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He, Feng,Wen, Hai-Shen,Li, Ji-Fang,Yu, Da-Hui,Ma, Rui-Qin,Shi, Dan,Mu, Wei-Jie,Zhang, Yuan-Qing,Hu, Jian,Liu, Miao,Han, Wei-Guo,Zhang, Jia-Nan,Wang, Qing-Qing,Yuan, Yu-Ren,Liu, Qun Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.4
Gonadotropin-releasing hormone receptor (GnRHR) gene is expressed at the anterior pituitary gland and plays a key role in gonad development. This study aimed to investigate molecular genetic characteristics of the GnRHR gene and elucidate the effects of single nucleotide polymorphisms (SNPs) of GnRHR gene on sex steroid level in Japanese flounder (Paralichthys olivaceus). We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the GnRHR gene in 75 individuals. We identified three SNPs in the GnRHR gene: P1 locus (C759A and C830T) in the coding region of exon2 which were both linked together and P2 locus (G984T) in the coding region of exon3, which added a new transcript factor (ADR1) and a new methylation site (CG). Only C830T of P1 leads to amino acid changes Thr266Ile. Statistical analysis showed that P1 was significantly associated with $17{\beta}$-estradiol ($E_2$) level (p<0.01) and gonadosomatic index (GSI) (p<0.05). Individuals with genotype BB of P1 had significantly higher serum $E_2$ levels (p<0.01) and GSI (p<0.05) than those of genotype AA or AB. Another SNP, P2, synonymous mutation, was significantly associated with GSI (p<0.05). Individuals with genotype AB of P2 had significantly higher GSI (p<0.05) than that of genotype AA. In addition, there was a significant association between one diplotype based on three SNPs and reproductive traits. The genetic effects for both serum $E_2$ level and GSI of diplotype D4 were super diplotypes (p<0.05). These results suggest that the SNPs in Japanese Flounder GnRHR are associated with $E_2$ level and GSI.
Mu Liu,Yongzhen Peng,Qing Yang,Tiantian Liu, Han Xiao,Shuying Wang 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.32 No.-
Landfill leachate was treated using the upflow anaerobic sludge blanket (UASB) combined with anoxic/aerobic reactor (A/O) for shortcut biological nitrogen removal. The treatment performance and nitrousoxide (N2O) emission were studied under different salinity. When salinity increased from 10 to 35 g/L,the removal efficiency of ammonium nitrogen and total nitrogen decreased from 99.3 to 83.9% and from85.4 to 68.4%, respectively while the nitrite accumulation rate always remained high at more than 94.3%. The N2O conversion ratio increased by 14.7 times, from 0.3 to 4.7%. The concentration of biodegradableCOD in influent of the A/O reactor increased with the increase of salinity, which lead to the decrease ofdissolved oxygen and thus stimulated N2O emission remarkably during the aerobic zone. Meanwhile, theN2O emissions were likely to occur by a combination of pathways since the simultaneous nitritation anddenitritation was occurred in aerobic zone. The increase of NH4+-N concentration, NO2-N concentrationand pH caused by high salinity also promoted the N2O emission. The population of Nitrosomonaseuropaea increased with salinity, which was important for N2O emission.
Molybdenum Dioxide-Anchored Graphene Foam as a Negative Electrode Material for Supercapacitors
Xuemei Mu,Xiaozhi Liu,Ke Zhang,Jian Li,Jinyuan Zhou,ER-QING XIE,Zhenxing Zhang 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.2
Molybdenum dioxide nanoparticles of diameter 100 nm were anchoreduniformly to a three-dimensional (3D) graphene foam using an ultrasonicationassisteddeposition method. X-ray diffraction and Raman spectroscopyindicated that the molybdenum dioxide nanoparticles had a monoclinic crystalstructure. The 3D graphene/MoO2 nanoparticle composite showed excellentpseudocapacitive ability as its specific capacitance reached 404 F g−1 at a scanrate of 2 mV s−1 in the negative potential range, −1.0 to −0.2 V, in a neutralsolution. Overall, the 3D graphene/MoO2 nanoparticle composite has greatpotential as an anode material for the next generation of high-performancesupercapacitors.
Zeng Jie,Mu Li-Li,Jin Lin,Ali Anjum Ahmad,Li Guo-Qing 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.2
Henosepilachna vigintioctopunctata, a major threat to commercial potato production, is sensitive to RNA inter ference (RNAi), a gene-silencing mechanism triggered by double stranded RNA (dsRNA) matching a specific target gene sequence. Vacuolar ATPases (vATPases) are ATP-driven proton pumps involved in numerous bio logical processes. A holoenzyme vATPase consists of at least 14 different subunits and accessory proteins. Pre vious results reveal that silencing vATPaseB decreases survival rate, reduces food consumption and inhibits development in H. vigintioctopunctata. In this report, we identified two other subunit genes (vATPasea and vATPased) and compared the RNAi efficacy of vATPasea and vATPased with that of vATPaseB. We found the highest expression level of HvvATPasea, HvvATPaseB and HvvATPased occurred in the hindgut, followed by those in the foregut, Malpighian tubules and midgut, and lowest in the epidermis and fat body. When the fourth-instar larvae were allowed to ingest corresponding dsRNA for three days, the relative transcript levels of HvvATPasea, HvvATPaseB and HvvATPased were significantly decreased by 79%, 83% and 73%, respectively. Knockdown of HvvATPasea, HvvATPaseB and HvvATPased caused 50%, 85% and 100% larval lethality. After the third-instar larvae had exposed to corresponding dsRNA for three days, the levels of HvvATPasea and HvvATPased signifi cantly reduced by 91% and 96% respectively. All the treated larvae were dead. Our results demonstrate that RNAi efficiencies varied among different vATPase subunit genes and various development stages. Moreover, our data imply the feasibility of RNAi as an alternative method for controlling this critical potato pest.
