연골외막세포가 포함된 alginate beads를 이용한 토끼에서의 골연골결손 치료

안현정,김은미,정미현,조현철,이인범,성상철,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

Alginate 배양내에서 Transglutaminase가 연골막세포에 미치는 영향

박정선,공차배,김충현,안현정,정미현,성상철,김희중,조현철,이상훈,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

반복성 혈뇨(IgA 신병증 및 non-IgA 신병증)와 알레르기성 자반증 신염의 면역지표의 변동에 관하여

현명철,고철우,구자훈 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.1

A prospective study was conducted to see the changes of immune system in recurrent gross hematuria(IgA nephropathy and non-IgA nephropathy) and HSP nephritis in children. Study patients consisted of 60 children with recurrent gross hematuria and Henoch-Scho¨nlein purpura nephritis (8 IgA nephropathy, 24 non-IgA nephropathy and 28 HSP nephritis). The cellular immune indices(total T, T4, T8 cells and T4/T8 ratio) and humoral immune indices (IgG, A, M and E) were measured during the hematuric and non-hematuric period. Following results were obtained. The proportion of T4 cells of peripheral blood during the hematuric period of patients with IgA nephropathy rose to 35.4±14.9% from the non-hematuric value of 20.0±9.1%. The T4/T8 ratio during hematuric period of patients with IgA nephropathy rose to 1.51±0.77 from non-hematuric value of 0.73±0.33. The values of serum IgA and IgE during hematuric period of patients with IgA nephropathy rose to 237±106 ㎎/dl, 231±226 IU/dl from non-hematuric values of 140±10, 28±23, respectively. These changes of cellular and humoral immune indices showed statistically significant differences(p<0.05). However, these changes were not found in patients with non-IgA nephropathy nor HSP nephritis. In conclusion, it can be said that the immune mechanism involved in IgA nephropathy is different from that of HSP nephritis.

齒科技工士의 健康障碍 呼訴와 關聯要因 分析

朴明子,南喆鉉 대한보건협회 2000 대한보건연구 Vol.26 No.1

The objective of this study was to obtain fundamental data for the development of health educational program about prevention of occupation- related disease and promotion of health among dental technicians. The subjects were 339 dental technicians who were working in 159 dental laboratories, Teagu area. A survey with a questionnaire was conducted from June, 15, 1998 to August, 15. 1998. 30 examiners were trained for the questionnaires surveys. The questionnaires composed of general characteristics, occupational characteristics, health life, working condition(such as stress, wearing protector, working posture), health knowledge. Subjects were also asked about experience on health complaints during last 1 year. The obtained results were as follows: (1) The distribution of subjects were male(88.5%), married(53.7%). The most characteristics were twenties(46.9%), below than 4 years of work duration(34.5%), other technicians(53.3%), all works of working part(17.4%), above 10 hours in a day of working time(68.2%). The 4 health life, 7 hours of sleep on the average were 35.7%, who regularly exercise were 25.3%, who drink 1-2 times per week were 42.8%, 3-4 times were 28.9%. (2) Health complaints by general characteristics, occupational characteristics, health life were significantly different as follows: Eye symptoms by gender(p<0.01), duration of work(p<0.05), position(p<0.05), working part(p<0.05), working time(p<0.05), hours of sleep(p<0.05); Ear symptoms by hours of sleep(p<0.05), exercise(p<0.05);General symptoms by gender(p<0.05), position(p<0.05), smoking(p<0.05);Dermal symptoms by age(p<0.05), marital status (p<0.05), position(p<0.01);Musculoskeletal symptoms by gender(p<0.05), age(p<0.01), duration of work(p<0.05), position(p<0.05), workingtime(p<0.05), exercise(p<0.05), smoking(p<0.05);Digestive symptoms by gender(p<0.01), age(p<0.05), duration of work(p<0.05), position(p<0.01), alcohol consumption(p<0.05);Respiratory symptoms by working part(p<0.01), exercise(p<0.05), smoking(p<0.05). (3) In the correlation of health complaints and stress, working posture, wearing protector, the stress was factor which had positive correlation to all symptoms (p<0.01), the working posture was factor which had positive correlation to general psymptoms(p<0.05), dermal symptoms(p<0.05), musculoskeletal symptoms(p<0.01). (4) In the correlation of health complaints and health knowledge were as follows: The knowledge level of occupation-related disease was factor which had positive correlation to eye symptoms(p<0.05), ear symptoms(p<0.01), general symptoms(p<0.05), musculoskeletal symptoms(p<0.015), digestive symptoms(p<0.05), respiratory symptoms(p<0.05). The knowledge level of work hazard was factor which had positive correlation to all symptoms(p<0.001). (5) In the regression analysis, The factors which affected health complaints were as follows: Eye symptoms were gender(β=0.4542), position(β=0.3409), hours of sleep(β=0.1733), alcohol consumption(β=0.2824), stress(β=0.2871), knowledge level of work hazard(β=0.2262), explained them by 13.4%. Ear symptoms were stress(β=0.4447), knowledge level of occupation related disease(β=0.1492), explained them by 11.3%. General symptoms were gender(β=0.2685), position(β=0.3196), stress(β=0.3570), explained them by 19.6%. Dermal symptoms were position(β=0.1437), stress(β=0.2734), explained them by 15.6%. Musculoskeletal symptoms were position(β=0.2411), stress(β=0.1335) explained them by 23.3%. Digestive symptoms were gender(β=0.3402), marital status(β=0.2073), position(β=0.2461), stress(β=0.2850), explained them by 17.7%. Respiratory symptoms were smoking(β=0.1851), stress(β=0.4542), knowledge level of work hazard(β=0.1780), explained them by 15.0%.

