제주 지역 초등학교 고학년의 교내 집단따돌림 피해 경험 관련요인 : 우울 증상과 가족 환경적 요인을 중심으로

김문두,홍성철,정영은,Kim, Moon-Doo,Hong, Seong-Chul,Jung, Young-Eun 대한불안의학회 2017 대한불안의학회지 Vol.13 No.1

Objective : The purpose of this study was to evaluate the factors associated with the experience of bullying victimization in school among elementary school students in the Jeju area. Methods : A total of 662 students were recruited from elementary schools for a school-based cross-sectional survey (age range : 11-12 years) in the Jeju area. This study used a self-reported questionnaire concerning the experience of being victimized by bullying, the Korean form of the Children's Depression Inventory (CDI) to assess depressive symptoms, and questions on sociodemographic characteristics, including school- and family-related factors. Results : The prevalence of bullying victimization in school among elementary school students was 10.0% (n=66). The factors associated with bullying victimization were lower socioeconomic status, lower than average academic achievement, more depressive symptoms, and family problems. Conclusion : This study not only indicates that bullying at school is a significant public health issue among elementary school students, but also confirms that children with family problems commonly exhibit bullying behaviors, which highlights the importance of considering family-related environmental factors when managing bullying victimization.

Cerebellum ane Schizophrenia

Moon-Doo Kim(김문두),Byung-Jo Kang(강병조) 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.1

소뇌는 주로 운동기능에만 관여하는 뇌구조인 것으로 생각되어왔고, 균형의 장애와 운동조정의 장애만이 소뇌 질환의 유일한 병리적 징후라고 여겨졌다. 그러나 소뇌가 운동영역만을 조정하고 통합하는 것은 아니라는 새로운 연구들이 보고되고 있다. 주의집중, 감각변별, 언어성 학습과 언어성 기억, 작업기억, 그리고 복잡한 문제 해결 등과 같은 다양한 인지처리과정 등이 이러한 소뇌의 부가적인 기능으로 생각된다. 또한, 소뇌병변이 있는 환자들이 보이는 증상들은 정신분열병의 대부분의 증상들을 설명할 수 있다. 이에 우리는 소뇌의 구조적, 기능적 해부학을 간략히 요약하고, 소뇌가 정신분열증의 증상 형성에 미치는 영향을 보고한 문헌들을 고찰하여 보았다.

아증후군적 양극성 장애

김문두,전봉희,윤보현,박원명,Kim, Moon-Doo,Jeon, Bong-Hee,Yoon, Bo-Hyun,Bhak, Won-Myong 대한생물정신의학회 2011 생물정신의학 Vol.18 No.4

Subsyndromal bipolar symptoms are common during maintenance treatment and appear to be associated with relapse into an episode of the same polarity. This implies subsyndromal symptoms are an important problem in recurrent bipolar disorder and require more additive and infallible therapeutic intervention. Undetected, untreated subsyndromal states lead patients to have poor prognosis and quality of life. The combination of a long undetected illness and significant psychosocial impairment renders early identification and intervention vital for the treatment of bipolar disorders. Methods for early identification includes finding prodromes, using screening tools such as the HCL-32 (Hypomania Checklist-32) and the BSDS (bipolar spectrum diagnostic scale). Various augmentation treatment methods would be needed to reduce subsyndromal symptoms, especially, psychosocial treatment has the potential to help patients address the multiple psychosocial problems associated with this chronic illness. To overcome difficulties of diagnosing subsyndromal disorder and to treat it appropriately, a staging system was suggested by some researchers. It assumes that earlier stages have better prognosis and require simpler therapeutic regimens. Staging may assist in treatment planning and prognosis of bipolar disorder, and emphasize the importance of early intervention. Further research is required in this exciting and novel area.

