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Joint hierarchical generalized linear models with multivariate Gaussian random effects
Molas, M.,Noh, M.,Lee, Y.,Lesaffre, E. North-Holland Pub. Co ; Elsevier Science Ltd 2013 Computational statistics & data analysis Vol.68 No.-
Likelihood based inference for correlated data involves the evaluation of a marginal likelihood integrating out random effects. In general this integral does not have a closed form. Moreover, its numerical evaluation might create difficulties especially when the dimension of random effects is high. H-likelihood inference has been proposed where the explicit evaluation of the integral is avoided. The approach also allows extensions handling e.g. (1) complex design experiments, (2) REML type of inference beyond the class of a linear model and (3) overdispersion modeling. The h-likelihood approach to multivariate generalized linear mixed models is extended. The h-likelihood computational algorithms is blended with a Newton-Raphson procedure for the estimation of the correlation parameters. This allows that components of the joint model are interlinked via correlated Gaussian random effects. Further, correlated random effects are allowed within each component. This approach can serve as a basis for further developments of joint double hierarchical generalized linear models with correlated random effects. The methods are illustrated with a rheumatoid arthritis study dataset, where the correlation between latent trajectories of three endpoints is evaluated.
Structural analysis of cracked R.C. members subjected to sustained loads and imposed deformations
Mola, F.,Gatti, M.C.,Meda, G. Techno-Press 2001 Structural Engineering and Mechanics, An Int'l Jou Vol.11 No.6
A structural analysis of cracked R.C. members under instantaneous or sustained loads and imposed displacements is presented. In the first part of the paper the problem of deriving feasible moment-curvature diagrams for a long term analysis of R.C. sections is approached in an exact way by using the Reduced Relaxation Function Method in state I uncracked and the method suggested by CEB in state II cracked. In both states the analysis of the main parameters governing the problem has shown that it is possible to describe the concrete creep behaviour in an approximate way by using the algebraic formulation connected to the Effective Modulus Method. In this way the calculations become quite simple and can be applied in design practice without introducing significant errors. Referring to continuous beams, the structural analysis is then approached in a general way, applying the Force Method and the Principle of Virtual Works. Finally, considering single members, the structural analysis is performed by means of a graphical procedure based on the application of feasible moment-rotation diagrams which allow to easily solve various structural problems and to point out the most interesting aspects of the long term behaviour of cracked R.C. members with rigid or elastically deformable redundant restraints.
Time-dependent analysis of launched bridges
Mapelli, M.,Mola, F.,Pisani, M.A. Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.24 No.6
The time-dependent analysis of prestressed concrete bridges built adopting the incremental launching technique is presented. After summarizing the well known results derived from the elastic analysis, the problem is approached in the visco-elastic domain taking into account the effects consequent to the complex load history affecting the structure. In particular, the effects produced by prestressing applied both in the launching phase and after it and by application of imposed displacements and of delayed restraints during the launching phases are carefully investigated through a refined analytical procedure. The reliability of the proposed algorithm is tested by means of comparisons with reference cases for which exact solutions are known. A case study of general interest is then discussed in detail. This case study demonstrates that a purely elastic approach represents a too crude approximation, which is unable to describe the specific character of the problem.
Thin-walled composite steel-concrete beams subjected to skew bending and torsion
Francesca Giussani,Franco Mola 국제구조공학회 2009 Steel and Composite Structures, An International J Vol.9 No.3
The long-term behaviour of simply supported composite steel-concrete beams with deformable connectors subjected to skew bending and torsion is presented. The problem is dealt with by recurring to the displacement method, assuming the bending and torsional curvatures and the longitudinal deformations of each sectional part as unknowns and obtaining a system of differential and integro-differential equations. Some solving methods are presented, in order to obtain exact and approximate solutions and evaluate the precision of the approximate ones. A case study is then presented. For the sake of clearness, the responses of the composite beam under loads applied in different directions are studied separately, in order to correctly evaluate the effects of each load condition.