만성 폐쇄성 폐질환 환자에서 장기간의 스테로이드 복용 중 발생한 중증 분선충 감염 1예

하원철,이영현,하경임,안명희 대한감염학회 2008 감염과 화학요법 Vol.40 No.5

Strongyloides stercoralis is a soil-transmitted intestinal nematode that may cause long-lived auto-infection in the host. It is distributed worldwide, especially in the tropical and subtropical regions, but has been rarely reported in Korea. Chronic infections by S. stercoralis are mostly inapparent infections that carry nonspecific gastrointestinal and pulmonary symptoms. However, In immunocompromised patients such as those receiving long-term steroid therapy and patients with AIDS or malignant tumors, S. stercoralis can induce hyperinfection by autoinfection. This may lead to increased rate of complications such as resistance to chemotherapy and sepsis, In such cases mortality rate of up to 87% has been reported. We report a case of severe strongyloidiasis in a patient with chronic obstructive pulmonary disease who was receiving long-term steroid therapy. The chief complaint was repeated dyspnea and hematochezia, and strongyloidiasis was diagnosed by the presence of rhabditiform larvae of S. stercoralis in the fecal smear and isolation of filari-form larvae from the stool culture. The patient developed septic shock during treatment with albendazole and showed clinical signs of hyperinfection of S. stercoralis. He eventually died despite aggressive treatment.

파손된 치면열구전색제의 수리 방법에 따른 미세누출 비교

강명봉,현홍근,김영재,김정욱,장기택,이상훈,한세현,김종철 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.2

