토속종교가 베트남 사람들의 생활문화에 끼친 영향

Ngo Van Le 조선대학교 국제문화연구원 2009 국제문화연구 Vol.2 No.1

Mekong delta is the largest delta in Vietnam with an area of 39000㎢, or 12% of the country’s. Therefore, the delta, together with Hochiminh City, has been and will be playing a very crucial role in Vietnam’s cultural-economic development strategies. Yet, while Mekong delta is a fairly new land in comparison with our nation’s long history, it has been a “promise land” or a “land of hope” to many migrants who have migrated to and resided over the delta in their pursuing of wealth and happiness. Many generations of the Vietnamese, side by side with other ethnic peoples, have exploited and protected the region which resulted in several magical achievements during wars against foreign invaders as well as in peace time. Mekong Delta is resided by multi-ethnic peoples. These peoples, who are different in terms of economic development level, social structure and religion, have come to existence over the land at different time points. However, through long history of co-residence, due to cultural exchange and acculturation, among the peoples there have emerged many common cultural features and this process is currently still on progress under proactive influences of modern circumstance. As a result, there have been many religions in the delta; besides world religions such as Buddhism, Christianity, and Islam, there have existed local religions. Obviously, these religions contribute greatly to the cultural diversity of the whole southern part of the country. The Vietnamese is a majority people in the region. The culture of the Vietnamese in Mekong delta has selectively inherited cultural values of Vietnamese tradition. During their residing in the delta, the people has also adopted and created cultural features that are adaptative to natural and social environment of the region. For instance, at the end of 19^(th) century and early 20^(th) century, the Vietnamese in Mekong delta created several religions with ubiquitous local identities. In general, local religions have played very crucial roles in the life of the Vietnamese in the delta; however, their impacts have seldom spread out of the Vietnamese communities. In this paper, by viewing religion as both a social phenomenon and a cultural one, I concentrate on proposing the reasons for the birth of local religions of the Vietnamese in Southern Vietnam at the end of 19^(th) and early 20^(th) century. Also, I want to take a look at these religions’ impacts over cultural life of the people in the region. Assumedly, they were born under specific conditions of the South and only have impacts upon the life of the people. Furthermore, the paper proposes that, on one hand, the Vietnamese in the South have selectively inherited traditional cultural values which have created Vietnamese cultural values as the whole; on the other hand, they have made their own ones within the context of their new living conditions.

Reduction of d-lactate content in sauerkraut using starter cultures of recombinant Leuconostoc mesenteroides expressing the ldhL gene

Jin, Q.,Li, L.,Moon, J.S.,Cho, S.K.,Kim, Y.J.,Lee, S.J.,Han, N.S. Society for Bioscience and Bioengineering, Japan ; 2016 Journal of bioscience and bioengineering Vol.121 No.5

<P>The n-form of lactate, which causes metabolic stress upon excessive dietary intake, is mainly produced by Leuconostoc sp., the predominant species in sauerkraut. To shift the metabolic flux of D-lactate from pyruvate to L-lactate, we expressed the L-lactate dehydrogenase (ldhL) gene in Leuconostoc mesenteroides ATCC 8293. The IdhL gene from Lactobacillus plantarum was introduced into L. mesenteroides using the shuttle vectors pLeuCM and pLeuCM42. To elevate the expression level of IdhL in L. mesenteroides, the nucleotides for pyruvate kinase promoter were fused to IdhL and cloned into above vectors to construct pLC18pkL and pLC42pkL. As results, introduction of pLC42pkL in L. mesenteroides significantly improved both L-LDH activity and L-lactate productivity during fermentation, decreasing the D-/L-lactate ratio. When used as a starter culture for sauerkraut fermentation, recombinant L. mesenteroides harboring pLC42pkL increased L-lactate concentration and decreased D-lactate concentration compared to the wild type strain. We newly developed a recombinant L. mesenteroides which has high L-lactate dehydrogenase activity and applied this strain to minimize the harmful effect of D-lactate during the sauerkraut fermentation. To the best of our knowledge, we demonstrate for the first time the effective use of recombinant Leuconostoc sp. for quality improvement of fermented foods. (C) 2015, The Society for Biotechnology, Japan. All rights reserved.</P>

Effects of the novel angiotensin II receptor type I antagonist, fimasartan on myocardial ischemia/reperfusion injury

