順序論理回路의 構成에 關한 硏究

文榮得,金明起 釜山 外國語 大學校 1986 外大論叢 Vol.4 No.1

All kinds of logic dircuits which are used in high density integrated circuit are composed of the sequential logic circuits. The sequential circuit are installed the memory elements, and the memory elements are feed back to the combinational circuits. The memory elements are a device in which the binary information can be stored, and it shows the state of the sequential logic circuit. The output of the sequential logic circuit is the function according to the present state of the memory elements, and it also shows state of the external input. In this paper, we anslyzed the composition of the sequential logic circuit and proposed that the necessity of decision of the input pattern for the fault detection by the investigating the relationship between the input and output of the circuit in the case of the failure.

광선각화증, 각화극세포종과 Bowen's병에서 p53과 p21의 표출 양상

조명구,조현득,양승하,김의한 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background The function of the p53 protein was known to regulate cell proliferation by inhibiting cells entering Sphase. So DNA damaged cell proliferation was inhibited by apoptosis. P21 is a cyclin dependent kinase inhibitor induced by wild type p53, not mutant p53. Thus p21 is thought go mediate the signal of p53 induced by DNA damaged agents to arrest the cell cycle in G1 phase. p53 and p21 were expressed in many malignant tumors, and its role in oncogenesis, tumor progression and prognosis were important. The authors analyzed immunohistochemical expression of mutant p53 and p21 protein in some skin tumors. Method Thirteen cases of actinic keratosis, 7 cases of keratoacanthoma and 8 cases of Bowen's disease were immunohistochemically stained with p53 and p21 monoclonal antibodies. Results; 1. In cases of positive p53 protein and negative p21 protein, the expressed p53 protein was suggested as mutant form. 2. Positive expression of p53 protein and p21 protein in prickle cell layer of actinic keratosis and Bowen's disease was suggesded that the composing cells of prickle cell layer were transformed into the proliferated cell. The p21 protein expression was suggested to be induced by the p53 independent pathway. 3. Negative expression of p53 protein and p21 protein in prickle cell layer of keratoacanthoma was suggested that the composing cells of prickle cell layer were completely mature cells, so the keratoacanthoma had good prognosis.

『군기(群旗)』 사건과 엄흥섭의 초기 소설

장명득 배달말학회 2004 배달말 Vol.34 No.-

이 글은 엄홍섭의 초기 소설의 성격을 규정하는데 목적이 있다. 카프의 동반자 규정과 『군기』사건의 성격, 그리고 제명 이후의 작품 분석을 통하여 엄홍섭을 동반자작가로 규정한 논의에 대해 살펴보았다. 동반자작가의 규정은 카프에 가입은 하지 않고 작품에 담긴 내용과 사상은 프롤레타리아문학에 찬동을 표하는 작가로 보는 경우이다. 이를 바탕으로 카프의 맹원인 개인이 나름대로의 근거를 두고 규정하였다. 그러나 엄홍섭은 카프 중앙위원이었다는 점과 당시에 대부분이 카프작가들이 동반자적 성향을 지녔다는 점, 그리고 그 평가가 상당히 주관적이었다는 점에서 엄홍섭을 동반자작가로 보기는 어렵다. 『군기』사건은 계급 예술운동의 실천과정에서 기관지의 편집을 놓고 일어난 조직 내부의 갈등으로, 카프 중앙부의 조직강화라는 명목 하에 일방적인 탄압의 논리만 강조되어 나타나는 결과를 보여준 것으로 이해된다. 그리고 제명 이전의 「흘러간 마을」, 「파산선고」, 「출범전후」에서 보여주었던 볼세비키화의 논리가 제명 이후에 쓰여진 「그대의 힘은 약하다」, 「온정주의자」에서 큰 차이를 보여주지 않는다. 오히려 제명 이전 작품과는 달리 노동자들의 필연적 승리를 의도적으로 드러내지도 않으며 구체적 현실과 연관되어 한층 진전된 모습을 보인다. This thesis is aimed at defining characteristics of Euhm Hueng-sub's early works. Most researchers have shared their opinions that he was one of the participatory writers after he was involved in the Kun-gi incident. This article consists of the description of these participatory writers by KAPF, properties of the Kun-gi incident, and Euhm's works after his expulsion from the group. This treatise is intended to define Euhm's standing in Korean literature based on this approach. These participatory writers are to be divided into two categories: Those who wrote proletarian literature albeit out of KAPF, and hard-core KAPF members who considered themselves participatory writers based on their own criteria. As for Euhm, it is hard to conclude that he was one of the participatory writers since he served as one of the commissioners of KAPF, most KAPF members smacked of the underground writers, and the criteria for participatory writers were too subjective. In addition, the Kun-gi incident was triggered by internal disputes among KAPF members over editorial rights to its bulletins. This event was a result of unilateral crackdowns committed in the name of streamlining the leadership of the group. Not only that, there is no noticeable changes in his ideological logic based on Bolshevism after the Kun-gi incident. This observation can be reinforced by analyzing his novels published prior to and after his bolt from KAPF such as 「A Village in the Past」, 「Insolvency」, 「Before and after the Launch」, 「The Frailty」and 「Humanitarian」. Rather, after the bolt, his writings took on a realistic maturity in that he did not intentionally draw a conclusion of the eventual advent of proletarian dominance, while paying attention to realistic problems.

