture in the ileum. We made the puncture incision in the body wall through which the cannula is drawn. The cannula was placed surgically at the ventral placement of cranial part and at the dorsal placement of caudal part. Cannula was fixed by placement of two outer washer, and sealed with cannula stopper. Laparotomy incision was closed by mattress suture. The pig was given postoperative penicillin(20,000 IU/㎏ IM) to prevent secondary infection for 3 days. There were not observed the entering of rubber cannula into the abdominal cavity, the contamination of ingesta and necrosis of skin, and good result was revealed.

UPS 응용을 위한 3상 PWM 인버터의 새로운 전압 제어 방법

박남주,임철우,정세교,이영조 慶尙大學校 工科大學 自動化및컴퓨터應用技術硏究所 1999 自動化 및 컴퓨터應用技術 Vol.6 No.1

This paper describes a novel control method of a three-phase PWM inverter for uninterruptible power supply(UPS) applications. To obtain the fast dynamics and excellent harmonic characteristics, a new state feedback control technique is proposed. The proposed control consists of the inner-loop current and outer-loop voltage controllers with a load current estimator to reduce the effects of the load variations and nonlinearity. In order to verify the effectiveness of the proposed control, the simulation is carried out for various load condition.

축산시설의 입지특성 분석 : 안성시 미양면을 중심으로

황한철,전우정,이남호,홍성구,김진태 안성산업대학교 1998 論文集 Vol.30 No.2

It is necessary to evaluate the location suitability of livestock facilities to guide reasonable livestock. The evaluation system could help plan new livestock facilities in rural areas. The assessment was performed based on location characteristics of livestock facilities such as land utilization around livestock facilities, size of livestock facilities, water and drainage condition, accessibility and distance from roads, floor condition, distance from village and house, direction of livestock facilities, ventilation facilities, animal Waste treatment, and so forth. In this study, location characteristics of livestock facilities were showed each location factors using statistical analysis.

치과용 아말감 합금의 인장강도에 관한 연구

임호남,선우양국,김철위 대한치과기재학회 1984 대한치과재료학회지 Vol.11 No.1

The purpose of this comparative study was to evaluate the diametral tensile strength of commercially available dental amalgams used in Korea. For this study, six kinds of Korean amalgams and nine kinds of imported amalgams were used. Diametral tensile test specimens were prepared in 4×8mm. stainless steel cylindrical molds and the prepared specimens were stored in 37±1℃ and 100% relative humidity conditions. Diametral tensile strength measurements were made on an Instron testing machine for five specimens, at 15 minutes, 1 hour, 24 hours and 7 days, using a cross head speed of 0.05mm/min. The results obtained in this study were as follows; 1. The diametral tensile strength of the high-copper amalgams were higher than that of the conventional amalgams. 2. The diametral tensile strength after fifteen minutes of Korean amalgams much better than the imported amalgams and the final diametral tensile strength of Korean products were also increased.

자기통제 피드백이 배구 언드핸드 토스의 수행과 학습에 미치는 영향

한남익,박종태,표내숙,박철용 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

The purpose of this study was to investigate where a feedback(self-controlled) schedule controlled by learner would be a more effective means of delivering feedback than any predetermined feedback schedule. Subjects(n=60) were randomly assigned to one of five conditions : Control condition, 50% relative frequency feedback condition, bandwidth feedback condition, self-controlled performance feedback condition, and yoked control condition. Experiment was designed to determine the optimal feedback condition for performance and learning of underhand toss. In experiments, subjects performed 50 acquisition and two retention trials blocks were analyzed with two experimental conditions to which they had been assigned. Data obtained from all subjects in five acquisition and two retention trials blocks were analyzed with two separate analyses of variance for each of four error scores. Analysis performed on the acquisition trials were a 5×5(condition ×trial block) analysis of variance(ANOVA) with repeated measures on the second factor. The retention trials were analyzed in a 5 ×2(condition ×trial block) analysis of variance with repeated measures on the second factor. Dependent measures were absolute error(AE), and variable error(VE). In conclusion, it should be stressed that the results of this study do support the guidance hypothesis of feedback and these findings showed that self-controlled subjects tend to produce improvements in the learning of underhand toss.