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( Muyeol Lee ),( Dong-geon Lee ),( Yujin Yang ),( Dae Hyun Kim ),( Bo Sik Choi ),( Hyeong Uk Ju ),( Neung Hwa Park ),( Byung Uk Lee ),( Jae Ho Park ),( Seok Won Jung ),( In Du Jeong ),( Sung-jo Bang ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Daclatasvir/asunaprevir (D/A) combination therapy has approved as a first interferon free oral regimen for chronic hepatitis C in Korea. D/A combination therapy has shown a high virological response for chronic genotype 1 hepatitis C virus (HCV) infected patients in clinical trials and real world data of Japanese. In the present study, we analyzed the real world efficacy and the safety of D/A combination therapy for patients with (HCV) in metropolitan city Ulsan. Methods: We retrospectively analyzed clinical data of chronic HCV genotype Ib patients treated with D/A combination therapy at five hospitals in the metropolitan city Ulsan. Of 146 patients treated with D/A combination therapy, 117 patients completed treatment were included in safety and efficacy analysis. Results: D/A combination therapy was the first-line treatment for 64 (54.7%) patients. 44 (37.6%) patients were null responders or relapsers of previous interferon treatment and nine patients (7.7%) were found to be intolerant of interferon. Fifty two (44.4%) patients exhibited cirrhotic change. Sustained virologic response at 12 weeks (SVR 12) rate was 90.6% (106//117) overall, 93.87% the treatment- naive group, 86.4% in the treatment-failure group, and 88.9% in the treatment-intolerant group. SVR12 rates for patients with and without cirrhosis were 86.5% and 93.8%, respectively (p>0.05). SVR was achieved in 89.2 % of patients aged order 65 years and 92.4 % of younger 65 years. There was no significant difference in SVR12 rate (86.2% vs 97.8%) between high viral load (HCV RNA > 80,000 IU/mL) group and low viral load group. Adverse treatment-related events were reported in 00 (17.1%). One patient stopped drug due to severe general weakness and died from aspiration pneumonia. Conclusions: D/A combination therapy combination treatment should be considered as a safe and effective treatment option for genotype 1 HCV-infected patient.
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분광학적 분석을 통한 혐기환경 하의 FeS의 pH조건에 따른 As(V)/Sb(V) 반응 연구
이무열(MuYeol Lee),한영수(Young-Soo Han) 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10
산소가 닿지 않는 깊은 토층이나, 포화대층, 유기물이 많은 호소의 저질층 등은 자연계에서 환원환경이 쉽게 형성된다. 이러한 조건에서의 지구화학적 반응은 주로 Fe<SUP>2+</SUP>, Mn<SUP>2+</SUP>, S<SUP>2-</SUP> 등 토양 및 지각의 주요구성 물질 중 환원상태로 존재하는 원소들에 의해 주도적으로 일어난다. 토양에 미량으로 존재하는 비소(As)와 안티모니(Sb)는 독성을 가지고 있는 물질로 주기율표상 같은 15족에 속하여 화학적 구조가 유사하다. 위 물질들은 pH에 따라 다양한 산화수의 변화를 보여주며, 이에 따라 독성 및 이동도, 흡착율 등의 특성이 변하게 된다. 그러므로 토양 환경 내에서 As와 Sb의 효율적인 제어를 위하여 다양한 지구화학적 조건 하에서 이들 원소들의 정확한 화학적 형태를 파악하고 반응 특성을 예측하는 것이 필요하다. 본 연구에서는 엄격한 혐기성 환경 하에서 합성된 FeS (mackinawite)와 As(V), Sb(V)가 다양한 pH 조건에서 어떠한 반응을 일으키는가를 알아보고자 산성(pH5), 중성(pH7), 염기성(pH9)의 조건을 고려한 배치실험을 수행하였다. 반응 후 FeS와 반응대상 원소의 반응 메커니즘을 알아보기 위하여 X-ray absorption spectroscopy (XAS), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) 등 분광학적 방법을 이용하여 시료를 분석하였다. 실험결과, pH5에서 As(V)와 Sb(V)는 , FeS의 환원력에 의해 As(III)와 Sb(III)로 환원되었으며, 산성 조건에서 FeS의 높은 용해도에 따라 해리된 황과 반응하여 As₂S₃ 및 Sb₂S₃와 같은 황화광물로 침전되어 높은 제거율을 보이는 것으로 판단된다. pH7과 9에서 As(V)는 주로 흡착반응으로 인한 제거, Sb(V)는 산화물 형태로 침전되어 높은 제거율을 보이는 것으로 판단된다. 황화광물인 FeS를 이용한 As(V)와 Sb(V)의 배치실험을 수행한 결과, 이들의 반응은 pH 및 FeS 및 각 원소의 산화광물의 용해도 등에 영향을 받음을 확인하였다.
