Roles of NMDA NR2B Subtype Receptor in Prefrontal Long-Term Potentiation and Contextual Fear Memory

Zhao, Ming-Gao,Toyoda, Hiroki,Lee, Yong-Seok,Wu, Long-Jun,Ko, Shanelle W.,Zhang, Xue-Han,Jia, Yongheng,Shum, Fanny,Xu, Hui,Li, Bao-Ming,Kaang, Bong-Kiun,Zhuo, Min Elsevier 2005 Neuron Vol.47 No.6

<P><B>Summary</B></P><P>Cortical plasticity is thought to be important for the establishment, consolidation, and retrieval of permanent memory. Hippocampal long-term potentiation (LTP), a cellular mechanism of learning and memory, requires the activation of glutamate N-methyl-D-aspartate (NMDA) receptors. In particular, it has been suggested that NR2A-containing NMDA receptors are involved in LTP induction, whereas NR2B-containing receptors are involved in LTD induction in the hippocampus. However, LTP in the prefrontal cortex is less well characterized than in the hippocampus. Here we report that the activation of the NR2B and NR2A subunits of the NMDA receptor is critical for the induction of cingulate LTP, regardless of the induction protocol. Furthermore, pharmacological or genetic blockade of the NR2B subunit in the cingulate cortex impaired the formation of early contextual fear memory. Our results demonstrate that the NR2B subunit of the NMDA receptor in the prefrontal cortex is critically involved in both LTP and contextual memory.</P>

Changes in Markers of Liver Function in HCV 1b Patients with Compensated Cirrhosis Treated with Ombitasvir/Paritaprevir/ Ritonavir plus Dasabuvir with Ribavirin

( Jeong Heo ),( Yan Luo ),( Wan-long Chuang ),( Jidong Jia ),( Kwang-hyub Han ),( Ming-lung Yu ),( Hong Tang ),( Young-suk Lim ),( Cheng-yuan Peng ),( Min Xu ),( Maorong Wang ),( Bo Fu ),( Niloufar Mo 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Patients chronically infected with HCV are at risk of developing extrahepatic manifestations of HCV as well as progressing to compensated or decompensated cirrhosis and HCC. Although current treatments have high rates of SVR, relatively little is known about possible regression of liver fibrosis after achieving an SVR. The ONYX-II trial examined the efficacy and safety of ombitasvir/paritaprevir/ritonavir plus dasabuvir + ribavirin (RBV) in Asian patients with HCV genotype 1b infection and compensated cirrhosis. Here we report changes in key markers of liver fibrosis and function. Methods: Patients with chronic HCV GT1b infection and compensated cirrhosis were enrolled in China, South Korea and Taiwan and received 12 weeks of OBV/PTV/r (25 mg/150 mg/100 mg once daily) and DSV (250 mg twice daily) with weight-based RBV. The primary objective of ONYX-II was to assess efficacy (SVR12) and safety of the regimen. Changes in markers of liver fibrosis and function between baseline (BL) and post-treatment week (PTW) 12 are presented. Results: Overall, 104 patients were enrolled and treated in ONYX-II. All patients (104/104, 100%) achieved SVR12. BL and PTW12 data for FibroTest score, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, albumin, platelet count and alpha fetoprotein (AFP) are shown in Table 1. All selected parameters showed numerical improvements between BL and PTW12. Mean ALT and AST levels returned to within normal range and FibroTest scores demonstrated a numerical improvement, suggesting improvement in liver status. The complete set of data between BL and PTW12 will be presented for these parameters and other liver composite parameters at the conference. Conclusions: Measurement of key liver function markers during the ONYX-II trial showed a numerical improvement within 12 weeks of completion of treatment in HCV GT1b-infected patients with compensated cirrhosis. Further follow-up of these patients will determine the long-term durability of these changes.

Case Report : Nutrition Therapy for Mitochondrial Neurogastrointestinal Encephalopathy with Homozygous Mutation of the TYMP Gene

( Jing Wang ),( Wei Chen ),( Fang Wang ),( Dong Wu ),( Jia Ming Qian ),( Jun Ren Kang ),( Hai Long Li ),( En Ling Ma ) 한국임상영양학회 2015 Clinical Nutrition Research Vol.4 No.2

Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is characterized by significant gastrointestinal dysmotility. Early and long-term nutritional therapy is highly recommended. We report a case of MNGIE in a patient who was undergoing longterm nutrition therapy. The patient was diagnosed with a serious symptom of fatty liver and hyperlipidemia complications, along with homozygous mutation of the thymidine phosphorylase (TYMP) gene (c.217G > A). To our knowledge, this is the first report of such a case. Herein, we describe preventive measures for the aforementioned complications and mitochondrial disease-specific nutritional therapy.

