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Contrast enhancement for ultrasound-guided interventions: when to use it and what to expect?
Zeno Sparchez,Tudor Mocan,Rares Craciun,Mihaela Sparchez,Christian Nolsoe 대한초음파의학회 2022 ULTRASONOGRAPHY Vol.41 No.2
The use of contrast-enhanced ultrasonography (CEUS) has recently become synonymous with high-standard ultrasonography (US). From expanding the reach of US diagnostics to improving the precision of various invasive procedures, CEUS is rapidly becoming a standard in numerous niches. However, proficiency in CEUS comes with a cost, both from a learning curve and material standpoint, and as every growing field, lacks firm evidence and standardization. Therefore, in the current paper, we aim to provide an evidence-based review of available methods and to discuss the advantages and pitfalls of CEUS in interventional procedures, trying to provide strong evidence whenever available, or at least an educated expert opinion if data are lacking.
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Adriana Filip,Doina Daicoviciu,Simona Clichici,Teodora Mocan,Adriana Muresan,Ion Dan Postescu 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.7
Solar ultraviolet radiation (UV) is the major cause of nonmelanoma skin cancer in humans. Photochemoprevention with natural products represents a simple but very effective strategy for the management of cutaneous neoplasia. We studied the photoprotective activity of Calluna vulgaris and red grape seed (Vitis vinifera L, Burgund Mare variety [BM]) extracts in vivo in an SKH-1 hairless mice skin model. Fifty 8-week-old female SKH-1 hairless mice were randomly divided into 5 groups (n = 10 each): controls, UVB-irradiated, C. vulgaris plus UVB–irradiated, BM plus UVB–irradiated, and epigallocatechin gallate (EGCG) plus UVB–irradiated. A dose of 4 mg/mouse per ㎠ of skin area for both extracts was topically applied to the mice 30 minutes before a single-dose (240 mJ/㎠) UVB exposure. EGCG dissolved in phosphate-buffered saline (pH 6.6; 0.067 M) was administered at 2 mg/mouse per ㎠. Glutathione peroxidase and catalase activities, reduced glutathione (GSH), malondialdehyde, nitric oxide, and caspase 3 activity were determined in skin homogenates 24 hours after irradiation. A single dose of UVB increased GSH levels and glutathione peroxidase activity in the exposed skin. C. vulgaris and BM pretreatment significantly decreased GSH formation and glutathione peroxidase activity (P < .001) and inhibited UVB-induced lipid peroxidation (P < .0001) and nitric oxide production (C. vulgaris: P < .06). Topical treatments with C. vulgaris and particularly BM extracts (P < .002) significantly reduced caspase 3 activity, indicating that the cells were protected against apoptosis. These results suggest that C. vulgaris and BM extracts might be chemopreventive candidates for reducing UV-induced risk for skin cancer.
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A Greenhouse Approach for Value Cultivation
( Jens J. Dahlgaard ),( Adrian Pugna ),( Sabina Potra ),( Romeo Negrea ),( Marian Mocan ) 한국품질경영학회 2015 한국품질경영학회 학술대회 Vol.2015 No.2
Background and Purpose: The present paper explores design requirements which companies need to take into consideration when designing and developing new products or services. After examining the ongoing debate regarding the theory of attractive quality, the so-called HWWP (Health, Weapon, Wealth, and Prospect) model to support new product or service design was proposed (2015) which aimed to provide better classification criteria for customer needs and requirements as a first step towards strategic decision support in new product and/ or service design. The purpose of this article is to refine the existing HWWP model as the basis for developing a strategic approach for analysing variations between potential customers‘ needs in order better to understand what qualities should be further cultivated before product launch. The new approach is called “A Greenhouse Approach for Value Cultivation”. Methodology/Approach: Case study data of a new web based customization service for a Romanian shoe manufacturing company is re-analysed to refine the existing HWWP model into the new “Greenhouse Model”, and a generalized regression model with non-linear curves is used for assessing the values of existing service attribute as the basis for further value cultivation. Findings: The -Greenhouse Model” envisages new perspectives of the evaluation of customer needs which better supports strategic decision making regarding further value cultivation for profound affection (= customer delight). Originality/Value of paper: Even if there is a need for further analyses the suggested -Greenhouse Approach for Value Cultivation” is regarded as a new and original contribution to the theory of attractive quality creation which deepens its position in the theory of attractive quality and transforms it into a practical management tool to support new product and service design.
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