AN EFFICIENT HEURISTIC APPROACH TO STATE ENCODING FOR PLA-BASED SEQUENTIAL CIRCUITS

Minato, Kenji,Ariyoshi, Hiromu,Shirakawa, Isao 대한전자공학회 1989 ICVC : International Conference on VLSI and CAD Vol.1 No.1

The present paper describes an efficient heunstic approach to state encoding of sequential circuits so that the total usage of silicon area of PLA-based two-level implementation for combinational circuits can be minimized. Apart from those conventional methods m which state encoding is determined one after another m a predetermined order of states, this approach is distinctive m that top priority is green to how to seek cubes which constitute a cover to be allocated to each group of states (where a group of states denotes a set of states which have the same next state and the same output for an input) on the basis of a magnitude estimation of cubes so that the total number of cubes to be used can be minimized. Implementation results are alsa shown to reveal how this approach is of practical use.

INFLUENCE OF AMMONIA TREATMENT OF RICE STRAW OFFERED TO CATTLE AS A FORAGE ON RUMINAL MICROBIAL POPULATIONS

Minato, H.,Mitsumori, M.,Adachi, Y.,Ishizaki, S. Asian Australasian Association of Animal Productio 1989 Animal Bioscience Vol.2 No.3

Rap Signaling in Normal Lymphocyte Development and Leukemia Genesis

Minato, Nagahiro The Korean Association of Immunobiologists 2009 Immune Network Vol.9 No.2

Although Rap GTPases of the Ras family remained enigmatic for years, extensive studies in this decade have revealed diverse functions of Rap signaling in the control of cell proliferation, differentiation, survival, adhesion, and movement. With the use of gene-engineered mice, we have uncovered essential roles of endogenous Rap signaling in normal lymphocyte development of both T- and B-lineage cells. Deregulation of Rap signaling, on the other hand, results in the development of characteristic leukemia in manners highly dependent on the contexts of cell lineages. These results highlight crucial roles of Rap signaling in the physiology and pathology of lymphocyte development.

Synthesis and Properties of Highly Pure Poly(arylene sulfide)s by Oxidative Polymerization of Disulfide

Minato AOKI,Kenichi OYAIZU,Hiroyuki NISHIDE 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

WATER TREATMENT SYSTEM FOR DRAINAGE FROM LAND REMEDIATION WORKS

( Hideo Minato ),( Tatsuo Morimoto ),( Michiharu Sakaguchi ),( Tetsuji Ozaki ),( Ki An Cho ),( Jae Wan Pak ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.1

The water that drained from land remediation works must be treated to satisfy the limit of required values for the concentration of pollutants. As the land remediation works occur temporarily site-by-site following the demands, and the nature of the drained water varies depending on the histories and conditions of each sites, design of water treatment system for the drained water must be flexible. Contaminants contained in the drained water are removed out by precipitation method. Materials that difficult to precipitate such as suspended substances or dissolved metal ions must be converted to the solid form to be removed out by the precipitation. Adjustment of pH and use of flocculating agent is helpful for the conversion and the precipitation. We found TRP is one of the most effective agents for recovery of heavy metals, reducing the amount of other additive agents so that to minimize the total operating cost.

Rap Signaling in Normal Lymphocyte Development and Leukemia Genesis

Nagahiro Minato 대한면역학회 2009 Immune Network Vol.9 No.2

Although Rap GTPases of the Ras family remained enigmatic for years, extensive studies in this decade have revealed diverse functions of Rap signaling in the control of cell proliferation, differentiation, survival, adhesion, and movement. With the use of gene-engineered mice, we have uncovered essential roles of endogenous Rap signaling in normal lymphocyte development of both T- and B-lineage cells. Deregulation of Rap signaling, on the other hand, results in the development of characteristic leukemia in manners highly dependent on the contexts of cell lineages. These results highlight crucial roles of Rap signaling in the physiology and pathology of lymphocyte development. Although Rap GTPases of the Ras family remained enigmatic for years, extensive studies in this decade have revealed diverse functions of Rap signaling in the control of cell proliferation, differentiation, survival, adhesion, and movement. With the use of gene-engineered mice, we have uncovered essential roles of endogenous Rap signaling in normal lymphocyte development of both T- and B-lineage cells. Deregulation of Rap signaling, on the other hand, results in the development of characteristic leukemia in manners highly dependent on the contexts of cell lineages. These results highlight crucial roles of Rap signaling in the physiology and pathology of lymphocyte development.