Time-degenerative Factors and the Risk of Hepatocellular Carcinoma after Antiviral Therapy among HCV Patients: A Model for Prioritization of Treatment

( Ming-lung Yu ),( Chung-feng Huang ),( Ming-lun Yeh ),( Jee-fu Huang ),( Chia-yen Dai ),( Wan-long Chuang ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: Age and hepatic fibrosis are the factors that increase the risk of hepatocellular carcinoma (HCC) over time. We aimed to explore their impac at the initiation of antiviral therapy on HCC among chronic hepatitis C (CHC) patients. Methods: A total of 1281 biopsy-proven CHC patients receiving interferon- based therapy were followed for a mean period of 5.5 years. Results: The 5-year cumulative incidence of HCC did not differ between non-SVR and SVR patients who were <40 years old (7.7 % vs. 0.5%, P=0.1), but was significantly higher in non-SVR patients between 40 and 55 years old (18.0% vs. 1.3%, P<0.001) and >55 years old (15.1% vs. 7.9%, P=0.03). Compared with SVR, non-SVR was independently predictive of HCC in patients 40-55 years old (hazard ratio [HR]/95% confidence intervals [CI]: 10.92/3.78-31.56, P<0.001) and >55 years old (HR/CI: 1.96/1.06-3.63, P=0.03) but not in patients <40 years old (HR/CI: 2.76/0.41-18.84, P=0.3). The 5-year cumulative incidence of HCC did not differ between non-SVR and SVR patients whose fibrosis stage was F0-1 (4.6% vs. 1.9%, P=0.25) but was higher in non-SVR patients with F2-3 (21.4% vs. 4.3%, P<0.001) or F4 (33.5% vs. 8.4%, P=0.002). Compared with SVR, non-SVR was independently predictive of HCC in patients with F2-3 (HR/CI: 4.36 /2.10-9.03, P<0.001) and F4 (HR/CI: 3.84/1.59-9.30, P=0.03) but not in those with F0-1 (HR/CI: 1.53/ 0.49-4.74, P=0.47). Conclusions: Delayed HCV clearance for patients with CHC > 40 years old or with a fibrosis stage > 2 increases the risk of HCC over time.

Chilling Tolerance of Cucumber during Germination is Related to Expression of Lysine Decarboxylase Gene

Ming-hui Lu,Xiao-ming Li,Jin-feng Chen,Long-zheng Chen,Chun-tao Qian 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Overexpression of Chalcone Isomerase (CHI) Increases Resistance Against Phytophthora sojae in Soybean

Jin-ming Zhao;Han Xing,Yang Zhou; Jian-li Huang; Xiao-li Zhang; Long-ming Zhu; Xin-fang Wang 한국식물학회 2018 Journal of Plant Biology Vol.61 No.5

Chalcone isomerase (CHI) is a key enzyme ofthe flavonoid pathway that plays crucial roles in plant responsesto various pathogens. Our previous study using comparativetranscriptome analysis of soybean inoculated with or withoutPhytophthora sojae revealed Glyma.20G241500, a homologof CHI1A in Arabidopsis thaliana, to be induced by P.sojaein soybean. In the present study, we isolated the gene fromsoybean cultivar Nannong 10-1, designating it GmCHI1A. GmCHI1A transcripts were detected in soybean roots, stemsand leaves, with the highest levels in roots. Interestingly,GmCHI1A localizes to the cortical endoplasmic reticulum(ER). GmCHI1A was overexpressed in hairy roots to furtheruncover the roles of CHIs in soybean. Compared to emptyvector-expressing hairy roots (EV) infected with P. sojae,hairy roots overexpressing GmCHI1A (OE) exhibited decreasedP. sojae biomass accumulation, shortened the lesion lengthsand reduced zoospores germination. These results demonstratethat GmCHI1A plays positive roles in the response ofsoybean to P. sojae.

SEPT12 Interacts with SEPT6 and This Interaction Alters the Filament Structure of SEPT6 in Hela Cells

( Xiang Ming Ding ),( Wen Bo Yu ),( Ming Liu ),( Su Qin Shen ),( Fang Chen ),( Bo Wan ),( Long Yu ) 생화학분자생물학회 2007 BMB Reports Vol.40 No.6

