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Risk Factors for Delayed Hyperthyrotropinemia in Late Preterm Infants
Mun Hui Jeong,Na Rae Lee,Mi Hye Bae,Young Mi Han,Kyung Hee Park,변신연 대한신생아학회 2019 Neonatal medicine Vol.26 No.4
Purpose: This study aimed to investigate the prevalence of delayed thyroid dysfunction based on iodine disinfectant use and to analyze associated risk factors. Methods: A retrospective study was conducted on late preterm infants admitted to the neonatal intensive care unit between January 2010 and June 2018, who underwent neonatal thyroid screening (NTS) and ≥2 thyroid function tests (TFTs). NTS was performed 3 days after birth, with at least two TFTs 1 week and 2 to 4 weeks after birth. To distinguish between normal and dysfunctional thyroid levels, we reviewed TFT results at 2 to 4 weeks and examined possible risk factors for the development of thyroid dysfunction. Results: Of 295 late preterm infants, 262 were enrolled with a mean gestational age and birth weight of 34.8±0.7 weeks and 2,170±454 g, respectively. A total of 7.6% developed hyperthyrotropinemia at the age of 24.3±14.6 days (range, 12 to 69). The incidence of hyperthyrotropinemia during iodine use was approximately 12.6%, while that during discontinuation was 2.4% (P=0.002). Multivariate analysis revealed that small for gestational age (SGA), iodine disinfectant use, and abnormal NTS results were significant risk factors for delayed hyperthyrotropinemia (adjusted odds ratio [AOR]: 4.27, P=0.008; AOR: 8.24, P=0.003; and AOR: 7.80, P=0.002, respectively). Conclusion: Delayed hyperthyrotropinemia was prevalent in late preterm infants exposed to topical iodine and those identified as being SGA. Secondary TFTs should be considered 2 to 4 weeks after birth for this population at risk.
Optimization of the Spreadable Modified Butter Manufacturing by Response Surface Methodology
Mun Hui Suh,Keon Bong Lee,Seung Chun Baick 한국축산식품학회 2012 한국축산식품학회지 Vol.32 No.6
The aim of this study was to optimize the manufacturing condition of spreadable modified butter by RSM. Based on the central composite design, the degree of optimization was expressed as a SFC as a dependent variable (Y, %) determined by NMR with 23 experimental groups. Three independent variables were the contents of butter (X1, 35-75%), the contents of grape seed oil (X2, 15-35%), and the contents of hydrogenated soybean oil (X3, 0-4%). As the result, SFC at 10oC was ranged from 32.37 to 42.76%. In addition, the regression coefficients were calculated for SFC at 10oC by RSREG. The regression model equation for the SFC was Y=39.18-0.04X1X3. Consequently, the optimal contents for manufacturing spreadable modified butter were determined as 55.18% for butter, 40.78% for grape seed oil, and 4.08% for hydrogenated soybean oil, respectively. The predicted response value for SFC at 10oC was 30.20%, comparable to the actual experimental SFC value as 29.85%. Finally hardness and spreadability in reference butter and spreadable modified butter produced under the optimal conditions was measured. The hardness in spreadable modified butter was 31.80 N as compared to 69.92 N in reference butter. The spreadability in spreadable modified butter was 5.6 point as compared to reference butter. This difference may be due to the contents of solid fat by butter and hydrogenated soybean oil. This study showed that the SFC value at 10oC could be a suitable indicator for the manufacturing spreadable modified butter to predict important attributes such as mouth feel, hardness and spreadability.
Mun, Hui-jin,Choi, Hyun-sik 인하대학교 다문화융합연구소 2023 다문화와 교육 Vol.8 No.2
This paper sought to present the direction of intercultural education by exploring the complex relationship between the literary expression of the Vietnam War and cultural communication in multicultural novels. To this end, this paper explored the appearance and attitude of characters in the works, events highlighted by mixed views, situations in which the characteristics of the Korean people are prominently revealed, and the background of the work, the place, and the social background of the times. The Vietnam War has taken an important place in history as its influence extends beyond the physical boundaries of the countries involved. As society becomes increasingly multicultural, examining(it is essential to examine) how this historical event is portrayed in literature and how it contributes to cross-cultural understanding. This study aims to shed light on how writers use literary devices and strategies to convey interactions between cultures in the context of the Vietnam War through a comprehensive review of related literature and analysis of selected multicultural novels, The analysis of these multicultural novels shows various experiences and interpretations of the Vietnam War. It emphasizes the importance of cross-cultural communication in bridging the gap between people from different cultural backgrounds and promoting empathy. Expressing war in literature serves as a platform for intercultural dialogue and promotes a deeper understanding of historical events and their effects in today's multicultural society. In addition, it contributes to the existing system of knowledge by providing insight into the role of multicultural fiction in cross-cultural communication and the depiction of the Vietnam War. Emphasizing the importance of literature as a medium for cultural exchange and understanding allows readers to participate in various perspectives and challenge their preconceptions.
