위식도역류질환 환자에서 산역류의 양상

장데레사(The Re Sa Jang),김백선(Baek Sun Kim),김선명(Sun Myung Kim),추교영(Kyo Young Choo),오정환(Jung Hwan Oh),현영근(Young Geun Hyun),박수현(Soo Heon Park),최명규(Myung Gyu Choi),한준열(Jun Yeol Han),김재광(Jae Kwang Kim),정인식(In 대한소화기기능성질환·운동학회 2000 Journal of Neurogastroenterology and Motility (JNM Vol.6 No.2

N/A Background/Aims : Generally, it is recommended for patients with gastroesophageal reflux disease to sleep with the head of the bed elevated; however, many patients in Korea do not have heartburn symptoms during the night. Methods: We investigated the pattern of acid reflux in patients who were diagnosed as having definite pathological acid reflux on 24-hour pH monitoring. Results : One hundred patients were categorized into 3 groups; upright refluxer (68%), supine refluxer (2%), or combined refluxer (30%). Acid reflux was rare in supine positions but instead, usually occurred in upright positions. Acid reflux was found to occur most commonly after meals. The reflux symptoms occurred during pH monitoring with the average frequency of 5.5 times (total of 254 times) in 46 patients. The acid related symptoms were more common in the upright period and postprandially than the supine period. The presence of an esophagitis, an esophageal motility disorder, or the LES pressure did not make a significant difference between upright refluxer and supine refluxer. Conclusions : Gastroesophageal reflux was found to be rare in supine positions but usually occurred in upright positions. Gastroesophageal reflux occurred most commonly after meals, and was frequently associated with reflux symptoms.

Factors predicting radiation pneumonitis in locally advanced non-small cell lung cancer

Kim, Myung-Soo,Lee, Ji-Hae,Ha, Bo-Ram,Lee, Re-Na,Lee, Kyung-Ja,Suh, Hyun-Suk The Korean Society for Radiation Oncology 2011 Radiation Oncology Journal Vol.29 No.3

Purpose: Thoracic radiotherapy is a major treatment modality of stage III non-small cell lung cancer. The normal lung tissue is sensitive to radiation and radiation pneumonitis is the most important dose-limiting complication of thoracic radiation therapy. This study was performed to identify the clinical and dosimetric parameters related to the risk of radiation pneumonitis after definitive radiotherapy in stage III non-small cell cancer patients. Materials and Methods: The medical records were reviewed for 49 patients who completed definitive radiation therapy for locally advanced non-small cell lung cancer from August 2000 to February 2010. Radiation therapy was delivered with the daily dose of 1.8 Gy to 2.0 Gy and the total radiation dose ranged from 50.0 Gy to 70.2 Gy (median, 61.2 Gy). Elective nodal irradiation was delivered at a dose of 45.0 Gy to 50.0 Gy. Seven patients (14.3%) were treated with radiation therapy alone and forty two patients (85.7%) were treated with chemotherapy either sequentially or concurrently. Results: Twenty-five cases (51.0%) out of 49 cases experienced radiation pneumonitis. According to the radiation pneumonitis grade, 10 (20.4%) were grade 1, 9 (18.4%) were grade 2, 4 (8.2%) were grade 3, and 2 (4.1%) were grade 4. In the univariate analyses, no clinical factors including age, sex, performance status, smoking history, underlying lung disease, tumor location, total radiation dose and chemotherapy were associated with grade ${\geq}2$ radiation pneumonitis. In the subgroup analysis of the chemotherapy group, concurrent rather than sequential chemotherapy was significantly related to grade ${\geq}2$ radiation pneumonitis comparing sequential chemotherapy. In the univariate analysis with dosimetric factors, mean lung dose (MLD), $V_{20}$, $V_{30}$, $V_{40}$, MLDipsi, $V_{20}$ipsi, $V_{30}$ipsi, and $V_{40}$ipsi were associated with grade ${\geq}2$ radiation pneumonitis. In addition, multivariate analysis showed that MLD and V30 were independent predicting factors for grade ${\geq}2$ radiation pneumonitis. Conclusion: Concurrent chemotherapy, MLD and $V_{30}$ were statistically significant predictors of grade ${\geq}2$ radiation pneumonitis in patients with stage III non-small cell lung cancer undergoing definitive radiotherapy. The cutoff values for MLD and $V_{30}$ were 16 Gy and 18%, respectively.