노인 아증후군적 우울증 환자의 인지기능 및 삶의 질 저하

류재성,김문두,이창인,박준혁,Ryu, Jae Sung,Kim, Moon Doo,Lee, Chang In,Park, Joon Hyuk 대한생물정신의학회 2013 생물정신의학 Vol.20 No.2

Objectives Non-major depression with fewer symptoms than required for a Diagnostic and Statistical Manual of Mental Disorders-4th edition diagnosis of major depressive disorder (MDD) has consistently been found to be associated with functional impairment. In this study, we aim to estimate the cognitive impairment and the quality of life in elderly patients with subsyndromal depression (SSD) compared with non-depressive elderly (NDE). Methods The Korean version of Mini International Neuropsychiatric Interview was administered to 194 outpatients with depression and 108 normal controls. SSD is defined as having five or more current depressive symptoms with core depressive symptoms (depressive mood or loss of interest or pleasure) during more than half a day and more than seven days over two weeks. Depression was evaluated by the Korean form of Geriatric Depression Scale of a 15-item short version. Global cognition was assessed by Mini-Mental State Examination in the Korean version of CERAD assessment packet (MMSE-KC). Subjective cognitive impairment was assessed by the Subjective Memory Complaint Questionnaire. Quality of life was evaluated by the Korean Version of Short-Form 36-Item Health Survey. Results The mean score of the MMSE-KC in the SSD group was lower than that in the NDE group with adjustment for age, gender, and education [F = 4.270, p = 0.04, analysis of covariance (ANCOVA)]. If we defined those having Z-score of MMSE-KC < -1.5 as a high risk group of cognitive impairment, the odds ratio for the high risk group of cognitive impairment was 1.86 [95% confidence intervals (CI) 1.04-3.34] in SSD and 7.57 (95% CI 3.50-16.40) in MDD compared to NDE. The scores of physical component summary (F = 9.274, p = 0.003, ANCOVA) and mental component summary (F = 53.166, p < 0.001, ANCOVA) in the SSD group were lower than those in the NDE group with adjustment for age, gender, and education. Conclusions The subjects with SSD, as well as those with MDD, showed impairment of global cognition and also experienced low quality of life in both physical and mental aspects, compared to the NDE group.

일 대학생들의 인터넷 중독실태와 도박에 대한 의식 조사

현미열(Mi Yeul Hyun),김문두(Moon Doo Kim) 한국간호과학회 정신간호학회 2009 정신간호학회지 Vol.18 No.1

해녀 우울장애 환자의 임상적 특징

박준혁,전병선,이창인,김문두,정지운,정영은,Park, Joon Hyuk,Jun, Byoung Sun,Lee, Chang In,Kim, Moon-Doo,Jeong, Ji Woon,Jung, Young-Eun 대한생물정신의학회 2016 생물정신의학 Vol.23 No.2

Objectives Haenyeo are Korean professional women breath-hold divers in Jeju island. The aim of this study was to investigate the clinical characteristics of depressed Haenyeo group, compared to non-Haenyeo depressed group. Methods This study included 75 Haenyeo and 340 non-Haenyeo with depressive disorders recruited from the Dementia Early Detection Program in Jeju island. Structural diagnostic interviews were performed using the Korean version of Mini International Neuropsychiatric Interview. All patients completed the questionnaires, including the Subjective Memory Complaints Questionnaire (SMCQ), the Patient Health Questionnaire-15 (PHQ-15), and the Blessed dementia scale. Depression was evaluated by the Korean version of short form the Geriatric Depression Scale (K-SGDS) and cognition was assessed by the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment packet. Results Although the mean scores of the K-SGDS were similar between Haenyeo and non-Haenyeo depressed groups, the Haenyeo group showed a higher mean score on the PSQ-15 (p < 0.001, ANCOVA adjusting for age, the K-SGDS and education). The Haenyeo group showed poorer performance on the Korean Version of Frontal Assessment Batter (p < 0.001), the Mini-Mental State Examination in the Korean version of the CERAD Assessment Packet (p < 0.018), the word fluency test (p < 0.001), and the word list memory test (p = 0.012) in ANCOVA adjusting for age and education. The mean SMCQ score was higher in the Haenyeo depressed group than in the non-Haenyeo depressed group. Conclusions The Haenyeo depressed group shows cognitive dysfunction, especially frontal lobe dysfunction, compared to the non-Haenyeo depressed group, indicating the Haenyeo depressed group may have more severe frontolimbic dysfunction due to chronic exposure to hypoxia. The Haenyeo depressed group suffers more somatic symptoms than the non-Haenyeo depressed group.