철도정비부지 내 매립된 폐기물에 의해 중금속으로 오염된 토양의 인체위해성 평가

Hatsue Minato Braatz,정민정,문세흠,박진규 유기성자원학회 2019 유기물자원화 Vol.27 No.3

본 연구에서는 대규모 철도부지를 상업부지로 개발함에 따라 과거 부지 내부에 산업 폐기물 등이 부적절하게처리되어 중금속 폐기물로 오염된 토양의 Cu, Pb, Zn, Ni 에 대한 인체 위해성 평가를 수행하였다. 위해성 평가는토양의 복원 및 복원과정에서 필요한 고려요소를 도출하는데 주요한 과정이다. 본 연구에서는 위해성 평가를 위해환경부 위해성평가지침을 준용하여 노출농도 결정, 노출량 산정, 발암 및 비발암 위해도를 결정하였다. 이를 통해철도부지의 중금속 오염토양의 인체 위해성 평가 결과를 제시하였다. 노출농도 산정결과 토양내 중금속 함량은621.3 Cu mg/kg, 2,824.5 Pb mg/kg, 1,559.1 Zn mg/kg, 45 Ni mg/kg이고, 독성금속별 인체 노출량 결과, 노출경로별로는토양의 실외비산 > 토양섭취 > 토양 접촉 순으로 나타났으며, 오염물질별로는 Pb > Zn > Cu > Ni 순으로 나타났다. 발암위해도 평가 결과, USEPA에서 제시한 허용발암위해도(TCR > 10-6) 보다 높게 나타났으며, 독성위해도(비발암성) 평가 결과, HI 지수(HI< 1.0)도 성인 3.5, 어린이 4.85, Cu 1.94 ~ 2.16, Pb 1.37 ~ 2.90으로 나타났다. 따라서 대상부지의중금속으로 오염된 토양의 복원관리가 필요할 것으로 판단된다. This study carried out a human risk assessment of Cu, Pb, Zn and Ni contained in soil contaminated by improperly buried heavy metal wastes in railway sites. The purpose of the human risk assessment is to derive the need for soil remediation and factors that should be considered during soil remediation. Risk assessment was performed in accordance with the Environment Ministry's Risk Assessment Guidelines. The results of the human risk assessment of contaminated heavy metal soil contaminated by improperly buried waste in the railway site were presented after the process of determining exposure concentration, calculating exposure, and determining carcinogenic hazards. The heavy metal content of soil is 621.3 Cu mg/kg, 2,824.5 Pb mg/kg, 1,559.1 Zn mg/kg and 45 Ni mg/kg, which is the exposure concentration of the target contaminant. The results of human exposure according to exposure pathways were high in the order of soil outdoor dust >soil ingestion >soil contact, and Pb >Zn >Cu >Ni were higher in order of contaminant. The carcinogenic and noncarcinogenic risks of soil contaminated with heavy metal waste were higher than the allowable carcinogenic risks (TCR> 10-6) and the risk index (Hi < 1.0) suggested by USEPA. Therefore, the site needs to be remediated.

오염된 토양과 점토 차단벽을 정화하기 위한 작업으로 제올라이트와 점토를 적용하는 신기술

( Hideo Minato ),( Tatsuo Morimoto ),( Ki An Cho ),( Jae Wan Pak ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.2

중금속이나 비소, 기타 독성 오염 물질에 의해 오염된 물과 토양은 항상 인간의 활동에 의해 만들어 진 것이다. 오염된 토양을 효과적으로 정화하는 기술은 화학물질이나 유기화합물, 콘크리트 들과 같은 인공 물질을 대신하여 제올라이트, 화산성 롬(풍화된 화산재), 돌로마이트와 같은 천연의 물질을 사용하는 것으로 개발되고 있다. 양이온 교환이나 흡착과정은 오염된 토양에서 이들 유해 중금속과 비소를 고정시키거나 함수된 알칼리류 또는 알칼리토류를 부 구성 성분으로 하는 알루미노실리케이트로 새롭게 결정체를 만들어 침전시킨다. 유해 중금속을 고정하거나 잡기위해 천연 물질을 사용하는 기술은 “Sealing Soil Technique (토양 밀봉 기술)” 이라 한다. 이 기술은 오염된 토양 뿐만 아니라 도시 지역의 최종 매립지의 차단벽이나 차단층으로 쓰이는 점토 차단벽의 물질을 정화하는 것에 적용될 수 있다. 이것의 커다란 장점 중의 하나는 정화 처리와 차단층 물질로 쓰이는 화학 물질이나 유기물이 분해된 것의 침투로부터 유래하는 2차 오염을 막는다는 것이다. 유사한 기술을 이용하여 다양한 오염원으로부터 중금속이나 비소로 오염된 물과 토양을 정화하기 위한 주된 천연 물질인 제올라이트, 점토, 돌로마이트와 “TRP”라 명명된 기타 다른 물질들의 혼합물을 이용한 저비용의 효과적인 방법이 개발되었다. 이것은 중화, 산화, 침전과 pH 조절로 침전된 중금속과 비소를 여과하는 과정을 포함한다. Contaminated soil and water by heavy metals, arsenic and other toxic pollutions are usually created under human activities. An effective remediation technique for the polluted land has been developed using of natural materials, such as zeolite, volcanic loam (weathered volcanic ash), and dolomite, instead of artificial materials, such as chemicals, organic compounds, concrete, and etc. The mechanism of cation exchange and/or adsorption conducts those hazardous heavy metals and arsenic in the polluted soil to be fixed and settled into newly crystallized hydrous alkaline and alkaline earth aluminosilicates as minor elements. The technique to use natural materials that trap and fix hazardous metals is called as Sealing Soil Technique. This is applicable not only for the remediation for polluted soil but also for materials of clay barrier to be used as a wall and/or bed of final waste disposal site of urban area. One of the immense advantages is to prevent secondary pollution derived from seepage that contains decomposed chemical substances and organic matters, used for the remediation treatment and barrier material. Using the similar technique we have develop effective procedure in low cost using a prescribed mixture of mainly natural material, zeolite, clay, dolomite and others under the name of TRP for remediation of contaminated water with heavy metals and arsenic from various sources. It includes a process to neutralize, oxidize, precipitate and filtrate out the precipitates of metals and arsenic under severe pH control.