An Inquiry into CLD Parent/Family Involvement

Kwon, Young Re,Lee, Myung Sook 미래유아교육학회 2002 미래유아교육학회지 Vol.9 No.1

본 연구는 미국의 펜실바니아주의 한 대학도시에 거주하는 아시안 부모들이 미국학교에서 교육받고있는 자녀들의 교육을 위한 부모개입을 어떻게 인식하고 학교에 대한 어떤 기대를 가지고 있는지를 탐색해 보는데 목적을 두고 있다. 본 연구의 대상은 미국에 살고 잇는 15명의 어머니들로서 11명의 한국어머니들과 4명의 대만 어머니들이며 미국유치원부터 초등학교 3학년까지의 자녀들이 있었다. 연구자가 12문항의 반구조화된 질문을 작성하여 어머니들을 면담하여 내용을 분석하였다. 다음과 같은 결과가 나왔다. 1) CLD 부모들은 언어와 문화장벽 때문에 CLD부모들을 위한 부모개입이 이루었으면 한다. 2) CLD 어린이들 위한 정보제공을 받기 원했다. 3) 부모와 지녀간의언어 문화적 갈등을 겪고 있다. 미국에 있는 교사나 교육자들이 CLD 부모나 그들의 자녀들을 올바르게 이해하여 이들을 위한 부모개입을 제공하는데 이 논문이 활용되기를 바란다.

예비유아교사들의 디지털 역량 강화를 위한 교수공동체 경험 탐색

김동례(Dong-Re Kim),박부숙(Boo-Sook Park),송명숙(Myung-Sook Song) K교육연구학회 2024 사회과학리뷰 Vol.9 No.1

본 연구는 예비유아교사들의 디지털 역량강화를 위한 교수공동체 경험을 탐색하였다. 참여자는 G시 S대학교 유아교육과 교수 6인으로, 디지털 역량 강화를 위한 프로그램을 구성하고 학습과정과 적용과정을 질적연구하였다. 디지털 역량 강화를 위한 교수들의 학습과정 탐색 결과 교수들은 디지털 친화력 부족에서 오는 두려움에서 벗어나고자 하였고, 디지털 기기 다루는 방법을 실행하며 서로 창의적 아이디어를 내면서 배우는 즐거움을 느꼈다. 디지털 역량 강화를 위한 목적을 가진 모임답게 팀워크를 발휘하며 지식을 구성해 갔다. 디지털 역량 강화를 위한 교수들의 현장 적용 탐색 결과 교수들은 디지털 교육을 접하면서 유아와 같은 호기심이 생겼고, 유아교육 현장과 연계하여 실천적 지식이 되도록 디지털 교육의 순기능을 살리고자 하였다. 또한 예비유아교사들의 역량을 키우기 위해서는 교과목마다 디지털 교육과정을 적용하기로 하였다. 연구결과를 바탕으로 예비유아교사들의 디지털 역량 강화를 위해서 교수자를 위한 다양한 공동체 모임과 연수가 활성화되기를 기대한다. This study explores faculty community experience to consolidate the digital competence of S University students in G City. The participants were six professors of the Department of Early Childhood Education, who formed a program to strengthen digital capabilities and conducted qualitative research on program learning and application processes to reinforce digital competence. As a result of learning process exploration of the professors for digital competence consolidation, they tried to get out of fear deriving from the lack of digital-friendliness, implemented digital devices handling methods, made creative ideas each other, and felt joy of learning. As a community with a goal of reinforcing digital competence, they demonstrated teamwork and built up knowledge. According to the professors’ onsite application exploration results to reinforce digital competence, they had child-like curiosities as they encountered digital education and tried to make good use of digital education’s positive function so that digital education can become practical knowledge in connection with early childhood education. They decided to apply digital education to the curriculum of each subject in order to enhance the preservice early childhood education teachers’ competence. Based on the study results, various communities and training for teachers are expected to be invigorated for consolidation of digital competence of the preservice early childhood education teachers.

