직장 카르시노이드 종양에서 Ki-67 발현의 예후적 중요성

홍수민 ( Su Min Hong ),김유선 ( You Sun Kim ),문정섭 ( Jung Seop Moon ),김진남 ( Jin Nam Kim ),오명기 ( Myoung Ki Oh ),권선옥 ( Sun Ok Kwon ),정성연 ( Seong Yeon Jeong ),홍성우 ( Seong Woo Hong ),강윤경 ( Yun Kyung Kang ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Background/Aims: Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors. Methods: We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis. Results: The mean age (±SD) of the patients was 56.3±10.7 years, and the male : female ratio was 3.6:1. The mean tumor size was 0.5±0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7±1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4±25.4 months, and no recurrences were observed. Conclusions: In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.

ISOLATION AND CHARACTERIZATION OF MOLECULAR MARKER FOR SEVERAL RACES OF PYRICULARIA ORYZAE USING RANDOM AMPLIFIED POLYMORPHIC DNA

Hong, Sun-Min,Bae, Dong-Won,Kim, Mee-Hyang,Shim, Chang-Ki,Kang, Kyu-Young,Kim, Nam-Soo,Kim, Hee-Kyu Plant Molecular Biology & Biotechnology Research C 1994 Plant molecular biology and biotechnology research Vol.1994 No.

Primer 155(GCTGGCGCTG) was the most useful primer with distinctive polymorphic DNA pattern to distinguish between KI races and KJ races. Primer 173(CAGGCGGCGT) showed polymorphic DNA pattern to distinguish isolates of KI-100 race. The specific DNA fragment of 0.6Kb, generated from 88-62 of KJ-201 race by RAPD with primer 412)TGCGCCGCTG), was promising as a molecular marker to identify the isolate.

성격유형에 따른 복식문양 이미지 평가에 관한 연구

남기선,한명숙 服飾文化學會 2004 服飾文化硏究 Vol.12 No.1

The objectives of this study were to investigate the perceptions of Korean female university students for clothing pattern tendency and structural element of clothing pattern image dimension and to find how individual personality type influence the preferred clothing pattern characteristics. For this study, a questionnaire was designed and sent to 600 female university students of Daejeon, Seoul and metropolitan area. The tool used in this study was MBTI(The Myers-Briggs Type Indicator) Form G Korean version and for the analysis of data SPSS 10.0 package were used. 10 representative patterns for this study were floral, dot, stripe, check, animal, abstract & artistic, geometric, vegetable & leaf, paisely, patchwork pattern. The data were analyzed by factor analysis, arithmetic mean, One-Way ANOVA, χ^(2)-test. The major findings were as follows: Clothing pattern image dimension perceived by Korean female university students for 10 representative patterns were basic form, deluxe, specialty, and cultral dimension. Among them, basic form and deluxe dimension were major dimensions. In basic form dimension, dot pattern score was high indicating female students perceive it as light, comfortable, clean, cool and simple pattern image. In deluxe dimension, floral pattern scored high and in specialty dimension, abstract and artistic pattern scored high among other pattern image. In cultural dimension, geometric pattern and check pattern scored high. Based on other detailed analysis results, It is concluded that the personality type greatly influence clothing pattern evaluation. For example, in case of color combination of patchwork pattern, there was a difference in color preference depend on a personality type such as sensing(S) or intuition(N). Therefore, sensing personality type preferred adjacent color combination than contrast color combination. Detailed marketing strategy is necessary in planning textile design of merchandise plan.

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

만성 골수성 백혈병 환자에서 발생한 거대 후복막강내 혈종 1예

박기령,김영선,박사영,최진혁,이순남,정화순 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.1

Thrombohemorrhagic complications in chronic myeloproliferative disease(CMPD) including chronic myelogenous leukemia(CML) are not rare. Lower incidence of disordered hemostasis is reported in CML compared with other CMPD. The mechanism of thrombohemorrhagic complications might be a consequence of qualitative platelet abnormalites and prolonged bleeding time rather than that of thrombocytosis. Although defect of platelet function has been extensively investigated, there was no established consistent correlation between clinical bleeding and number and function of platelet. The most common site of bleeding complications in the CMPD is superficial mucosa. Bleeding in deep tissue and viscera is very unusual. We report a case of CML which developed a huge spontaneous retroperitoneal hematoma.