치면열구전색은 수 십년간 교합면 우식의 예방에 가장 효과적인 방법 중 한가지로 알려져 왔다. 하지만 치면열구전색제의 마모와 파절 때문에 치면열구전색제의 재시술 또는 수리를 필요로 하게 되었다. 본 연구의 목적은 파손된 치면열구전색제를 수리할 때 치질과 잔여 전색제의 표면처리 방법에 따른 미세누출 차이를 알아보고자 하는 것이다. 120개의 영구 대구치에 치면열구전색제를 적용하고 인위적인 파손을 만든 뒤 인공타액에 4주 동안 보관하였다. 4주 후 근심 또는 원심의 치면열구전색제가 완전히 파손 양상을 나타내는 치아 60개를 선택하여 각각 15개씩 4개 군으로 나누어 실험에 사용하였다. 각 군을 산부식만 시행한 경우(1군), air-abrasion만 시행한 경우(2군), 산부식 후 결합제를 적용한 경우(3군), air-abrasion 후 결합제를 적용한 경우(4군)로 나눠 각각의 치아를 표면처리한 후 치면열구전색제를 도포하였다. 고온(55℃)과 저온(5℃)에서 각각 30초씩 500회의 열순환을 시행한 뒤 미세누출도를 검사하여 다음과 같은 결과를 얻었다. 1. 치면열구전색제/치면열구전색제 경계면에서 미세누출도는 결합제 사용 유무에 관계없이 air-abrasion을 처리한 2군, 4군에서 산부식을 사용한 1군, 3군보다 낮은 값을 보였고(p<0.05) 1군과 2군, 3군과 4군 사이에는 통계적 유의차가 없었다(p>0.05). 2. 치면열구전색제/치아 경계면에서 미세누출도는 결합제를 사용한 3군, 4군에서 결합제를 사용하지 않은 1군, 2군보다 낮은 값을 보였고(p<0.05) 산부식을 사용한 1, 3군과 air-abrasion을 사용한 2, 4군 사이에는 통계적 유의차가 없었다(p>0.05). 3. SEM 상에서 치면열구전색제를 산부식 처리하였을 때 표면거칠기의 증가가 적었으나 air-abrasion 하였을 경우 표면거칠기가 현저하게 증가하는 것을 관찰하였다. The aim of this study was to investigate whether differences in surface treatment Prior to repair influenced the seal of a resin fissure sealant placed on the occlusal surfaces of permanent molar teeth. One hundred and twenty extracted human molars were selected and a light curing sealant was placed on their occlusal surface following cleaning by prophylaxis and acid etching. The teeth were deliberately damaged, and then stored in artificial saliva for four weeks. Sixty teeth with the desired morphology of sealant failure were randomly divided into four groups where one group was treated with only etching agent, another by only air-abrasion, another by applying an etching agent followed by a bonding agent, and the last by air-abrasion followed by a bonding agent each. After sealant application, the samples were thermocycled and the degree of microleakage was determined. The results were as follows: 1. In the sealant/sealant interface, group 2(0.22), 4(0.23) using air-abrasion showed a significantly lower microleakage score than group 1(0.38), 3(0.35) using an etching agent(p<0.05). There were no statistically significant differences(p>0.05) between groups 1, 2 and groups 3, 4. 2. In the sealant/tooth interface, group 3(0.20), 4(0.20) which used a bonding agent showed a significantly lower microleakage score than group 1(0.35), 2(0.40)(p<0.05). There were no statistically significant differences (p>0.05) between groups 1, 3 and groups 2, 4. 3. In SEM examination, while sealant surfaces treated with etching did not result in highly rough surfaces, those treated with air-abrasion did show rough surfaces.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

