http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Toward mindful development of action learning in business education
Gang Chen,Xin Zheng,Yanmei Zhang,Mingji Xu 한국교육개발원 2020 KEDI Journal of Educational Policy Vol.17 No.2
This article addresses questions raised at a recent academic discussion of action learning for business education: What are the pitfalls of existing action learning practices? How do educators mindfully and effectively develop action learning in business education? To examine these issues, we provide an overview of, and analyze, the evolution of ongoing action learning programs established by a leading Chinese business school with its partner schools in the US from 2007 to 2019. Based on this qualitative case study, we reveal implicit pitfalls of existing practices, propose an experiential learning-based conceptual framework for an in-depth understanding of curriculum design, and provide instructional guidelines for better implementation. All the findings help educators mindfully embed action learning essentials into an educational curriculum and innovate the educational policy of teaching pedagogies.
POUDEL, BARUN,NEPALI, SARMILA,XIN, MINGJIE,KI, HYEON-HUI,KIM, YOUNG-HO,KIM, DAE-KI,LEE, YOUNG-MI SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.2
<P>The present study aimed to compare the potential anti-adipogenic effects and underlying mechanisms of the luteolin, isoscoparin and isoorientin flavonoids, purified from Triticum aestivum sprout (TA) in 3T3-L1 cells. The cells were treated with different concentrations of flavonoids for 8 days and the lipid accumulation was assessed using Oil-Red-O staining. The expression levels of the transcription factors and the genes involved in adipogenesis in the cells were assessed by reverse transcription-quantitative polymerase chain reaction and western blotting. The results demonstrated that 10 μM luteolin, isoscoparin or isoorientin inhibited lipid deposition in the cells by 74, 63 and 65%, respectively. The flavonoids also significantly inhibited the transcriptional regulators of adipogenesis, including peroxisome proliferator-activated receptor-γ, CAAT/enhancer binding protein-α and sterol regulatory element binding protein (SREBP)-1c, compared with the control cells. Similarly, there was a significant downregulation of the adipocyte specific markers associated with lipid metabolism, including activating protein-2, fatty acid synthase, hormone-sensitive lipase and lipoprotein lipase, in the flavonoid treated cells. Notably, the cells treated with the flavonoids demonstrated increased expression levels of the insulin-induced genes, insig-1 and insig-2, which may have inhibited the activation of the adipogenic transcription factor, SREBP, eventually leading to the inhibition of adipogenesis. Taken together, these results revealed that the flavonoids from TA possessed an inhibitory effect on adipogenesis through downregulation of adipogenic transcription factors and genes associated with lipid metabolism, and the upregulation of insig 1 and 2, suggesting that the flavonoids from TA may be potential therapeutic agents for the prevention and treatment of obesity.</P>
Cha, Ji-Yun,Jeon, Yong-Deok,Xin, Mingjie,Kim, Do-Kuk,Lee, Hoon-Yeon,Kim, Bo-Ram,Hwang, Sung-Woo,Kim, Dae-Ki,Jin, Jong-Sik,Lee, Young-Mi Informa UK (TaylorFrancis) 2017 Bioscience, Biotechnology, and Biochemistry Vol.81 No.11