Choroidal Thickness in Multiple Sclerosis: An Optical Coherence Tomography Study
Alessandro Masala,Ilaria Di Mola,Maria Cellerino,Valentina Pera,Aldo Vagge,Antonio Uccelli,Cordano Christian,Carlo E Traverso,Michele Iester 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.3
Background and Purpose To identify changes in the choroidal thickness (CT) in multiple sclerosis (MS) patients with and without optic neuritis (ON) using enhanced-depth-imaging optical coherence tomography (EDI-OCT). Methods This cross-sectional study included 96 eyes with MS and 28 eyes of healthy controls. All participants underwent an ophthalmologic examination and EDI-OCT scanning (Spectralis, Heidelberg Engineering, Germany) to assess the CT and the retinal nerve fiber layer (RNFL) thickness. MS patients were divided into two groups: 1) with and 2) without a history of ON. The CT was evaluated in the fovea and at six horizontal and six vertical points at 500, 1,000, and 1,500 µm from the fovea. Paired t-tests were used to compare the groups, and p-value<0.05 was considered as significant. Results At all 13 measurements points, the CT was thicker in MS patients than in the healthy controls and was thinner in eyes with ON than in the contralateral eyes, but these differences were not statistically significant. However, the CT was always larger in all points in eyes with a history of ON than in the control eyes. The RNFL was significantly thinner (p<0.05) in both MS and ON eyes than in the control eyes. Conclusions The CT did not differ between MS and control eyes, but it was significantly larger in patients with a history of ON, in whom the RNFL was thinner. Further studies are necessary to establish the possible role of the choroid in MS
John Miller,Kathy Nwe,윤용준,황경준,최철민,Paul Waliaula Mola II,김영진,진성호 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.6
Concentrated solar power utilizes a field of mirrors to redirect solar rays onto a central receiver to generate thermal energy through heat transfer media and a Rankine steam cycle. To effectively transfer heat to the heat transfer material, the receiver has to efficiently convert/absorb the incoming solar flux without losing energy to radiation. Receivers are coated with a solar absorber coating evaluated with a figure of merit which weighs the energy absorbed by the sample against the total incident energy. The structure of the painted coating plays a large part in the long-term stability and optical properties of the solar absorber coatings. We investigated the effects of different solvents on the micro-structure of black oxide coated paint tiles and evaluated the stability of the paint colloid using the Gibbs free energy of mixing. We also investigated the use of low environmental impact solvents as potential alternates to standard solvents to create low-stress films. The results show that paint blends thinned by blends of dimethyl carbonate and tertbutylbenzene have low-stress surface morphology with pore-like structures due to the favorable Gibbs free energy value of the colloid and reduced evaporation rate of the primary solvents. These coatings also exhibited strong optical performance with figure of merit and solar absorbance values of 91.60% and 96.86%, making them ideal coatings for next generation concentrated solar power plants.
Resonantly hybridized excitons in moiré superlattices in van der Waals heterostructures
Alexeev, Evgeny M.,Ruiz-Tijerina, David A.,Danovich, Mark,Hamer, Matthew J.,Terry, Daniel J.,Nayak, Pramoda K.,Ahn, Seongjoon,Pak, Sangyeon,Lee, Juwon,Sohn, Jung Inn,Molas, Maciej R.,Koperski, Maciej Nature Publishing Group 2019 Nature Vol.567 No.7746
Moura Felipe Henrique de,Costa Thaís Correia,Trece Aline Souza,Melo Luciano Prímola de,Manso Marcos Rocha,Paulino Mário Fonseca,Rennó Luciana Navajas,Fonseca Mozart Alves,Detmann Edenio,Gionbelli Mate 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.9
Objective: Twenty-four pregnant Nellore primiparous grazing cows were used to evaluate the effects of energy-protein supplementation and supplementation frequency during pre (105 d before calving) and postpartum (105 d after calving) on performance and metabolic characteristics. Methods: Experimental treatments consisted of a control (no supplementation), daily supplementation (1.5 kg/d of concentrate/animal) and infrequent supplementation (4.5 kg of concentrate/ animal every three days). During the pre and postpartum periods, concentrations of blood metabolites and animal performance were evaluated. Ureagenesis and energy metabolism markers were evaluated at prepartum period. Results: Supplementation frequency did not alter (p>0.10) body weight (BW), average daily gain (ADG), and carcass traits during pre and postpartum. The BW (p = 0.079), adjusted BW at day of parturition (p = 0.078), and ADG (p = 0.074) were greater for supplemented cows during the prepartum. The body condition score (BCS; p = 0.251), and carcass traits (p>0.10) were not affected by supplementation during prepartum. On postpartum, supplementation did not affect animal performance and carcass traits (p>0.10). The dry mater intake was not affected (p>0.10) by supplementation and supplementation frequency throughout the experimental period. Daily supplemented animals had greater (p<0.001) glucose levels than animals supplemented every three days. Supplementation and supplementation frequency did not alter (p>0.10) the levels of blood metabolites, neither the abundance of ureagenesis nor energy metabolism markers. Conclusion: In summary, our data show that the reduction of supplementation frequency does not cause negative impacts on performance and metabolic characteristics of primiparous grazing cows during the prepartum.