긴 말뚝기초의 축하중 전이 거동에 관한 연구

김명학,이호근,이성철,김상현 인제대학교 1999 仁濟論叢 Vol.14 No.3

현행 우리 나라 말뚝 기초는 대부분 선단 지지 말뚝으로만 설계되어 말뚝 주변에서 크게 발휘되는 주변 마찰력을 무시하므로 매우 비경제적인 설계가 이루어지고 있고, 뿐만 아니라 말뚝 축하중 전이 거동은 전혀 반영하지 못한 추정 설계 (또는 예비 설계) 만이 이루어지고 있는 실정이다. 본 연구에서는 국내 외의 말뚝 설계 사례들을 각 지반 종류별로 선정하여, 이들을 APILEPLUS로 해석하여 예측된 계산치와 측정된 결과치 들을 분석하여 축하중 전이 특성을 고찰하였다. 하중 전이 실험이 수반된 말뚝 정재하 시험 결과, 주변마찰력의 전지지력에 대한 비율은 점성토의 경우 80%를 상회하였으며, 사질토의 경우 70% 정도였다. 그리고, APILEPLUS에 의한 예측 결과에 대한 마찰력 분담률은 점성토의 경우 95% 이상이었으며, 사질토의 경우 60-70% 정도였다. 말뚝 선단이 단단한 지층에 관입되어 있더라도 사질토층 이외의 지층에서는 마찰력에 의해 지지되고 있으며, 사질토층에서도 상대관입 깊이가 10 이하로 극히 작은 단말쪽이 아닌 경우에는 마찰력이 전체 극한 지지력의 20%이상을 차지하고 있었다. 따라서, 현행 설계 개념에서 무시하고 있는 마찰력을 고려한 설계를 수행할 때에 비로소 말뚝 기초의 최적화 설계가 이루어질 수 있을 것이다. Current design method on pile foundation in Korea depend highly on the estimated design method without performing the pile load test, which means most pile foundation have been designed as end-bearing capacity pile only. Due to the neglect of side shear friction capacity of pile that should be large enough to support the superstructure, the highly uneconomical and estimated design has been conducted. Thus the behavior study of axial load transfer for long piles has not been considered. In this study, several research examples with different types of soil in domestic and out of country were selected to analyze the axial load transfer, with comparison between measured results in field and estimated results by the calculated from the program APILEPLUS. The friction ratio from pile load test showed more than 80% in cohesive soils and about 70% in cohesionless soils, while from the program APILEPLUS more than 95% in cohesive soils. Even though the tip of pile penetrated into a relative hard layer, except being installed in a cohesionless soil, mostly a side friction resistance supported the pile. In case of being installed in a cohesionless soil, the friction ration was more than 20%. Therefore, the proper and economical design procedure that shall utilize both end hearing and side friction resistance should be conducted.

경피적 자궁동맥 색전술로 치료한 산후 출혈 1례

정명철,김호성,김경철,노지현,고재환,김용봉,권동일 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Postpartum hemorrhage remains one of the leading causes of maternal deaths. The major causes of postpartum hemorrhage include uterine atony, retained placental fragment, placenta accreta, and lower genital tract lacerations. Conservative treatment is based on administration of uterotonic drugs, vaginal packing, and surgical repair of genital tract lacerations. When bleeding fails to respond to conservative treatment, surgical ligation of uterine vessels or hemostatic hysterectomy is performed. We present a case of postpartum bleeding treated by selective uterine arterial embolization with a brief review of previous literatures of postpartum hemorrhage & uterine arterial embolization.

방사선치료 후 영구치 치배 발육장애 증례보고 : REPORT OF CASE

강명봉,김영재,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

두경부 악성 종양에 대한 방사선치료는 유용한 방법이다. 하지만 방사선치료의 부작용으로 다양한 구강내 합병증을 동반한다. 이 글에서 치열 발육 단계에 방사선치료를 받은 두 증례를 보고하는 바이다. 첫 번째 증례는 생후 19개월에 급성 골수성 백혈병으로 진단 받아 방사선치료를 받은 7세 여자 환아로 영구치 치배의 선천적 결손과 왜소치 소견을 보였다. 두 번째 증례에서는 생후 13개월에 양측성 망막아세포종으로 진단 받아 방사선치료를 받았고 영구치 치배의 선천적 결손, 왜소치, 치근의 저형성 그리고 법랑질 저형성증 소견을 보였다. Radiotherapy for head and neck tumors is a viable treatment modality. However, a wide range of potentially debilitating dental complications may be accompanied by this treatment. We report two cases of developmental disturbance of permanent tooth germs after radiotherapy. The one was that of a seven-year-old girl, who had congenitally missing teeth, and microdontia of permanent tooth germs. she had received radiotherapy for acute myelocytic leukemia at the age of 19 months. The other was that of a nine-year-old boy, in which congenitally missing teeth, microdontia, root hypoplasia, and enamel hypoplasia of permanent teeth were observed. He had undergone a course of radiotherapy for bilateral retinoblastoma at the age of 13 months.