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김성주(Sungju Kim),조무열(Muyeol Cho),최성진(Sungjin Choi),안장모(Jangmo Ahn) 한국자동차공학회 2020 한국자동차공학회 부문종합 학술대회 Vol.2020 No.7
In this paper, we presented a platform that can switch control authority of Autonomous vehicle. For this purpose, the control transition status was defined and the messages and signals were defined and embodied. In addition, in order to simulate the real vehicle confirmation situation of stable control right conversion, scenario confirmation and driving record signal for autonomous vehicle registration were constructed and confirmed. The MRM mode of the presented platform was confirmed to decelerate to a certain speed in the control switching situation or to stably stop the vehicle in the presence of obstacles.
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김석현(Seockhyun Kim),박무열(Muyeol Park),C.X.Cui 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.11
Vibration characteristics of a small stand alone W/T(wind turbine) system are experimentally and theoretically investigated. Vibration is monitored on a wind turbine structure model and the data are analysed with the analytical results. Resonance problem is investigated under various operating speed. To predict the resonance speed of W/T, Rayleigh-Ritz method is applied to the tower-guy cable coupled system. The effect of the cable tension on the vibration characteristics is considered experimentally and analytically. Results of the study are utilized to design the stable structure of small size wind turbines which consist of the pivoted tower and the guy cable.
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Lee, Byongsoon,Kim, Muyeol 한국유전학회 2004 Genes & Genomics Vol.26 No.1
To elucidate the origin of a Korean endemic species Lycoris chejuensis, we carried out C-banding, fluorescent in situ hybridization (FISH) with the 45S rDNA, and genomic in situ hybridization (GISH). Morphological characteristics and karyotype of L. chejuensis are very similar to those of L. sanguinea var. koreana and L. chinensis var. sinuolata. Among thirty chromosomes of L. chejuensis, rDNA loci by FISH were mapped on seven chromosomes like C-banding patterns. Combining this information with the previously obtained rDNA maps, i.e. three loci that the genome of L. chejuensis (2n=30, 22A+3M+ISM+4T) composed of the diploid genuolata (6M+2SM+8T). GISH was used to verify the hypothesized parental genome of L. chejuensis. Biotinylated total genomic DNA probes from L. sanguinea var. korena hybridized more strongly to twenty-two chromosomes among L. chejuensis chromosomes. In a reciprocal GISH, the reverse result was obtained. These results confirmed that L. chejuensis is an allopolyploid hybrid between reduced gamete of L. chinensis var. sinuloata and unreduced gamete of L. sanguinea var. koreana.
