Thiazolylazo 화합물의 분광학적, 자기적, 그리고 열적성질

Masoud, M.S.,Mohamed, G.B.,Abdul-Razek Y.H.,Ali A.E.,Khairy F.N. 대한화학회 2002 대한화학회지 Vol.46 No.2

Thiazolylazo 화합물과 barbituric산, uracil, thiouracil, citrazinic산 chromotrotropic산, gallict산, pyrogallol 그리고 salicylic산의 Co(II), Ni(II) 그리고 Cu(II) 착화합물의 제조하였고, $^1H$ NMR, IR, 그리고 전기 흡수 스펙트럼에 대한 pHdudgid에 의하여 규명하였다. 이온화형태, 전기적 전이 그리고 해리상수에 대하여 설명하였다. 구리 착화합물은 등방형 ESR스펙트럼이었으며 자기적으로 궤도 기여를 갖는 묽은 성질이었다. 상세한 DTA데이타를 얻었고, 그 결과를 토론하였다. The thiazolylazo compounds and their Co(II), Ni(II) and Cu(II) complexes of barbituric acid, uracil, thiouracil, citrazinic acid, chromotropic acid, gallic acid, pyrogallol and salicylic acid were pre-pared and characterized by $^1H$ NMR , IR and the effect of pH on the electronic absorption spectra . The mode of ionization, the electronic transitions and the dissociation constants were discussed. The stoichiometries of the complexes were of 1:1, 2:1 and 3:2 (M:L). The copper complexes are of isotropic ESR spectra (except that of gallic acid which showed a complicated one) and are of magnetically diluted behaviour with orbital con-tribution. Detailed DTA data were obtained and discussed.

Membrane operations for produced water treatment

Drioli, Enrico,Ali, Aamer,Lee, Young Moo,Al-Sharif, Sharaf F.,Al-Beirutty, Mohammed,Macedonio, Francesca Balaban Publishers 2016 Desalination and Water Treatment Vol. No.

<P>Growing energy demand associated with improved living standards and rising population has increased the consumption of petroleum-based energy sources. To bridge the gap between demand and supply of petroleum-based energy resources, enhanced oil recovery and exploration of new nonconventional resources including shale gas, coal bed methane gas, and tight gas have gained popularity. These new techniques, however, use relatively fresh water and produce huge volumes of highly contaminated produced water. From compositional and potential treatment options, bilge water can also be included in the category of produced water. This work provides an overview of the investigations carried out for the removal of oil and greases using a membrane bioreactor and various other membrane operations. An analysis of a current and future scenario of produced water generated through conventional and nonconventional sources of energy and the perspective of produced water treatment in Saudi Arabia are also given. Finally, a cost estimation for the treatment of produced water using membrane operations is discussed.</P>

Post HCV Infection Due to MX Gene Stimulation Produced Post Treatment with Imported and Locally Produced Egyptian Biosimilar IFN

Mohamed, Shereen H,Mahmoud, Nora F,Mohamed, Aly F,Kotb, Nahla S Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

Background: Cirrhosis is regarded as a possible end stage of many liver diseases, including viral infection. It occurs when healthy liver tissue becomes damaged and is replaced by scar tissue and finally may lead to hepatocellular carcinoma. Interferons (IFNs)are two general categories, type I and II. Type I includes one beta interferon and over 20 different alpha interferons. Alpha interferons are very similar in how they work, interacting with other proteins on cells like receptors. The main objective of this study was to compare Mx gene productivity post different cell line treatment with imported and Egyptian biosimilar locally produced IFNs, as well as the efficacy of those tested IFNs. Also, an assessment was made of sensitivity of different cell lines as alternatives to that recommended for evaluation of antiviral activity. Materials and Methods: Different cell lines (Vero, MDBK and Wish) were employed to evaluate cytotoxicity using the MTT assay. Antiviral activity was evaluated compared with standard IFN against VSV, Indiana strain -156, on tested rh-IFNs (imported; innovated and Egyptian biosimilar locally produced IFNs) in the pre-treated cell lines previously mentioned. The virus was propagated in the Wish cell line as recommended. Finally we estimated up-regulation of the Mx gene as a biomarker. Results: Data recorded revealed that test IFNs were safe in test cell lines. Viability was around 100%. Locally tested interferon did not realize the international potency limits, while the imported one was accepted compared with the standard IFN. These results were the same either using infectivity titer reduction assay or crystal violet staining of residual non- infected cells. Mx protein production was cell type related and confirmed by the detected Mx gene expressed in imported and locally produced IFN pre-treated cell lines. The expression of the gene was arranged in the order of Vero> wish > MDBK for the imported IFN, while for the Egyptian biosimillar locally produced one it was MDBK> Vero> wish. With regard to the antiviral activity there was a significant difference of imported IFN potency compared with the locally produced IFN (P<0.05), the IFN potential (antiviral activity) was not cell line related and showed non-significant difference for each separate product. Conclusions: Vero cells can be used as an alternative cell line for evaluation of IFN potency in case of unavailable USP recommended cell lines. Alternative potency evaluation assay could be used and proved significant difference in IFN potency in case of local and imported agents. Evaluation of antiviral activity could be used in parallel to viral infectivity reduction assay for better accuracy. Mx gene can be used as a marker for IFN potential.

Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus from Nasal Specimens: Overcoming MRSA with Silver Nanoparticles and Their Applications

Abo-Amer Aly E.,Gad El-Rab Sanaa M. F.,Halawani Eman M.,Niaz Ameen M.,Bamaga Mohammed S. 한국미생물·생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.12

Staphylococcus aureus is a cause of high mortality in humans and therefore it is necessary to prevent its transmission and reduce infections. Our goals in this research were to investigate the frequency of methicillin-resistant S. aureus (MRSA) in Taif, Saudi Arabia, and assess the relationship between the phenotypic antimicrobial sensitivity patterns and the genes responsible for resistance. In addition, we examined the antimicrobial efficiency and application of silver nanoparticles (AgNPs) against MRSA isolates. Seventy-two nasal swabs were taken from patients; MRSA was cultivated on Mannitol Salt Agar supplemented with methicillin, and 16S rRNA sequencing was conducted in addition to morphological and biochemical identification. Specific resistance genes such as ermAC, aacA-aphD, tetKM, vatABC and mecA were PCR-amplified and resistance plasmids were also investigated. The MRSA incidence was ~49 % among the 72 S. aureus isolates and all MRSA strains were resistant to oxacillin, penicillin, and cefoxitin. However, vancomycin, linezolid, teicoplanin, mupirocin, and rifampicin were effective against 100% of MRSA strains. About 61% of MRSA strains exhibited multidrug resistance and were resistant to 3-12 antimicrobial medications (MDR). Methicillin resistance gene mecA was presented in all MDR-MRSA strains. Most MDR-MRSA contained a plasmid of > 10 kb. To overcome bacterial resistance, AgNPs were applied and displayed high antimicrobial activity and synergistic effect with penicillin. Our findings may help establish programs to control bacterial spread in communities as AgNPs appeared to exert a synergistic effect with penicillin to control bacterial resistance.

GeneXpert MTB/RIF Testing in the Management of Patients with Active Tuberculosis; A Real Life Experience from Saudi Arabia

Ali S. Omrani,Mohammed F. Al-Otaibi,Souad M. Al-Ateah,Fahad M. Al-Onazi,Kamran Baig,Noura A. El-Khizzi,Ali M. Albarrak 대한감염학회 2014 Infection and Chemotherapy Vol.46 No.1