Effect of caspases and RANKL induced by heavy force in orthodontic root resorption

Yukari Minato,Masaru Yamaguchi,Mami Shimizu,Jun Kikuta,Takuji Hikida,Momoko Hikida,Masaaki Suemitsu,Kayo Kuyama,Kazutaka Kasai 대한치과교정학회 2018 대한치과교정학회지 Vol.48 No.4

Objective: Orthodontic root resorption (ORR) due to orthodontic tooth movement is a difficult treatment-related adverse event. Caspases are important effector molecules for apoptosis. At present, little is known about the mechanisms underlying ORR and apoptosis in the cementum. The aim of the present in vivo study was to investigate the expression of tartrate-resistant acid phosphatase (TRAP), caspase 3, caspase 8, and receptor activator of nuclear factor kappa-B ligand (RANKL) in the cementum in response to a heavy or an optimum orthodontic force. Methods: The maxillary molars of male Wistar rats were subjected to an orthodontic force of 10 g or 50 g using a closed coil spring. The rats were sacrificed each experimental period on days 1, 3, 5, and 7 after orthodontic force application. And the rats were subjected to histopathological and immunohistochemical analyses. Results: On day 7 for the 50-g group, hematoxylin and eosin staining revealed numerous root resorption lacunae with odontoclasts on the root, while immunohistochemistry showed increased TRAP- and RANKL-positive cells. Caspase 3- and caspase 8-positive cells were increased on the cementum surfaces in the 50-g group on days 3 and 5. Moreover, the number of caspase 3- and caspase 8-positive cells and RANKL-positive cells was significantly higher in the 50-g group than in the 10-g group. Conclusions: In our rat model, ORR occurred after apoptosis was induced in the cementum by a heavy orthodontic force. These findings suggest that apoptosis of cementoblasts is involved in ORR.[Korean J Orthod 2018;48(4):253-261]

NEW TECHNIQUES WITH AN APPLICATION OF ZEOLITES AND CLAYS TO REMEDIATION WORKS FOR POLLUTED SOILS AND CLAY BARRIERS

( Hideo Minato ),( Tatsuo Morimoto ),( Kian Cho ),( Jaewan Pak ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.1

Contaminated soil and water by heavy metals, arsenic and other toxic pollutions are usually created under human activities. An effective remediation technique for the polluted land has been developed using of natural materials, such as zeolite, volcanic loam (weathered volcanic ash), and dolomite, instead of artificial materials, such as chemicals, organic compounds, concrete, and etc. The mechanism of cation exchange and/or adsorption conducts those hazardous heavy metals and arsenic in the polluted soil to be fixed and settled into newly crystallized hydrous alkaline and alkaline earth aluminosilicates as minor elements. The technique to use natural materials that trap and fix hazardous metals is called as Sealing Soil Technique. This is applicable not only for the remediation for polluted soil but also for materials of clay barrier to be used as a wall and/or bed of final waste disposal site of urban area. One of the immense advantages is to prevent secondary pollution derived from seepage that contains decomposed chemical substances and organic matters, used for the remediation treatment and barrier material. Using the similar technique we have develop effective procedure in low cost using a prescribed mixture of mainly natural material, zeolite, clay, dolomite and others under the name of TRP for remediation of contaminated water with heavy metals and arsenic from various sources. It includes a process to neutralize, oxidize, precipitate and filtrate out the precipitates of metals and arsenic under severe pH control.