http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
개별검색 DB통합검색이 안되는 DB는 DB아이콘을 클릭하여 이용하실 수 있습니다.
통계정보 및 조사
예술 / 패션
<해외전자자료 이용권한 안내>
- 이용 대상 : RISS의 모든 해외전자자료는 교수, 강사, 대학(원)생, 연구원, 대학직원에 한하여(로그인 필수) 이용 가능
- 구독대학 소속 이용자: RISS 해외전자자료 통합검색 및 등록된 대학IP 대역 내에서 24시간 무료 이용
- 미구독대학 소속 이용자: RISS 해외전자자료 통합검색을 통한 오후 4시~익일 오전 9시 무료 이용
※ 단, EBSCO ASC/BSC(오후 5시~익일 오전 9시 무료 이용)
Purpose - This study investigated the effects of lectures in the English medium (EML) on understanding and learning outcomes. Sixty percent of EML lectures in Korea also use Korean for further support. Thus, this situation needs to clearly distinguish the specific impacts of the EML classes on learning outcomes. Here, we use the same English materials, including PowerPoint slides and video content, given in the Korean and English lectures. The difference between the lectures becomes only whether the lecture is delivered in Korean or English. Thus, we can clearly identify whether the language difference makes any difference in learning outcomes. Research design, data, and methodology – Our sample consisted of 91 students taking an international business course the spring of 2015. All course materials, including textbooks, PowerPoint slides, exams, video, and support content, were presented in English. Survey data and exam results were used. Students filled out their student identification number and name, so we could match the surveys against the exam results. Results – First, results show that whether the lecture was delivered in English or Korean was an important factor when students chose the class. Second, English proficiency related to international business and general English levels were higher in the English class than in the Korean class. However, the understanding of key concepts and reading abilities of international business newspapers were the same for students in both classes. Third, teaching materials and lectures were the most important material for the understanding of key concepts in the business major. Fourth, the exam results showed no difference in performance of the students in the English versus the Korean class. This shows that EML classes were not necessarily detrimental to the understanding of major concepts of the lecture. Thus, it is important that researchers carefully design empirical settings to study the effectiveness of EML. Conclusions – The English lecture can be as helpful for enhancing knowledge in the business major as the Korean lecture. For further research, various English lecture forms can be considered to distinguish the effects of the English lecture.
Caspases and c-Jun N-terminal kinase (JNK) are activated in tumor cells during induction of apoptosis. We investigated the signaling cascade and function of these enzymes in cisplatin-induced apoptosis. Treatment of Jurkat T-cells with cisplatin induced cell death with DNA fragmentation and activation of caspase and JNK. Bcl-2 overexpression suppressed activation of both enzymes, whereas p35 and CrmA inhibited only the DEVDase (caspase-3-like) activity, indicating that the activation of these enzymes may be differentially regulated. Cisplatin induced apoptosis with the cytochrome c release and caspase-3 activation in both wild-type and caspase-8-deficient JB-6 cells, while the Fas antibody induced these apoptotic events only in wild-type cells. This indicates that caspase-8 activation is required for Fas-mediated apoptosis, but not cisplatin-induced cell death. On the other hand, cisplatin induced the JNK activation in both the wildtype and JB-6 cells, and the caspase-3 inhibitor ZDEVD- fmk did not inhibit this activation. The JNK overexpression resulted in a higher JNK activity, AP-1 DNA binding activity, and metallothionein expression than the empty vector-transfected cells following cisplatin treatment. It also partially protected the cells from cisplatin-induced apoptosis by decreasing DEVDase activity. These data suggest that the cisplatin- induced apoptotic signal is initiated by the caspase- 8-independent cytochrome c release, and the JNK activation protects cells from cisplatin-induced apoptosis via the metallothionein expression.
Myoung-Sik,Han,Im-Ho,Han,이다혜,Jun,Min,An,Su-Nam,Kim,Myoung-Sook,Shin,Noriko,Yamabe,Gwi,Seo,Hwang,Hye,Hyun,Yoo,Suk-Jung,Choi,Ki,Sung,Kang,Hyuk-Jai,Jang 고려인삼학회 2016 Journal of Ginseng Research Vol.40 No.2
Background: Nephrotoxicity is a common side effect of medications. Panax ginseng is one of the bestknown herbal medicines, and its individual constituents enhance renal function. Identification of its efficacy and mechanisms of action against drug-induced nephrotoxicity, as well as the specific constituents mediating this effect, have recently emerged as an interesting research area focusing on the kidney protective efficacy of P. ginseng. Methods: The present study investigated the kidney protective effect of fermented black ginseng (FBG) and its active component ginsenoside 20(S)-Rg3 against cisplatin (chemotherapy drug)-induced damage in pig kidney (LLC-PK1) cells. It focused on assessing the role of mitogen-activated protein kinases as important mechanistic elements in kidney protection. Results: The reduced cell viability induced by cisplatin was significantly recovered with FBG extract and ginsenoside 20(S)-Rg3 dose-dependently. The cisplatin-induced elevated protein levels of phosphorylated c-Jun N-terminal kinase (JNK), p53, and cleaved caspase-3 were decreased after cotreatment with FBG extract or ginsenoside 20(S)-Rg3. The elevated percentage of apoptotic LLC-PK1 cells induced by cisplatin treatment was significantly abrogated by cotreatment with FBG and the ginsenoside 20(S)-Rg3. Conclusion: FBG and its major ginsenoside 20(S)-Rg3, ameliorated cisplatin-induced nephrotoxicity in LLC-PK1 cells by blocking the JNKep53ecaspase-3 signaling cascade.