Rhizopus nigricans 를 이용한 Progesterone 의 11α-Hydroxylation 반응에서의 고정화 재료와 조건의 최적화

김명희,이정진,김말남,민병례 ( Myung Hee Kim,Jung Jin Lee,Mal Nam Kim,Byung Re Min ) 한국균학회 1990 韓國菌學會誌 Vol.18 No.2

토양미생물 생태계의 발달지표에 관한 연구

안연준,한명수,민병례,최영길 ( Yeon Jun Ahn,Myung Soo Han,Byung Re Min,Yong Keel Choi ) 한국환경생물학회 1995 환경생물 : 환경생물학회지 Vol.13 No.2

To determine the successional level of soil ecosystem, microbial population was examined and environmental factors were measured. Sampling site were evergreen forests area. Among the environmental factors, total organic matter was ranged 11.880(Yesong-Ri, Wando-Gun, Jeoranam-Do)∼66.20㎎/g dried soil(Ggamak Island, Kangjin-Gun, Jeoranam-Do) in surface soil and 4.500(Mok Island, Uljoo-Kun Kyungsangbuk-Do)∼17.000㎎/g dried soi(Ggamak Island, Kangjin-Gun, Jeoranam-Do) in deep soil. Average total organic matter were 23.940 in surface soil and 11.988㎎/g dried soil in 15㎝ depth of soil. Soluble sugar content were measured from 0.045(Maengsun-ri, Wando-Gun, Jeoranam-Do) to 0.172㎎/g dried soil(Mira-ri, Wando-Gun, Jeoranam-Do) and average was 0.103㎎/g dried soil in surface. In 15㎝ depth of soil, it was ranged 0.019 (Maengwun-Ri, Wando-Gun, Jeoranam-Do)∼10.131㎎/g dried soil and average was 0.065㎎/g dried soil. On the basis of these experimental data, S/O value, the ratio of soluble sugar against total organic matter, in surface soil was ranged 0.002(Ggamak Island, Kangjin-Gun, Jeoranam-Do)∼0.095 (Jindo-Gun. Jeoranam-Do), and average was 0.005. And also it was ranged 0.001 (Maengsun-Ri, Wando-Gun. Jeoranam-Do) in lower depth of soil and average was 0.006. And all of S/O value were higher than 0.00371 in Mt. Palwang, 0.0018 in Mt. Weolchul and 0.0005 in Mt. Jukyeop. However, they were much lower than 0.0252 in Mt. Jiri and 0.16 in Mt. Kyebang. From the above result, it can be concluded that S/O value, the ratio of soluble sugar against total organic matter, in soil, was useful parameters for soil environment of climax forest in ecosystem.

양파즙이 에탄올에 의한 백서의 지질과산화물 생성에 미치는 영향

박평심(Pyoung-Sim Park),이병래(Byoung-Re Lee),이명렬(Myung-Yul Lee) 한국식품영양과학회 1994 한국식품영양과학회지 Vol.23 No.5

