간경변 및 간암과 혈청 구리와 아연농도와의 관련성

현명수,서석권,윤능기,이종영,이승훈,이무식,Hyun, Myung-Soo,Suh, Suk-Kwon,Yoon, Nung-Ki,Lee, Jong-Young,Lee, Seoung-Hoon,Lee, Mu-Sik 대한예방의학회 1992 예방의학회지 Vol.25 No.2

현재까지도 완전히 규명되지 못한 간질환과 혈청 구리 및 아연농도와의 관련성을 밝히고, 이들의 진단적 가치를 알아보고자 1990년 10월에서 1991년 8월 사이에 대구시 소재 모 대학병원 내과와 건강진단센터에 내원한 사람들 중에서 무작위로 선정한 정상 63명, 간경변 60명 그리고 간암 33명을 대상으로 일반적 특성을 조사하였고, 체내 일일 변동을 고려하여 공복시 오전 9시에서 11시 사이에 혈액을 채취하여 간기능검사의 생화학적 표지자와 혈청 구리 및 아연농도의 분석에 사용하였다. 혈청 구리의 평균농도는 대조군 $91.97{\pm}4.76{\mu}g/dl$, 간경화군 $106.21{\pm}2.73{\mu}g/dl$ 그리고 간암군 $127.05{\pm}0.77{\mu}g/dl$이었고, 대조군과 간경화군 사이에 통계적으로 유의한 차이는 없었으나, 간경화군과 간암군사이에는 통계적으로 유의한 차이를 보였다(p<0.05). 아연에 있어서는 대조군 $110.82{\pm}7.24{\mu}g/dl$,간경화군 $68.10{\pm}5.43{\mu}g/dl$ 그리고 간암군 $63.78{\pm}2.20{\mu}g/dl$로 나타났고, 간경화군과 간암군 사이에 통계적으로 유의한 차이는 없었으나, 대조군과는 두 군 모두 통계적으로 유의한 차이를 보였다(P<0.05). Cu/Zn비는 세 군 사이에 모두 통계적으로 유의한 차이가 있었다(p<0.05). 간기능검사의 생화학적 표지자들 중에 총 단백, 알부민, ALP 그리고 총 빌리루빈은 세 군 간에 모두 통계적으로 유의한 차이가 있었으나(p<0.05), ALT와 AST의 간경화군과 간암군 간의 차이는 통계적으로 유의하지 않았고, 직접 빌리루빈은 대조군에 대해 간암군에서 통계적으로 유의한 차이가 없었다. 헐청 구리와 아연농도 그리고 Cu/Zn비와 통계적으로 유의한 상관관계를 보인 표지자는 세 군에서 다양하게 나타났다. 다중 로지스틱 회귀분석에서 간경화 및 간암에 대한 odds ratio는 혈청 아연농도만이 각각 0.951, 0.952로 통계적으로 유의하였고(p<0.05), 혈 청 구리 농도와 Cu/Zn비는 통계적인 유의성이 없었다. 세 군에 대한 판별분석에서 구분을 위한 주요변수로 선정된 것은 알부민, ALP, 혈청 아연농도, 나이 그리고 총 빌리루빈이었고, 이를 적용하여 판별한 결과 바른구분의 백분율은 대조군 95.4%, 간경변군 73.4%, 간암군 75.7%로 총 84.0% 였다. 본 연구는 아연이 간질환에 대해 독립적으로도 억제하는 효과가 있을 것이며, 혈청 아연농도의 측정은 간질환의 진단에 유용하게 이용될 수 있을 것임을 시사하고 있다고 생각된다. This study was done to identify the association between serum copper and zinc levels and the cirrhosis and hepatocellular carcinoma(HCC), and to evaluate its diagnostic value on liver diseases. Sixty-three healthy persons, 60 patients with cirrhosis and 33 patients with hepatocellular carcinoma were rendomly selected and investigated for their general characteristics from October 1990 to August 1991. For analysis of the biochemical markers in liver function test and the serum copper and zinc levels, their fasting venous blood were sampled at 9:00 to 11:00 in the morning and centrifuged to separate the serum within one hour. All the samples were immediately analysed for biochemical markers and stored at $-20^{\circ}C$ in polypropylene tubes further copper and zinc analysis. Mean of serum coppper levels was $91.97{\pm}4.76{\mu}g/dl$ in control, $106.21{\pm}2.73{\mu}g/dl$ in cirrhosis and $127.05{\pm}0.77{\mu}g/dl$ in HCC. The value of HCC was statistically significantly higher than that of the control and cirrhosis(p<0.05). Serum zinc levels were $110.82{\pm}7.24{\mu}g/dl$ in control, $68.10{\pm}5.43{\mu}g/dl$ in cirrhosis and $63.78{\pm}2.20{\mu}g/dl$ in HCC. The values of cirrhosis and HCC were statistically significantly lower than that of control(p<0.05). The Cu/Zn ratio was statiatically significantly different among three groups(p<0.05). Test total protein, albumin, ALP and total bilirubin of biochemical markers of liver function were statistically significantly different among three groups(p<0.05). Differences between cirrhosis and HCC for ALT and AST, and between the control and HCC for direct bilirubin were not statistically significant. Biochemical markers statistically significantly correlated with serum copper and zinc levels and Cu/Zn ratio(p<0.05), were variable in three groups. In multiple logistic regression, odds ratio of serum copper level and Cu/Zn ratio had no statistical significance on the cirrhosis and the HCC, but that of serum sinc was statistically significant as 0.951 and 0.952(p<0.05). Serum copper and zinc levels and Cu/Zn ratio were not statistically significantly different between the cirrhosis and HCC. H\Albumin, ALP, zinc, total bilirubin and age among all variables were selected as main variables for three-group discriminant analysis. Percentage of 'grouped' cases correctly classified by these five variables was 98.4 for control, 73.4 for cirrhosis, 75.7 for HCC and 84.0 for all subjects. This study suggests that zinc level is considered to play a role as diagnostic marker on the hepatic disorders and be more useful than serum copper level and Cu/Zn ratio in diagnosis of the liver diseases.