일 요양병원에 입원한 만성질환자들의 건강증진 프로그램 적용후 임상검사치 변화

임기동,이영선,박계남,류소연,김기순 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Objectives and Method : To find the change of clinical laboratory value change of some chronic degenerative disease patients who were admitted to E sanatorium hospital in Y city from January 2001 to June 2002 after a health promotion program, a quasi-experimental study was done. Results : 1. The characteristics of study subjects showed 47.5% of male, 52.5% of female, 50% under 50 years in age Their common disease was cancer and cardiovascular disease, endocrine disease, liver disease followed in frequency. Before admission 74.2% smoked, 67.5% enjoyed drinking alcohol and 92.5% preferred to take meat 2. After health promotion program mean systolic blood pressure, diastolic blood pressure, serum total cholesterol, serum triglyceride, fasting blood sugar and serum total protein were decreased statistically significantly, compared to the value at the beginning of admission 3. By the group of patients characteristics like sex, age, smoking status, drinking status, meat intake preference and kind of diseases suffering from, mean systolic blood pressure, diastolic blood pressure, serum total cholesterol, serum triglyceride showed consistent decrease after health promotion program compared to the beginning of admission Mean levels of fasting blood sugar, serum total protein, white blood cell (WBC) counts, red blood cell (RBC) counts, GPT showed irregular change in some patients characteristics group Conclusion : Keen and consistent change was shown at blood pressure and lipid parameter after a health promotion program toward chronic degenerative disease patients. To confirm that the cause of change was due to life style change or accidental reason, further systematic studies are required.

大邱市 住居地域 大氣中 粒子狀 多環芳香族炭火水素의 濃度

박선미,최진수,김기남,백성옥,박상곤 嶺南大學校 環境問題硏究所 1994 環境硏究 Vol.14 No.1

본 연구는 도시 주거지역을 대상으로 환경 대기 중에 존재하는 18종류의 다환방향족 탄화수소(PAH)의 농도를 측정하였다. 시료포집은 하절기는 1992년 8월에서 10월까지, 동절기는 1992년 11월에서 1993년 1월까지 Hi-Vol sampler를 사용하여 실시하였으며, 포집된 시료의 분석은 fluorescence 검출기가 장착된 HPLC(High Performance Liquid Chromatography)로 하였다. 본 연구의 실험 결과에서 여름철 14종류의 PAHs농도는 6.44ng/㎥로 나타났고, 겨울철의 농도는 27.55ng/㎥으로 나타났으며, 농도가 가장 높게 나타난 PAH는 Benzo(e)pyrene이었다. Naphthalene, Acenaphthylene, Acenaphthene, Fluorene은 입자상 물질에서 아주 낮은 농도치를 보였고, Fluoranthene, Pyrene, Benz(a)anthracene, Chrysene과 같은 비교적 저분자 PAHs는 여름철 보다 겨울철에 높은 농도치를 나타냄을 알 수 있었다. This study was carried out to investigate the ambient concentration of 18 particulate Polycyclic Aromartic Hydrocarbons(PAHs) in a residental area in Taegu city. The sampling was conducted using Hi-Vol sampling from August 1992 to October 1992 for summer and from November 1992 to January 1993 for winter. The analysis of PAHs was carried out using reversed phase HPLC with fluorescence detection. It was found that the summation of the concentrations of 14 PAHs during summer were 6.44ng/㎥, and during winter were 27.55ng/㎥. The most abundant PAH appeared to be Benzo(e)pyrene. The concentrations of Naphthalene, Acenaphthylene, Acenaphthene, Fluorene were too low to be determined in particulate metter the contribution of lower molecular weight PAH(Fluoranthene, Pyrene, Benz(a)anthracene, Chrysene) during winter was higher than those of during summer, indicating that gas-particle may play a significant role distribution of PAH concentrations in ambient air.