양파즙이 에탄올에 의한 백서의 간손상에 미치는 영향을 알아보기 위하여 정상군, 양파즙 투여군, 에탄올투여군, 에탄올과 양파즙병합 투여군으로 나누어 3주, 6주간 사육하여 간장의 TBA반응성 산물량, glutathione 함량, 총 sulfhydryl 함량, 비단백질성 sulfhydryl량 및 SOD, catalase, GPX, xanthine oxidase, 혈청중의 AST, ALT 및 ALP 활성의 변화를 관찰하였다. 양파즙은 3주간 투여에서 에탄올에 의하여 증가된 간 TBA 반응성 산물량을 유의하게 감소시켰으며 (p<0.05), glutathione 함량은 3주, 6주에서 에탄올 투여군에 비하여 유의한 증가를 나다냈다(p<0.0l, p<0.05). 총 sulfhydryl group 함량은 3주간 양파즙 투여에서 에탄올 투여군에 비하여 유의성 있게 증가되었으며 정상군의 함량에 근접하였다. 그러나 양파즙이 유리기 손상에 대한 효소계 항산화물질로 알려진 SOD, catalase, GPX 및 xanthine oxidase에서는 에탄올 투여군에 비하여 약간의 변화는 있었으나 유의한 변화는 나타내지 않았다. 양파즙은 에탄올 투여군에 비하여 혈청중의 aminotransferase와 alkaline phosphatase활성도 저하시켰다. 이상의 결과로 미루어 양파즙의 흰쥐에서 에탄올투여로 증가된 간지질과 산화물생성에 대한 양파즙의 억제효과는 효소적 항산화작용 보다는 비효소적 항산화작용을 나타내는 glutathione 및 sulfhydryl group 함량이 증가되므로서 산화물에 대한 방어력이 증강되어 나타난 결과로 여겨지며, 또한 간손상에 대한 지표효소로 알려진 혈청 amlnotransferase 및 alkaline phosphatase 효소활성을 유의성있게 감소시켰음은 양파즙이 에탄올에 의한 간세포 손상에 대한 방지작용이 있는 것으로 사료된다. The effects of onion juice on ethanol-induced lipid peroxidation were studied in rats. The contents of thiobarbituric acid (TBA)-reactants increased significantly in liver of ethanol (4ml/㎏/day) administered-rats. The activities of serum alanine aminotransferase and alkaline phosphatase increased by ethanol administration compared with control group, but alterations of antioxidant enzymes activites in liver of ethanol administeredrats were not significant vs control group. The glutathione contents in liver decreased by ethanol, whereas the glutathione levels increased in ethanol and onion juice group compared with ethanol group. The contents of hepatic TBA-reactants and serum aminotransferase activity in ethanol group were reduced by onion juice administration. In these results, increased hepatic TBA-reactants of liver in ethanol group might be due to decreased glutathione contents in liver. Reduced glutathione (GSH) plays an important roles in the liver in several detoxification and the reduction of lipid peroxides. So the protective effects of onion juice on ethanol-induced increment of TBA-reactants may be due to the increament of glutathions content. The glutathione depletion by ethanol was an important factor of ethanol-induced cell damage, and the prevention of onion juice to the glutathione depletion reduced by ethanol may be an important factor on the protection from ethanol-induced lipid peroxidation in rats.

양파식이가 흰쥐에서 사염화탄소 독성에 미치는 영향

박평심(Pyoung-Sim Park),이병래(Byoung-Re Lee),이명렬(Myung-Yul Lee) 한국식품영양과학회 1991 한국식품영양과학회지 Vol.20 No.2