A Rare Case of Oligodendroglioma in Sacrococcygeal Mature Teratoma Diagnosed in Preterm Infant
Mun Hui Jeong,Seong Hee Jeong,Chung Su Hwang,조용훈,변신연,Na Rae Lee 대한신생아학회 2022 Neonatal medicine Vol.29 No.3
Sacrococcygeal teratoma is the most common congenital tumor in neonates, and is reported in approximately 1/35,000 to 1/40,000 live births. Oligodendroglioma is a rare central nervous system tumor that is usually found in the cerebral hemisphere of young and middle aged adults. When associated with a teratoma, it is mainly identified in ovarian teratoma in adolescents and adults. We describe a rare case of a preterm infant with oligodendroglioma in a mature sacrococcygeal teratoma. The male neonate was born at a gestational age of 30 weeks with a protruding mass in the sacrococcygeal region. Pelvic magnetic resonance imaging showed a sacrococcygeal teratoma of approximately 11 cm comprising fat components and skeletal structure, that extended from the anterior part of the sacrum to the abdominal cavity. Radical resection was performed at 36 days of age. Macroscopically, the resected intra-abdominal mass had the characteristics of a cystic lesion, and the intrapelvic mass was a predominantly solid mixed cystic-solid lesion. Histologically, this solid lesion in the intrapelvic mass was composed of mature glial tissue, which comprised as a proliferation of monotonous cells with small and round nuclei, surrounded by a perinuclear halo (“fried egg” appearance). Additionally, these cells were immunohistochemically positive for glial fibrillary acidic protein. These findings confirmed the diagnosis of oligodendroglioma in sacrococcygeal mature teratoma. After the treatment, no recurrence was observed during the follow-up period, and no additional intervention was required. However, the patient is undergoing treatment for voiding dysfunction caused by a neurogenic bladder.
Mun Hui Jeong,Seong Hee Jeong,Su Jeong Park,Na Rae Lee,Mi Hye Bae,박경희,변신연,김충락,Young Mi Han 대한신생아학회 2022 Neonatal medicine Vol.29 No.1
Purpose: We used the Bayley Scales of Infant and Toddler Development (BSID)-III to analyze the incidence and risk factors of developmental delay in very-low-birth-weight infants without severe brain lesions. We further examined the correlation between the cumulative dexamethasone dose and developmental assessment results. Methods: We retrospectively analyzed data of preterm infants (birth weight <1,500 g) admitted to our neonatal intensive care unit between January 2014 to December 2020. The BSID-III scores obtained between the corrected ages of 12 and 24 months and after 24 months were analyzed. Developmental delay was defined as a composite score of <85 for the cognition, language, and motor domains. Univariate and multivariate analyses of developmental delay risk factors and developmental changes from the first to second BSID-III were performed. Correlations between the accumulated dexamethasone dose used for bronchopulmonary dysplasia (BPD) and the first and second test scores were analyzed. Results: Seventy-one and thirty-six infants completed the first and second tests, respectively. In both tests, developmental delay was most commonly observed in the language domain (26.8%, 47.2%). In multivariate analysis, mild BPD was identified as a developmental delay risk factor (P<0.05), whereas prenatal steroid use reduced the developmental delay risk (P<0.05). All domain scores were lower in the second test than in the first test. The cognition and language domain scores in the second test decreased with increasing cumulative dexamethasone doses. Conclusion: Very-low-birth-weight infants typically experience language delay, which can persist as they age.
A Rare Case of Oligodendroglioma in Sacrococcygeal Mature Teratoma Diagnosed in Preterm Infant
Mun Hui Jeong,Seong Hee Jeong,Chung Su Hwang,Yong Hoon Cho,Shin-Yun Byun,Na Rae Lee 대한신생아학회 2022 Neonatal medicine Vol.29 No.3
Sacrococcygeal teratoma is the most common congenital tumor in neonates, and is reported in approximately 1/35,000 to 1/40,000 live births. Oligodendroglioma is a rare central nervous system tumor that is usually found in the cerebral hemisphere of young and middle aged adults. When associated with a teratoma, it is mainly identified in ovarian teratoma in adolescents and adults. We describe a rare case of a preterm infant with oligodendroglioma in a mature sacrococcygeal teratoma. The male neonate was born at a gestational age of 30 weeks with a protruding mass in the sacrococcygeal region. Pelvic magnetic resonance imaging showed a sacrococcygeal teratoma of approximately 11 cm comprising fat components and skeletal structure, that extended from the anterior part of the sacrum to the abdominal cavity. Radical resection was performed at 36 days of age. Macroscopically, the resected intra-abdominal mass had the characteristics of a cystic lesion, and the intrapelvic mass was a predominantly solid mixed cystic-solid lesion. Histologically, this solid lesion in the intrapelvic mass was composed of mature glial tissue, which comprised as a proliferation of monotonous cells with small and round nuclei, surrounded by a perinuclear halo (“fried egg” appearance). Additionally, these cells were immunohistochemically positive for glial fibrillary acidic protein. These findings confirmed the diagnosis of oligodendroglioma in sacrococcygeal mature teratoma. After the treatment, no recurrence was observed during the follow-up period, and no additional intervention was required. However, the patient is undergoing treatment for voiding dysfunction caused by a neurogenic bladder.