Application of time series based damage detection algorithms to the benchmark experiment at the National Center for Research on Earthquake Engineering (NCREE) in Taipei, Taiwan

Noh, Hae Young,Nair, Krishnan K.,Kiremidjian, Anne S.,Loh, C.H. Techno-Press 2009 Smart Structures and Systems, An International Jou Vol.5 No.1

In this paper, the time series based damage detection algorithms developed by Nair, et al. (2006) and Nair and Kiremidjian (2007) are applied to the benchmark experimental data from the National Center for Research on Earthquake Engineering (NCREE) in Taipei, Taiwan. Both acceleration and strain data are analyzed. The data are modeled as autoregressive (AR) processes, and damage sensitive features (DSF) and feature vectors are defined in terms of the first three AR coefficients. In the first algorithm developed by Nair, et al. (2006), hypothesis tests using the t-statistic are applied to evaluate the damaged state. A damage measure (DM) is defined to measure the damage extent. The results show that the DSF's from the acceleration data can detect damage while the DSF from the strain data can be used to localize the damage. The DM can be used for damage quantification. In the second algorithm developed by Nair and Kiremidjian (2007) a Gaussian Mixture Model (GMM) is used to model the feature vector, and the Mahalanobis distance is defined to measure damage extent. Additional distance measures are defined and applied in this paper to quantify damage. The results show that damage measures can be used to detect, quantify, and localize the damage for the high intensity and the bidirectional loading cases.

Application of time series based damage detection algorithms to the benchmark experiment at the National Center for Research on Earthquake Engineering (NCREE) in Taipei, Taiwan

Hae Young Noh,Krishnan Nair,Anne S. Kiremidjian,C-H. Loh 국제구조공학회 2009 Smart Structures and Systems, An International Jou Vol.5 No.1

In this paper, the time series based damage detection algorithms developed by Nair, et al. (2006) and Nair and Kiremidjian (2007) are applied to the benchmark experimental data from the National Center for Research on Earthquake Engineering (NCREE) in Taipei, Taiwan. Both acceleration and strain data are analyzed. The data are modeled as autoregressive (AR) processes, and damage sensitive features (DSF) and feature vectors are defined in terms of the first three AR coefficients. In the first algorithm developed by Nair, et al. (2006), hypothesis tests using the t-statistic are applied to evaluate the damaged state. A damage measure (DM) is defined to measure the damage extent. The results show that the DSF’s from the acceleration data can detect damage while the DSF from the strain data can be used to localize the damage. The DM can be used for damage quantification. In the second algorithm developed by Nair and Kiremidjian (2007) a Gaussian Mixture Model (GMM) is used to model the feature vector, and the Mahalanobis distance is defined to measure damage extent. Additional distance measures are defined and applied in this paper to quantify damage. The results show that damage measures can be used to detect, quantify, and localize the damage for the high intensity and the bidirectional loading cases.

Improvement in the Commercial Traits of Silkworm, Bombyx mori L. by Administration of a Juvenoid, R394

Nair, K.Sashindran,Vijayan, V.A,,Trivedy, Kanika,Nair, Jula S. Korean Society of Sericultural Science 2001 International Journal of Industrial Entomology Vol.3 No.2

A synthetic juvenoid, R394 (Ethyl 9-cyclohexyl-3, 7-dimethyl-2, 4-nonadienoate) which is known to be a strong pest control agent was administered to silkworm, Bombyx mori L. in minute quantity for improving the silk yield. Based on the result of an earlier preliminary screening, three concentrations of the compound, viz., 0.1563, 0.3125, 31.25 nl/ml were prepared in the form of an emulsion and administered topically as a single dose, to separate batches of $5^{th}$ instar silkworm at 24, 48, 72 and 96 hrs to determine the required concentration and critical time of application for an economically favourable response. Two popular commercial silkworm hybrids, PM ${\times}$ NB4D2 (multivoltine${\times}$bivoltine) and KA${\times}$NB4D2 (bivoltine$\times$bivoltine) were subjected to the experiment. The medium and absolute control were maintained in parallel to compare the results. The results showed that 0.3125 nl/ml was the best concentration of the compound and 72 hrs of $5^{th}$instar was the most favourable age for its administration to get the maximum improvement in the commercial traits. The possible role of exogenous juvenoids in eliciting favourable response in silkworm which ultimately leads to improvement in the commercial traits is discussed.

