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Baik, Myunggi,Kim, Jangseon,Piao, Min Yu,Kang, Hyeok Joong,Park, Seung Ju,Na, Sang Weon,Ahn, Sung-Hoon,Lee, Jae-Hyuk Elsevier 2017 The Journal of nutritional biochemistry Vol.39 No.-
<P>Signal transducers and activators of transcription 5 (STAT5) mediates growth hormone signals, which may control hepatic cholesterol uptake and bile acid metabolism. Deregulation of liver cholesterol homeostasis and bile acid metabolism may cause liver damage and cholesterol gallstone development. The purpose of this study was to understand the role of local STAT5 signaling in cholesterol and bile acid metabolism using liver-specific STAT5 knock-out (STAT5 LKO) mice on a normal diet and a cholesterol- and bile acid-containing lithogenic diet. STAT5 LKO mice showed significant down-regulation of STAT5 and insulin-like growth factor-1 genes. STATS gene deletion had a minor effect on cholesterol metabolism, as evidenced by a minor change in circulating cholesterol levels and no changes in expression of hepatic low-density lipoprotein receptor and cholesterol synthesis genes in STAT5 LKO mice. In contrast, bile acid synthesis and uptake genes were profoundly down-regulated and bile acid detoxification genes were up-regulated in STATS LKO mice. In STAT5 fl/fl mice, a lithogenic diet induced liver damage, as evidenced by moderate increases in liver ballooning, inflammation and fibrosis. However, STATS deletion ameliorated the degree of liver damage induced by the lithogenic diet. In STATS LKO mice, a lithogenic diet did not alter the incidence or severity of cholesterol gallstones. In conclusion, local STATS signaling does not have a significant role in cholesterol metabolism. In contrast, hepatic STAT5 signaling has significant roles in regulating transcription of genes for synthesis, transport and detoxification of bile acids, but it has only a minor role in bile acid metabolism. (C) 2016 Elsevier Inc. All rights reserved.</P>
BAIK, MYUNGGI,HARROLD, ROBERT L.,CHOI, CHANG B.,SLANGER, WILLIAM D.,SUNG, CHANG K.,PARK, CHUNG S. 충남대학교 생물공학연구소 1993 생물공학연구지 Vol.3 No.-
Effects of testosterone and energy restriction (30%) on enzyme activity and mRNA level of ornithine decarboxylase (ODC) were studied in 19-wkold female Sprague-Dawley rats. Testosterone implantation for 1 wk elicited a sixfold increase in ODC activity and a fourfold increase in ODC mRNA transcripts in the kidney. Energy restriction also increased renal ODC activity. Further, the 56% increase in ODC enzyme activity observed in the testosterone-implanted, energy-restricted group was greater than the 24% increase in the placebo-implanted, energy-restricted group. No changes in renal ODC mRNA levels were observed in the energyrestricted groups. These observations suggest that translational or post-translational mechanism(s) are in-volved in the greater renal OCD activity in energy-restricted rats. J. Nutr. 122: 1056-1061, 1992.
[통신] 자기간섭제거 성능의 개선을 위한 확장형 BFN의 설계와 특성 평가
김명기(Myunggi Kim),안창영(Changyoung An),유흥균(Heung-Gyoon Ryu) 대한전자공학회 2019 전자공학회논문지 Vol.56 No.4
5G 이동통신 기술은 기존 기술 대비 3배의 스펙트럼 효율 향상이 요구된다. 이를 맞추기 위해 스펙트럼 효율 향상을 위한 연구가 활발히 이루어지고 있다. IBFD(In-Band Full Duplex)를 사용하게 되면 이론상 스펙트럼 효율을 약 2배 향상시킬 수 있다. 그러나 IBFD에서는 SI(Self-Interference)가 발생하기 때문에 이를 줄이는 SIC(Self-Interference Cancellation) 성능이 매우 중요하다. 본 논문에서는 자기간섭제거 성능의 개선을 위한 확장형 BFN(Balanced Feed Network)를 설계하고 특성을 평가한다. 본 논문에서는 SIC 성능을 평가하기 위해서 중심 주파수를 2.45GHz를 기준으로 성능을 평가하였다. 시뮬레이션 결과 SIC 성능은 –77dB로 기존의 Double-BFN 대비 약 3dB의 성능 향상이 있는 것을 확인하였다. 다만 기존 시스템 대비 송신전력이 3dB 감소하는 것을 확인하였다. 5G mobile communication technology requires three times higher spectral efficiency than existing technologies. So research is being actively conducted to improve spectral efficiency to meet spectral requirements. Using In-Band Full Duplex (IBFD) can theoretically improve spectral efficiency by a factor of two. However, since Self-Interference (SI) occurs in IBFD, the performance of Self-Interference Cancellation (SIC) is very important. In this paper, we design and evaluate the extended Balanced Feed Network (BFN) for improving the performance of SIC. In this paper, the performance is evaluated based on the center frequency of 2.45GHz to evaluate the SIC performance. Simulation results show that the SIC performance is –77dB, which is about 3dB better than the conventional Double-BFN. However, it was confirmed that the transmission power was reduced by 3dB compared with the conventional system.
