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Written Heritage in the Mediterranean: Research Developments in Spain
( M Teresa Ortega Monasterio ) 부산외국어대학교 지중해지역원 2011 The Mediterranean Review Vol.4 No.1
Studies of written heritage have been encouraged during the last years in Europe. They have recently introduced new fields of study within its methodology such as palaeography and codicology, mainly in cataloguing documents. Many libraries have been updated through new catalogues and editions of its manuscripts collections in different ancient languages. Other collections have been restored or inventoried by specialists. The research group devoted to the study of original texts in languages developed in the Mediterranean basin since antiquity is trying to contribute to this field. A survey on the studies carried out during the last years in the CSIC is here presented.
Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones
Julio Benites,Jaime A. Valderrama,David Ríos,Rosalba Lagos,Octavio Monasterio,Pedro Buc Calderon,Pedro Buc Calderon 대한독성 유전단백체 학회 2016 Molecular & cellular toxicology Vol.12 No.3
Dihydroxynaphthyl aryl ketones 1-5 exhibit activity as tubulin polymerization inhibitors by targeting the colchicine binding site of microtubules making them potential anticancer drugs. Therefore, analogues 1-5 have been evaluated for their cytotoxic activity against the cancer cell lines DU-145 (prostate), T24 (bladder) and MCF-7 (breast). Notable differences in biological activity were observed for compounds 1-5, most likely related to the nature of the aryl substituent bonded to the carbonyl group. Among the tested compounds, only compound 5 showed selectivity for cancer cells over healthy, non-transformed cells. T24 cancer cells treated with compound 5 presented a concentration-dependent decrease in cell proliferation and a loss of migration ability. The cytotoxicity of compounds 1-5 on the selected cell-based assays is discussed in terms of it lipophilicity and polarizability parameters.