THYROID ULTRASOUND : A REVIEW OF 405 CASES

Ramachandran Nair Parameswaran,Pradeep,Nair, Krishnan 대한핵의학회 1984 핵의학 분자영상 Vol.18 No.1

ACUTE INTERMITTENT PORPHYRIA AND HYPER THYROIDISM : A CASE REPORT

Parameswaran, Ramachandran Nair,Pradeep,Nair, Krishnan 대한핵의학회 1984 핵의학 분자영상 Vol.18 No.1

Improvement in the Commercial Traits of Silkworm, Bombyx mori L. by Administration of a Juvenoid, R394

( K. Sashindran Nair ),( V. A. Vijayan ),( Kanika Trivedy ),( Jula S. Nair ) 한국잠사학회 2001 International Journal of Industrial Entomology Vol.3 No.2

A synthetic juvenoid, R394 (Ethyl 9-cyclohexyl-3, 7-dimethyl-2, 4-nonadienoate) which is known to be a strong pest control agent was administered to silkworm, Bombyx mori L. in minute quantity for improving the silk yield. Based on the result of an earlier preliminary screening, three concentrations of the compound, viz., 0.1563, 0.3125, 31.25 nl/ml were prepared in the form of an emulsion and administered topically as a single dose, to separate batches of 5th instar silkworm at 24, 48, 72 and 96 hrs to determine the required concentration and critical time of application for an economically favourable response. Two popular commercial silkworm hybrids, PM×NB4D2 (multivoltine×bivoltine) and KA×NB4D2 (bivoltine×bivoltine) were subjected to the experiment. The medium and absolute control were maintained in parallel to compare the results. The results showed that 0.3125 nl/ml was the best concentration of the compound and 72 hrs of 5th instar was the most favourable age for its administration to get the maximum improvement in the commercial traits. The possible role of exogenous juvenoids in eliciting favourable response in silkworm which ultimately leads to improvement in the commercial traits is discussed.

1, 25-(OH)2D3 protects against ER stress and miRNA dysregulation in Mus musculus neurons

Jayachandran Parvathy,Koshy Linda,Sudhakaran Perumana R.,Nair Govindapillai Mohanadasan,Gangaprasad Appukuttan Nair,Nair Ananthakrishnan Jayakumaran 한국유전학회 2022 Genes & Genomics Vol.44 No.12

Background: The pathophysiology of neurodegenerative diseases (NDDs) is closely associated with cellular oxidative stress which can result in the accumulation of toxic proteins in the endoplasmic reticulum (ER) leading to ER stress and subsequent unfolded protein response (UPR) signaling, a mechanism that aggravate these disorders. Vitamin D has been suggested to have important neuroprotective role and its administration has been shown to reduce neuronal injury, neurotoxicity and oxidative stress in various animal systems. Objective: The current study was undertaken to examine the effect of vitamin D3 on UPR in ER stress induced Mus musculus neuronal cells. Methods: Mus musculus cortical and hippocampal primary neuronal cultures were pretreated with 1,25-dihydroxyvitamin D3 (1, 25-(OH)2D3), the active form of vitamin D, followed by ER stress induction with a chemical ER stress inducer thapsigargin and with an advanced glycated protein, AGE-BSA. The UPR genes and related microRNAs (miRNA) expressions were analyzed mainly using real-time PCR. Results: The experiment resulted in the suppression of ER stress marker BiP and UPR pathway genes such as Perk, Ire1α, Chop and Puma which mediate cellular apoptosis indicating the protective effect of 1, 25-(OH)2D3 against neuronal ER stress. Further studies into the molecular aspects showed that ER stress mediated down-regulated expression of microRNAs (miRNAs) such as mmu-miR-24, 27b, 124, 224, 290, 351 and 488 which are known to regulate the UPR pathway genes were also reduced with vitamin pretreatment, of which the miRNAs miR-24 and 27b which shares the same cluster are potentially involved in various human diseases. Conclusion: This study emphasizes the therapeutic role of vitamin D in reducing neuronal ER stress and the need for maintaining sufficient amount of this vitamin in our diet.