환경의 질서(무질서)가 소비자의 자아고갈, 해석수준 및 제품 선택과 선호도에 미치는 영향

룽광밍(Long Kwang Ming),이진용(Lee, Jinyong) 한국상품학회 2020 商品學硏究 Vol.38 No.5

본 연구는 환경이 사람들의 인지자원과 해석수준에 영향을 미치고 바람직성과 실행가능성이 높은 무료증정품을 포함한 패키지를 선택, 선호도에도 영향을 미치는 관계를 연구하였다. 사람들은 무질서 환경에서 질서 환경보다 자아고갈이 높아지고 해석수준이 낮아지기 때문에 바람직성이 높은 무료 증정품에 비해서 실행가능성이 높은 무료 증정품을 더욱 많이 선택하고 선호하였다. 질서 환경에서는 무질서 환경보다 자아고갈이 낮고 해석수준이 높아지기 때문에 실행가능성이 높은 무료 증정품 패키지에 비해 바람직성이 높은 무료증정품 패키지를 주로 선택하였고 선호하였다. 의지력의 조절효과에 의하여 무한 의지력 상황에서는 무질서 환경과 질서 있는 환경의 해석수준이 차이가 없기 때문에 실행가능성이 높은 무료 증정품 패키지에 대한 선호도가 약화되었고, 유한 의지력 상황에서만 무질서 환경은 인지적 자원이 고갈되면서 해석수준이 낮아지기 때문에 질서 있는 환경보다 실행가능성이 높은 무료증정품 패키지를 더 선호하였다. 본 연구의 실험은 자아통제 및 해석수준에 영향을 미치는 환경의 질서(무질서)과 의지력의 조절 효과를 살펴보았다. 분석 결과에 의하면 유한 의지력 조건에서 자아 조절 자원 및 해석수준의 차이에 의하여 무질서 환경과 질서 환경은 바람직성과 실행가능성이 높은 무료 증정품을 포함한 패키지에 대한 선호도가 유의한 차이가 나타났으나, 무한 의지력 조건에서 자아 조절 자원 및 해석수준의 차이가 없었고 바람직성과 실행가능성이 높은 무료 증정품을 포함한 패키지에 대한 선호도가 유의한 차이가 나타나지 않았다. 본 연구는 환경의 질서, 무질서의 효과가 해석수준을 매개로 하여 제품 선택와 선호도에 영향을 미친다는 사실을 살펴보았다는 차별적 기여도를 가지고 있다. This study investigates the effects of environmental orderliness on cognitive resource depletion, construal level and choices and preferences of products. Consumers in environmental disorder suffered from resource depletion, and were in low construal levels and, thus, chose and preferred feasibility free-gifts to desirability ones. In contrast, consumers in ordered environments did not suffer from resource depletion, and were in high construal levels and, thus, chose and preferred desirability free-gifts to feasibility ones. The beliefs about will power showed an moderation effect. Under the belief of limited will power, the same results were drawn. That is, disorder led to choices and preferences of feasibility products whereas orderliness led to opposite outcomes. The choices and preferences of feasibility products in the condition of environmental disorder were derived from cognitive resource depletion, and low construal levels but the choices and preferences of desirability products in the condition of environmental order were determined by low or no resource depletion, and high construal levels. However, the belief of unlimited will power diluted the differential effect s of environmental order vs. disorder on resource depletion, construal levels, and choices and preferences of products and did not show any statistical differences. This study examines the mediating effect of construal levels on choices and preferences of products unlike previous studies.

중국 타오바오 앱 품질과 감성 가치가 타오바오(淘宝)에 대한 소비자 만족도와 사용의도에 미치는 영향

용해명(HAI-MING LONG),남인용(Inyong Nam) 한국인터넷전자상거래학회 2021 인터넷전자상거래연구 Vol.21 No.5

This study focuses on the Stimulus-Organism-Response Model to find out how it affects quality, positive emotional value, satisfaction, and usability of Taobao apps. The data collection was conducted online through the Wenjuanxing (问卷星) Survey from May 5 to June 5 2021, and the final 310 copies were used for analysis. Summarizing the results of the analysis is as follows. First, Taobao app quality had a significant impact on user satisfaction. Taobao app quality was not significant on user intention. Emotional value had a significant impact on user satisfaction. Emotional value had a significant impact on user intention. The implications of this study are that it is most important for consumers to increase their positive satisfaction and willingness to use Taobao apps, which should be considered when developing and managing shopping apps.

Removal of NO with the hexamminecobalt(II) solution catalyzed by the activated carbon treated with acetic acid

Xiang-li Long,Bei-bei Duan,Hai-xia Cao,Ming-lei Jia,Long-an Wu 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.62 No.-

The simultaneous scrubbing of NO and SO2 can be finished with the Co(NH3)62+ ammonia solution. Activated carbon aids the regeneration of Co(NH3)62+ to retain the ability of absorbing NO. Acetic acid is tried to improve the catalytic capability of activated carbon. The best treatment condition is the carbon samples impregnated in 2.0 mol l−1 HAc solution for 20 h followed by being calcined at 600 °C for 4 h. The HAc modification increases surface area and acidic groups on the carbon surface. The experiments prove that the modified carbon can obtain a higher NO removal efficiency than the original carbon.