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한국산 비비추속(Hosta Tratt.) 식물의 분류학적 연구
조현,김무열,Jo, Hyun,Kim, Muyeol 한국식물분류학회 2017 식물 분류학회지 Vol.47 No.1
한국산 비비추속(Hosta)에 대해 외부형태형질을 기초로 분류학적 연구를 수행하여 종의 한계를 재검토하였다. Hosta clausa의 변종들은 근경에 기는 줄기가 있고, 화경이 매끈하며, 약이 자색이라는 점에서 특징을 공유하나, 비비추(H. clausa var. normalis)는 개방화이고 암술이 수술보다 훨씬 길며 종자를 결실하는 반면에 참비비추(H. clausa var. clausa)는 폐쇄화이고 종자를 맺지 못하며, 금강비비추(H. clausa var. geumgangensis)는 개방화이나 종자를 결실하지 못하고, 엽병이 녹색이며, 암술이 수술 길이와 비슷하고, 화피협통부는 길이가 짧아 구별되었다. 또한 이삭비비추(H. clausa var. ensata)는 좁고 엽병으로 흘러내리는 잎 형태의 특징이 비비추의 연속변이에 포함되어 이명처리하였다. 다도해비비추(H. jonesii)는 화경이 매끈하며, 약이 노란색이고, 광통부가 부풀어 오른 종형으로 대마도비비추(H. tsushimensis)와는 광통부의 형태로 구별되었다. 흑산도비비추(H. yingeri)는 꽃이 깔때기형이고, 수술 3개는 길고 3개는 짧고, 화경이 매끈하며, 신안비비추(H. laevigata)는 수술의 길이가 모두 같고 좁은 피침형의 잎, 엽연이 파형을 띠어 신종으로 기재되었으나 흑산도 주변섬에서 동일 특징을 보이는 개체가 발견되지 않아 분류학적 처리를 유보하였다. 한라비비추(H. minor var. venusta)는 화경에 종주선이 있고 약이 노란색이라는 점에서 좀비비추(H. minor)와 유사하지만 식물체의 크기, 꽃의 수, 잎의 크기와 형태 등 주요형질에서 중첩되어 좀비비추의 변종으로 처리하였다. 따라서 한국산 비비추속은 5종 3변종 6품종으로 정리되었다. A taxonomic study of the genus Hosta (Lilliaceae) in Korea was conducted based on morphological characteristics. Hosta clausa varieties share several characteristics (rhizomes with underground stolons, smooth scapes, and purple anthers). Hosta clausa var. normalis has an open perianth, long pistils, and fertile fruit. H. clausa var. clausa can be distinguished from H. clausa var. normalis by its closed perianth and sterile fruit. H. clausa var. geumgangensis has sterile fruit, green petioles, short pistils, and short narrow perianth tubes. H. clausa var. ensata has very narrow, sword-shaped leaves. It can be included in H. clausa var. normalis, which has a large degree of variation in leaf and petiole shape. H. jonesii has smooth scapes, yellow anthers, and bell-shaped flowers. It can be distinguished from the related species H. tsushimensis found on the Tushima islands in Japan by its wide perianth tube. H. yingeri is distinguished by its funnel-shaped flowers, 3 long and 3 short stamens, and smooth scape; the related species H. laevigata has 6 equally-sized stamens, narrowly lanceolate leaves, and wavy leaf margins. Because H. laevigata is not found in its type locality Isl. Heugsando, its taxonomic position must be determined at a later time. H. minor shares several characteristics (scapes with ridges and yellow-colored anthers) with the related taxa H. venusta. However, H. venusta is changed to H. minor var. venusta because it has overlapping characteristics in plant size, number of flowers, leaf size, and leaf shape. Consequently, the genus Hosta in Korea is classified into 5 species, 3 varieties, and 6 forms.
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황상일 ( Hwang Sangill ),정무열 ( Jung Muyeol ),윤순옥 ( Yoon Soon-ock ) 한국지형학회 2016 한국지형학회지 Vol.23 No.4
Commonly found sedimentary horizons from bottom to top in the Susanje reservoir area, Miryang, are lower gray silty horizon, peaty horizon deposited during 2,300-1,600 yr BP, and black gray or black brown silty horizon. Sedimentary facies, diatom and AMS(Accelerator Mass Spectrometer) dating are analyzed with bored samples from alluvial plain in this area and sea level change during approximately 4,300- 2,300 yr BP are reconstructed. Sea level smoothly fell after since approximately 4,300 yr BP and nearly reached to the current sea level at approximately 4,000 yr BP. Sea level reached to approximately 1.9 m.a.s.l. at approximately 3,000 yr BP with two small fluctuations in between. Since then, sea level fell again and reached to approximately 0.9 m.a.s.l. at approximately 2,300 yr BP.
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