Han, J.,Park, S.J.,Thu, V.T.,Lee, S.R.,Long, L.T.,Kim, H.K.,Kim, N.,Park, S.W.,Jeon, E.S.,Kim, E.J.,Yoon, C.H.,Cho, G.Y.,Choi, D.J. Elsevier/North-Holland Biomedical Press 2013 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.168 No.3

Background: The aim of this study was to investigate the cardioprotective effect of fimasartan, a newly developed angiotensin II receptor type I blocker (ARB), against myocardial ischemia/reperfusion (I/R) injury and to identify the mechanism by which it reduces mitochondrial damage. Methods: Fimasartan was administered intravenously to Sprague-Dawley rats (3mg/kg), cardiomyocytes (50μM), and H9c2 cells (50μM) before ischemia or hypoxia. Myocardial infarction (MI), echocardiograms, DNA fragmentation, terminal deoxynucleotidyl transferase-mediated dUTP in situ nick-end labeling, immunoblotting, oxygen consumption, confocal microscopic appearance, and L-type Ca<SUP>2+</SUP> current (I<SUB>Ca,L</SUB>) were then assessed. Results: Fimasartan pretreatment remarkably reduced the rate of MI and improved cardiac performance well after I/R (n=9/group). Fimasartan also reduced apoptotic cell death both in vivo and in hypoxia/reoxygenation (H/R)-treated H9c2 cells (n=5~8/group). H/R-induced mitochondrial O<SUB>2</SUB><SUP>-</SUP> production and collapse of membrane potential were markedly attenuated in fimasartan-treated cardiomyocytes (n=4~6/group). Additionally, mitochondrial Ca<SUP>2+</SUP> overload during reoxygenation was suppressed by fimasartan (n=4~6/group), and this was found to be possibly related to the inhibition of I<SUB>Ca,L</SUB> and mitochondrial Ca<SUP>2+</SUP> uniporter. Furthermore, fimasartan pretreatment increased phosphorylations of Akt and glycogen synthase kinase-3β (n=5~7/group), decreased pro-apoptotic p53 levels, and increased anti-apoptotic Bcl-2 levels (n=4) during reperfusion. Conclusions: Fimasartan preconditioning has the potential to modulate Bcl-2 and suppress I/R-induced Ca<SUP>2+</SUP> overload by inhibiting I<SUB>Ca,L</SUB> and MCU. These beneficial effects could prevent the mitochondrial dysfunction and apoptosis accompanied by I/R.

PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing

López-Cánovas Juan L.,Hermán-Sánchez Natalia,del Rio-Moreno Mercedes,Fuentes-Fayos Antonio C.,Lara-López Araceli,Sánchez-Frias Marina E.,Amado Víctor,Ciria Rubén,Briceño Javier,de la Mata Manuel,Casta 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing machinery components (spliceosome and splicing factors) and aberrant expression of oncogenic splice variants. We aimed to analyze the expression and potential role of the spliceosome component PRPF8 (pre-mRNA processing factor 8) in HCC. PRPF8 expression (mRNA/protein) was analyzed in a retrospective cohort of HCC patients (n = 172 HCC and nontumor tissues) and validated in two in silico cohorts (TCGA and CPTAC). PRPF8 expression was silenced in liver cancer cell lines and in xenograft tumors to understand the functional and mechanistic consequences. In silico RNAseq and CLIPseq data were also analyzed. Our results indicate that PRPF8 is overexpressed in HCC and associated with increased tumor aggressiveness (patient survival, etc.), expression of HCC-related splice variants, and modulation of critical genes implicated in cancer-related pathways. PRPF8 silencing ameliorated aggressiveness in vitro and decreased tumor growth in vivo. Analysis of in silico CLIPseq data in HepG2 cells demonstrated that PRPF8 binds preferentially to exons of protein-coding genes, and RNAseq analysis showed that PRPF8 silencing alters splicing events in multiple genes. Integrated and in vitro analyses revealed that PRPF8 silencing modulates fibronectin (FN1) splicing, promoting the exclusion of exon 40.2, which is paramount for binding to integrins. Consistent with this finding, PRPF8 silencing reduced FAK/AKT phosphorylation and blunted stress fiber formation. Indeed, HepG2 and Hep3B cells exhibited a lower invasive capacity in membranes treated with conditioned medium from PRPF8-silenced cells compared to medium from scramble-treated cells. This study demonstrates that PRPF8 is overexpressed and associated with aggressiveness in HCC and plays important roles in hepatocarcinogenesis by altering FN1 splicing, FAK/AKT activation and stress fiber formation.

Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults

Yeliana L. Sánchez,Manuela Yepes-Calderón,Luis Valbuena,Andrés F. Milán,María C. Trillos-Almanza,Sergio Granados,Miguel Peña,Mauricio Estrada-Castrillón,Juan C. Aristizábal,Raúl Narvez-Sanchez,Jaime G 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.5

Background: We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity. Methods: A cross-sectional study was performed in sedentary adults with or without metabolic syndrome (MS). Serum musclin wasmeasured by enzyme-linked immunosorbent assay. Insulin resistance (IR) was evaluated by the homeostatic model assessment(HOMA-IR). Body composition was determined by dual-energy X-ray absorptiometry and muscle composition by measuring carnosine in the thigh, a surrogate of fiber types, through proton magnetic resonance spectroscopy. Cardiorespiratory capacity was assessed through direct ergospirometry. Results: The control (n=29) and MS (n=61) groups were comparable in age (51.5±6.5 years old vs. 50.7±6.1 years old), sex(72.4% vs. 70.5% women), total lean mass (58.5%±7.4% vs. 57.3%±6.8%), and peak oxygen consumption (VO2peak) (31.0±5.8mL O2./kg.min vs. 29.2±6.3 mL O2/kg.min). Individuals with MS had higher body mass index (BMI) (30.6±4.0 kg/m2 vs. 27.4±3.6 kg/m2), HOMA-IR (3.5 [95% confidence interval, CI, 2.9 to 4.6] vs. 1.7 [95% CI, 1.1 to 2.0]), and musclin (206.7 pg/mL [95%CI, 122.7 to 387.8] vs. 111.1 pg/mL [95% CI, 63.2 to 218.5]) values than controls (P˂0.05). Musclin showed a significant relationship with HOMA-IR (β=0.23; 95% CI, 0.12 to 0.33; P˂0.01), but not with VO2peak, in multiple linear regression models adjusted forage, sex, fat mass, lean mass, and physical activity. Musclin was significantly associated with insulin, glycemia, visceral fat, and regional muscle mass, but not with BMI, VCO2peak, maximum heart rate, maximum time of work, or carnosine. Conclusion: In humans, musclin positively correlates with insulinemia, IR, and a body composition profile with high visceral adiposity and lean mass, but low body fat percentage. Musclin is not related to BMI or cardiorespiratory capacity.

Growth and characterisation of n- and p-type ZnTe thin films for applications in electronic devices

O.I. Olusola,M.L. Madugu,N.A. Abdul-Manaf,I.M. Dharmadasa 한국물리학회 2016 Current Applied Physics Vol.16 No.2

The growth of n- and p-type ZnTe thin films have been achieved intrinsically by potentiostatic electrodeposition method using a 2-electrode system. Cyclic voltammogram have been used to obtain range of growth voltages required to form stoichiometric thin films of ZnTe. The ZnTe thin films have been electrodeposited (ED) on glass/fluorine-doped tin oxide (FTO) conducting substrates in aqueous solutions of ZnSO4$7H2O and TeO2. The films have been characterised for their structural, electrical, morphological, compositional and optical properties by using X-ray diffraction (XRD), Raman spectroscopy, Photoelectrochemical (PEC) cell measurements, DC conductivity measurements, Scanning electron microscopy (SEM), Atomic force microscopy (AFM), energy-dispersive X-ray analysis (EDX) and Optical absorption techniques. The XRD results reveal that the electroplated films are polycrystalline and have hexagonal crystal structure with the preferred orientation along (002) plane. UVeVisible spectrophotometer has been used for the bandgap determination of as-deposited and heat-treated ZnTe layers. The bandgap of the heat-treated ZnTe films are in the range (1.90e2.60) eV depending on the deposition potential. PEC cell measurements show that the ED-ZnTe films have both n- and p-type electrical conductivity. The DC conductivity measurements revealed that the average resistivity of n-ZnTe and p-ZnTe layers of equal thickness is of the order of 104 Ucm; the magnitude of the electrical resistivity of p-ZnTe is almost five times greater than that of the n-ZnTe layer. Using the n- and p-type ZnTe layers, p-n homo-junction diodes with device structure of glass/FTO/n-ZnTe/p-ZnTe/Au were fabricated. The fabricated diodes showed rectification factor of 102, reverse saturation current of ~10.0 nA and potential barrier height greater than 0.77 eV indicating electronic device quality of these layers.

