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Mizoguchi Yasushi,Guan Le Luo 아세아·태평양축산학회 2024 Animal Bioscience Vol.37 No.2
Advanced and innovative breeding and management of meat-producing animals are needed to address the global food security and sustainability challenges. Beef production is an important industry for securing animal protein resources in the world and meat quality significantly contributes to the economic values and human needs. Improvement of cattle feed efficiency has become an urgent task as it can lower the environmental burden of methane gas emissions and the reduce the consumption of human edible cereal grains. Cattle depend on their symbiotic microbiome and its activity in the rumen and gut to maintain growth and health. Recent developments in high-throughput omics analysis (metagenome, metatranscriptome, metabolome, metaproteome and so on) have made it possible to comprehensively analyze microbiome, hosts and their interactions and to define their roles in affecting cattle biology. In this review, we focus on the relationships among gut microbiome and beef meat quality, feed efficiency, methane emission as well as host genetics in beef cattle, aiming to determine the current knowledge gaps for the development of the strategies to improve the sustainability of beef production. Advanced and innovative breeding and management of meat-producing animals are needed to address the global food security and sustainability challenges. Beef production is an important industry for securing animal protein resources in the world and meat quality significantly contributes to the economic values and human needs. Improvement of cattle feed efficiency has become an urgent task as it can lower the environmental burden of methane gas emissions and the reduce the consumption of human edible cereal grains. Cattle depend on their symbiotic microbiome and its activity in the rumen and gut to maintain growth and health. Recent developments in high-throughput omics analysis (metagenome, metatranscriptome, metabolome, metaproteome and so on) have made it possible to comprehensively analyze microbiome, hosts and their interactions and to define their roles in affecting cattle biology. In this review, we focus on the relationships among gut microbiome and beef meat quality, feed efficiency, methane emission as well as host genetics in beef cattle, aiming to determine the current knowledge gaps for the development of the strategies to improve the sustainability of beef production.
Mizoguchi, Tadashi,Saga, Yoshitaka,Tamiaki, Hitoshi Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
Eight intact bacteriochlorophyll (BChl)-d homologs and isomers were isolated from a strain of green sulfur bacterium Chlorobium vibrioforme. All the molecular structures of the BChl-d components were fully determined by a combination of mass spectrometry and $^1$H-NMR spectroscopy. The aggregation behavior of the isomerically pure BChls-d in hydrophobic organic solvents was examined with respect to the stereoisomeric configuration at the C3$^1$ position as well as the bulkiness of the C8 and C12 side-chains by using electronic- absorption spectroscopy.
Generic model for the hyperkagome iridateNa4Ir3O8in the local-moment regime
Mizoguchi, Tomonari,Hwang, Kyusung,Lee, Eric Kin-Ho,Kim, Yong Baek American Physical Society 2016 Physical Review B Vol.94 No.6
<P>The hyperkagome iridate, Na4Ir3O8, has been regarded as a promising candidate material for a three-dimensional quantum spin liquid. Here the three-dimensional network of corner-sharing triangles forms the hyperkagome lattice of Ir4+ ions. Due to strong spin-orbit coupling, the local moments of Ir4+ ions are described by the pseudospin j(eff) = 1/2 Kramers doublet. The Heisenberg model on this lattice is highly frustrated, and quantum/classical versions have been studied in earlier literature. In this work, we derive a generic local-moment model beyond the Heisenberg limit for the hyperkagome iridate by considering multiorbital interactions for all the t(2g) orbitals and spin-orbit coupling. The lifting of massive classical degeneracy in the Heisenberg model by various spin-anisotropy terms is investigated at the classical level, and the resulting phase diagram is presented. We find that different anisotropy terms prefer distinct classes of magnetically ordered phases, often with various discrete degeneracy. The implications of our results for recent mu SR and NMR experiments on this material and possible quantum spin liquid phases are discussed.</P>
Does caffeine have a double-edged sword role in inflammation and carcinogenesis in the colon?
( Emiko Mizoguchi ),( Takayuki Sadanaga ),( Toshiyuki Okada ),( Takanori Minagawa ),( Jun Akiba ) 대한장연구학회 2023 Intestinal Research Vol.21 No.3
Caffeine (1,3,7-trimethylxanthine, also abbreviated to CAF) is a natural chemical with stimulant effects and is commonly included in many drinks and foods, including coffee, tea, cola, energy drinks, cocoa, chocolates, and so on. Our group previously reported that oral administration of CAF efficiently suppressed the development of intestinal inflammation in a dextran sulfate sodium (DSS)-induced murine acute colitis model by suppressing the expression of chitinase 3-like 1, one of the mammalian chitinases without enzymatic activity. Chitinases are hydrolytic enzymes that break down chitin, a polymer of N-acetylglucosamine, and chitinase-like proteins have no enzymatic activity with preserving chitin-binding ability. CAF binds a cleft of the chitinase active site and plays a role as a pan-chitinase inhibitor. Although CAF showed an anti-inflammatory effect in the above model, oral administration of low-dose CAF with 10% sucrose showed potentially neoplastic effects in colonic epithelial cells in a DSS-induced murine chronic colitis model. In this review, we would like to discuss the pros and cons of coffee/CAF in colonic inflammation and neoplasia with an example of pathological finding. (Intest Res 2023;21:306-317)
Toru Mizoguchi,Isao Takehara,Tohru Masuzawa,Toshiro Saito,Yo Naoki 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.3
In order to clarify the physiological effects of Chlorella intake on subjects with high-risk factors for lifestyle-related diseases, we conducted Chlorella ingestion tests on 17 subjects with high-risk factors for lifestyle-related diseases and 17 healthy subjects over a 16-week period, including a 4-week post-observation period. We conducted blood biochemical tests and analyzed gene expression profile in whole blood cells in the peripheral blood before and after Chlorella intake. We confirmed that in both groups, Chlorella intake resulted in noticeable reductions in body fat percentage, serum total cholesterol, and fasting blood glucose levels. Through gene expression analysis, we found that gene expression profiles varied with Chlorella intake and identified many genes that exhibited behavior such that after the completion of the intake period, expression levels returned to pre-intake expression ones. Among these were genes related to signal transduction molecules, metabolic enzymes, receptors, transporters, and cytokines. A difference in expression level was found between the two groups at the start of the tests, and we were able to identify genes with noticeable variance in expression level resulting from Chlorella intake in the high-risk factor group. These included genes involved in fat metabolism and insulin signaling pathways, which suggests that these pathways could be physiologically affected by Chlorella intake. There were clear variations in the expression profiles of genes directly related to uptake of glucose resulting from Chlorella intake, indicating that the activation of insulin signaling pathways could be the reason for the hypoglycemic effects of Chlorella.