Meta-Analysis of Circulating Endothelial Cells and Circulating Endothelial Progenitor Cells as Prognostic Factors in Lung Cancer

Yu, Min,Men, Hai-Tao,Niu, Zhi-Min,Zhu, Yu-Xi,Tan, Ben-Xu,Li, Long-Hao,Jiang, Juan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

Background: The aim of this study was to analyze the prognostic implications of pretreatment circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs) for the survival of patients with lung cancer. Materials and Methods: Relevant literature was identified using Medline and EMBASE. Patient clinical characteristics, overall survival (OS) and progression-free survival (PFS) together with CEC and CEPC positive rates before treatment were extracted. STATA 12.0 was used for our analysis and assessment of publication bias. Results: A total of 13 articles (8 for CEC and 5 for CEPC, n=595 and n=244) were pooled for the global meta-analysis. The odds ratio (OR) for OS predicted by pretreatment CECs was 1.641 [0.967, 2.786], while the OR for PFS was 1.168 [0.649, 2.100]. The OR for OS predicted by pretreatment CEPCs was 12.673 [5.274, 30.450], while the OR for PFS was 4.930 [0.931, 26.096]. Subgroup analyses were conducted according to clinical staging. Odds ratio (OR) showed the high level of pretreatment CECs only correlated with the OS of patients with advanced lung cancer (stage III-IV). Conclusions: High counts of CECs seem to be associated only with worse 1-year OS in patients with lung cancer, while high level of pretreatment CEPCs correlate with both worse PFS and OS.

A Fast Immune Recognition Model based on Immune Response

Yuan Tao,Min Hu 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.11

This paper proposes a fast immune recognition model based on immune response. Inspired by biological immune system, AIS for anomaly detection has been adopted widely because of its analogy with body resistance in the immune system provided against agents which causes diseases. This paper mainly studies correspondence between immune response and anomaly detection. Compared with traditional AIS, the change of antigen type is judged by statistical techniques, which ignores the differences of the different systems. Antibody recognition is initiated by the proposed model only when the type of antigen has changed, which improves the efficiency of the algorithm. Complexity analysis shows the proposed algorithm is a linear algorithm. The usefulness of the proposed model is demonstrated through experiments. The experiments illustrate the availability and feasibility of the model.

Development of stress-tolerant transgenic plants via RNA metabolism control

Hunseung Kang,Tao Xu,Lili Gu,Min Kyung Kim,Su Jung Park 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07

Environmental stresses including drought, extreme temperatures, and high salinity are major factors that severely limit crop productivity worldwide. To overcome yield loss due to these environmental stresses, a large number of researches have been conducted to understand how plants respond to and adapt these environmental stresses. Posttranscriptional regulation as well as transcriptional regulation of gene expression is recognized as a key regulatory process in plant stress responses, and these cellular processes are regulated by diverse RNA-binding proteins (RBPs). Over the last years, we have extensively investigated the functional roles of RBPs that harbor an RNA-recognition motif at the N-terminal half and a glycine-rich region at the C-terminal half (glycine-rich RNA-binding proteins, GRPs), zinc finger-containing GRP, and cold shock domain proteins (CSDPs) in Arabidopsis thaliana, rice (Oryza sativa), wheat (Triticum aestivum), and rapeseed (Brasicca napus) under stress conditions. Our comparative analysis demonstrated that certain family members display RNA chaperone function during stress adaptation process in monocotyledonous plants as well as in dicotyledonous plants. These findings point to the importance of the regulation of mRNA metabolism in plant response to environmental stresses and shed new light on the practical application of these RBPs to develop stress-tolerant transgenic crops.

유아 스마트교육 관련 미디어 연구동향 분석: 한국과 미국의 학술지 논문을 중심으로

우민지(Woo, Min Ji),타오양(Tao, Yang),임민정(Lim, Min Jung) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.23