양파식이가 CCl₄독성에 미치는 영향을 알아보기 위하여 생양파, 삶은양파, 양파즙을 실험식이로 흰쥐를 4주간 사육하여 체중, 식이섭취량, 장기중량, 형청지질농도와 간 및 신장의 SOD, catalase활성도 및 지질과산화도의 변화를 관찰하였다. 체중, 식이섭취량 및 장기의 중량에 있어서 유의적인 변화는 없었으나 신장의 무게는 CCl₄투여에 의해 증가 되었으나 양파로 유의한 감소효과를 나타냈다(p<0.05). 혈청 콜레스테롤 농도는 CCl₄투여로 증가를 나타냈으나 양파로 유의한 감소를 나타냈는데 생양파와 양파즙을 투여한 군에서 우수한 효과를 나타냈다. 간 및 신장의 SOD 및 catalase활성도는 모두 CCl₄투여로 효소활성도가 증가되었으나 양파투여로 효소활성도가 억제되었는데 양파즙이 우수한 영향을 나타냈다. 간 및 신장의 지질과산화도는 CCl₄투여로 증가되었던 지질과산화물인 malondialdehyde양이 양파투여로 인하여 감소되었다.<br/> 이상의 결과로 미루어 양파는 흰쥐에서 CCl₄투여로 증가된 혈청중의 지질함량을 낮추고 간장 및 신장의 MDA, SOD 및 catalase활성의 변화를 둔화시키는 것으로 보아 CCl₄독성을 완화시키는 작용이 있는것으로 시료된다. This study designs to investigate effects of onion diet on carbon tetrachloride toxicity of rats. Experiments were performed with week's feeding, body weight, food intake, ratio of organ weight/body weight, serum lipid levels, superoxide dismutase and catalase activity and malondialdehyde(MDA) content in liver and kidney were determined. The contents of serum total cholesterol in each group were lower than those of control group(p<0.05), especially at onion juice treated group. Serum HDL-cholesterol level of CBB and CBJ groups was significantly lower than that of control group (p<0.05). Superoxide dismutase activities of liver and kidney were significantly increased by carbon tetrachloride treatment and decreased by onion feeding. MDA contents in liver and kidney of CCl₄ treated rats were significantly decreased by boiled and fresh onion fed group, compared with CCl₄ treated control group. This result suggested that onion diet has a protective effect on CCl₄ induced hepatotoxicity and nephrotoxicity of rat.

진행된 위암에서 Ftorafur 및 CCNU의 병용요법

김관엽 ( Kwan Yop Kim ),이오정 ( Oh Jeong Lee ),김예희 ( Re Hwe Kim ),김명진 ( Myung Jin Kim ) 대한내과학회 1981 대한내과학회지 Vol.24 No.7

렬결(列缺),려구(려溝)에 대한 용량별 He-Ne 레이저 침 조사(照射)가 고지방(高脂肪) 식이(食餌)로 유발된 고지혈증(高脂血症) 백서(白鼠)에 미치는 영향(影響)

방상희 ( Sang Hee Bang ),윤대환 ( Dae Hwan Youn ),나창수 ( Chang Su Na ),조명래 ( Myung Re Cho ),임현지 ( Hyun Jin Yim ) 대한경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.1

Objectives: This research was performed to investigate the effect of invasive Low Level Laser acupuncture therapy(LLLAT) at Yolgyol+Yogu(LU7+LR5) on weight gain, food intake, food efficiency, Lipid metabolism and Liver function in hyperlipemia rats. Methods: Experimental groups were divided into high fat diet group(Control group), high fat diet and 15 mW/5 min LLLAT at LU7+LR5(15 mW/5 min group), 15 mW/10 min LLLAT at LU7+LR5 (15 mW/10 min group), 30 mW/5 min LLLAT at LU7+LR5(30 mW/5 min group), 30 mW/10 min LLLAT at LU7+LR5(30 mW/10 min group). LLLAT was treated at the 15,30mW-5,10min once a 2day during 5 weeks. Results: Body weight was decreased significantly in 30 mW/5 min group and 30 mW/10 min group compared with control group. Food intake was decreased significantly in 15 mW/5 min group and 15 mW/10 min group compared with control group. Food efficiency was decreased significantly in 30 mW/10 min group compared with control group. In the Lipid metabolism, total cholesterol, HDL-cholesterol and free fatty acid were increased significantly in 15 mW/5 min group and 30 mW/10 min group compared with control group. LDL-cholesterol was increased in 30 mW/10 min group and phospholipids was decreased significantly in all experimental group compared with control group. triglyceride was not showed significant result in all experimental group. In the Liver function, AST was not showed significant result in all experimental group, ALT and ALP were increased significantly in 30 mW/10 min group, ALP was decreased in 30 mW/5 min group compared with control group. Conclusions: LLLAT at LU7 and LR5 can manage hyperlipemia by controlling body weight, food intake, food efficiency ratio and Lipid metabolism.