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Identification of the prognostic immune subtype in copy-number high endometrial cancer
Mingyi Mao,Fang Jiang,Ruiqin Han,Yang Xiang 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.1
Objective: The TCGA molecular subtype of endometrial cancer (EC) is widely applied,among which the copy-number high (CNH) subtype has the poorest prognosis. However,the heterogeneity of this subtype remains elusive. In this study, we aimed to identif yheterogeneous immune subtypes in CNH EC and explore their prognostic significance. Methods: We collected 60 CNH EC cases in the TCGA database and performed unsuper visedcluster analysis based on the enrichment scores of immune-related gene signatures toidentif y immune subtypes. We described their immune characteristics and prognoses andconducted differential gene analysis and lasso regression to identif y a prognostic biomarker,GZMM. For experimental validation, we performed immunohistochemical staining of GZMMin 39 p53-positive EC surgical samples. Results: We defined two immune subtypes, immune-hot (IH) and immune-cold (IC), whichdiffered in immune cell infiltration, cytokine and chemokine expression and prognosis. TheIH subtype has significantly stronger immune activation than the IC subtype, showing asignificant infiltration of immune effector cells and high expression of relevant chemokines,with better prognosis. Moreover, the immunohistochemical staining of GZMM in a cohortof 39 p53-positive EC surgical samples confirmed GZMM as a unique prognostic biomarker,with high expression in both tumor cells and lymphocytes predicting a better prognosis. Conclusion: Our study revealed heterogeneous immune subtypes in CNH EC and identifiedGZMM as a prognostic biomarker. The stratified classification strategy combining molecularand immune subtypes provides valuable insights for future clinical practice.
An Automatic and Scalable Application Crawler for Large-Scale Mobile Internet Content Retrieval
( Mingyi Huang ),( Yongqiang Lyu ),( Hao Yin ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.10
The mobile internet has grown ubiquitous across the globe with the widespread use of smart devices. However, the designs of modern mobile operating systems and their applications limit content retrieval with mobile applications. The mobile internet is not as accessible as the traditional web, having more man-made restrictions and lacking a unified approach for crawling and content retrieval. In this study, we propose an automatic and scalable mobile application content crawler, which can recognize the interaction paths of mobile applications, representing them as interaction graphs and automatically collecting content according to the graphs in a parallel manner. The crawler was verified by retrieving content from 50 non-game applications from the Google Play Store using the Android platform. The experiment showed the efficiency and scalability potential of our crawler for large-scale mobile internet content retrieval.
Liu Mingyi,Pu Jiaqi,Pu Jing 아시아사회과학학회 2021 Jornal of Asia Social Science Vol.4 No.2
In 2019, the European Commission published its Strategic Outlook, which described China as a partner, economic competitor and systemic rival (European Commission, 2019). As Europe struggles with the survival crisis caused by the COVID- 19 epidemic, the complexity of its relationship with China is fully revealed. The year 2020 marks the 45th anniversary of the establishment of diplomatic relations between China and the European Union, which was originally an important year for China-EU relations. Sudden epidemics disrupted the established diplomatic schedules of China and the EU, and many political, economic, trade and cultural cooperation agendas were temporarily postponed. At the same time, the original differences between the two sides are becoming more and more complicated with different understandings and responses to the epidemic situation. The epidemic poses a challenge to both sides’ ability to respond to public health emergencies, and at the same time, it also poses a major test to the political mutual trust between the two sides. How to promote the healthy development of China-EU relations has become a topic for scholars to think about. France is an important driving force for European integration and plays an important role in European affairs. France’s perception of China-EU relations influences the attitude towards the interaction between China and Europe, and think tank is an important way to understand a country’s policies. Therefore, we can learn about France’s interpretation of China-EU relations through the relevant reports of the French Institute of International Relations, the most famous think tank in France, and the strategic interests of Europe in France’s eyes will help us to promote the development of China-EU relations.
A Novel 43-kDa Protein as a Negative Regulatory Component of Phenoloxidase-induced Melanin Synthesis
Zhao, Mingyi,Sö,derhä,ll, Irene,Park, Ji Won,Ma, Young Gerl,Osaki, Tsukusa,Ha, Nam-Chul,Wu, Chun Fu,Sö,derhä,ll, Kenneth,Lee, Bok Luel American Society for Biochemistry and Molecular Bi 2005 The Journal of biological chemistry Vol.280 No.26
Network Security Prediction Method Based on Kalman Filtering Fusion Decision Entropy Theory
Yunfa Li,Mingyi Li,Yangyang Shen 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.12
Network security situation prediction is of great significance for the use of the Internet, and it is the focus of production and life issues. Under the guidance of the model combination forecasting method, In this paper, based on the Kalman filtering model a new method of network security prediction is presented, which is based on the theory of decision entropy. In this method, the Kalman state equation and measurement equation are constructed according to the key attributes of the network security state, and then combined with the decision entropy theory to predict the future state of network security. The experimental results show that the proposed method has high prediction accuracy and is suitable for the state prediction of network security.
Lu Li,Mingyi Zhang,Ying Liu,Xitian Zhang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.5
BiOX ( X=Cl , Br, I) nanosheet arrays have been grown on the surface of carbon cloth as recycled photocatalysts. Photocatalytic tests display that the BiOCl/carbon cloth heterostructures possess a much higher degradation rate compared with BiOCl grown on a fluorine-doped tin oxide(FTO) planar substrate. The photocatalytic experimental results indicate that BiOCl/carbon cloth heterostructures show excellent cyclic properties.
Wei Wang,Mingyi He,Huan Zhang,Yatang Dai 한국자기학회 2016 Journal of Magnetics Vol.21 No.2
In this paper, 10 nm Fe₃O₄ nanoparticles were modified on the surface of 2 μm flower-like bismuth oxychloride (BiOCl) spheres by a facile co-precipitation method. The results showed that the Fe₃O₄/BiOCl nanocomposites exhibited excellent photocatalytic activity and superparamagnetic property (Ms = 3.22 emu/g) under visible light for Rhodamine B (RhB) degradation. Moreover, the Fe₃O₄-BiOCl photocatalyst possessed magnetic recyclable property, which could maintain high photocatalytic effective even after 20 cycle times. These characteristic indicates a promising application for wastewater treatment.
Flow Features of a Prefabricated Pumping Station Operating under High Flow Rate Conditions
Qing Li,Can Kang,Mingyi Li 한국유체기계학회 2018 International journal of fluid machinery and syste Vol.11 No.2
A prefabricated pumping station catering to the delivery of medium with high flow rate is investigated. Two configurations of storage tanks are devised. Computational fluid dynamics (CFD) is utilized to acquire flow patterns in the pumping station as the pumps operate concurrently. Flow rate allocation and the disturbance of pump operation to ambient medium are depicted. It is demonstrated that both the serial and parallel configurations can fulfill the requirements of high flow rate. Flow rate differs over storage tanks and pumps as well, as is intensified with the serial configuration. The operation of the pumps arouses non-symmetric flow structures in the tank. In comparison, the parallel configuration is desirable in consideration of the uniformity of cross-sectional total pressure and velocity distributions in the outlet pipe of the prefabricated pumping station.