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건강보험에서 5인 미만 사업장의 직장보험 편입 효과 평가와 정책 방향
송명섭,김창보,고수경,임정수,박지연 한국사회보장학회 2002 사회보장연구 Vol.18 No.2
본 논문은 건강보험공단이 2001년 「월 이후 추진하고 있는 5인 미만 사려장의 직장보험 편입을 평가하고 향후 정책방향을 제시하는데 목적을 두고 있다. 5인 미만 사업장의 직장보험 편입은 보험 가입자의 보험료 부과의 형평성을 제고하고, 영세사업장 노동자들의 보험료 부담을 경감시키며 건강보험재정 안정 효과를 위한 것이다. 2001년 7월 이후 12월 31일까지 직장보험으로 신규편입한 대상자는 모두 약 64만명이었으나 편입이전지역보험 대상자는 약 53만명, 직장보험 대상자는 약 10만명이었다. 또한 동일 기간동안 직장보험으로 편입된 사업장은 모두 88,751개였다. 편입 전후 개인별 보험료 수준 변화를 살펴보면 보험료 부과대상 중 77.6%는 본인이 부담해야 할 보험료가 감소하였다. 대신 사업주의 보험료 부담은 상대적으로 늘어났다. 한편 2001년 7월 이후 12월까지 직장보험 편입으로 건강보험의 재정은 약 19,530백만원의 재정절감효과가 있었다. 직장보험은 7,331백만원의 보험료 수입 증가가 발생하였으며, 지역보험은 12,199백만원의 재정절감 효과가 있었다. 향후 5인 미만 사업장의 직장보험 편입이 원만히 추진되기 위해서는 피부양자 인정기준의 개선과 영세사업장 사업주의 보험료 부담을 경감시켜주기 위한 방안을 강구해야 하며, 사회적으로는 비정규직 노동자에 대한 사회보장 적용 확대를 위한 노력이 동시에 추구되어야 할 것이다. This study was conducted for the purpose of evaluating coverage of small companies with less than 5 persons by Corporate Insurance since July 2001 and of suggesting policy implication. This coverage expansion by Corporate Insurance was intended for improving equity level of contribution imposition, alleviating financial burden of employees and achieving financial stability of health insurance. While, from July 2001 to December, the number of newly covered beneficiaries was about 642 thousand persons, the number of Regional beneficiaries before the new coverage expansion by Corporate Insurance was 533 thousand persons. And the number of Corporate Insurance beneficiaries before the coverage expansion was 101 thousand persons. For the same period, the number of companies by the new coverage expansion of Corporate Insurance was 88,751. Before and after the expansion, taking into account changes of individual contribution levels, payment share levels of contribution were reduced to the 77.6% of the beneficiaries newly covered by Corporate Insurance. Instead, payment share level of contribution of employers was increased more than before. And 19,530 million won was increased in National Health Insurance Expenditure. 7,331million won was increased in Corporate Insurance revenue. Expenditure reduction effect of 12,199 million won was able to be obtained in Regional Insurance. In order to implement successfully the coverage expansion by Corporate Insurance in times ahead, employers' contribution share should be reduced, when considering low profitability levels of small companies.
최승익,변명섭,안태석 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-
The total bacterial numbers were estimated by acridine orange direct count method in Lake Soyang monthly from January 1990 to 1992 The range of total bacterial number was from 0.4*10^(6) to 4.7*10^(6) cell*㎖^(-1). In epilimnion,the variation range was wider than other depths. while in hypolimnion was narrower. At August, when water temperature was highest. the bacterial numbers was also highest . This means that water temperature was highest the bacterial numbers was also highest. This means that water temperature was one of the factor governing the bacterial abundance. In metalimnion. the bacterial number was higher than other depths during stratigication. And spacially the bacterial numbers near aquaclture net-cages were higher than those of dam site. This means that allochthonous materials such as terrestorial originated particle, organics and microbes from watershed and fish feed stinmulated the bacterial growth.
