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Cytotoxic Constituents of Diadema setosum
Minh, Chau-Van,Kiem, Phan-Van,Huong, Le-Mai,Kim, Young-Ho The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.7
5,8-Epidioxycholest-6-en-3-ol (1), cholesterol (2), glycerol 1-palmitate (3) and glycerol 1,3-dioleate-2-stearate (4) were isolated from the methanol extract of the sea urchin Diadema setosum, which was collected from the Halong sea, Vietnam. Chemical structures were established based on extensive 1D, 2D-NMR, FAB-MS, EI-MS spectroscopic data and GC-MS analysis. The NMR spectral data of compound 1 were reassigned by using HMQC and HMBC. Compound 1 was found to have strong cytotoxic effect against various cancer cell lines, such as KB ($IC_{50}$, 2.0 $\mu\textrm{g}$/mL), FL($IC_{50}$, 3.93 $\mu\textrm{g}$/mL), and Hep-2 ($IC_{50}$, 2.4 $\mu\textrm{g}$/mL) by in vitro assay.
Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities
Chau Van Minh,Nguyen Xuan Nhiem,Hoang Thi Yen,Phan Van Kiem,Bui Huu Tai,Hoang Le Tuan Anh,Truong Thi Thu Hien,박선주,김나영,김승현 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.8
One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-b-D-glucopyranoside (5), chrysoeriol-7- O-b-D-glucopyranoside (6), 10a-cucurbita5,24-dien-3b-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 lM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 lM.
Cytotoxic Constituents of Diadema setosum
Chau Van Minh,Phan Van Kiem,Le Mai Huong,김영호 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.7
5,8-Epidioxycholest-6-en-3-ol (1), cholesterol (2), glycerol 1-palmitate (3) and glycerol 1,3- dioleate-2-stearate (4) were isolated from the methanol extract of the sea urchin Diadema setosum, which was collected from the Halong sea, Vietnam. Chemical structures were established based on extensive 1D, 2D-NMR, FAB-MS, EI-MS spectroscopic data and GC-MS analysis. The NMR spectral data of compound 1 were reassigned by using HMQC and HMBC. Compound 1 was found to have strong cytotoxic effect against various cancer cell lines, such as KB (IC50, 2.0 mg/mL), FL (IC50, 3.93 mg/mL), and Hep-2 (IC50, 2.4 mg/mL) by in vitro assay.
Chemical components from the leaves of Ardisia insularis and their cytotoxic activity
Nguyen Thi Hong Van,김승현,Trinh Anh Vien,Phan Van Kiem,Chau Van Minh,Nguyen Xuan Nhiem,Pham Quoc Long,Luu Tuan Anh,김난영,박선주 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.11
One new oleanane triterpene glycoside, ardinsuloside(1), and twelve known compounds, demethoxybergenin(2), norbergenin (3), bergenin (4), 4-O-galloylbergenin(5), quercitrin (6), myricitrin (7), myricetin 3-O-(300-O-galloyl)-a-L-rhamnopyranoside (8), desmanthine-2 (9), epicatechin3-O-galloyl ester (10), 30-methoxyepicatechin 3-Ogalloylester (11), gallic acid (12), and methyl galloate (13)were isolated from the leaves of Ardisia insularis. Theirstructures were established on the basis of spectral and chemicalevidence, which were in agreement with those reportedin literature. The cytotoxic activities of these compounds wereevaluated on three cancer cell lines namely A-549 (humanlung cancer), HT-29 (Human colon adenocarcinoma), andOVCAR (human ovarian carcinoma). The results revealedthat compound 1 inhibited A-549, HT-29, and OVCAR celllines with IC50 values of 8.5 ± 1.2, 16.4 ± 3.1, and13.6 ± 2.4 lM, respectively. The remaining compoundshowed weak cytotoxic activity. This result indicated thatcompound 1 could be useful in the treatment of cancer disease.
New Dibenzocyclooctadiene Lignan from Kadsura induta and Their Cytotoxic Activities
Pham, Thi Hong Minh,Do, Tien Lam,Nguyen, Quyet Tien,Nguyen, Ngoc Tuan,Vu, Phuong Nhung,Nong, Van Hai,Phan, Van Kiem,Nguyen, Xuan Nhiem,Chau, Van Minh,Park, SeonJu,Kim, Seung Hyun Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.6
Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Ban, Ninh Khac,Cuong, Nguyen Xuan,Tung, Nguyen Huu,Ha, Le Minh,Ha, Do Thi,Tai, Bui Huu,Quang, Tran Hong,Ngoc, Tran Minh,Kwon, Young-In,Jang, Hae-Dong,K The Pharmaceutical Society of Japan 2010 Chemical & pharmaceutical bulletin Vol.58 No.5
<P>Fourteen cucurbitane-type triterpene glycosides (1—14) were isolated from a methanol extract of <I>Momordica charantia</I> fruits, including three new compounds, charantosides A—C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for α-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against α-glucosidase. Whereas, 2, 3, 6—11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive.</P>
Distribution of Factors Affecting Foreign Direct Investment in ASEAN Countries
Anh Thi Lan NGUYEN(Anh Thi Lan NGUYEN ),Chau Thi Minh PHAM(Chau Thi Minh PHAM ),Hanh Hong NGUYEN(Hanh Hong NGUYEN ),Dat Ngoc NGUYEN(Dat Ngoc NGUYEN ),Duy Van NGUYEN(Duy Van NGUYEN ) 한국유통과학회 2023 유통과학연구 Vol.21 No.2
Purpose: Research on attracting foreign direct investment plays an important role in ASEAN countries. ASEAN has needed FDI capital for development and integration with many developing countries. Research design, data and methodology: This study is conducted to assess the impact of factors: inflation (INF), economic growth (GDP), population (POP), and trade (TRADE) on attracting foreign direct investment (FDI) of ASEAN countries. The study will find out how factors distribution contributes to FDI attraction. The study collects data from 10 ASEAN countries from 2010 to 2020. With data collected for ten countries from 2010 to 2020, data analysis with panel data will be used in this study. The Regression with Driscoll-Kraay standard errors correction model will be used in the study. Results: Panel data analysis shows that economic growth and population positively impact FDI attraction in ASEAN countries. However, two factors: INF and TRADE, do not affect FDI. Conclusions: Countries need to focus on economic development, create many good conditions for people and domestic enterprises and create opportunities for foreign investors to pay more attention. improving the quality of domestic human resources will help to better improve the working quality factor when the demand for high-quality human resources increases.