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Guenova, Emmanuella,Skabytska, Yuliya,Hoetzenecker, Wolfram,Weindl, Gü,nther,Sauer, Karin,Tham, Manuela,Kim, Kyu-Won,Park, Ji-Hyeon,Seo, Ji Hae,Ignatova, Desislava,Cozzio, Antonio,Levesque, Mitc National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.7
<P>Interleukin 4 (IL-4) can suppress delayed-type hypersensitivity reactions (DTHRs), including organ-specific autoimmune diseases in mice and humans. Despite the broadly documented antiinflammatory effect of IL-4, the underlying mode of action remains incompletely understood, as IL-4 also promotes IL-12 production by dendritic cells (DCs) and IFN-gamma-producing T(H)1 cells in vivo. Studying the impact of IL-4 on the polarization of human and mouse DCs, we found that IL-4 exerts opposing effects on the production of either IL-12 or IL-23. While promoting IL-12-producing capacity of DCs, IL-4 completely abrogates IL-23. Bone marrow chimeras proved that IL-4-mediated suppression of DTHRs relies on the signal transducer and activator of transcription 6 (STAT6)-dependent abrogation of IL-23 in antigen-presenting cells. Moreover, IL-4 therapy attenuated DTHRs by STAT6-and activating transcription factor 3 (ATF3)-dependent suppression of the IL-23/T(H)17 responses despite simultaneous enhancement of IL-12/T(H)1 responses. As IL-4 therapy also improves psoriasis in humans and suppresses IL-23/ T(H)17 responses without blocking IL-12/T(H)1, selective IL-4-mediated IL-23/T(H)17 silencing is promising as treatment against harmful inflammation, while sparing the IL-12-dependent T(H)1 responses.</P>
J. L. Ullmann,A. J. Couture,A. L. Keksis,D. J. Vieira,,J. M. ODonnell,J. M. Wouters,M. Jandel,R. C. Haight,R. S. Rundberg,T. A. Bredeweg,T. Kawano,C. Y. Wu,J. A. Becker,A. Chyzh,B. Baramsai,G. E. Mitc 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
A careful new measurement of the ^(238)U(n,γ) cross section from 10 eV to 100 keV has been made using the DANCE detector at LANSCE. DANCE is a 4π calorimetric scintillator array consisting of 160 BaF^2 crystals. Measurements were made on a 48 mg/cm^2 depleted uranium target. The cross sections are in general in good agreement with previous measurements. The gamma-ray emission spectra, as a function of gamma multiplicity, were also measured and compared to model calculations.