16S와 23S rRNA에 결합하는 probe를 이용한 겨울철 소양호 세균 군집 구조의 분석
홍선희,변명섭,안태석 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-
겨울철 소양호에서 세균 군집 구조를 파악하고자 총세균수와 EUB338, ALF1b, BET4a, GAM42a와 CF probe등 fluorescent rRNA targeted oligonucleotide probe와 반응하는 세균 개체수를 수심별로 측정하였다. 총세균수는 0.7×10^(6)~1.1×10^(6)cell·㎖^(-1)이였으며, 5m와 10m 수층에서 높게 나타났다. 총세균수에 대한, Eubacteria의 비율은 34~90%이였으며, 5m와 10m에서 낮게 나타났다. Proteobacteria α-group은 Eubacteria의 10.8-28.7%, β-group은 4.5-53.5%, γ-group은 4.9-35.5%, 그리고 Cytophaga-Flavobacterium group은 6.1-21.1%이였다. 0.5m 수심에서는 β-group이 28.6-53.3%로 우점하고 있었으며, 10m에서는 γ-group이 35.5%로 우점하였다. 30, 50m 수심에서는 α-group과 Cytophaga-Flavobacterium group이 우점하였다. 세균 군집 구조로 보면 0-2m, 5-10m 그리고 30-50 m의 3개층은 각각 독특한 특징을 나타내었다. 이 방법으로 호수 생태계에 대한 새로운 정보를 얻을 수 있었다. To scrutinize the bacterial community composition of Lake Soyang in winter, bacterial numbers blonging to Eubacteria, Proteobacteria and Cytophaga-Flavobacterium group were estimated by using 16S and 23S rRNA targeted oligonucleotide probes. Total bacterial numbers ranged from 0.7Χ10^(6)~1.1Χ10^(6)cell ·㎖^(-1)and vertical profile of total bacteria showed a peak at 5m and 10m depths those were low exhibiting, 39 and 34%, respectively, The percentage of proteobacteria α-group ranged 10.8~28.7%, β-group 4.5~535%, Υ-group 4.9~35.5% and Cytophaga-Flavobacterum group 6.1~21.1%. The dominant groups were β-group at 0, 2 and 5m Υ-group at 10m, α-group at 30m and Cytophaga-Flavobacterium group at 50m depth. In winter season, Lake Soyang can be divided into into three layer, 0~2m, 5~20m and 30~50m, by bacteria community composition. By this method, new informations about aquatic ecostem were developed.
안태석,최승익,변명섭,박호완 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-
To define the ecological roles of bacteria in Lake Soynng, the depth profiles of bacterial numbers and their biovolume were estimated temporally. In August, 1992, the bacterial numbers and biovolume were ranged from 12×10^(5) to 28×10^(5) cells ml^(-1) and from 0.4 to 1.0 ㎛³ cell^(-1), respectively. At 30m depth, the biovolume was highest as 1.0㎛³ cell^(-1) while the numbers were not changed. These large bacteria might be allochthonous bacteria originated from terrestrial during the heavy rain. In October, 1882, the bacterial numbers were ranged from 6×10^(5) to 17×10^(5) cells ml³ , and biovolumes at epilimnion were about 0.5 ㎛³ cell^(-1), while at metalimnion and hypolimnion, larger than 0.9 ㎛³ cell^(-1). In this time, zooplankton grazing pressure and nutrients release from sediment might affect the bacterial numbers and biovolume. In April, 1993, when Asterionella and Fragifaria were dominant species of phytoplankton only in epilimnion, the bacterial numbers were about 20×10^(5) cells ml^(-1), and biovolumes were about 0.8㎛³ cell^(-1). While at other depths, the numbers and biovolumes were smaller. These results suggest that the bacterial numbers were dynamically changed with season, while their mean cell volume were commonly stable as 0.5㎛³ cell^(-1). But by the allochthonous bacteria, organic materials released by phytoplnnkton and grazing pressure by zooplankton might increase the biovolume.
Bacterial Abundances and Enzymatic Activities under Artificial Vegetation Island in Lake Paldang
( Myeong Seop Byeon ),( Jae Jun Yoo ),( Ok Sun Kim ),( Seung Ik Choi ),( Tae Seok Ahn ) 한국하천호수학회 2002 생태와 환경 Vol.35 No.4
팔당호에 설치된 인공식물섬에서 미생물의 역할을 알아보기 위하여 동물플랑크톤 군집 크기, 총세균수, 활성세균수, β-glucosidase와 phosphatase의 체외효소활성도를 2001년 11월 3일부터 2002년 4월까지 격주로 인공식물섬이 설치된 지역과 바깥지역을 대상으로 조사 분석하였다. 인공식물섬 아래에서는 일반적으로 측정하는 환경요인들은 대조구보다 수질이 나쁜 것으로 나타났다. 그러나, 동물 플랑크톤의 수는 대조구보다 평균 25배, 활성세균의 수는 평균 3-8배, 그리고 체외효소활성도는 훨씬 높은 값을 보였다. 이러한 결과는 인공식물섬에서는 동물플랑크톤-식물플랑크톤-수초-세균의 밀접한 관계가 존재하고, 이 관계에 의하여 동물플랑크톤과 세균의 호흡, 분해작용으로 유기물이 제거되는 것으로 판단되었다. For analyzing function of a microbial ecosystem which was created under the artificial vegetation island(AVI) installed at Lake Paldang, zooplankton and bacteria numbers and exoenzyme activities(β-glucosidase and phosphatase) were measured biweekly from 3 November 2001 to 20 April 2002 at AVI site and control site. Under the AVI, the water quality was worse than control site in term of comparing the environmental parameters. Respiratory active bacterial numbers were 3-8 time higher at AVI site. These results suggest that the zooplankton-phytoplankton-bacteria relationships are closely coupled with each other and organic materials are eliminated by respiration of zooplankton and bacterial activities.
