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( Myon-hee Lee ),( Srivalli Swathi Mamillapalli ),( Brett D. Keiper ),( Dong Seok Cha ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.2
Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. In this review, we propose a mechanism that controls GSCs and their cell fate through selective activation, repression and mobilization of the specific mRNAs. This mechanism is acutely controlled by known signal transduction pathways (e.g., Notch signaling and Ras-ERK MAPK signaling pathways) and P granule (analogous to mammalian germ granule)-associated mRNA regulators (FBF-1, FBF-2, GLD-1, GLD-2, GLD-3, RNP-8 and IFE-1). Importantly, all regulators are highly conserved in many multi-cellular animals. Therefore, GSCs from a simple animal may provide broad insight into vertebrate stem cells (e.g., hematopoietic stem cells) and their cell fate specification. [BMB Reports 2016; 49(2): 93-98]
Survival of Korean Cancer Patients Diagnosed in 1995
Jong-Myon Bae,Young-Joo Won,Kyu-Won Jung,Kyung-Ae Suh,Young-Ho Yun,Myung-Hee Shin,Yoon-Ok Ahn,Duk-Hee Lee,Hai-Rim Shin,Don-Hee Ahn,Dae-Kyu Oh,Jae-Gahb Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.5
Purpose: To produce the nationwide 5-year survivalrates of Korean cancer patients by primary cancer site.Materials and Methods: The study subjects were cancerpatients diagnosed in 1995, as documented by the KoreaCentral Cancer Registry (KCCR) Program. This data wascollected in 120 (93%) of 129 nationwide intern- andresident-training hospitals and 75 (94%) of the 80 Koreanuniversity hospitals. Follow-up was performed by obtaininginformation upon vital status (i.e., whether living ordead) from the government administered whole populationfiles. Cumulative observed survival rate (OSR) wascalculated by using the life table method and the relativesurvival rate (RSR) was computed using the life-time tablefor the years 1995, 1997, and 1999.Results: Of the 55,042 study subjects, the OSR for allKorean cancer patients was 61.4% at 1 year and 38.1%at 5 years. The RSR for all cancers was 62.5% at 1 yearand 41.4% at 5 years, and the 5-year RSRs for all cancersin men and women were 32.6% and 53.2%, respectively.Conclusion: This is the first nationwide report upon5-year cancer survival by primary site in Korea. Menshowed a lower survival rate than women in most malignancies.Pancreatic and thyroid cancer had the lowestand highest 5-year survival rates, respectively. (Cancer Res Treat. 2002;34:319-325)
강면희 ( Myon Hee Kang ) 한국축산학회 1968 한국축산학회지 Vol.10 No.1
An elucidation of the origin of Chejudo goats and a study of their phenotypic characteristics are very important for the purpose of improving the native species in general, as well as of tracing their origin. They are also of interest, because they may be helpful in solving the problems of the origin and descent of Korean people. For the islands of the south-western coast of Korean hold a special significance in that they may have served as stopping-stones for Korean farm animal, and Korean people as well, to occupy their present habitat. It is with these objects in view that present writer has made this research, observing and measuring 148 individuals, as well as making inquiries into relevant historical document. The results of the research may be summarized as follows. 1. It was about 60 years ago, around 1910 that goat feeding was stared in Chejudo, with some heads of native breed introduced from the Korean mainland. The heads of native breed in the island totalled 63 in 1946 and 1900 in 1966. No evidence was found by the present writer that the Chejudo goat was introduced from the south or the west. The present population of goats in the island consists of hybrids of various grades between the native Korean breed and Saanen, with a small exception of pure Saanen breeds distributed around Cheju and Sogwipo and of pure native breeds around Mt. Sanbang. 2. As shown in Table 1, the present writer has made the following observations on the genetic characteristics of the goats in Chejudo. Of 148 beads: a. About 72℃ white and the rest coloured. b. 39% with wattles; 1.5% intersex; 15% with supernumerary teats. c. All have strong resistance io the lumber paralysis(Filariosis Cerebrospinalis). 3. As shown in Table 2, 3, 4, 5, 6, 7 and in Fig. 1, 2, 3, the present writer has obtained the following biometric constants and other statistical data concerning the Chejudo goat. a. The mean value of the withers height in the case of female is 60.51±5.23㎝ and that of the body length 61.28?.38cm. Therefore, the body type of the Chejudo goat is intermediate between that of the Takara native breed and Saanen. b. These differences among the Chejudo goat, the Takara native and Saanen are very significant, statistically showing at value of 27.9 in comparison with Saanen and 10.98 in comparison with the Takara native. c. Its standard deviation and coefficient of variation are comparatively large. d. A comparison of the Chejudo goat with the Japanese inland breeds and with Saanen in terms of standard deviation shows that the body type of the Chejudo goat clearly differs from those of the other two breeds.
Hai-Rim Shin,Yoon-Ok Ahn,Jong-Myon Bae,Myung-Hee Shin,Duk-Hee Lee,Choong-Won Lee,Heechoul Ohrr,Don-Hee Ahn,Jacques Ferlay,Dornald Maxwell Parkin,Dae-Kyu Oh,Jae-Gahb Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.6
Purpose: We estimated the incidence of cancer inKorea.Materials and Methods: The indicence of cancer wasestimated using national mortality data, and the incidencedata from four frontier regional cancer registries,including Kangwha, Seoul, Busan and Deagu. These fourregistries served a population about seventeen million,which is almost 38% of entire population in Korea.Results: The overall age-standardized incidence rates(ASR) were 287.0 and 163.1 per 100,000 for males andfemales, respectively. Among males, stomach cancer wasthe most frequent (ASR 69.6), followed by lung cancers,including bronchus cancer (ASR 54.5), liver cancer (ASR47.0) and colo-rectal cancer (ASR 25.2). The most frequentsites of cancer in females, by rank order, were stomach(ASR 26.8), breast (ASR 20.1), uterine cervix (ASR 18.0),colo-rectum (ASR 15.9), lung (ASR 13.0) and liver (ASR12.0).Conclusion: It is hoped that these results will providevaluable leads for cancer research and cancer control inKorea. (Cancer Res Treat. 2002;34:405-408)