침전반응법으로 합성한 수산아파타이트 분말의 중금속 흡착 특성 및 폐수중의 유해 금속 제거제로서의 유용성

이무성,나춘기,이미숙,김옥배,김문영,Lee, Mu Seong,Na, Choon Ki,Lee, Mi Suk,Kim, Oak Bae,Kim, Moon Young 대한자원환경지질학회 1995 자원환경지질 Vol.28 No.3

It is well known that hydroxyapatite [$Ca_{10}(PO_4)_6(OH)_2$] have an exchangeability for various heavy metal ions in aqueous solution. To evalute the feasibility of employing the synthetic hydroxyapatites as an eliminatable exchanger for environmentally noxious caions in waste water, the adsorption properties, the removal capacities and the selectivity of the apatites for various cations were investigated in more detailed. The heavy metal cations have been exchanged in calcium part of hydroxyapatite. The order of the degree of amount exchanged of the investigated cations is $Pb^{2+}>Cd^{2+}>Zn^{2+}>Ba^{2+}$. The molar ratios between released $Cd^{2+}$ ions and remeved divalent metal cations in the reacted solution with hydroxyapatite are roughly close to an integer 1.0, suggesting that an ion-exchange reaction could have played a major role in the removal of heavy metals rather then an adsorption effect. The exchangeability of the hydroxyapatite powder of Ca/P molar ratio 1.67, which have specipic surface area of $104.5m^2g^{-1}$, appeared to be better then $237.6{\mu}g$ per g for $Pb^{2+}$ ions. The removal capacity of the heavy metal ions varies directly as particle size of hydroxyapatites. All evidences obtained indicate that the synthesized hydroxyapatite powders by precipitation reaction method can be employed as an effective cation exchanger for eliminating noxious ions in waste water even in some improvemental.

출혈성 소화성 궤양의 장기 재발률

심기남,정훈용,양석균,홍원선,박의련,박무인,김해련,민영일 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.2

