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- 저자 : Montalbano (검색결과 4 건)
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IL-17A-associated IKK-α signaling induced TSLP production in epithelial cells of COPDpatients
Giulia Anzalone,Giusy Daniela Albano,Angela Marina Montalbano,Loredana Riccobono,Anna Bonanno,Rosalia Gagliardo,Fabio Bucchieri,Roberto Marchese,Monica Moscato,Mirella Profita 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Thymic stromal lymphopoietin (TSLP) is a cytokine expressed in the epithelium, involved in the pathogenesis of chronic disease. IL-17A regulates airway inflammation, oxidative stress, and reduction of steroid sensitivity in chronic obstructive pulmonary disease (COPD). TSLP and IL-17A were measured in induced sputum supernatants (ISs) from healthy controls (HC), healthy smokers (HS), and COPD patients by enzyme-linked immunosorbent assay. Human bronchial epithelial cell line (16HBE) and normal bronchial epithelial cells were stimulated with rhIL-17A or ISs from COPD patients to evaluate TSLP protein and mRNA expression. The effects of the depletion of IL-17A in ISs, an anticholinergic drug, and the silencing of inhibitor kappa kinase alpha (IKKα) on TSLP production were evaluated in 16HBE cells. Coimmunoprecipitation of acetyl-histone H3(Lys14)/IKKα was evaluated in 16HBE cells treated with rhIL- 17A and in the presence of the drug. TSLP and IL-17A levels were higher in ISs from COPD patients and HS compared with HC. TSLP protein and mRNA increased in 16HBE cells and in normal bronchial epithelial cells stimulated with ISs from COPD patients compared with ISs from HC and untreated cells. IKKα silencing reduced TSLP production in 16HBE cells stimulated with rhIL-17A and ISs from COPD patients. RhIL-17A increased the IKKα/acetyl-histone H3 immunoprecipitation in 16HBE cells. The anticholinergic drug affects TSLP protein and mRNA levels in bronchial epithelial cells treated with rhIL-17A or with ISs from COPD patients, and IKKα mediated acetyl-histone H3(Lys14). IL-17A/IKKα signaling induced the mechanism of chromatin remodeling associated with acetyl-histone H3(Lys14) and TSLP production in bronchial epithelial cells. Anticholinergic drugs might target TSLP derived from epithelial cells during the treatment of COPD.
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Delayed puberty versus hypogonadism: a challenge for the pediatrician
Mauro Bozzola,Elena Bozzola,Chiara Montalbano,Filomena Andreina Stamati,Pietro Ferrara,Alberto Villani 대한소아내분비학회 2018 Annals of Pediatirc Endocrinology & Metabolism Vol.23 No.2
Constitutional delay of growth and puberty (CDGP) is the most common cause of delayed puberty (DP), is mainly found in males, and is characterized by short stature and delayed skeletal maturation. A family history of the subject comprising the timing of puberty in the parents and physical examination may provide clues regarding the cause of DP. Delayed onset of puberty is rarely considered a disease in either sex. In fact, DP usually represents a common normal variant in pubertal timing, with favorable outcomes for final height and future reproductive capacity. In adolescents with CDGP, a linear growth delay occurs until immediately before the start of puberty, then the growth rate rapidly increases. Bone age is often delayed. CDGP is a diagnosis of exclusion; therefore, alternative causes of DP should be considered. Functional hypogonadotropic hypogonadism may be observed in patients with transient delay in hypothalamic-pituitary-gonadal axis maturation due to associated conditions including celiac disease, inflammatory bowel diseases, kidney insufficiency, and anorexia nervosa. Permanent hypogonadotropic hypogonadism (pHH) showing low serum value of testosterone or estradiol and blunted follicle-stimulating hormones (FSH) and luteinizing hormones (LH) levels may be due to abnormalities in the central nervous system. Therefore, magnetic resonance imaging is necessary to exclude morphological abnormalities and neoplasia. Moreover, pHH may be isolated, as observed in Kallmann syndrome, or associated with other hormone deficiencies, as found in panhypopituitarism. Baseline or gonadotropin-releasing hormone pituitary stimulated gonadotropin level is not sufficient to easily differentiate CDGP from pHH. Low serum testosterone in male patients and low estradiol values in female patients, associated with high serum FSH and LH levels, suggest a diagnosis of hypergonadotropic hypogonadism. A genetic analysis can reveal a chromosomal abnormality (e.g., Turner syndrome or Klinefelter syndrome). In cases where the adolescent with CDGP is experiencing psychological difficulties, treatment should be recommended.
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New tricyclic systems as photosensitizers towards triple negative breast cancer cells
Marilia Barreca,Angela Maria Ingarra,Maria Valeria Raimondi,Virginia Spanò,Antonio Palumbo Piccionello,Michele De Franco,Luca Menilli,Valentina Gandin,Giorgia Miolo,Paola Barraja,Alessandra Montalbano 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.11
Nineteen pyrrolo[1,2- h ][1,7]naphthyridinonesand pyrido[2,3- c ]pyrrolo[1,2- a ]azepinones were synthesizedas new tricyclic systems in which the pyridine ringis annelated to the 6,7-dihydroindolizin-8(5 H )-one and5,6,7,8-tetrahydro-9 H -pyrrole[1,2- a ]azepine-9-one moietiesto obtain potential photosensitizing agents. They were testedfor their photoantiproliferative activity on a triple-negativebreast cancer cell line, MDA-MB-231, in the dark and underUVA light (2.0 J/cm 2 ). We demonstrated that their toxicity,only when exposed to light, was primarily due to the generationof reactive oxygen species while their photodegradationproducts were not responsible for their activity. The mostactive compounds exhibited photocytotoxicity with IC 50 valuesat low micromolar level inducing a decrease in the intracellularcontent of thiol, thus triggering cancer cell deaththrough apoptosis. All the pyridone derivatives revealed tobe pure photosensitizers with preferential photocytotoxicactivity towards cancerous over healthy cells. Altogether,the results obtained confi rm pyrrolo[1,2- h ][1,7]naphthyridinonesand pyrido[2,3- c ]pyrrolo[1,2- a ]azepinones as promisingphotosensitisers against triple-negative breast cancer.
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