본 연구의 목적은 유아 스마트교육과 관련한 한국과 미국의 미디어 연구들을 대상으로 학술지 논문 분석을 통해 연구동향을 파악하고 시사점을 도출하려는 것이다. 본 연구의 목적을 달성하기 위해 2017년 11월부터 2018년 1월까지 자료수집 및 분석이 실시되었고, 2018년 7월부터 9월 동안 타당도 검증을 위한 추가분석이 수행되었다. 연구동향 분석을 위한 자료수집은 2011년부터 2017년까지 최근 7년간 출간된 국내 논문 79편과 미국 논문 50편, 총 129편을 선정하여, 출간년도, 연구주제, 연구대상, 연구방법의 준거를 토대로 분석하였다. 연구결과를 살펴보면, 첫째 연도별 논문편수는 한국과 미국 모두 증가 추이를 나타냈으며, 국내는 2012년 이후 출간된 논문편수가 급증하였다. 둘째, 연구주제는 양국 모두 교수학습방법에 대한 높은 빈도를 보였으며, 한국의 경우 스마트교육의 인식 및 현황, 미국은 이론 및 철학에 대한 연구가 상대적으로 많았다. 셋째, 연구대상은 한국의 경우 유아, 매체 순으로 연구가 이루어졌고, 미국은 유아, 교사 순으로 분석되었다. 넷째, 연구방법으로는 한국의 경우 양적 연구가 빈번히 사용되었고, 미국은 문헌 연구의 빈도가 높았다. 이러한 연구결과를 토대로 우리나라 유아 스마트교육의 적용을 위한 연구방향을 제안하였다. The purpose of this study was to examine the research trends in early childhood smart education in Korea and the United States. To do this, data collection and preliminary analysis were conducted from November 2017 to January 2018, following by additional final analysis from July to September in 2018. 79 Korean and 50 US peer-reviewed journal articles published from 2011 to 2017 were selected and analyzed by the number of articles published per year, research topics, subjects, media use, and research methods. The analysis revealed that first, publication on early childhood smart education has steadily increased, with a sharp increase in Korean studies since 2012. Second, in Korea and the United States, research topics have commonly focused on teaching and learning methods in smart education. Korean studies have showed a strong interest in identifying viewpoints toward smart education and educational conditions, while US studies have relatively preferred examining topics of theory and philosophy. Third, the most frequently studied subjects were children in both countries, followed by the subject of media in Korea and the subject of teachers in the United States. Fourth, quantitative methods were frequently used in Korean studies while the method of literature review showed more popularity in the United States. Based on the results, educational implications and recommendations for further research were discussed.

Asparagus Polysaccharide and Gum with Hepatic Artery Embolization Induces Tumor Growth and Inhibits Angiogenesis in an Orthotopic Hepatocellular Carcinoma Model

Weng, Ling-Ling,Xiang, Jian-Feng,Lin, Jin-Bo,Yi, Shang-Hui,Yang, Li-Tao,Li, Yi-Sheng,Zeng, Hao-Tao,Lin, Sheng-Ming,Xin, Dong-Wei,Zhao, Hai-Liang,Qiu, Shu-Qi,Chen, Tao,Zhang, Min-Guang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.

Effect of Sorbitol on In Vitro Porcine Oocyte Maturation and Subsequent Developmental after Parthenogenetic Activation

Tao Lin,Jin-Yu Zhang,Yun-Fei Diao,Min-Gu Lee,Rong-Xun Han,Reze K. Oqani,Dong-Il Jin 한국동물번식학회 2012 Reproductive & Developmental Biology(Supplement) Vol.36 No.2s

The objective of the present study was to investigate the effects of different concentrations of sorbitol supplementation for in vitro maturation medium and in vitro culture medium, on porcine cumulus oocyte complexe(COC) maturation and subsequent developmental capacity after parthenogenetic activation. Porcine COC were cultured for 44 h(0~ 22 h termed MI stage and 22~44 h termed MII stage) in TCM199 without(- ) or with(+) sorbitol (20 μM, 100 μM, 200 μM), and the resultant metaphase II oocytes cultured in PZM-3 for 7 days following activation. Our results showed that supplementation with appropriate concentrations of sorbitol (20 μM) during full term maturation culture(MI+/MII+) significantly(p<0.05) improved blastocyst formation rates and total cell number. When the concentration of sorbitol were increased to 100 μM and 200 μM during maturation culture, the maturation rate of COC were significantly reduced compared with 20 μΜ or control groups. Also blastocyst formation rates significantly(p<0.05) reduced with increasing concentration of sorbitol(200 μM). Supplementation with sorbitol(20 μM, 50 μM, 100 μM) into PZM-3 for in vitro culture significantly(p<0.05) inhibited blastocyst formation compared with control group. However, the blastocyst formation rates start to rise again when 50 μ M sorbitol was used for the first 48 hours and then cultured in PZM-3 without sorbitol. There was no significant difference in cell number between control and sorbitol treated groups. When the activated oocytes were cultured in PZM-3 for 48h and then cultured in PZM-3 with sorbitol, interestingly, the blastocyst formation rate was similar to that of PZM-3 with sorbitol for in vitro culture and significantly lower than control group. These results suggest that addition of low concentrations of sorbitol(20 μM) during oocyte maturation is beneficial for subsequent blastocyst development and improved embryo quality. However, treatment with sorbitol supplementation during in vitro culture medium is negative effect to blastocyst formation.