Background/Aims: Bleeding from a peptic ulcer is one of the common and serious complications associated with the rate of reported mortality, which ranges from 5% to 10%. Endoscopic therapy is effective in controlling active bleeding and reducing the emer-gency surgery, the immediate mortality rate and the incidence of early rebleeding. But few recent studies have documented the long-term recurrent bleeding rate after discharge in patients with bleeding peptic ulcers. The aim of this study was to determine the long-term recurrent bleeding rate and factors predisposing to recurrent bleeding. Methods: Eighty-eight patients with bleeding peptic ulcers discharged after medical treatment between Dec. 1990 and Jul. 1992 were included in this study and retrospectively followed up with medical records and telephone interviews. The end point of follow-up was recur-rent hemorrhage, surgery for treatment of ulcer complication, or death. Results: By July 1997, retrospective follow-up was available in 76 patients. Recurrent bleeding occurred in 23 patients (30.3%) with bleeding peptic ulcers and the median follow-up period was 69 months (range, 1 ∼79 months). The estimated cumulative recurrent bleeding rate after 1, 2, 3, 4, 5 and 6 years was 11.8%, 14.5%, 19.9%, 24.2%, 27.2% and 34.2%, respectively. There was no difference between the recurrent bleeding group and the non-recurrent bleed-ing group according to age, sex, prior NSAIDs use, previous history of bleeding or pepticulcer, site of ulcer, stigmata of recent hemorrhage at initial examination, method of treatment and amount of transfusion. Conclusion: Recurrent bleeding occurred in one-third of patients with bleeding peptic ulcers after 6 years of follow-up and one-third of recurrent bleeders rebled within 1 year. The factors predisposing to recurrent bleeding in the long-term follow-up could not be found. Therefore, further studies designed to identify factors predisposing to recurrent bleeding are needed and the evaluation of Helicobacter pylori status in bleeding pepic ulcer is needed because Helicobacter pylori is an important factor of peptic ulcer recurrence.

西部慶南에서 發生한 소의 GLOBIDIUM病에 關한 報告

馬点述,박응복,李熙碩,文武洪 진주농과대학 1969 진주농과대학 연구논문집 Vol.- No.8

이번에 慶南 山淸郡에서 調査한 Globidium病發症牛 3例의 觀察에서 다음과 같은 結果를 얻었다. (1) 從來의 全南道 南部海岸地方의 本病發生地域 以外에 西部慶南에서도 Globidium病의 發生이 確認되었다. (2) 重症例에서 皮膚內의 原蟲胞囊의 分布密度는 매우 稠密하고 全身皮膚는 한점 남김없이 胞囊에 占據되어 있어 臨床的으로 瀕死期에 이룬 重態이었다. (3) 臟器, 組織別 胞囊의 分布는 皮膚上皮組織內, 眞皮層, 皮下骨格筋, 口唇腺 및 體淺部淋巴節에 있었다. (4) 皮膚외의 藏器의 組織學的所見은 口唇腺組織의 慢性增殖性炎, 骨格筋의 Zenker氏變性 및 體表淋巴節의 慢性淋巴節炎 이었다. Globiodiosis, cyst-forming protozoan disease which occur in South Africa, Sudan, France, Iberian Peninsula, Mexico and Korea, has been reported as an endemic skin disease in southern coast district of Cholranam-do, Korea. In the course of systemic examination of cattles in western Kyongsangnam-do showing thickend, rugous skin lesion during September, 1968, three cases of bovine Globiodiosis were observed. And in histological examination of the skin and other organs, we found characteristic globidial cysts of about 380-470μin diameter, composed of a thick wall of homogenous, pale blue staining substance lined on its inner surface by a thin ring of cytoplasm which contains two or eight large nuclei and with its inner contents, tiny crescentic bodies. And so, on the pathological studies of these globidial patients some findings were summerized as follows: 1. One of the affected patients exhibited extreme emaciation caused by cachexic condition with dispnea, oculonasal discharge, progressive scleroderma, thickening and fissuring of the skin and a alopecia representing umerous globidial cysts, present on any area of the whole skin. 2. The globidial cysts were distributed through the squamous epithelium of the skin, the dermal layer, the cutaneous skeletal muscle, the labial gland, and the superficial lymphnodes of the body. 3. Histopathological entity of the involved organs was characterized by chronic hyperplastic inflamation in the labial gland, Zenker's degeneration of the skeletal muscle and chronic lymphadenitis accompanying with diffuse reticular cell hyperplasia, multiple focal proliferation of plasma cells and macrophages in the medulally cords, and occupation with reticular cells macrophages and erythrocytes in the distend sinuses.