Lee, Kyoung-Mu,Kang, Daehee,Clapper, Margie L,Ingelman-Sundberg, Magnus,Ono-Kihara, Masko,Kiyohara, Chikako,Min, Shen,Lan, Qing,Le Marchand, Loic,Lin, Pinpin,Lung, Maria Li,Pinarbasi, Hatice,Pisani, P American Association for Cancer Research 2008 Cancer Epidemiology, Biomarkers & Prevention Vol.17 No.5
<P>To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database. This pooled analysis included 1,971 cases and 2,130 controls. Lung cancer risk was estimated as odds ratios (OR) and 95% confidence intervals (95% CI) using unconditional logistic regression model adjusting for age, sex, and pack-year. The CYP1A1 6235C variant was associated with squamous cell lung cancer (TC versus TT: OR, 1.42; 95% CI, 0.96-2.09; CC versus TT: OR, 1.97; 95% CI, 1.26-3.07; P trend = 0.003). In haplotype analysis, 462Val-6235T and Ile-C haplotypes were associated with lung cancer risk with reference to the Ile-T haplotype (OR, 3.41; 95% CI, 1.78-6.53 and OR, 1.39; 95% CI, 1.12-1.71, respectively). The GSTM1-null genotype increased squamous cell lung cancer risk (OR, 1.36; 95% CI, 1.05-1.77). When the interaction was evaluated with smoking, increasing trend of lung cancer risk as pack-year increased was stronger among those with the CYP1A1 6235 TC/CC genotype compared with those with TT genotype (P interaction = 0.001) and with the GSTM1-null genotype compared with the present type (Pinteraction = 0.08, when no genotype effect with no exposure was assumed). These results suggest that genetic polymorphisms in CYP1A1 and GSTM1 are associated with lung cancer risk in Asian populations. However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking.</P>
Polymorphisms in DNA Repair Genes and Risk of Glioma and Meningioma
Luo, Ke-Qin,Mu, Shi-Qing,Wu, Zhong-Xue,Shi, Yi-Ni,Peng, Ji-Cai Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Polymorphisms in DNA repair genes have been shown to influence DNA repair processes and to modify cancer susceptibility. Here we conducted a case-control study to assess the role of potential SNPs of DNA repair genes on the risk of glioma and meningioma. We included 297 cases and 458 cancer-free controls. Genotyping of XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC2 Arg188His, XRCC3 Thr241Met, XRCC4 Ala247Ser, ERCC1 Asn118Asp, ERCC2 Lys751Gln and ERCC5 Asp1558His were performed in a 384-well plate format on the Sequenom MassARRAY platform. XRCC1 Arg194Trp (rs1799782) and ERCC2 Asp312Asn rs1799793 did not follow the HWE in control group, and genotype distributions of XRCC1 Gln399Arg rs25487, XRCC2 Arg188His rs3218536 and ERCC2 Asp312Asn rs1799793 were significantly different between cases and controls (P<0.05). We found XRCC1 399G/G, XRCC1 194 T/T and XRCC3 241T/T were associated with a higher risk when compared with the wild-type genotype. For ERCC5 Asp1558His, we found G/G genotype was associated with elevated susceptibility. In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas. This finding could be useful in identifying the susceptibility genes for these cancers.
Efficient Anonymous Broadcast Encryption with Adaptive Security
( Fu-cai Zhou ),( Mu-qing Lin ),( Yang Zhou ),( Yu-xi Li ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.11
Broadcast encryption is an efficient way to distribute confidential information to a set of receivers using broadcast channel. It allows the broadcaster to dynamically choose the receiver set during each encryption. However, most broadcast encryption schemes in the literature haven`t taken into consideration the receiver`s privacy protection, and the scanty privacy preserving solutions are often less efficient, which are not suitable for practical scenarios. In this paper, we propose an efficient dynamic anonymous broadcast encryption scheme that has the shortest ciphertext length. The scheme is constructed over the composite order bilinear groups, and adopts the Lagrange interpolation polynomial to hide the receivers` identities, which yields efficient decryption algorithm. Security proofs show that, the proposed scheme is both secure and anonymous under the threat of adaptive adversaries in standard model.
Shen, Min,Zhang, Luoping,Lee, Kyoung-Mu,Vermeulen, Roel,Hosgood, H. Dean,Li, Guilan,Yin, Songnian,Rothman, Nathaniel,Chanock, Stephen,Smith, Martyn T.,Lan, Qing Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.6
Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity in a cross-sectional study of workers exposed to benzene (250 workers and 140 controls). A total of 1,236 tag SNPs in 149 gene regions of six pathways were included in the analysis. Six gene regions were significant for their association with white blood cell (WBC) counts ($MBP$, $VCAM1$, $ALOX5$, $MPO$, $RAC2$, and $CRP$) based on gene-region (P < 0.05) and SNP analyses (FDR <0.05). $VCAM1$ rs3176867, $ALOX5$ rs7099684, and $MPO$ rs2071409 were the three most significant SNPs. They showed similar effects on WBC subtypes, especially granulocytes, lymphocytes, and monocytes. A 3-SNP block in $ALOXE3$ (rs7215658, rs9892383, and rs3027208) showed a global association (omnibus P = 0.0008) with WBCs even though the three SNPs were not significant individually. Our study suggests that polymorphisms in innate immunity genes may play a role in benzene-induced hematotoxicity; however, independent replication is necessary.