여성들의 수유양상 및 수유방식의 선택에 영향 주는 요인들

김기남,현태선,강남미 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.3

In order to obtain baseline data for the development of an educational program on breastfeeding, a survey was carried out to investigate infant feeding practices, the characteristics the subjects have in common, and the factors that influence the feeding methods among women in Seoul and the Chungbuk area. Subjects included 671 lactating mothers who visited public health centers or pediatric clinics between December 1999 and february 2000, and were interviewed using a questionnaire. The results were as follows : With respect to feeding methods, the incidence of breastfeeding, formula feeding, mixed feeding and formula feeding switched from breastfeeding was 20.6%, 29.8%, 11.6%, and 38.0%, respectively. With respect to the characteristics the subjects had in common, the incidence of women who planned their infants' feeding methods before pregnancy, during pregancy, and after delivery was 48.7%, 31.0%, and 20.3%, respectively. The incidence of women who started breastfeeding in the hospital after delivery was 38.8%. About seventy seven percet of the subjects had not previously attended an educational program on breastfeeding, and most of these wanted to participate in the future in an educational program to learn about breastfeeding. Some of the topics they were interested in were "Nutritional Management for Sufficient Breast Milk" (60.3%), "Breast Care" (25.0%), and "Correct Nursing positions" (9.8%). Most (88.2%) of the women who breastfed suffered from physical discomforts including discomfort of the waist, and legs and discomfort due to cracked or sore nipples. "Insufficient breast milk" was the main reason for breastfeeding cessation or for switching to formula feeding. FIith respect to formula feeding practices, the main reasons for selecting a specific brand of formula were "the same brand the hospital used after delivery" (34.3%) and "an advertised brand" (23.3%). The strongest factor for promoting breastfeeding was "the support of husband or parents", next were "breastfeeding in the hospital after delivery" and "planning to breastfeed before pregnancy" in that order. The characteristics the subjects had in common relating to formula feeding were "mother's job", "high economic level", "Caesarian section" and "planning to breastfeed after delivery". In conclusion, it is recommended that breastfeeding be promoted, and educational programs be developed and offered as soon as possible to each group which had unfavorable attitudes toward breastfeeding. In addition, the monitoring and supervision of formula advertisements is required to protect consumers from the adverse effects of exaggerated advertising.

거주 형태에 따른 에너지 섭취량과 소비량의 균형도 조사

박순목,고성경,남인수,윤재만,임승현,전중기,이종삼 대구대학교 인문과학연구소 2008 人文科學硏究 Vol.31 No.-

We investigated that the effects of residential type on energy balance in college students. Total sixteen college students were participated in this study, all subjects were assigned one of three groups: either school attendee students group, self-governed living students group, dormitory students group. Routine physical activity level (for 5 days including three weekday and two weekend) and food intake were surveyed. For investigation of degree of physical activity, all subjects were requested to record on their physical movements as possible as detail should be obtained. To all subjects, five-day dietary log form was given, and used for examining of calorie intake from their routine diet. There was no statistical difference in energy intake and consumption in each. However energy consumption was significantly higher than energy uptake in school attendee students group. All other groups were shown a similar energy values between energy uptake and consumption. There were no significant differences in energy intake and consumption in any of experimental groups when comparisons were made between weekdays and weekend. As far as energy uptake was concerned it was no statistical difference in any of major nutrients among groups. In conclusion, partial imbalance was found between energy intake and uptake in school attendee groups. This may be due to their more active life style than other groups'. In future studies, better controlled study should be performed not only more subjects are recruited but also minor nutrients are included for examining of energy balance.

볼엔드밀 가공에서 미변형 칩두께의 이론적 해석

심기중,유종선,서남섭 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2003 工學硏究 Vol.34 No.-

This paper presents a theoretical analysis to estimate the undeformed chip thickness required for cutting force simulation model development in ball-end milling. In machining, cutting force is estimated by multiplying cutting cross-section area to specific cutting forces. Specific cutting force, that is cutting parameter, is one of the important factors for cutting force prediction model and has different values according to workpiece materials. Cutting cross-section area is simply estimated in 2 dimensional cutting, but not simply estimated in 3 dimensional cutting due to complex cutting mechanics. In finishing cutting of free form surface using ball-end milling, cutting is almost performed in the ball part of the cutter and tool geometry such as tool radius, helix angle along length from tool tip are varied. As a result, cutting speed, effective helix angle and rake angle of the ball end mill are different according to length from tool tip. Study on undeformed chip thickness can be based other research, for example, cutting force prediction, tool deflection and dimensional error characteristics simulation. For undeformed chip thickness estimation, tool and chip geometry are analyzed and then the definition of chip thickness and estimation method are described. The results of analysis are compared with geometrical simulation and other method.