Androgenesis induction in microspore culture of sweet pepper (Capsicum annuum L.)

Csaba Lantos,Aniko´ Ge´mes Juhasz,Pa´l Va´gi,Ro´bert Miha´ly,Zolta´n Kristo´f,Ja´nos Pauk 한국식물생명공학회 2012 Plant biotechnology reports Vol.6 No.2

Isolated microspore culture experiments were carried out in sweet pepper (Capsicum annuum L.) F1hybrid genotypes. In the first experiment, four culture media (W14, B5, MS and NLN) were compared to test their effectiveness in inducing the formation of microsporederived structures in two genotypes. The experiments revealed the superiority of B5 medium. In the second experiment, the effects of different ratios of 2,4-dichlorophenoxyacetic acid (2,4-D) (0, 0.1, 0.2 and 0.5 mg l-1) and kinetin (0, 0.2 and 0.5 mg l-1) were also investigated in B5medium with two genotypes. The effect of growth regulators were investigated on the production of microsporederived calli and embryo-like structures (ELSs), the ratio of the two and plant regeneration (number of regenerated plantlets) in microspore culture. The histological experiments revealed the differences between the microsporederived ELSs and calli. The most promising results were obtained on the investigated parameters in the presence of 0.1 mg l-1 2,4-D and 0.2 mg l-1 kinetin producing the highest number of plantlets in both genotypes tested. In the response of 11 genotypes, the androgenesis induction was successful in each sweet pepper genotypes tested using the best basic medium and growth regulators combination. In case of 11 genotypes, the number of ELSs ranged from 20 to 100/Petri dish (an average of 48.1 ELS/Petri dish),while the number of green plantlets varied from 0 to 8plantlets/Petri dish (an average of 1.5 plantlets/Petri dish)depending on the genotype. The spontaneous rediploidization rate obtained was 25% in isolated microspore.

Ferromagnetic Order in Rapidly Cooled Nd-Fe-Co-Al Alloy Ribbons

Phan, T. L.,Zhang, Y. D.,Dan, N. H.,Thang, D. D.,Thanh, T. D.,Zhang, P.,Yu, S. C. IEEE 2013 IEEE transactions on magnetics Vol.49 No.7

<P>We have studied the magnetic properties of Nd<SUB>45</SUB>Fe<SUB>30</SUB>Co<SUB>15</SUB>Al<SUB>10</SUB> alloy ribbons with various thicknesses of about 120 (N<SUB>1</SUB>) and 50 μm (N<SUB>2</SUB>) prepared by melt-spinning. Structural analyses based on an X-ray diffractometer and a high-resolution transmission electron microscope revealed an existence of nanocrystals with sizes of 10 ~ 20 nm surrounded by an amorphous host matrix. With decreasing ribbon thickness and nanocrystalline size, magnetic studies upon a vibrating sample magnetometer indicated the decrease of the Curie temperature (T<SUB>C</SUB>), coercive force (H<SUB>c</SUB>), and magnetic entropy change (ΔS<SUB>m</SUB>). In the ferromagnetic region, however, magnetization values determined for N<SUB>2</SUB> are greater than those determined for N<SUB>1</SUB>. These results are related to the differences in the critical exponents of N<SUB>1</SUB> (β=0.418 and γ=1.173), and N<SUB>2</SUB> (β=0.512 and γ=1.077), which are characteristic for the ferromagnetic nature existing in the alloy ribbons with different thicknesses.</P>

Jacobi–Stirling numbers, Jacobi polynomials, and the left-definite analysis of the classical Jacobi differential expression

Everitt, W.N.,Kwon, K.H.,Littlejohn, L.L.,Wellman, R.,Yoon, G.J. Koninklijke Vlaamse Ingenieursvereniging 2007 Journal of computational and applied mathematics Vol.208 No.1