Regulation of morphological, molecular and nutrient status in <i>Arabidopsis thaliana</i> seedlings in response to ZnO nanoparticles and Zn ion exposure

Nair, Prakash M. Gopalakrishnan,Chung, Ill Min Elsevier BV 2017 Science of the Total Environment Vol.575 No.-

<P><B>Abstract</B></P> <P>This study examined the mechanism of toxicity in <I>Arabidopsis thaliana</I> seedlings to zinc oxide nanoparticles (ZnO NPs) and zinc (Zn) ions. We subjected plants to different ZnO NPs and Zn ion concentrations (0, 20, 50, 100 and 200mg/L) and analyzed resulting morphological changes, transcriptional regulation of genes involved in Zn-homeostasis, macro- and microelement homeostasis, as well as auxin regulation. Except for 20mg/L, the fresh weight and primary root length was reduced after exposure to all other concentrations of Zn ion and ZnO NP concentrations. An increase in lateral root formation (19 and 32%) was observed after exposure to 20 and 50mg/L of Zn ions respectively; whereas 20mg/L ZnO NPs treatment triggered a 9% increase in lateral root formation. Both qualitative, using Zynpyr-1 fluorescent probe and quantitative analysis revealed Zn uptake and translocation from roots to shoots after Zn ion exposure. However, ZnO NPs-treated seedlings resulted in no root to shoot translocation and Zn accumulation was mainly located in root tips, primary-lateral root junctions and root- shoot junctions. The macronutrients viz. P (1.34mg/kg DW), K (13.29mg/kg DW), S (1.29mg/kg DW) and micronutrients Cu (0.004mg/kg DW) and Fe (0.345mg/kg DW) contents were highly decreased as a result of exposure to 200mg/L of Zn ions. Similarly, the highest reduction of P (2.30mg/kg DW), K (6.36mg/kg DW), S (2.63mg/kg DW) and Cu (0.004mg/kg DW) was observed after exposure to 200mg/L of ZnO NPs. Gene regulation studies indicated the transcriptional modulation of various genes involved in Zn, macro- and micro nutrient homeostasis as well as hormone regulation. Taken together, it was observed that the mechanism of toxicity of Zn ions and ZnO NPs were different. These findings will help to design safer strategies for the application of ZnO NPs as plant fertilizer without compromising the morphological and nutritional qualities as well as for the future phytoremediation purposes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ZnO NPs and Zn ions induced morphological changes in <I>Arabidopsis thaliana</I>. </LI> <LI> Changes in roots system architecture was observed. </LI> <LI> Modulated the expression of metal homeostasis and hormone regulation genes </LI> <LI> Changed macro- and micro-nutrient contents </LI> <LI> Provides insights for future application of ZnO NPs as fertilizer. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Optimum Hybrid SVPWM Technique for Three-level Inverter on the Basis of Minimum RMS Flux Ripple

Nair, Meenu D.,Biswas, Jayanta,Vivek, G.,Barai, Mukti The Korean Institute of Power Electronics 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.2

This paper presents an optimum hybrid SVPWM technique for three-level voltage source inverters (VSIs). The proposed hybrid SVPWM technique aims to minimize total harmonic distortion (THD). A new parameter is introduced to incorporate the heterogeneous nature of switching sequences of SVPWM technique. The proposed hybrid SVPWM technique is implemented on a low-cost PIC microcontroller (PIC18F452) and verified experimentally with a 2 KVA three-phase three-level insulated gate bipolar transistor-based VSI. Optimum switching sequence results in the three-level inverter configuration are demonstrated. The proposed hybrid SVPWM technique improves the THD performance by 17.3% compared with the best available three-level SVPWM technique.

Performance Evaluation of Various Bus Clamped Space Vector Pulse Width Modulation Techniques

Nair, Meenu D.,Biswas, Jayanta,Vivek, G.,Barai, Mukti The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.5

The space vector pulse width modulation (SVPWM) technique is a popular PWM method for medium voltage drive applications. Conventional SVPWM (CSVPWM) and bus clamped SVPWM (BCSVPWM) are the most common SVPWM techniques. This paper evaluates the performance of various advanced BCSVPWM strategies in terms of their harmonic distortion and switching loss based on a uniform frame work. A uniform frame work, pulse number captures the performance parameter variations of different SVPWM strategies for various number of samples with heterogeneous pulse numbers. This work compares different advanced BCSVPWM techniques based on the modulation index and location of the clamping position (zero vector changing angle ) of a phase in a line cycle. The frame work provides a fixed fundamental frequency of 50Hz. The different BCSVPWM switching strategies are implemented and compared experimentally on a 415V, 2.2kW, 50Hz, 3-phase induction motor drive which is fed from an IGBT based 2 KVA voltage source inverter (VSI) with a DC bus voltage of 400 V. A low cost PIC microcontroller (PIC18F452) is used as the controller platform.