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Antigenotoxic Effects of Satureja hortensis L. on Rat Lymphocytes Exposed to Oxidative Stress
Mosaffa Fatemeh,Behravan Javad,Karimi Gholamreza,Iranshahi Mehrdad The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.2
The protective properties of Satureja hortensis L. on the rat lymphocytes DNA lesions were tested. Lymphocytes were isolated from blood samples taken from healthy rats. DNA breaks and resistance to $H_{2}O_{2}$-induced damage were measured with the comet assay. Rat lymphocytes were incubated in S. hortensis ethanolic extract (SHE) (0.05, 0.1, 0.5, 1.0, and 2.5 mg/mL), essential oil (SHEO)(0.05, 0.1, 0.5, 1.0, and 2.5 ${mu}L/mL$), $H_{2}O_{2}$ (50, 100, and 200 ${\mu}M$), a combination of $H_{2}O_{2}$ (200 mM) with either SHE (1.0, 2.5 mg/mL) or SHEO (1.0, 2.5 ${\mu}L/mL$) at $4^{\circ}C$ for 30 min, and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions. Treatment of rat lymphocytes with SHE or SHEO resulted in significant reduction of $H_{2}O_{2}$-induced DNA damage compared to controls. SHE exhibited a significant (P<0.01) inhibitory effect on oxidative DNA damage at 2.5 mg/mL. SHEO (1.0 and 2.5 ${\mu}L/mL$) also showed significant inhibitory effects (P<0.01) on $H_{2}O_{2}$ induced chromosomal damage. In conclusion both the ethanolic extract and the essential oil of the plant reversed the oxidative damage to rat lymphocytes induced by hydrogen peroxide.
Antigenotoxic Effects of Satureja hortensis L. on Rat Lymphocytes Exposed to Oxidative Stress
Fatemeh Mosaffa,Javad Behravan,Gholamreza Karimi,Mehrdad Iranshahi 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.2
The protective properties of Satureja hortensis L. on the rat lymphocytes DNA lesions were tested. Lymphocytes were isolated from blood samples taken from healthy rats. DNA breaks and resistance to H2O2-induced damage were measured with the comet assay. Rat lymphocytes were incubated in S. hortensis ethanolic extract (SHE) (0.05, 0.1, 0.5, 1.0, and 2.5 mg/ mL), essential oil (SHEO)(0.05, 0.1, 0.5, 1.0, and 2.5 µL/mL), H2O2 (50, 100, and 200 µM), a combination of H2O2 (200 mM) with either SHE (1.0, 2.5 mg/mL) or SHEO (1.0, 2.5 µL/mL) at 4oC for 30 min, and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions. Treatment of rat lymphocytes with SHE or SHEO resulted in significant reduction of H2O2-induced DNA damage compared to controls. SHE exhibited a significant (P<0.01) inhibitory effect on oxidative DNA damage at 2.5 mg/mL. SHEO (1.0 and 2.5 µL/mL) also showed significant inhibitory effects (P <0.01) on H2O2 induced chromosomal damage. In conclusion both the ethanolic extract and the essential oil of the plant reversed the oxidative damage to rat lymphocytes induced by hydrogen peroxide.
Syphacia obvelata: A New Hope to Induction of Intestinal Immunological Tolerance in C57BL/6 Mice
Niloofar Taghipour,Nariman Mosaffa,Mohammad Rostami-Nejad,Mohamad Mohsen Homayoni,Esmaeil Mortaz,Hamid Asadzadeh Aghdaei,Mohammad Reza Zali 대한기생충학열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.4
Hamid-Reza Ahmadi,Ali Afzali-Kusha,Massoud Pedram,Mahdi Mosaffa 한국전자통신연구원 2015 ETRI Journal Vol.37 No.1
This paper presents an energy-efficient (low power) prime-field hyperelliptic curve cryptography (HECC) processor with uniform power draw. The HECC processor performs divisor scalar multiplication on the Jacobian of genus 2 hyperelliptic curves defined over prime fields for arbitrary field and curve parameters. It supports the most frequent case of divisor doubling and addition. The optimized implementation, which is synthesized in a 0.13 m standard CMOS technology, performs an 81-bit divisor multiplication in 503 ms consuming only 6.55 J of energy (average power consumption is 12.76 W). In addition, we present a technique to make the power consumption of the HECC processor more uniform and lower the peaks of its power consumption.
Seismic mitigation of substation cable connected equipment using friction pendulum systems
Reza Karami Mohammadi,Masoud Mirtaheri,Mojtaba Salkhordeh,Erfan Mosaffa,Golsa Mahdavi,Mohammad Amin Hariri-Ardebili 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.72 No.6
Power transmission substations are susceptible to potential damage under seismic excitations. Two of the major seismic failure modes in substation supplies are: the breakage of brittle insulator, and conductor end fittings. This paper presents efficient isolation strategies for seismically strengthening of a two-item set of equipment including capacitive voltage transformer (CVT) adjacent to a Lightning Arrester (LA). Two different strategies are proposed, Case A: implementation of base isolation at the base of the CVT, while the LA is kept fixed-base, and Case B: implementation of base isolation at the base of the LA, while the CVT is kept fixed-base. Both CVT and LA are connected to each other using a cable during the dynamic excitation. The probabilistic seismic behavior is measured by Incremental Dynamic Analysis (IDA), and a series of appropriate damage states are proposed. Finally, the fragility curves are derived for both the systems. It is found that Friction Pendulum System (FPS) isolator has the potential of decreasing flexural stresses caused by intense ground motions. The research has shown that when the FPS is placed under LA, i.e. Case B (as oppose to Case A), the efficiency of the system is improved in terms of reducing the forces and stresses at the bottom of the porcelain. Several parametric studies are also performed to determine the optimum physical properties of the FPS.