응급실 방문 자살기도자들의 기도 원인, 방법, 정신과적 진단에 대한 다기관 분석

김혜영,김보라,강승걸,김문두,김민혁,김수인,김재민,문은수,안준호,이경욱,이상혁,이승재,정성훈,정영철,정희연,주가원,차보석,하태현,안용민,Kim, Hyeyoung,Kim, Bora,Kang, Seung-Gul,Kim, Moon-Doo,Kim, Min-Hyuk,Kim, Soo In,Kim, Jae Min,Moon, Eunsoo,Ahn, Joon-Ho,Lee, 대한생물정신의학회 2015 생물정신의학 Vol.22 No.4

Objectives To examine direct causes of attempted suicides, methods adopted to commit suicide, and psychiatric diagnoses among suicide attempters in South Korea. Methods A total of 1359 suicide attempters who had visited emergency department of 17 medical centers due to suicide attempt from May 2013 to Nov 2013 were interviewed using semi-structured questionnaires. Results Psychiatric symptoms were the most common cause of suicide attempts (62.2%), followed by interpersonal relationships (24.4%). Women attempted suicide more often for interpersonal reasons, whereas men were more likely to do so for financial and job-related reasons. Half of participants (55.8%) attempted suicide by drug intoxication, which was more prevalent among females and those who had previous history of psychiatric disease or previous suicide attempt. Men were more likely to use more lethal methods such as pesticide poisoning and gas inhalation than women. Pesticide poisoning was also prevalent among the elderly group and the rural population. Near ninety-five percent (94.5%) of participants received a psychiatric diagnosis : the most frequent diagnosis was depressive disorder. Conclusions This is the first nationwide study of cases of attempted suicide. When stratified by age groups, gender, urbanicity, living alone or not, presence of physical illness, previous psychiatric history, and previous suicide attempt, there were significant differences with respect to causes, methods of attempted suicides and psychiatric diagnoses of suicide attempters.

연구논문 : 자연과학 ; 유전자변형 유채의 환경방출실험에서 격리포장 외부로의 도입유전자 이동가능성 모니터링

김도영 ( Do Young Kim ),남기정 ( Ki Jung Nam ),문예슬 ( Ye Seul Moon ),김대인 ( Dae In Kim ),김영중 ( Young Joong Kim ),문두범 ( Doo Bum Moon ),천영진 ( Young Jin Chun ),남경희 ( Kyong Hee Nam ),안주희 ( Joo Hee An ),이범규 ( Bum 한국국제농업개발학회 2012 韓國國際農業開發學會誌 Vol.24 No.2

1. 본 연구에서는 GM 유채(Brassica napus)의 환경방출실험시의 안전관리를 위한 모니터링을 수행하였다. 2. 문헌조사를 통해 유채의 품종 순도 유지를 위한 격리거리와 교잡가능한 종을 확인함으로써 모니터링의 범위와 모니터링 대상 식물종을 결정하였다. 3. GM 유채의 격리포장으로부터 1.3 km 거리 범위 내에서 발견된 B. napus, B. juncea 및 B. oleracea를 대상으로 모니터링을 실시한 결과, 교잡을 통한 유전자의 유출은 발견되지 않았다. One of the main concerns in field trials of GM crops is transgene escape from GM crops to conventional crops or weedy (wild) relatives via pollen dispersal. The management of field trials is therefore aimed at the detection and prevention of hybridization between GM crops and their closely related species around the field. This study monitored the escape of introduced genes of GM oilseed rapes (Brassica napus) outside the trial site during a small-scale field trial. First, a monitoring area (up to 1.3 km from the isolated field site) was determined according to recommended isolation distances for maintaining varietal purities of oilseed rapes. Then, target species (B. napus, B. juncea and B. oleracea) for monitoring were chosen using a literature search of plant species reproductively compatible with oilseed rapes. Hybrids between GM oilseed rapes and sexually compatible species were not detected and this result indicated that transgene escape outside the trial site did not occur during a field trial.