推計學的 Modelling에 必要한 合成資料의 發生

柳明辰,金聲得,黃成一 울산대학교 1977 연구논문집 Vol.8 No.2

대기온도, 수온 같은 時系別을 推計學的으로 분석함으로써 자료를 합성할 수 있는 模擬發生모델을 시도하였다. 周期成分은 Fourier급수 형태로 표시하였고, 推計學的成分은 1차 Markov모델로 나타내었다. 일반적으로 수온자료는 희귀하거나 단기인 것이 보통인데 대기온도와 수온과의 관계를 이용하여도 수온을 발생시킬 수 있을 것이다. This paper presents a model for synthesising daily average air temperature and water temperature data. Periodic components are descreied by the Foorier series and stochastic somponents are produced using a first order Markov model. A cross correlation model can be used to generate water temperatures, providing correlation coefficient is high.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

WTO體制下의 分爭解決制度에 관한 小考

金鍾得,姜明保 조선대학교 경영경제연구소 1997 經營經濟硏究 = Management and economics research Vol.20 No.1

근로자의 보건교육 요구도에 영향을 미치는 요인에 관한 연구

공득희,이명선 韓國保健敎育學會 1994 보건교육건강증진학회지 Vol.11 No.1

Health Education is very important not only in school or community fields but also in industrial fields. And health education is most fundamental and enthusiastic area in industrial health. The purpose of this study was to analyze the workers' health education needs and the factors which could affect them. The subjects for this study was 855 workers selected from 57 factories in Inchon. The results were as follows : 1. For demographic variables, sex, age, educational level, and income of the workers were investigated. Most of the workers were males (80.2%). Of the respondents, 30~39 years old were 41.3%. Approximately 62% of the workers were high school graduates. In additions, those who reported they earned 500,000~800,000 won monthly were 41.9%. 2. Behavioral characteristics of the workers investigated in this study included smoking, drinking and physical activities. Of the respondents, 55.9% were smoking cigarettes, and 26.8% of the workers reported they drank alcohol once or twice a week. The workers who were taking any form of exercise regularly were 31.6%. 3. Occupational characteristics of the workers included working period working hours a day, medical examination, and so on. About 37.6% of the workers had worked 1~5 years and 53.6% of the respondents were working less than 8 hours a day. More than half of the workers in this study were taking special medical examination(59.3%) and 59.6% of the respondents were working at the production line in the factories. And most of the respondents (69.0%) were mere members of the staffs. 4. For perceived health status of the respondents, 41.1% answered they were healthy. And for the level of heath status, health grade 20.4% of the workers were unhealthy. 5. Health education areas the workers in this study wanted to learn were as follows : 1) Mental health 2) Worksite environment 3) Safety control 4) Disease control. 6. Those who reported having ever received health education in the factories were 20.9%. 7. Women had more health education needs in personal health care, disease control and family health areas than men. Each age group had different health education needs in all health areas and the differences were significant statistically. 8. The workers who had received special medical examination had more health education needs in worksite environment, safety control, and disease control areas than those who had received general medical examination. The lower the satisfaction of the work and the working environment was, the higher the health education needs of worksite environment area were. 9. For the levels of health status healthy workers were more likely than unhealthy workers to have health education needs in all health areas.

