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김경래,박 현,정윤자,김숙향,소진탁 INSTITUTE OF TROPICAL MEDICINE YONSEI UNIVERSITY 1991 YONSEI REPORTS ON TROPICAL MEDICINE Vol.22 No.1
통상적인 이질아메바 배지내에는 분변에서 유래된 각종 세균 특히 장내세균등이 배지에 첨가한 항균제에 의하여 차츰 감소되기는 하나 대부분의 경우 몇 가지 종류는 그대로 남아 있어 특수한 무균처치(axenization)를 하지 않을 경우 거의 영구적인 공존 미생물(concomitant micro-organism)로서 이질아메바 배지에서 없어지지 않는다. 본 연구는 현재 실험실에서 계대 보관중인 10개 이질아메바를 대상으로 그 배지 modified Boeck-Drbohlab's diphasic medium으로부터 6가지 공존 세균을 분리하였다. 즉 Escherichia coli, Klebsiella pneumoniae, Acinetobacter sp., Aeromonas hydrophilus, unidentified gram negative Diplococcus, glucose-gas negative but not Salmonella등 6개 종류를 검출하였는데 그중 E. coli 및 D. pneumoniae와 또 TTY-SB monophasic 배지내의 이질아메바 공존 원충인 Crithidia sp.를 재료로 하여 그들이 이질아메바의 간농양 형성에 미치는 영향을 실험적으로 검토한 바 그 얻어진 성적을 요약하면 다음과 같다. 1) Escherichia coli는 간조직내에서 약 1개월 또는 그 이상 생존 가능하다 단독으로는 병변을 야기할 수 없었고 이질아메바와 공존시 아메바성 간농양 형성을 조장하였다. 2) K. pneumoniae는 단독으로는 간조직에 농양을 형성하지 않았으나 아메바성 간농양 형성은 조장하였다. 3) Crithidia sp.는 간조직에서 병변을 야기하지 않았고 6시간 이내에 소실되나 이질아메바와 섞여 간조직에 주입할 경우 아메바성 농양 형성을 조장하였다. 4) 무균적으로 배양된 이질아메바는 간조직에 주입하여도 농양형성을 볼 수 없었으나 배지에 Escherichia coli를 혼합한뒤 6시간 경과된 아메바성 간농양 형성이 가능하였다. 이상의 성적으로 미루어 이질아메바 배지내 공존 세균과 무균배지내 이질아메바는 각각 단독으로는 간농양을 형성할 수 없으나 특수미생물과 이질아메바가 일정한 시간 공존하면 세균이 이질아메바의 병원성을 조장하여 아메바성 간농양이 더 촉진되는 것으로 생각된다.
김태윤,백무준,김성용,신응진,박내경,이문수,김창호,송옥평 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1
Locally recurrent rectal cancer is a difficult clinical problem. Local recurrence following treatment for rectal cancer is a major cause of morbidity and mortality. The reported range of local recurrence rates following surgical treatment for rectal cancer has varied from 4% to 50%. We retrospectively reviewed the charts of 142 rectal cancer patients from January 1991 to December 1999. Analysis of patients factors included age, gender, type of surgery, and adjuvant therapy. Tumors were assessed for level, stage, and grade. Local recurrence and distant metastases were also documented. Variables influencing local recurrence in this group were identified and disease-free survival is determined. Of the 142 patients(74 males, 68 females; mean age 62.6 years), 137 consecutive patients operated on for rectal cancer and followed up to December 2000 (range 23-118months) were analyzed. Local recurrence rate was 18.3%. Age and sex of patients, type of surgery, location of tumor in the rectum, size, morphology and grading of the tumor were all unrelated to the event under investigation. At Cox regression, the Dukes stage and the postoperative radiotherapy were the only independent prognostic factors for local recurrence, and Dukes stage (Hazard ratio=2.89, p<0.001) and local recurrence (Hazard ratio=3.31, p<0.01) were the only independent factors associated with improved survival.
Isotretinoin exposure in pregnant women in Korea
( Nae Ry Kim ),( So Ra Yoon ),( June Seek Choi ),( Hyun Kyong Ahn ),( So-young Lee ),( Dal Soo Hong ),( Jeong Sup Yun ),( Seong Yeon Hong ),( Yoon Ha Kim ),( Jung Yeol Han ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.6
Objective Isotretinoin is a notorious teratogen otherwise used for the treatment of acne vulgaris. Some countries, including those in North America and the European Union, implemented the pregnancy prevention program (PPP); however, no PPP has yet been established in South Korea. So the aim of this study was to evaluate the rate of pregnant women exposed to isotretinoin among the callers of the Korean Mother Safe Counseling Center. Methods This is a prospective cohort study. We evaluated the demographic characteristics, obstetric history, and isotretinoin exposure of pregnant women based on the mother safe registry from April 2010 to July 2016. Results Among 22,374 callers, 650 (2.9%) pregnant women were exposed to isotretinoin. The mean age was 29.0±4.4 years in the isotretinoin-exposed group and 32.0±4.2 years in the unexposed group (P<0.001). Moreover, the incidence of pregnancies within 30 days after isotretinoin discontinuation or during isotretinoin intake was 78.9% (513/650). The median duration of isotretinoin exposure was 18 (1-4,231) days. Furthermore, from 2011 to 2015, the incidence of isotretinoin exposure was 2.9±1.2 pregnancies per 10,000 births in South Korea. Conclusion Approximately 80% of pregnant women are exposed to isotretinoin within the recommended 30 days of contraception or during pregnancy. Therefore, the PPP has to be established in South Korea.