<P>The aim of this study is to examine the anti-inflammatory effect of Euphorbia supina (ES) ethanol extract in dextran sulfate sodium (DSS)-induced experimental colitis model. ES was per orally administered at different doses of 4 or 20 mg/kg body weight with 5% DSS in drinking water for 7 days. Twenty mg/kg of ES administration regulated body weight decrease, recovered colon length shortening, and increased disease activity index score and myeloperoxidase level in DSS-induced colitis. Histological features showed that 20 mg/kg of ES administration suppressed edema, mucosal damage, and the loss of crypts induced by DSS. Furthermore, ES suppressed the expressions of COX-2, iNOS, NF-kB, IkBa, pIkBa in colon tissue. These findings demonstrated a possible effect of amelioration of ulcerative colitis and could be clinically applied.</P>
3T3-L1 세포에서 소맥엽 에탄올추출물의 지질생성 억제효과
이선희(Sun-Hee Lee),신명걸(Mingjie Xin),Bui Thi Thuy Luyen,차지윤(Ji-Yun Cha),임지영(Ji-Young Im),권세욱(Se-Uk Kwon),임성원(Sung-Won Lim),서주원(Joo-Won Suh),김영호(Young-Ho Kim),김대기(Dae-Ki Kim),이영미(Young-Mi Lee) 대한약학회 2011 약학회지 Vol.55 No.6
Non-alcoholic fatty liver disease is known to be frequently associated with obesity and type 2 diabetes. We examined the effects of EtOH extracts from Triticum aestivum on lipid accumulation during the differentiation of 3T3-L1 preadipocytes to screening the candidate materials in preventing non-alcoholic fatty liver disease. The lipid level in adipocytes was determined by Oil Red O staining. The treatment of 50% ethanol, but not water and 100% ethanol extracts, from Triticum aestivum at concentration of 0.5 mg/ml inhibited lipid accumulation in 3T3-L1 cells, revealing no cell toxicity. Thus, the fractions of CH2Cl2, EtOAc and BuOH were separated from 50% EtOH extract to characterize anti-adipogenic effect. The CH2Cl2 fraction at concentration of 50 μg/ml effectively inhibited the lipid accumulation in the adipocytes compared to those of EtOAc and BuOH at concentration of 50 μg/ml. The intracellular triglyceride accumulation also was significantly reduced by treatment of CH2Cl2 fraction in concentration-dependent manner. Western blot analysis showed that the CH2Cl2 fraction attenuated the intracelluar level of fatty acid synthase(FAS) accompanied by attenuated expression of Peroxidase proliferator-activated receptor γ (PPARγ) adipogenic transcription factor. These results suggest that CH2Cl2 fraction from 50% EtOH extract of Triticum aestivum may has the potent anti-adipogenic effects by inhibiting the transactivation of PPARγ.
Antithrombotic activity of Vitis labrusca extract on rat platelet aggregation
Kwon, Se-Uk,Lee, Hoon-Yeon,Xin, Mingjie,Ji, Su-Jeong,Cho, Hyoung-Kwon,Kim, Dae-Sung,Kim, Dae-Ki,Lee, Young-Mi YEAR Wolters Kluwer Health, Inc. All rights reserv 2016 Blood coagulation & fibrinolysis Vol.27 No.2
<P>Vitis labrusca is a grapevine that has antioxidant, neuroprotective, hepatoprotective, and anticarcinogenic activity. However, the antithrombotic effect of Vitis labrusca leaves on platelets is yet to be ascertained. We investigated the inhibitory effect of V. labrusca leaf extract (VLE) on platelet aggregation in vitro and ex vivo. The thromboxane B-2 (TXB2) and serotonin concentrations were measured by ELISA. The flavonoids content was measured by ultraperformance liquid chromatography (UPLC). The antithrombotic activity of VLE was evaluated using various agonists in vitro. VLE strongly inhibited adenosine diphosphate (ADP)-induced platelet aggregation. In rats, VLE treatment (100mg/kg) reduced ADP-stimulated platelet aggregation, without affecting tail bleeding and coagulation time. Moreover, VLE significantly suppressed TXB2 and serotonin secretion. UPLC analysis indicated that VLE contains quercetin, isorhamnetin, and rutin. Our results indicate that VLE possesses antiplatelet activity via the suppression of TXB2 and serotonin, without affecting bleeding. Further, we identified the flavonoids present in VLE. Thus, VLE may be a potential agent for the prevention of cardiovascular diseases. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.</P>
Anti-obesity effect of Triticum aestivum sprout extract in high-fat-diet-induced obese mice.