Effect of Pole and Slot Combination on Noise and Vibration in Permanent Magnet Synchronous Motor

Tao Sun,Ji-Min Kim,Geun-Ho Lee,Jung-Pyo Hong,Myung-Ryul Choi IEEE 2011 IEEE transactions on magnetics Vol.47 No.5

<P>This paper investigates the effect of pole and slot combination on the vibration and noise in permanent magnet synchronous motor (PMSM). Two PMSMs that have the same performances but different pole and slot combinations are studied. A numerical analysis process for the vibration is introduced. First, by using the electromagnetic field finite element analysis (FEA) and Maxwell stress tensor method, the radial forces of these two motors are analyzed. In order to evaluate the effect of the radial force on the vibration, then the equivalent magnetizing current method is used to calculate the local force which then is employed in the mechanical FEA analysis. Finally, an experiment is processed to test the vibration and noise of these two motors, and verify the proposed analysis process. The effect of the pole and slot combination on the noise and vibration are revealed.</P>

Effect of Mechanical Alloying and Sintering Behavior on the Microstructure and Properties of NbMoTaWRe Refractory High Entropy Alloy

Tao Gu,Li‑Min Wang,Qiang Hu,Xiu‑Bing Liang,Dong‑Xing Fu,Yong‑Xiong Chen,Xin‑Ming Zhao,Yan‑Wei Sheng 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.11

An equiatomic refractory high-entropy alloy (RHEA) NbMoTaWRe is prepared by mechanical alloying (MA) and sparkplasma sintering (SPS). The effects of mechanical alloying and sintering behaviors on the microstructure and propertiesof the RHEA are investigated. After ball-milling for 30 h, the metastable and supersaturated MA powders with the bodycenteredcubic (BCC) structure are obtained. Then, the MA powders are sintered using the SPS method under the sinteringtemperature range of 1700–1900 °C, and the C atoms and WC introduced by the MA process reacts with the metastable andsupersaturated Ta/Nb phase of the MA powers to form the face-centered cubic (FCC) structure (Nb, Ta)C particles alongthe BCC matrix boundaries during the SPS process. The NbMoTaWRe alloy sintered at 1800 °C consisted of BCC matrixand FCC-type (Nb, Ta)C particles has high compactness (porosity fraction is 0.32%), fracture strength (2630 MPa), plasticstrain (6.82%), and hardness (992 ± 20 HV). These excellent properties of this RHEA are mainly attributed to the combinationof multi-effects, including sintering densification, grain refinement strengthening from the refined sizes (3.80 μm) BCCmatrix, precipitation strengthening from the (Nb, Ta)C particles, solid solution strengthening from multi-principal elementsand interstitial solid solution strengthening from C atoms dissolving into BCC matrix.

A Novel In Situ Gel Formulation of Ranitidine for Oral Sustained Delivery

( Tao Ma ),( Hao Ping Xu ),( Min Shi ),( Jin Ling Jiang ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.2

The main purpose of this study was to develop a novel, in situ gel system for sustained delivery of ranitidine hydrochloride. Ranitidinein situ gels at 0.2%, 0.5%, and 1.0% gellan gum concentration (w/v) were prepared, respectively, and characterized in termsof preparation, viscosity and in vitro release. The viscosity of the gellan gum formulations in solution increased with increasingconcentrations of gellan gum. In vitro study showed that the release of ranitidine from these gels was characterized by an initialphase of high release (burst effect) and translated to the second phase of moderate release. Single photon emission computingtomography technique was used to evaluate the stomach residence time of gel containing 99mTc tracer. The animal experimentsuggested in situ gel had feasibility of forming gels in stomach and sustained the ranitidine release from the gels over the periodof at least 8 h. In conclusion, the in situ gel system is a promising approach for the oral delivery of ranitidine for the therapeuticeffects improvement.

Faithful Quantum Secure Communication with Authentication based on Bell States and Classical XOR Resisting Collective Noise

Tao Fang,Min Li 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.9

Two faithful quantum secure communication and authentication schemes based on Bell states and classical XOR operation are proposed, which withstand collective noises. The authentication and eavesdropping detection are completed by using logical decoy photons generating by previously shared identity string. The logical decoy photons are decoherence-free states over the two collective noisy channels respectively. The transmission of secret message is a one-time pad system, which guarantees the absolute security of secret message. Encoding secret message after particle transmission ensures the accuracy of secret message.