<P><B>Abstract</B></P><P>We develop the left-definite analysis associated with the self-adjoint Jacobi operator Ak(α,β), generated from the classical second-order Jacobi differential expression<SUB>ℓα,β,k</SUB>[y](t)=1<SUB>wα,β</SUB>(t)((-(1-t<SUP>)α+1</SUP>(1+t<SUP>)β+1</SUP><SUP>y′</SUP>(t)<SUP>)′</SUP>+k(1-t<SUP>)α</SUP>(1+t<SUP>)β</SUP>y(t))(t∈(-1,1)),in the Hilbert space Lα,β2(-1,1)≔<SUP>L2</SUP>((-1,1);<SUB>wα,β</SUB>(t)), where <SUB>wα,β</SUB>(t)=(1-t<SUP>)α</SUP>(1+t<SUP>)β</SUP>, that has the Jacobi polynomials {Pm(α,β)}m=0∞ as eigenfunctions; here, α,β>-1 and <I>k</I> is a fixed, non-negative constant. More specifically, for each n∈N, we explicitly determine the unique left-definite Hilbert–Sobolev space Wn,k(α,β)(-1,1) and the corresponding unique left-definite self-adjoint operator Bn,k(α,β) in Wn,k(α,β)(-1,1) associated with the pair (Lα,β2(-1,1),Ak(α,β)). The Jacobi polynomials {Pm(α,β)}m=0∞ form a complete orthogonal set in each left-definite space Wn,k(α,β)(-1,1) and are the eigenfunctions of each Bn,k(α,β). Moreover, in this paper, we explicitly determine the domain of each Bn,k(α,β) as well as each integral power of Ak(α,β). The key to determining these spaces and operators is in finding the explicit Lagrangian symmetric form of the integral composite powers of <SUB>ℓα,β,k</SUB>[·]. In turn, the key to determining these powers is a double sequence of numbers which we introduce in this paper as the <I>Jacobi–Stirling numbers</I>. Some properties of these numbers, which in some ways behave like the classical Stirling numbers of the second kind, are established including a remarkable, and yet somewhat mysterious, identity involving these numbers and the eigenvalues of Ak(α,β).</P>

High Sustained Virologic Response with Daclatasvir plus Asunaprevir in HCV GT-1b Chinese, Korean and Taiwanese without Baseline NS5A Polymorphisms

( F. Mcphee ),( L. Wei ),( Q. Xie ),( Y. Suzuki ),( J. Toyota ),( Y. Karino ),( K. Chayama ),( Y. Kawakami ),( M. L. Yu ),( S. H. Ahn ),( N. Zhou ),( H. Kumada ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: Daclatasvir (DCV) plus asunaprevir (ASV) has demonstrated highsustained virologic response (SVR) in HCV genotype (GT-)1b infection.NS5A-Y93H and NS5A-L31 resistance-associated polymorphisms(RAPs) to DCV are known to impact DCV+ASV response in GT-1b-infectedJapanese. The effect of RAPs on SVR at posttreatment week12 (SVR12) to DCV+ASV was explored in mainland Chinese, Korean,and Taiwanese.Methods: Pooled data from 2 studies of DCV (60 mg daily) + ASV(100 mg capsule, twice-daily) for 24 weeks in GT-1b-infected interferon/ribavirin-naive and -experienced patients from mainland China,Korea, and Taiwan. Similar Japanese data (4 studies; n=445) werepooled for comparison. SVR12 with versus without baseline Y93Hand/or L31 RAPs was compared by age (<65 vs ≥65 years), cirrhosisstatus, and baseline HCV-RNA.Results: SVR12 and baseline NS5A sequences were available for 282patients (126 mainland Chinese [45%〕, 80 Koreans [28%〕, 76Taiwanese [27%〕). NS5A-Y93H and/or -L31 RAPs were observed pretreatmentin 8% mainland Chinese, 14% Korean, and 18%Taiwanese patients, compared with 19% in Japanese. SVR12 in allnon-Japanese patients is shown (Figure); rates were broadly similarbetween countries and with Japanese data (Japanese: 96% overallwithout RAPs, 41% with RAPs). Responses were lower among patientswith baseline RAPs. By contrast, SVR12 in patients without RAPs washigh (92-100%), irrespective of cirrhosis, age, or baseline HCV-RNA.Conclusions: At least 95% of HCV GT-1b-infected patients from mainlandChina, Korea or Taiwan without baseline NS5A-Y93H or -L31polymorphisms who had HCV-RNA ≤7 log10 IU/mL achieved SVR12on DCV+ASV, regardless of cirrhosis status and age.