Background: GeneXpert MTB/RIF is a real-time PCR assay with established diagnostic performance in pulmonary and extra-pulmonaryforms of tuberculosis. The aim of this study was to assess the contribution of GeneXpert MTB/RIF assay to the management ofpatients with any form of active tuberculosis in a single large tertiary center in Saudi Arabia, with a special focus on the impact ontime to start of antituberculous therapy compared with Ziehl-Neelsen (ZN) smears and mycobacterial cultures. Materials and Methods: Clinical, radiological and laboratory records for all patients who were commenced on antituberculous therapybetween March 2011 and February 2013 were retrospectively reviewed. Results: A total of 140 patients were included, 38.6% of which had pulmonary tuberculosis. GeneXpert MTB/RIF was requested for only39.2% of patients and was the only reason for starting antituberculous therapy for only 12.1%. The median time to a positive GeneXpertMTB/RIF result was 0 days (IQR 3) compared with 0 day (IQR 1) for smear microscopy (P > 0.999) and 22 days (IQR 21) for mycobacterialcultures (P < 0.001). No patients discontinued antituberculous therapy because of a negative GeneXpert MTB/RIF result. Conclusions: In a setting wherein physicians are highly experienced in the diagnosis and treatment of tuberculosis, GeneXpertMTB/RIF was remarkably under-utilized and had only a limited impact on decisions related to starting or stopping antituberculoustherapy. Cost-effectiveness and clinical utility of routine testing of all smear-negative clinical samples submitted for tuberculosisinvestigations by GeneXpert MTB/RIF warrant further study.

Dexmedetomidine during suprazygomatic maxillary nerve block for pediatric cleft palate repair, randomized double-blind controlled study

Mohamed F. Mostafa,Fatma A. Abdel Aal,Ibrahim Hassan Ali,Ahmed K. Ibrahim,Ragaa Herdan 대한통증학회 2020 The Korean Journal of Pain Vol.33 No.1

Background: For children with cleft palates, surgeries at a young age are necessary to reduce feeding or phonation difficulties and reduce complications, especially respiratory tract infections and frequent sinusitis. We hypothesized that dexmedetomidine might prolong the postoperative analgesic duration when added to bupivacaine during nerve blocks. Methods: Eighty patients of 1-5 years old were arbitrarily assigned to two equal groups (forty patients each) to receive bilateral suprazygomatic maxillary nerve blocks. Group A received bilateral 0.2 mL/kg bupivacaine (0.125%; maximum volume 4 mL/side). Group B received bilateral 0.2 mL/kg bupivacaine (0.125%) + 0.5 µg/kg dexmedetomidine (maximum volume 4 mL/side). Results: The modified children’s hospital of Eastern Ontario pain scale score was significantly lower in group B children after 8 hours of follow-up postoperatively (P < 0.001). Mean values of heart rate and blood pressure were significantly different between the groups, with lower mean values in group B (P < 0.001). Median time to the first analgesic demand in group A children was 10 hours (range 8-12 hr), and no patients needed analgesia in group B. The sedation score assessment was higher in children given dexmedetomidine (P = 0.03) during the first postoperative 30 minutes. Better parent satisfaction scores (5-point Likert scale) were recorded in group B and without serious adverse effects. Conclusions: Addition of dexmedetomidine 0.5 μg/kg to bupivacaine 0.125% has accentuated the analgesic efficacy of bilateral suprazygomatic maxillary nerve block in children undergoing primary cleft palate repair with less postoperative supplemental analgesia or untoward effects.

Special types of bipolar single valued neutrosophic graphs

Ali Hassan,Muhammad Aslam Malik,Said Broumi,Assia Bakali,Mohamed Talea,F. Smarandache 원광대학교 기초자연과학연구소 2017 ANNALS OF FUZZY MATHEMATICS AND INFORMATICS Vol.14 No.1

Neutrosophic theory has many applications in graph theory, bipolar single valued neutrosophic graphs (BSVNGs) is the generalization of fuzzy graphs and intuitionistic fuzzy graphs, SVNGs. In this paper we introduce some types of BSVNGs, such as subdivision BSVNGs, middle BSVNGs, total BSVNGs and bipolar single valued neutrosophic line graphs (BSVNLGs), also investigate the isomorphism, co weak isomorphism and weak isomorphism properties of subdivision BSVNGs, middle BSVNGs, total BSVNGs and BSVNLGs.