Development of a type II diabetic mellitus animal model using Micropig®
Myeong-Seop Lee,Hee-Jun Yang,Chester D. Solis,Ki-Duk Song,Soo-Hyeon Kim,Woon-Kyu Lee 한국실험동물학회 2012 Laboratory Animal Research Vol.28 No.3
Diabetes, which has shown an explosive increase in terms of its incidence, is regarded as a serious disease that must be overcome for the sake of human life. Among animal models used for testing of drug efficacy, the mini-pig model has shown a rapid upload due to its many similarities with human, particularly concerning the pharmacokinetics of compounds after subcutaneous administration, the structure and function of the gastrointestinal tract, the morphology of the pancreas, and overall metabolic status. Based on these various advantages, we sought to develop an animal model of type II diabetic mellitus using the Micro-pig, which differs from other miniature pigs. We used six male Micro-pigs for induction of a moderate insulin deficient model with nicotinamide (NIA)/streptozotocin (STZ) treatment and three animals for control. For evaluation of incidence of type II diabetes, we measured blood glucose level, and performed oral glucose tolerance test and immunohistochemistry on pancreatic tissue using insulin antibody. Compared to control animals, all animals treated with NIA/STZ showed high levels of glucose and low levels of insulin. In addition, we observed the partially destroyed beta cell population from tissue of the pancreas in treated animals. Based on these results, we report that the Micro-pig model developed in this study can be used for testing of the efficacy of therapeutic agents for treatment of Type 2 diabetic mellitus.
Myeong-Seop Kim,Jeong-Oh Yang,Bong-Su Kim,Eul-Jai Myung,Byung-Ho Lee 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.04
Aphids are common pests frequently found in imported and exported fruits and vegetables. Methyl bromide(MB), a Quarantine and Pre Shipment(QPS) fumigant, could offer eradication of aphids within short period. However, MB is limited in use because of poor gas evaporation at low temperature(<5℃) and there is phytotoxic effect or damage on quality in post-harvest vegetables and fruits even at >5℃. Two candidates of MB alternative, ethyl formate(EF) and phosphine(PH3), are used and being investig at edonvarious fruits and vegetables fumigation to replace MB. Aphids are known as quarantine pest that are hard to control when conduct short period fumigation with PH3 and low dosage of EF. In this paper, dose response assessment of EF and PH3 are presented for three different aphid pecies : cotton aphid(Aphisgossypii), green peach aphid(Myzuspersicae) and turnip aphid (Lipaphiserysimi). The LCt99% values of EF at room temp. and low temp. (5℃) were 4.42 and 4.45 g·h·m-3 for cotton aphid, 3.23 and 5.58 g·h·m-3 for turnip aphid, 3.23 and 5.58 g·h·m-3 for green peach aphid when 2-hours fumigation. PH3 showed 0% efficacy on all species when 2-hours fumigation.
Myeong Seop Kim,Soo Youn Lee,Kyung-Hee Kim 영남대학교 의과대학 2023 Yeungnam University Journal of Medicine Vol.40 No.-
Hereditary transthyretin (ATTRv) amyloidosis is a rare and complex genetic disorder that can lead to life-threatening cardiac amyloidosis and rapid disease progression. Early diagnosis and treatment with disease-modifying drugs can improve patient outcomes; however, heart transplantation may be necessary in some patients. We present the unique case of a 65-year-old Korean woman diagnosed with ATTRv amyloidosis after experiencing progressive neurological symptoms, followed by heart failure. Despite the absence of significant symptoms of heart failure, subsequent screening revealed cardiac amyloid infiltration, which caused left ventricular hypertrophy and rapid disease progression. The patient underwent successful heart transplantation, and subsequent genetic testing revealed a pathogenic variant, NM_000371.3:c.425T>C (p.Val142Ala), which affects both the nerves and heart and has not been previously reported in Korea. Our report underscores the potential benefits of heart transplantation in managing advanced ATTRv amyloidosis and emphasizes the need for continued research on the genetic heterogeneity of the disease. Clinicians should consider ATTRv amyloidosis in the differential diagnosis of patients presenting with neurological symptoms and heart failure, particularly in those with a family history of the disease.