시나리오 기반 조선 실행계획 평가 향상을 위한 시뮬레이션 시스템 개발
백명기(Myunggi Back),김영민(Youngmin Kim),황인혁(Inhyuck Hwang),이광국(Kwang-Kook Lee),류철호(Cheolho Ryu),신종계(Jong Gye Shin) (사)한국CDE학회 2013 한국CDE학회 논문집 Vol.18 No.3
Today’s ever-increasingly competitive shipbuilding market makes it essential for a shipbuilding company to have more efficient production processes and higher productivity as well as better design ability to obtain its competitiveness. A well-established production execution schedule plays an indispensable role to achieve this goal. Most shipbuilding companies carry out an evaluation on their mid-term plan once it is established. However, no evaluation activity exists for a production execution schedule, because practically all the companies depend on the field workers for the production execution scheduling. In this study, a prototype of a ship production execution schedule evaluation system is developed based on the component based design (CBD) methodology. This system enables one to make a production execution schedule that reflects upto- date shipyard situation and to validate whether the schedule is feasible or not by running a production simulation according to the schedule. Users can also make use of the system as a decision supporting tool that compares several different execution schedules and evaluates which one is the best execution schedule.
Effects of Castration on Expression of Lipid Metabolism Genes in the Liver of Korean Cattle
Baik, Myunggi,Nguyen, Trang Hoa,Jeong, Jin Young,Piao, Min Yu,Kang, Hyeok Joong Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.1
Castration induces the accumulation of body fat and deposition of intramuscular fat in Korean cattle, resulting in improved beef quality. However, little is known about the metabolic adaptations in the liver following castration. To understand changes in lipid metabolism following castration, hepatic expression levels of lipid metabolism genes were compared between Korean bulls and steers. Steers had higher (p<0.001) hepatic lipids contents and higher (p<0.01) mRNA levels of lipogenic acetyl-CoA carboxylase. This differential gene expression may, in part, contribute to increased hepatic lipid content following the castration of bulls. However, we found no differences in the hepatic expression levels of genes related to triglyceride synthesis (mitochondrial glycerol-3-phosphate acyltransferase, diacylglycerol O-acyltransferase 1 and 2) and fatty acid (FA) oxidation (carnitine palmitoyltransferase 1A, C-4 to C-12 straight chain acyl-CoA dehydrogenase, very long chain acyl-CoA dehydrogenase) between bulls and steers. No differences in gene expression for very-low-density lipoprotein (VLDL) secretion, including apolipoprotein B mRNA and microsomal triglyceride transfer protein (MTTP) protein, were observed in the liver although MTTP mRNA levels were higher in steers compared to bulls. In conclusion, FA synthesis may contribute to increased hepatic lipid deposition in steers following castration. However, hepatic lipid metabolism, including triglyceride synthesis, FA oxidation, and VLDL secretion, was not significantly altered by castration. Our results suggest that hepatic lipid metabolism does not significantly contribute to increased body fat deposition in steers following castration.
Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism.
Baik, Myunggi,Yu, Ji Hoon,Hennighausen, Lothar New York Academy of Sciences 2011 Annals of the New York Academy of Sciences Vol.1229 No.1
<P>The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH-STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH-STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH-STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.</P>