Flutamide가 수컷 생쥐의 유해감각예민도에 미치는 영향

장세헌,김명정,박제민,양구범,한병득 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

Objectives : Previous findings on nociception modulatory effect of testosterone were controversial. In this study, androgen receptor antagonist flutamide was used to reveal testosterone effect on baseline nociceptive sensitivity and stress-induced antinociception in male mice. Methods : Experiments consist 3 Parts: 1) tail flick latency(TFL, sec, 52±1℃) was measured before and 30 minutes after intraperitoneal injection of flutamide 150, 100, 50mg/kg or vehicle(N=15 for each group); 2) TFL was measured before and after serial injection of LHRH antagonist antide(1mg/kg, ip), and 30 minutes after flutamide(100mg/kg, ip) or vehicle; 3) With pretreatment of flutamide(100mg/kg, ip) or vehicle(N=15 for each group), TFL was measured before and after 5 minutes of forced-swim in cold water(15±1℃). Results : 1.TFL was significantly elongated(hypoalgesic) in the flutamide 100 and 150mg/kg groups. TFL of flutamide 150mg/kg group was significantly longer than 50mg/kg group. 2.Though pretreatment with antide itself did not make any change in TFL, it blocked antinociceptive effect of flutamide. TFL was elongated by serial injections in both flutamide and control group. 3.TFL was elongated by FS in both flutamide and control group. FS-induced elongation of TFL was significantly more prominent in flutamide group. Conclusions : From these results, it is suggested flutamide has antinociceptive effect on baseline TFL and potentiates FS- induced antinociception.

랫드에서 l-muscone의 급성독성 및 아급성독성시험 연구

오승민,연제덕,남혜운,박대규,조명행,정규혁 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

l-Muscone is synthesized for use as substitutive material of musk which is the active ingredient of woohwangchungsimwon. The objective of this investigation was to evaluate the acute and subacute toxicity of l-muscone in rats. In oral acute toxicity test, SPF Sprague-Dawley male and female rats were gavaged with l-muscone of two doses(0, 5.0g/㎏). No dead animal and abnormal autopsy findings were found in control and treated group. Body weights were slightly decreased in both sexes of rats treated with 5.0g/㎏. Therefore, oral LD_50 of l-muscone was consider to be higher than 5.0g/㎏ in male and female rats. In intraperitoneal acute toxicity test, rats were injected intraperitoneally with dosages of 0, 1,000, 1,316, 1,732, 2,279 and 3,000 ㎎/㎏. Decreased body weights and motor activities were observed at high dose group. Intraperitoneal LD_50 of l-muscone were 1,920 ㎎/㎏ in male and female rats. In the subacute study. l-muscone was administrated orally to both sexes of rats for 4 weeks as several doses(0, 10, 100 and 1,000 ㎎/㎏). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysis, and other findings. Above data suggest that no observed adverse effect level of l-muscone in rats might be over 1,000 ㎎/㎏/day in this study.

간호사의 근골격계질환 증상유병정도 및 관련요인

박종,강명근,이영선,강성득,김철호 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Objectives : The purpose of this study were to identify musculoskeletal symptom among nurses in a hospital and to explore its related factors . Methods : A self-administered questionnaire survey including work condition and presence of musculoskeletal symptom was made toward 190 nurses at a university hospital. Results : The prevalence of musculoskeletal symptom was calculated as 20.4% at neck, 27.7% at shoulder, 15.7% at arm or hand and 29.3% at leg. By multiple logistic regression, the prevalence of musculoskeletal symptom was 3.57 times (95% CI : 1.53 - 8.35) higher among persons with general illness symptom than persons without symptom, 2.99 times (95% CI : 1.22-7.36) higher among persons with psycho-rieuro subjective symptom than without symptom, 3.48 times (95% CI : 1.46 - 8.27) higher among irregular menstruation period than regular period. The subjective symptom prevalence at the shoulder was 2.24 times (95% CI : 1.06 - 4.71) among persons with past history of certain chronic diseases than without the history. The prevalence at the upper arm was 4.60 times (95 % CI : 1.24 - 17.08) higher among persons drinking two cups of coffee a day and 9. 92 times (95 % CI : 2.28 - 34.91) higher than persons who drank a cup of coffee a day or less. The prevalence of backache was 3.18 times (95 % CI : 1.10 - 11.01) higher among 30-34 year old group than group less than 25 years old persons. The prevalence of subjective symptom at leg showed 3.93 times (95% CI : 1.44 - 10.71) higher among persons with irregular menstruation period than regular period. Conclusion : Many nurses under study had musculoskeletal symptom and the symptom was related with complicated combination of general characteristics, subjective symptom at other site, occupational characteristics and characteristics related with diseases, by various site of the system. Therefore appropriate intervention programs are needed ot be developed to prevent musculoskeletal illness among nurses.