학교 따돌림 피해 경험이 청소년의 우울 증상에 미치는 영향 : 회복탄력성의 조절 효과를 중심으로

배정은,홍현미,김경민,정영은,김문두,윤보현,Bae, Jungeun,Hong, Hyeonmi,Kim, Kyung-Min,Jung, Young-Eun,Kim, Moon-Doo,Yoon, Bo-Hyun 대한불안의학회 2020 대한불안의학회지 Vol.16 No.1

Objective : The purpose of this study was to examine the effects of bullying victimization on depressive symptoms in adolescents, and to determine how depression depends on resilience. Methods : A total of 4,160 students were recruited, from middle and high schools in Goheung, Yeosu, and the Jangheung area of Jeollanam-do Province. All participants completed self-report questionnaires, that included demographic variables, the Beck Depression inventory (BDI) the School Bullying Self-Rating Questionnaire (SBSRQ), and the Resilience Test (RT). Results : Prevalence of depression was 30.3%. A total of 220 (5.3%) students were evaluated likely to be bullied and 45 (1.1%) students were evaluated very likely to be bullied. Depressive symptoms positively correlated with bullying victimization. Depressive symptoms and resilience, bullying victimization and resilience negatively correlated. Results from regression analyses indicated that, while controlling for a range of demographic variables, resilience moderated the association between bullying victimization and depressive symptoms. Conclusion : Based on the results, professionals must consider resilience for treatment to reduce depression in adolescents of bullying victimization.

Clozapine이 인체내에서 인간조직적합성항원에 미치는 영향

강병조(Byung-Jo Kang),김문두(Moon-Doo Kim),곽경필(Kyung-Phil Kwak) 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.2

친자 감별, 개인 식별, 장기 이식 및 수혈 등에 널리 쓰이고 있는 HLA가, 난치성 정신분열증 치료에 가장 좋은 약인 clozapine에 의해서는 어떠한 변화가 생기는지를 알아보기 위하여, 3명을 대상으로 연구를 실시하였다. 이들은 적어도 2개월 이상 정신과약을 일체 투여받지 않은 성인 만성 정신분열증 환자들이었다. 이들에게 clozapine을 평균 200㎎/day씩 투여하기 전과 평균 90일 투여한 후 두번에 걸쳐서 HLA-A, B, C와 DR형을 검사하여 그 결과를 비교하였다. HLA class Ⅰ형은 Terasaki 등의 임파구세포상해시험법으로, class Ⅱ형은 PCR방법으로 결정하였다. 그 결과 class Ⅰ형에서는 3명중 2명에서 변화가 나타났고, class Ⅱ형에서는 변화가 없었다. 이와같은 결과는 clozapine이 적어도 DNA 수준까지는 영향을 미치지 않는다는 것을 말해준다. The histocompatibility antigen (human leukocyte antigen : HLA) has been used for organ transplantation, discrimination of one's real children and transfusion, etc. The objective of this study was to find out how clozapine affects HLA class Ⅰ and Ⅱ type in the humanbody when therapeutic doses are applied. The subject consists of 3 persons for class Ⅰ and class Ⅱ. They were administered for about 3 months with clozapine 150~250㎎/day (mean dally dose 200㎎). Analysis of HLA class Ⅰ type was the microcytotoxicity test of Terasaki and class Ⅱ type was PCR method of Erhlich. The results were as followings: Two of 3 were changed in HLA-A, B, C type. All three were not changed in HLA-DR type. In conclusion, the short-term application, about 3 months, of therapeutic dose of clozapine is not considered to bring about changes in DNA level.