Im, Ji-Young,Ki, Hyeon-Hui,Xin, Mingjie,Kwon, Se-Uk,Kim, Young Ho,Kim, Dae-Ki,Hong, Sun-Pyo,Jin, Jong-Sik,Lee, Young-Mi Japan Society for Bioscience, Biotechnology, and A 2015 Bioscience, Biotechnology, and Biochemistry Vol.79 No.7
<P>Obesity is a common disease worldwide that often results in serious conditions including hypertension, diabetes, and hyperlipidemia. Many herbal medicines have been examined with regard to ameliorating obesity. We investigated the anti-obesity effects of 50% EtOH extract of Triticum aestivum sprout (TAEE) in high-fat-diet (HFD)-induced obese mice. TAEE administration (10, 50, or 200 mg/kg) for 6 weeks significantly decreased the body weights, serum total cholesterol (TC), and low-density lipoprotein cholesterol levels in HFD-fed mice. TAEE treatment reduced lipid accumulation in epididymal white adipose tissue (EWAT) and liver. Moreover, TC and lipid levels were decreased by TAEE treatment in liver. Serum leptin and adiponectin concentrations were reduced by TAEE treatment. TAEE-treated mice showed decreases in peroxisome proliferator-activated receptor γ (PPARγ) and fatty acid synthase expression in EWAT. Furthermore, TAEE administration elevated levels of PPARα protein in the liver of HFD-induced obese mice. These results suggest that TAEE supplementation might be beneficial for the treatment and prevention of obesity and related diseases.</P>
Lee-Rang Im,이영미,Ji-Young Ahn,Jun-Ho Kim,Mingjie Xin,권세욱,김윤경,김대기 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.2
Kyungohkgo (KOG) is one of the most important formulas in traditional oriental medicine. We investigated the remedial effect of KOG on the development of atopic dermatitis (AD) in female NC/Nga mice. AD-like lesion was induced by the application of 2,4-Dinitrochlorobenzene on to the back skin repeatedly; KOG was administered orally (12.5 and 25.0 mg/kg) and topically (0.5 and 1.0 mg/mouse) to NC/Nga mice once a day for all through the period of this experiment and every mouse body weight was periodically taken. The effects of KOG on 2,4-Dinitrochlorobenzene-treated NC/Nga mice were determined by measuring AD-like skin lesions, the infiltration of mast cells and serum immunoglobulin E concentration. After the KOG applications are over, the KOG groups had less skin lesions than the atopy one, their immunoglobulin E levels were significantly downregulated and the infiltration of mast cells in the dorsal skin were reduced. Our results suggest that KOG may be effective in alleviating the development of AD. The inhibition of AD in NC/Nga mice may be influenced by the prevention of mast cell activation.
Effects of Poria cocos Water Extract on DNCB-induced Atopic Dermatitis
Im, Lee-Rang,Ahn, Ji-Young,Kim, Jun-Ho,Xin, Mingjie,Yoo, Jae-Soo,Song, Bong-Suk,Song, Bong-Jun,Kim, Dae-Keun,Kim, Ok-Jin,Lee, Hyun-A,Kim, Dae-Ki,Lee, Young-Mi 대한한약학회 2009 Journal of oriental pharmacy Vol.2 No.2
Poria cocos has been traditionally used for the treatment of edema, scanty urine, dizziness due to retention of fluid, reduced appetite due to asthenia of spleen, loose stool, diarrhea, distraction, sudden palpitation and insomnia in East Asia. The aim of this study was to confirm whether Poria cocos wonfire whethe(PCWE) and Poria cocos ointment (PCO) have a preventive e of ter Pthe development of afire wdethe(PCWE (AD) in 2,4-Diniwhochlorobenzene (oria)-applied Balb/ wme e. Oral administration (12.5wmg/kg, 25wmg/kg) of PCWE and fire al application (O.5wmg/mouse, 1.0mg/mouse) of PCO decreased the development of AD-like skin lesions, ear swelling, spleen weight, total serum IgE. PCWE and PCO significantly also inhibited the infiltration of mast cells in the dorsal skin.
Kwon, Se-Uk,Cha, Ji-Yoon,Lee, Hoon-Yeon,Xin, Mingjie,Ji, Su-Jeong,Kim, Dae-Ki,Park, Do-Sim,Pyo, Mi-Kyung,Lee, Young-Mi D. A. Spandidos 2015 MOLECULAR MEDICINE REPORTS Vol.11 No.6
<P>Euphorbia maculata (EM) is a traditionally used antidiarrheal, antibacterial, antifungal and antioxidant agent. However, the effects of EM on platelet activity remain to be elucidated. Therefore, the present study investigated the antiplatelet effect of various EM extract fractions on platelet aggregation in rats. The antiplatelet activity of the EM fractions on collagen or adenosine diphosphate (ADP)?induced platelet aggregation was evaluated in?vitro and ex?vivo. Thromboxane?B2 (TXB2) formation, rat?tail bleeding time and coagulation time were also measured. Among the fractions, the chloroform fraction of EM (CFEM) significantly inhibited ADP?induced platelet aggregation in?vitro. Furthermore, oral administration of 50?mg/kg CFEM to rats significantly reduced ADP?induced platelet aggregation without increasing the tail bleeding time or coagulation time. In addition, EM significantly inhibited the level of TXB2 formation in a dose?dependent manner. These results suggest that CFEM exhibits antiplatelet activity, without causing bleeding, via the suppression of TXB2 formation. CFEM may be a type of food which has the potential for preventing cardiovascular disease.</P>