Gravimetric Measurements and Theoretical Calculations of 4-Aminoantipyrine Derivatives as Corrosion Inhibitors for Mild Steel in Hydrochloric Acid Solution: Comparative Studies

A. A. Al-Amiery,Firas F. Sayyid,Ali M. Mustafa,Slafa I. Ibrahim,Mustafa K. Mohsin,Mahdi M. Hanoon,Mohammed H. H. Al-Kaabi,A. A. H. Kadhum,Wan Nor Roslam Wan Isahak 한국부식방식학회 2023 Corrosion Science and Technology Vol.22 No.2

Due to continuous promotion of green alternatives to toxic petrochemicals by government policies,research efforts towards the development of green corrosion inhibitors have intensified recently. The objectiveof the current work was to develop novel green and sustainable corrosion inhibitors derived from 4-aminoantipyrine to effectively prevent corrosion of mild steel in corrosive environments. Gravimetricmethods were used to investigate corrosion inhibition of 4-((furan-2-ylmethylene)amino)antipyrine (FAP)and 4-((pyridin-2-ylmethylene)amino)antipyrine (PAP) for mild steel in 1 M HCl. FAP and PAP were subjectedto quantum chemical calculations using density functional theory (DFT). DFT was used to determinethe mechanism of mild steel corrosion inhibition using inhibitors tested in HCl. Results demonstratedthat these tested inhibitors could effectively inhibit mild steel corrosion in 1.0 M HCl. At 0.0005 M, theseinhibitors’ efficiencies for FAP and PAP were 93.3% and 96.5%, respectively. The Langmuir adsorptionisotherm was obeyed by these inhibitors on the mild steel surface. Values of adsorption free energies,, revealed that FAP followed chemical and physical adsorptions.

Conventional versus Doxorubicin-Eluting Beads Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma: a Tertiary Medical Centre Experience in Malaysia

Rahman, F Abdul,Naidu, J,Ngiu, CS,Yaakob, Y,Mohamed, Z,Othman, H,Jarmin, R,Elias, MH,Hamid, N Abdul,Mokhtar, N Mohd,Ali, RA Raja Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

Background: Hepatocellular carcinoma (HCC) is a common cancer that is frequently diagnosed at an advanced stage. Transarterial chemoembolisation (TACE) is an effective palliative treatment for patients who are not eligible for curative treatment. The two main methods for performing TACE are conventional (c-TACE) or with drug eluting beads (DEB-TACE). We sought to compare survival rates and tumour response between patients undergoing c-TACE and DEB-TACE at our centre. Materials and Methods: A retrospective cohort study of patients undergoing either treatment was carried out from January 2009 to December 2014. Tumour response to the procedures was evaluated according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST). Kaplan-Meier analysis was used to assess and compare the overall survival in the two groups. Results: A total of 79 patients were analysed (34 had c-TACE, 45 had DEB-TACE) with a median follow-up of 11.8 months. A total of 20 patients in the c-TACE group (80%) and 12 patients in the DEB-TACE group (44%) died during the follow up period. The median survival durations in the c-TACE and DEB-TACE groups were $4.9{\pm}3.2$ months and $8.3{\pm}2.0$ months respectively (p=0.008). There was no statistically significant difference noted among the two groups with respect to mRECIST criteria. Conclusions: DEB-TACE demonstrated a significant improvement in overall survival rates for patients with unresectable HCC when compared to c-TACE. It is a safe and promising approach and should potentially be considered as a standard of care in the management of unresectable HCC.

Significance of endangered and threatened plant natural products in the control of human disease

Ibrahim, Mohamed Ali,Na, MinKyun,Oh, Joonseok,Schinazi, Raymond F.,McBrayer, Tami R.,Whitaker, Tony,Doerksen, Robert J.,Newman, David J.,Zachos, Louis G.,Hamann, Mark T. National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.42

<P>One in five of the world’s plant species is threatened with extinction according to the 2010 first global analysis of extinction risk. Tilman et al. predicted a massive ecological change to terrestrial plants within the next 50–100 y, accompanied by an increase in the number of global plant species facing extinction [Tilman D, et al. (2001) <I>Proc Natl Acad Sci USA</I> 98(10):5433–5440]. Most of the drug-producing plant families contain endangered species never previously studied for their utility to human health, which strongly validates the need to prioritize protection and assessment of these fragile and endangered groups [Zhu F, et al. (2011) <I>Proc Natl Acad Sci USA</I> 108(31):12943–12948]. With little prior attention given to endangered and rare plant species, this report provides strong justification for conservation of the rare plant <I>Diplostephium rhododendroides</I> Hieron., as well as other potential drug-producing endangered species in this and other groups.</P>