아침형과 저녁형 사람에서 야간의 졸리움, 수행 및 체온의 비교

윤진상,국승희,신일선,신만식,최영,이무석,이형영 大韓睡眠-精神生理學會 1994 수면·정신생리 Vol.1 No.1

형광등용 고효율 전자안전기 개발

이무영(Mu Young Lee),이무석(Mu Suk Lee) 영남대학교 정보통신연구소 1996 정보통신연구소논문집 Vol.3 No.1

N/A

록두(綠豆) 발아(發芽) 중(中) 유리(遊離)아미노산(酸) 함량(含量) 변화(變化)에 관(關)한 연구(硏究)

고무석(Mu Suk Ko) 전남대학교 교육문제연구소 1981 교육연구 Vol.7 No.-

특성화고등학교 비장애학생의 장애인식, 장애인권감수성 및 장애수용태도에 관한 연구

이무숙(Mu Suk Lee),정대영(Dae Young Jung) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.14

본 연구의 목적은 특성화고등학교 비장애학생의 장애인식, 장애인권감수성 및 장애수용태도의 관계와 매개 효과를 알아보는 것이다. 경남 소재 특성화고등학교 7개교의 비장애학생 448명에게 설문지를 배부하였으며, 413부를 본 연구의 자료로 활용하였다. 연구 결과의 해석을 위해 IBM SPSS 25.0을 사용하고, 기술통계분석, 독립표본 T검증, 일원배치 분산분석, 상관분석, 단순회귀 분석, 위계적 회귀분석을 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 특성화고등학교 비장애학생의 장애인식, 장애인권감수성 및 장애수용태도의 전반적 경향에서 장애인식이 가장 긍정적으로 나타났으며, 장애수용태도, 장애인권감수성 순으로 나타났다. 둘째, 장애인식, 장애인권감수성 및 장애수용태도가 양의 관계, 즉, 서로 정적인 관계에 있으며, 이 세 변인은 서로 정적인 영향을 미치는 것으로 나타났다. 셋째, 장애인식과 장애수용태도 사이에 장애인권감수성이 매개효과가 있는 것으로 나타났다. 본 연구는 장애인식과 장애수용태도에 대한 장애인권감수성의 관계와 매개 역할을 밝혀 장애학생에 대한 인권 침해를 예방하고, 인권친화적인 학교환경을 조성하는데 기초자료를 제공하는데 기초자료를 제공하였다는데 의의가 있다. The objective of this study is to understand the relationships and mediating effects of disability awareness, sensitivity to disability human rights, and disability acceptance attitude targeting the specialized vocational high school students without disabilities. After selecting seven specialzed vocational high schools in gyeongnam were distributed a questionnaire to total 448 students without disabilities, total 413 questionnaires were used for the data of this study. The collected data was analyzed using the IBM SPSS 25.0 for interpreting the results of this study, the descriptive statistical analysis, the independent two samples t-test and one-way ANOVA, the correlation analysis and simple regression analysis, and the hierarchical regression analysis was performed. The results of this study are as follows. First, in the overall trends of disability awareness, sensitivity to disability human rights, and disability acceptance attitude of specializd vocational high school students without disabilities, the disability awareness was the most positive, which was followed by the disability human rights in order. Second, the disability awareness, sensitivity to disability acceptance attitude and the sensitivity to disability human rights, and disability acceptance attitude were in the positive(+) relationships to each other while those three variables had positive effects on each other. Third, the sensitivity to disability human rights had the mediating effects on the relationship between disability awareness and disability acceptance attitude. In the results of this study, the significance of this study is to provide the basic data for preventing the violation of human rights of the students with disabilities and also establishing a human rights-friendly school environment by revealing the relationship and midiating roles of sensitivity to disability human rights in the relationship between disability awareness and disability acceptance attitude.

韓國產 綠豆의 成熟過程中 遊離 Amino Acid 含量變化에 關한 硏究

高武錫(Mu Suk Ko) 한국영양학회 1980 Journal of Nutrition and Health Vol.13 No.3

국내 우주 중점기술 개발 동향 - 스페이스파이오니어사업 중심으로 -

석병석(Suk, Byong-suk),박신무(Park, Shin-mu),채희상(Chae, Hee-sang),송복섭(Song, Bok-sub),용상순(Yong, Sang-soon),유명종(Yu, Myoung-jong) 한국항공우주연구원 2022 항공우주산업기술동향 Vol.20 No.1